| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 9,053,034 | 9,060,144 | +7,110 | 0.01 | 0.01 | +0.00 | buy |
| Fairmount Funds Management LLC | 4,018,101 | 4,018,101 | 0 | 7.79 | 6.06 | -1.73 | hold |
| BlackRock, Inc. | 4,007,296 | 3,982,744 | -24,552 | 0.00 | 0.00 | +0.00 | sell |
| RTW INVESTMENTS, LP | 3,621,996 | 3,621,996 | 0 | 0.77 | 0.75 | -0.02 | hold |
| TANG CAPITAL MANAGEMENT LLC | 3,200,000 | 3,200,000 | 0 | 2.42 | 2.06 | -0.36 | hold |
| VANGUARD GROUP INC | 3,066,586 | 3,050,730 | -15,856 | 0.00 | 0.00 | +0.00 | sell |
| VR Adviser, LLC | 2,685,448 | 2,685,448 | 0 | 3.01 | 2.53 | -0.48 | hold |
| BRAIDWELL LP | 2,578,404 | 2,578,404 | 0 | 1.32 | 1.28 | -0.04 | hold |
| Capital International Investors | 2,392,541 | 2,392,541 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,085,590 | 2,060,375 | -25,215 | 0.25 | 0.25 | -0.00 | sell |
| Commodore Capital LP | 1,988,084 | 1,988,084 | 0 | 2.10 | 1.63 | -0.47 | hold |
| STATE STREET CORP | 1,595,291 | 1,785,206 | +189,915 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,513,478 | 1,640,312 | +126,834 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 1,870,445 | 1,467,266 | -403,179 | 1.20 | 0.73 | -0.47 | sell |
| Affinity Asset Advisors, LLC | 606,678 | 1,419,299 | +812,621 | 1.34 | 2.21 | +0.87 | buy |
| Jefferies Financial Group Inc. | 1,388,854 | 1,388,854 | 0 | 0.34 | 0.21 | -0.13 | hold |
| PERCEPTIVE ADVISORS LLC | 1,529,445 | 1,229,445 | -300,000 | 0.86 | 0.60 | -0.26 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,227,232 | 1,225,153 | -2,079 | 0.00 | 0.00 | +0.00 | sell |
| TCG Crossover Management, LLC | 0 | 1,100,582 | +1,100,582 | 0.00 | 0.91 | +0.91 | buy |
| Pictet Asset Management Holding SA | 1,079,443 | 1,036,218 | -43,225 | 0.02 | 0.02 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 626,703 | 1,000,000 | +373,297 | 0.09 | 0.12 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 795,275 | 795,275 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Polar Capital Holdings Plc | 745,000 | 788,788 | +43,788 | 0.06 | 0.06 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 930,481 | 620,620 | -309,861 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 613,665 | 613,665 | 0 | 0.17 | 0.16 | -0.01 | hold |
| EMERALD ADVISERS, LLC | 565,863 | 548,712 | -17,151 | 0.31 | 0.29 | -0.02 | sell |
| Blackstone Inc. | 489,248 | 500,998 | +11,750 | 0.03 | 0.04 | +0.00 | buy |
| NORTHERN TRUST CORP | 436,947 | 442,036 | +5,089 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 418,503 | 425,345 | +6,842 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 408,199 | +408,199 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 246,030 | 404,362 | +158,332 | 0.02 | 0.04 | +0.01 | buy |
| UBS Group AG | 462,863 | 385,589 | -77,274 | 0.00 | 0.00 | -0.00 | sell |
| Siren, L.L.C. | 368,598 | 368,598 | 0 | 0.29 | 0.24 | -0.04 | hold |
| BANK OF AMERICA CORP /DE/ | 396,351 | 344,803 | -51,548 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 671,044 | 334,722 | -336,322 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 523,416 | 329,533 | -193,883 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 354,116 | 326,081 | -28,035 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 223,320 | 315,909 | +92,589 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 329,430 | 308,212 | -21,218 | 0.30 | 0.27 | -0.03 | sell |
| JPMORGAN CHASE & CO | 47,279 | 275,984 | +228,705 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 278,920 | 264,317 | -14,603 | 0.02 | 0.01 | -0.00 | sell |
| HighVista Strategies LLC | 112,805 | 215,746 | +102,941 | 0.62 | 0.89 | +0.27 | buy |
| Parkman Healthcare Partners LLC | 0 | 200,753 | +200,753 | 0.00 | 0.37 | +0.37 | buy |
| Capital World Investors | 350,774 | 200,172 | -150,602 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 216,646 | 168,330 | -48,316 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 172,000 | 156,000 | -16,000 | 0.10 | 0.08 | -0.02 | sell |
| Bank of New York Mellon Corp | 132,150 | 135,960 | +3,810 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 465,152 | 131,876 | -333,276 | 0.04 | 0.01 | -0.03 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 109,284 | 110,456 | +1,172 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 129,558 | 107,738 | -21,820 | 0.00 | 0.00 | -0.00 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 106,142 | 106,664 | +522 | 0.00 | 0.00 | -0.00 | buy |
| B Group, Inc. | 80,000 | 100,000 | +20,000 | 1.03 | 1.60 | +0.57 | buy |
| Nuveen, LLC | 135,068 | 96,172 | -38,896 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 96,057 | +96,057 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 84,216 | +84,216 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 81,474 | +81,474 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 113,968 | 72,368 | -41,600 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 79,896 | 71,948 | -7,948 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 73,168 | 70,914 | -2,254 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 68,600 | 70,200 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 82,977 | 68,563 | -14,414 | 0.02 | 0.02 | +0.00 | sell |
| AlphaQuest LLC | 4,174 | 66,163 | +61,989 | 0.01 | 0.07 | +0.07 | buy |
| Opaleye Management Inc. | 0 | 65,000 | +65,000 | 0.00 | 0.15 | +0.15 | buy |
| Rafferty Asset Management, LLC | 50,957 | 59,667 | +8,710 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 52,546 | 54,893 | +2,347 | 0.03 | 0.04 | +0.01 | buy |
| Invesco Ltd. | 34,680 | 50,702 | +16,022 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 65,042 | 48,496 | -16,546 | 0.01 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 34,969 | 46,841 | +11,872 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 85,702 | 39,498 | -46,204 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 34,409 | 39,319 | +4,910 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 33,938 | 38,543 | +4,605 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 36,230 | 36,230 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAR1 Capital Management, LLC | 34,051 | 34,051 | 0 | 0.08 | 0.06 | -0.03 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 35,046 | 33,546 | -1,500 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,201 | 33,203 | +2 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 29,261 | 32,896 | +3,635 | 0.00 | 0.00 | +0.00 | buy |
| DLD Asset Management, LP | 0 | 30,000 | +30,000 | 0.00 | 0.06 | +0.06 | buy |
| MetLife Investment Management, LLC | 29,918 | 29,918 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jump Financial, LLC | 0 | 27,100 | +27,100 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,812 | 26,448 | -3,364 | 0.00 | 0.00 | -0.00 | sell |
| Waverly Advisors, LLC | 19,453 | 25,953 | +6,500 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 25,799 | 25,799 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Optimize Financial Inc | 0 | 24,967 | +24,967 | 0.00 | 0.22 | +0.22 | buy |
| Assenagon Asset Management S.A. | 22,136 | 22,136 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 0 | 21,739 | +21,739 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 24,945 | 20,360 | -4,585 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 30,046 | 20,232 | -9,814 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 0 | 19,366 | +19,366 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 18,500 | +18,500 | 0.00 | 0.00 | +0.00 | buy |
| Global Endowment Management, LP | 18,184 | 18,184 | 0 | 0.04 | 0.04 | +0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 18,172 | +18,172 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 17,973 | 17,047 | -926 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,565 | 16,565 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 14,733 | +14,733 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 11,525 | 13,809 | +2,284 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 11,043 | 13,223 | +2,180 | 0.01 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 13,000 | 13,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRW Securities, LLC | 0 | 11,475 | +11,475 | 0.00 | 0.01 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,873 | 10,874 | -1,999 | 0.00 | 0.00 | -0.00 | sell |
| Arizona State Retirement System | 10,512 | 10,693 | +181 | 0.00 | 0.00 | +0.00 | buy |