| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 0 | 1,100,582 | +1,100,582 | 0.00 | 0.91 | +0.91 | buy |
| Affinity Asset Advisors, LLC | 606,678 | 1,419,299 | +812,621 | 1.34 | 2.21 | +0.87 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 408,199 | +408,199 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 626,703 | 1,000,000 | +373,297 | 0.09 | 0.12 | +0.03 | buy |
| JPMORGAN CHASE & CO | 47,279 | 275,984 | +228,705 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 200,753 | +200,753 | 0.00 | 0.37 | +0.37 | buy |
| STATE STREET CORP | 1,595,291 | 1,785,206 | +189,915 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 246,030 | 404,362 | +158,332 | 0.02 | 0.04 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,513,478 | 1,640,312 | +126,834 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 112,805 | 215,746 | +102,941 | 0.62 | 0.89 | +0.27 | buy |
| JANE STREET GROUP, LLC | 0 | 96,057 | +96,057 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 223,320 | 315,909 | +92,589 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 84,216 | +84,216 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 81,474 | +81,474 | 0.00 | 0.01 | +0.01 | buy |
| Opaleye Management Inc. | 0 | 65,000 | +65,000 | 0.00 | 0.15 | +0.15 | buy |
| AlphaQuest LLC | 4,174 | 66,163 | +61,989 | 0.01 | 0.07 | +0.07 | buy |
| Polar Capital Holdings Plc | 745,000 | 788,788 | +43,788 | 0.06 | 0.06 | +0.01 | buy |
| DLD Asset Management, LP | 0 | 30,000 | +30,000 | 0.00 | 0.06 | +0.06 | buy |
| Jump Financial, LLC | 0 | 27,100 | +27,100 | 0.00 | 0.01 | +0.01 | buy |
| Optimize Financial Inc | 0 | 24,967 | +24,967 | 0.00 | 0.22 | +0.22 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 21,739 | +21,739 | 0.00 | 0.01 | +0.01 | buy |
| B Group, Inc. | 80,000 | 100,000 | +20,000 | 1.03 | 1.60 | +0.57 | buy |
| Quadrature Capital Ltd | 0 | 19,366 | +19,366 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 18,500 | +18,500 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 18,172 | +18,172 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 34,680 | 50,702 | +16,022 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 14,733 | +14,733 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 34,969 | 46,841 | +11,872 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 489,248 | 500,998 | +11,750 | 0.03 | 0.04 | +0.00 | buy |
| DRW Securities, LLC | 0 | 11,475 | +11,475 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 50,957 | 59,667 | +8,710 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 7,883 | +7,883 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 9,053,034 | 9,060,144 | +7,110 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 418,503 | 425,345 | +6,842 | 0.00 | 0.00 | +0.00 | buy |
| Waverly Advisors, LLC | 19,453 | 25,953 | +6,500 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 436,947 | 442,036 | +5,089 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 34,409 | 39,319 | +4,910 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 33,938 | 38,543 | +4,605 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 142 | 4,234 | +4,092 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 132,150 | 135,960 | +3,810 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 29,261 | 32,896 | +3,635 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 52,546 | 54,893 | +2,347 | 0.03 | 0.04 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 11,525 | 13,809 | +2,284 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 11,043 | 13,223 | +2,180 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 68,600 | 70,200 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 109,284 | 110,456 | +1,172 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 5,310 | 6,425 | +1,115 | 0.03 | 0.03 | +0.00 | buy |
| Sterling Capital Management LLC | 524 | 1,214 | +690 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 106,142 | 106,664 | +522 | 0.00 | 0.00 | -0.00 | buy |
| Optiver Holding B.V. | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 401 | +401 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,712 | 1,960 | +248 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 10,512 | 10,693 | +181 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 546 | 705 | +159 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 121 | +121 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 11 | 123 | +112 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 170 | 216 | +46 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 174 | 208 | +34 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 6 | 12 | +6 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,331 | 2,335 | +4 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,201 | 33,203 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 30 | 32 | +2 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 23 | 24 | +1 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 613,665 | 613,665 | 0 | 0.17 | 0.16 | -0.01 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 36,230 | 36,230 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 3,200,000 | 3,200,000 | 0 | 2.42 | 2.06 | -0.36 | hold |
| JANUS HENDERSON GROUP PLC | 13,000 | 13,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parkside Financial Bank & Trust | 35 | 35 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 206 | 206 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 3,621,996 | 3,621,996 | 0 | 0.77 | 0.75 | -0.02 | hold |
| Global Endowment Management, LP | 18,184 | 18,184 | 0 | 0.04 | 0.04 | +0.00 | hold |
| MetLife Investment Management, LLC | 29,918 | 29,918 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Assenagon Asset Management S.A. | 22,136 | 22,136 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Capital International Investors | 2,392,541 | 2,392,541 | 0 | 0.01 | 0.01 | +0.00 | hold |
| VR Adviser, LLC | 2,685,448 | 2,685,448 | 0 | 3.01 | 2.53 | -0.48 | hold |
| EverSource Wealth Advisors, LLC | 65 | 65 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KLP KAPITALFORVALTNING AS | 7,800 | 7,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fairmount Funds Management LLC | 4,018,101 | 4,018,101 | 0 | 7.79 | 6.06 | -1.73 | hold |
| Commodore Capital LP | 1,988,084 | 1,988,084 | 0 | 2.10 | 1.63 | -0.47 | hold |
| Covestor Ltd | 6 | 6 | 0 | 0.00 | 0.00 | 0.00 | hold |
| BRAIDWELL LP | 2,578,404 | 2,578,404 | 0 | 1.32 | 1.28 | -0.04 | hold |
| ADAR1 Capital Management, LLC | 34,051 | 34,051 | 0 | 0.08 | 0.06 | -0.03 | hold |
| Siren, L.L.C. | 368,598 | 368,598 | 0 | 0.29 | 0.24 | -0.04 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 1,589 | 1,589 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 10 | 10 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 795,275 | 795,275 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HUNTINGTON NATIONAL BANK | 1,470 | 1,470 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 25,799 | 25,799 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,565 | 16,565 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,379 | 1,379 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 1,388,854 | 1,388,854 | 0 | 0.34 | 0.21 | -0.13 | hold |
| BNP Paribas Asset Management Holding S.A. | 377 | 335 | -42 | 0.00 | 0.00 | +0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 140 | 80 | -60 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 165 | 70 | -95 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 102 | 0 | -102 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 145 | 0 | -145 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,502 | 1,299 | -203 | 0.00 | 0.00 | -0.00 | sell |