SPYRE THERAPEUTICS INC
| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| Affinity Asset Advisors, LLC | 606,678 | 1,419,299 | +812,621 | 1.34 | 2.21 | +0.87 | buy |
| BAKER BROS. ADVISORS LP | 626,703 | 1,000,000 | +373,297 | 0.09 | 0.12 | +0.03 | buy |
| Candriam S.C.A. | 246,030 | 404,362 | +158,332 | 0.02 | 0.04 | +0.01 | buy |
| HighVista Strategies LLC | 112,805 | 215,746 | +102,941 | 0.62 | 0.89 | +0.27 | buy |
| Polar Capital Holdings Plc | 745,000 | 788,788 | +43,788 | 0.06 | 0.06 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 129,558 | 107,738 | +21,820 | 0.00 | 0.00 | -0.00 | sell |
| B Group, Inc. | 80,000 | 100,000 | +20,000 | 1.03 | 1.60 | +0.57 | buy |
| ExodusPoint Capital Management, LP | 82,977 | 68,563 | +14,414 | 0.02 | 0.02 | 0.00 | sell |
| Rafferty Asset Management, LLC | 50,957 | 59,667 | +8,710 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 52,546 | 54,893 | +2,347 | 0.03 | 0.04 | +0.01 | buy |
| PROFUND ADVISORS LLC | 11,043 | 13,223 | +2,180 | 0.01 | 0.01 | 0.00 | buy |
| Virtus Investment Advisers, LLC | 5,310 | 6,425 | +1,115 | 0.03 | 0.03 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 170 | 216 | +46 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,502 | 1,299 | -203 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 12,122 | 10,587 | -1,535 | 0.02 | 0.01 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 172,000 | 156,000 | -16,000 | 0.10 | 0.08 | -0.02 | sell |
| EMERALD ADVISERS, LLC | 565,863 | 548,712 | -17,151 | 0.31 | 0.29 | -0.02 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 329,430 | 308,212 | -21,218 | 0.30 | 0.27 | -0.03 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,085,590 | 2,060,375 | -25,215 | 0.25 | 0.25 | -0.00 | sell |
| Capital World Investors | 350,774 | 200,172 | -150,602 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 1,529,445 | 1,229,445 | -300,000 | 0.86 | 0.60 | -0.26 | sell |
| Woodline Partners LP | 465,152 | 131,876 | -333,276 | 0.04 | 0.01 | -0.03 | sell |
| Paradigm Biocapital Advisors LP | 1,870,445 | 1,467,266 | -403,179 | 1.20 | 0.73 | -0.47 | sell |