| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 0 | 3,785,877 | +3,785,877 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 81,116 | 2,606,679 | +2,525,563 | 0.03 | 1.25 | +1.22 | buy |
| VR Adviser, LLC | 0 | 2,372,714 | +2,372,714 | 0.00 | 3.50 | +3.50 | buy |
| RTW INVESTMENTS, LP | 0 | 2,232,760 | +2,232,760 | 0.00 | 0.75 | +0.75 | buy |
| Deep Track Capital, LP | 0 | 1,952,760 | +1,952,760 | 0.00 | 1.47 | +1.47 | buy |
| Avoro Capital Advisors LLC | 11,458 | 1,839,138 | +1,827,680 | 0.00 | 0.55 | +0.54 | buy |
| Commodore Capital LP | 116,324 | 1,884,084 | +1,767,760 | 0.17 | 3.54 | +3.38 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.04 | +0.04 | buy |
| Cormorant Asset Management, LP | 0 | 937,080 | +937,080 | 0.00 | 0.97 | +0.97 | buy |
| FRANKLIN RESOURCES INC | 0 | 687,090 | +687,090 | 0.00 | 0.01 | +0.01 | buy |
| BVF INC/IL | 0 | 687,080 | +687,080 | 0.00 | 0.37 | +0.37 | buy |
| EcoR1 Capital, LLC | 199,996 | 887,076 | +687,080 | 0.08 | 0.50 | +0.41 | buy |
| HighVista Strategies LLC | 0 | 577,616 | +577,616 | 0.00 | 4.51 | +4.51 | buy |
| BRAIDWELL LP | 0 | 515,000 | +515,000 | 0.00 | 0.41 | +0.41 | buy |
| Global Endowment Management, LP | 0 | 513,436 | +513,436 | 0.00 | 1.23 | +1.23 | buy |
| CITADEL ADVISORS LLC | 97,053 | 576,711 | +479,658 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 299,929 | 635,455 | +335,526 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 242,297 | 517,554 | +275,257 | 0.97 | 2.22 | +1.25 | buy |
| Polar Capital Holdings Plc | 300,000 | 500,000 | +200,000 | 0.03 | 0.07 | +0.04 | buy |
| GREAT POINT PARTNERS LLC | 0 | 125,000 | +125,000 | 0.00 | 0.46 | +0.46 | buy |
| MILLENNIUM MANAGEMENT LLC | 37,813 | 108,486 | +70,673 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 0 | 55,000 | +55,000 | 0.00 | 0.48 | +0.48 | buy |
| BARCLAYS PLC | 0 | 45,498 | +45,498 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 28,095 | +28,095 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 26,210 | +26,210 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 26,150 | +26,150 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 23,229 | 48,536 | +25,307 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 20,252 | +20,252 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 19,991 | +19,991 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 10,297 | +10,297 | 0.00 | 0.00 | +0.00 | buy |
| Carlyle Group Inc. | 0 | 9,620 | +9,620 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 33,077 | 39,446 | +6,369 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 6,239 | +6,239 | 0.00 | 0.09 | +0.09 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 26,800 | 30,326 | +3,526 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 422 | 2,580 | +2,158 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 365 | +365 | 0.00 | 0.00 | +0.00 | buy |
| Pacific Capital Wealth Advisors, Inc. | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 162,395 | 162,395 | 0 | 0.11 | 0.16 | +0.05 | hold |
| IFP Advisors, Inc | 114 | 114 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fairmount Funds Management LLC | 378,421 | 378,421 | 0 | 0.56 | 0.86 | +0.30 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 11,888 | 1,169 | -10,719 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 800,853 | 771,902 | -28,951 | 0.13 | 0.20 | +0.07 | sell |
| Logos Global Management LP | 210,000 | 150,000 | -60,000 | 0.37 | 0.36 | -0.01 | sell |
| Aisling Capital Management LP | 67,645 | 0 | -67,645 | 0.34 | 0.00 | -0.34 | sell |
| Rock Springs Capital Management LP | 136,556 | 0 | -136,556 | 0.04 | 0.00 | -0.04 | sell |