| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 687,080 | 2,803,655 | +2,116,575 | 0.17 | 0.54 | +0.37 | buy |
| BRAIDWELL LP | 2,189,836 | 2,578,404 | +388,568 | 1.83 | 1.78 | -0.05 | buy |
| RTW INVESTMENTS, LP | 3,258,360 | 3,621,996 | +363,636 | 1.39 | 1.28 | -0.11 | buy |
| JANUS HENDERSON GROUP PLC | 1,120,531 | 1,456,740 | +336,209 | 0.02 | 0.02 | 0.00 | buy |
| Affinity Asset Advisors, LLC | 498,420 | 824,328 | +325,908 | 2.00 | 2.57 | +0.57 | buy |
| Logos Global Management LP | 200,000 | 500,000 | +300,000 | 0.63 | 1.36 | +0.73 | buy |
| Paradigm Biocapital Advisors LP | 1,267,581 | 1,527,205 | +259,624 | 1.30 | 1.24 | -0.07 | buy |
| EMERALD ADVISERS, LLC | 292,569 | 546,791 | +254,222 | 0.33 | 0.49 | +0.16 | buy |
| Polar Capital Holdings Plc | 500,000 | 750,000 | +250,000 | 0.07 | 0.10 | +0.03 | buy |
| Blackstone Inc. | 292,995 | 449,201 | +156,206 | 0.04 | 0.05 | +0.01 | buy |
| Candriam S.C.A. | 105,000 | 247,591 | +142,591 | 0.01 | 0.03 | +0.02 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 253,550 | 386,384 | +132,834 | 0.39 | 0.55 | +0.16 | buy |
| SOROS FUND MANAGEMENT LLC | 145,000 | 250,000 | +105,000 | 0.06 | 0.09 | +0.03 | buy |
| Woodline Partners LP | 264,256 | 352,680 | +88,424 | 0.07 | 0.06 | -0.01 | buy |
| ARMISTICE CAPITAL, LLC | 136,000 | 200,000 | +64,000 | 0.06 | 0.06 | -0.00 | buy |
| EFG Asset Management (North America) Corp. | 52,210 | 82,818 | +30,608 | 0.26 | 0.26 | +0.01 | buy |
| Rafferty Asset Management, LLC | 70,586 | 76,740 | +6,154 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 14,075 | 14,862 | +787 | 0.02 | 0.01 | 0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,848 | 2,972 | +124 | 0.04 | 0.03 | -0.01 | buy |
| NBW CAPITAL LLC | 26,930 | 19,430 | -7,500 | 0.15 | 0.08 | -0.07 | sell |
| HighVista Strategies LLC | 105,351 | 95,159 | -10,192 | 1.07 | 0.82 | -0.24 | sell |
| Ikarian Capital, LLC | 302,247 | 282,159 | -20,088 | 1.24 | 0.89 | -0.35 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,055,000 | 1,030,000 | -25,000 | 0.05 | 0.04 | -0.01 | sell |
| Cinctive Capital Management LP | 61,256 | 19,567 | -41,689 | 0.10 | 0.02 | -0.08 | sell |
| PERCEPTIVE ADVISORS LLC | 2,872,547 | 2,574,723 | -297,824 | 1.79 | 1.65 | -0.14 | sell |
| Deep Track Capital, LP | 1,000,000 | 219,015 | -780,985 | 0.94 | 0.19 | -0.75 | sell |