| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 687,080 | 2,803,655 | +2,116,575 | 0.17 | 0.54 | +0.37 | buy |
| FMR LLC | 7,623,881 | 8,801,266 | +1,177,385 | 0.01 | 0.01 | -0.00 | buy |
| Jefferies Financial Group Inc. | 454,807 | 1,216,954 | +762,147 | 0.22 | 0.32 | +0.10 | buy |
| BlackRock, Inc. | 2,663,147 | 3,399,591 | +736,444 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 169,314 | 747,552 | +578,238 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 450,000 | +450,000 | 0.00 | 0.20 | +0.20 | buy |
| BRAIDWELL LP | 2,189,836 | 2,578,404 | +388,568 | 1.83 | 1.78 | -0.05 | buy |
| Capital World Investors | 0 | 378,573 | +378,573 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 0 | 374,000 | +374,000 | 0.00 | 0.38 | +0.38 | buy |
| CITADEL ADVISORS LLC | 707,586 | 1,079,307 | +371,721 | 0.02 | 0.02 | +0.00 | buy |
| RTW INVESTMENTS, LP | 3,258,360 | 3,621,996 | +363,636 | 1.39 | 1.28 | -0.11 | buy |
| JANUS HENDERSON GROUP PLC | 1,120,531 | 1,456,740 | +336,209 | 0.02 | 0.02 | +0.00 | buy |
| UBS Group AG | 57,838 | 392,197 | +334,359 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,515,920 | 2,846,473 | +330,553 | 0.00 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 498,420 | 824,328 | +325,908 | 2.27 | 3.00 | +0.72 | buy |
| Logos Global Management LP | 200,000 | 500,000 | +300,000 | 0.66 | 1.36 | +0.70 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 268,076 | +268,076 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 825,706 | 1,092,124 | +266,418 | 0.03 | 0.03 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 1,267,581 | 1,527,205 | +259,624 | 1.30 | 1.24 | -0.07 | buy |
| EMERALD ADVISERS, LLC | 292,569 | 546,791 | +254,222 | 0.33 | 0.49 | +0.16 | buy |
| Polar Capital Holdings Plc | 500,000 | 750,000 | +250,000 | 0.07 | 0.10 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 167,804 | +167,804 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 292,995 | 449,201 | +156,206 | 0.04 | 0.05 | +0.01 | buy |
| Candriam S.C.A. | 105,000 | 247,591 | +142,591 | 0.02 | 0.03 | +0.02 | buy |
| STATE STREET CORP | 1,541,555 | 1,680,936 | +139,381 | 0.00 | 0.00 | -0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 253,550 | 386,384 | +132,834 | 0.39 | 0.55 | +0.16 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 113,620 | +113,620 | 0.00 | 0.00 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 145,000 | 250,000 | +105,000 | 0.09 | 0.10 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,507,200 | 1,604,508 | +97,308 | 0.01 | 0.01 | -0.00 | buy |
| Woodline Partners LP | 264,256 | 352,680 | +88,424 | 0.07 | 0.06 | -0.01 | buy |
| Prosight Management, LP | 0 | 80,000 | +80,000 | 0.00 | 0.52 | +0.52 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 429,127 | 506,450 | +77,323 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 891,048 | 966,129 | +75,081 | 0.00 | 0.00 | -0.00 | buy |
| ARMISTICE CAPITAL, LLC | 136,000 | 200,000 | +64,000 | 0.10 | 0.11 | +0.00 | buy |
| F/m Investments LLC | 0 | 48,806 | +48,806 | 0.00 | 0.04 | +0.04 | buy |
| CITIGROUP INC | 25,191 | 73,752 | +48,561 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 333,275 | 379,650 | +46,375 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 314,290 | 348,983 | +34,693 | 0.00 | 0.00 | -0.00 | buy |
| EFG Asset Management (North America) Corp. | 52,210 | 82,818 | +30,608 | 0.26 | 0.26 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 0 | 23,550 | +23,550 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 26,441 | 48,981 | +22,540 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 49,600 | 68,600 | +19,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 18,784 | +18,784 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 105,467 | 123,071 | +17,604 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 0 | 17,300 | +17,300 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 16,899 | +16,899 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 18,315 | 31,484 | +13,169 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 12,531 | +12,531 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 12,440 | +12,440 | 0.00 | 0.03 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 52,768 | 64,968 | +12,200 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 11,767 | +11,767 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 243,742 | 255,256 | +11,514 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 10,383 | +10,383 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 21,508 | 31,418 | +9,910 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13,198 | 23,089 | +9,891 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 43,460 | 52,762 | +9,302 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 29,155 | 37,490 | +8,335 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 520 | 8,574 | +8,054 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 24,675 | 32,598 | +7,923 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 9,733 | 16,691 | +6,958 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 17,810 | 24,718 | +6,908 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 8,477 | 15,231 | +6,754 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 70,586 | 76,740 | +6,154 | 0.01 | 0.01 | -0.00 | buy |
| JPMORGAN CHASE & CO | 29,473 | 35,248 | +5,775 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 8,371 | 14,043 | +5,672 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 21,154 | 25,799 | +4,645 | 0.01 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 53,935 | 57,657 | +3,722 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 7,310 | 10,115 | +2,805 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,955 | +1,955 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 0 | 1,470 | +1,470 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 20,132 | 21,382 | +1,250 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,825 | 22,741 | +916 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 115 | 1,009 | +894 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 14,075 | 14,862 | +787 | 0.02 | 0.01 | -0.00 | buy |
| ROYAL BANK OF CANADA | 3,786 | 4,022 | +236 | 0.00 | 0.00 | -0.00 | buy |
| Venturi Wealth Management, LLC | 0 | 231 | +231 | 0.00 | 0.00 | +0.00 | buy |
| Sugar Maple Asset Management, LLC | 0 | 180 | +180 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,848 | 2,972 | +124 | 0.04 | 0.03 | -0.01 | buy |
| Brooklyn Investment Group | 0 | 120 | +120 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 68 | +68 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 111 | 120 | +9 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 7 | 9 | +2 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 3 | 4 | +1 | 0.00 | 0.00 | 0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,392 | 3,392 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 36,230 | 36,230 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 82,475 | 82,475 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Global Endowment Management, LP | 18,184 | 18,184 | 0 | 0.05 | 0.05 | +0.00 | hold |
| Carlyle Group Inc. | 9,620 | 9,620 | 0 | 0.03 | 0.01 | -0.02 | hold |
| VR Adviser, LLC | 2,685,448 | 2,685,448 | 0 | 4.14 | 4.29 | +0.15 | hold |
| Fairmount Funds Management LLC | 4,018,101 | 4,018,101 | 0 | 9.58 | 9.30 | -0.28 | hold |
| Pacific Capital Wealth Advisors, Inc. | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Commodore Capital LP | 1,988,084 | 1,988,084 | 0 | 3.65 | 3.39 | -0.26 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 1,589 | 1,589 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,265 | 10,265 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 40 | 40 | 0 | 0.00 | 0.00 | -0.00 | hold |