| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 1,229,445 | 3,069,225 | +1,839,780 | 0.60 | 1.79 | +1.20 | buy |
| Capital International Investors | 2,392,541 | 3,492,541 | +1,100,000 | 0.01 | 0.02 | +0.01 | buy |
| VR Adviser, LLC | 2,685,448 | 3,685,448 | +1,000,000 | 2.53 | 5.96 | +3.43 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,060,375 | 2,882,420 | +822,045 | 0.25 | 0.64 | +0.39 | buy |
| TCG Crossover Management, LLC | 1,100,582 | 1,900,582 | +800,000 | 0.91 | 2.06 | +1.15 | buy |
| RTW INVESTMENTS, LP | 3,621,996 | 4,171,996 | +550,000 | 0.75 | 1.37 | +0.62 | buy |
| Siren, L.L.C. | 368,598 | 818,598 | +450,000 | 0.24 | 0.80 | +0.56 | buy |
| Commodore Capital LP | 1,988,084 | 2,388,245 | +400,161 | 1.63 | 5.21 | +3.58 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 308,212 | 412,371 | +104,159 | 0.27 | 0.66 | +0.39 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 613,665 | 710,626 | +96,961 | 0.16 | 0.30 | +0.14 | buy |
| EMERALD ADVISERS, LLC | 548,712 | 636,109 | +87,397 | 0.29 | 0.64 | +0.35 | buy |
| F/m Investments LLC | 54,893 | 103,718 | +48,825 | 0.04 | 0.13 | +0.09 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 107,738 | 61,574 | +46,164 | 0.00 | 0.00 | +0.00 | sell |
| ARMISTICE CAPITAL, LLC | 156,000 | 196,426 | +40,426 | 0.04 | 0.08 | +0.04 | buy |
| Susquehanna Portfolio Strategies, LLC | 21,739 | 53,101 | +31,362 | 0.01 | 0.03 | +0.02 | buy |
| Candriam S.C.A. | 404,362 | 425,534 | +21,172 | 0.04 | 0.07 | +0.03 | buy |
| Affinity Asset Advisors, LLC | 1,419,299 | 1,432,591 | +13,292 | 2.21 | 3.37 | +1.16 | buy |
| PROFUND ADVISORS LLC | 13,223 | 20,593 | +7,370 | 0.01 | 0.02 | 0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 18,500 | 24,950 | +6,450 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,587 | 12,644 | +2,057 | 0.01 | 0.03 | +0.02 | buy |
| Virtus Investment Advisers, LLC | 6,425 | 7,913 | +1,488 | 0.03 | 0.07 | +0.04 | buy |
| Optimize Financial Inc | 24,967 | 25,331 | +364 | 0.22 | 0.42 | +0.20 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,299 | 1,523 | +224 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 216 | 181 | -35 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 59,667 | 53,410 | -6,257 | 0.00 | 0.01 | +0.00 | sell |
| HighVista Strategies LLC | 215,746 | 188,206 | -27,540 | 0.89 | 1.59 | +0.70 | sell |
| Polar Capital Holdings Plc | 788,788 | 740,326 | -48,462 | 0.06 | 0.11 | +0.05 | sell |
| Parkman Healthcare Partners LLC | 200,753 | 124,485 | -76,268 | 0.37 | 0.39 | +0.02 | sell |
| BRAIDWELL LP | 2,578,404 | 1,634,615 | -943,789 | 1.28 | 1.71 | +0.43 | sell |
| TANG CAPITAL MANAGEMENT LLC | 3,200,000 | 1,892,200 | -1,307,800 | 2.06 | 3.06 | +1.00 | sell |