| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 9,060,144 | 11,638,819 | +2,578,675 | 0.01 | 0.02 | +0.01 | buy |
| BlackRock, Inc. | 3,982,744 | 5,522,101 | +1,539,357 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 3,621,996 | 4,171,996 | +550,000 | 0.75 | 1.37 | +0.62 | buy |
| VANGUARD GROUP INC | 3,050,730 | 4,035,074 | +984,344 | 0.00 | 0.00 | +0.00 | buy |
| Fairmount Funds Management LLC | 4,018,101 | 4,018,101 | 0 | 6.06 | 10.02 | +3.96 | hold |
| VR Adviser, LLC | 2,685,448 | 3,685,448 | +1,000,000 | 2.53 | 5.96 | +3.43 | buy |
| Capital International Investors | 2,392,541 | 3,492,541 | +1,100,000 | 0.01 | 0.02 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 1,229,445 | 3,069,225 | +1,839,780 | 0.60 | 1.84 | +1.25 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,060,375 | 2,882,420 | +822,045 | 0.25 | 0.64 | +0.39 | buy |
| Commodore Capital LP | 1,988,084 | 2,388,245 | +400,161 | 1.63 | 5.21 | +3.58 | buy |
| STATE STREET CORP | 1,785,206 | 2,262,839 | +477,633 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 1,100,582 | 1,900,582 | +800,000 | 0.91 | 2.06 | +1.15 | buy |
| TANG CAPITAL MANAGEMENT LLC | 3,200,000 | 1,892,200 | -1,307,800 | 2.06 | 3.06 | +1.00 | sell |
| JANUS HENDERSON GROUP PLC | 13,000 | 1,829,009 | +1,816,009 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,225,153 | 1,659,140 | +433,987 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 2,578,404 | 1,634,615 | -943,789 | 1.28 | 1.71 | +0.43 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,621,620 | +1,621,620 | 0.00 | 0.54 | +0.54 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 620,620 | 1,601,882 | +981,262 | 0.00 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,640,312 | 1,549,284 | -91,028 | 0.00 | 0.01 | +0.00 | sell |
| Paradigm Biocapital Advisors LP | 1,467,266 | 1,467,266 | 0 | 0.73 | 1.29 | +0.56 | hold |
| Affinity Asset Advisors, LLC | 1,419,299 | 1,432,591 | +13,292 | 2.21 | 3.37 | +1.16 | buy |
| FRANKLIN RESOURCES INC | 795,275 | 1,109,274 | +313,999 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 1,000,000 | 1,000,000 | 0 | 0.12 | 0.19 | +0.07 | hold |
| Pictet Asset Management Holding SA | 1,036,218 | 913,960 | -122,258 | 0.02 | 0.03 | +0.01 | sell |
| Siren, L.L.C. | 368,598 | 818,598 | +450,000 | 0.24 | 0.80 | +0.56 | buy |
| Polar Capital Holdings Plc | 788,788 | 740,326 | -48,462 | 0.06 | 0.11 | +0.05 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 613,665 | 710,626 | +96,961 | 0.16 | 0.30 | +0.14 | buy |
| UBS Group AG | 385,589 | 680,566 | +294,977 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 662,351 | +662,351 | 0.00 | 0.03 | +0.03 | buy |
| EMERALD ADVISERS, LLC | 548,712 | 636,109 | +87,397 | 0.29 | 0.64 | +0.35 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 425,345 | 574,622 | +149,277 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 442,036 | 561,023 | +118,987 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 500,998 | 500,998 | 0 | 0.04 | 0.07 | +0.04 | hold |
| Candriam S.C.A. | 404,362 | 425,534 | +21,172 | 0.04 | 0.07 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 344,803 | 419,727 | +74,924 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 308,212 | 412,371 | +104,159 | 0.27 | 0.66 | +0.39 | buy |
| GOLDMAN SACHS GROUP INC | 329,533 | 275,065 | -54,468 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 131,876 | 265,892 | +134,016 | 0.01 | 0.03 | +0.02 | buy |
| Capital World Investors | 200,172 | 200,172 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ARMISTICE CAPITAL, LLC | 156,000 | 196,426 | +40,426 | 0.08 | 0.16 | +0.08 | buy |
| Bank of New York Mellon Corp | 135,960 | 192,830 | +56,870 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 215,746 | 188,206 | -27,540 | 0.89 | 1.59 | +0.70 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 187,737 | +187,737 | 0.00 | 0.89 | +0.89 | buy |
| MORGAN STANLEY | 334,722 | 182,734 | -151,988 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 168,330 | 182,524 | +14,194 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 110,456 | 171,211 | +60,755 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 96,172 | 150,980 | +54,808 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 50,702 | 150,934 | +100,232 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 0 | 150,000 | +150,000 | 0.00 | 1.05 | +1.05 | buy |
| TD ASSET MANAGEMENT INC | 72,368 | 149,822 | +77,454 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 326,081 | 146,079 | -180,002 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 71,948 | 129,013 | +57,065 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 200,753 | 124,485 | -76,268 | 0.37 | 0.39 | +0.02 | sell |
| DEUTSCHE BANK AG\ | 38,543 | 121,941 | +83,398 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 106,664 | 106,316 | -348 | 0.00 | 0.01 | +0.00 | sell |
| F/m Investments LLC | 54,893 | 103,718 | +48,825 | 0.04 | 0.13 | +0.09 | buy |
| CITIGROUP INC | 32,896 | 100,058 | +67,162 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.25 | +0.25 | buy |
| B Group, Inc. | 100,000 | 100,000 | 0 | 1.60 | 2.43 | +0.82 | hold |
| Swiss National Bank | 70,200 | 96,500 | +26,300 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 70,914 | 82,956 | +12,042 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 39,319 | 82,416 | +43,097 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 84,216 | 77,290 | -6,926 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 408,199 | 76,194 | -332,005 | 0.01 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 73,465 | +73,465 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 36,230 | 67,500 | +31,270 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 63,904 | +63,904 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 63,708 | +63,708 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 275,984 | 62,951 | -213,033 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 39,498 | 62,216 | +22,718 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 107,738 | 61,574 | -46,164 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 46,841 | 56,448 | +9,607 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 59,667 | 53,410 | -6,257 | 0.00 | 0.01 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 21,739 | 53,101 | +31,362 | 0.01 | 0.03 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,203 | 48,038 | +14,835 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 38,256 | +38,256 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 29,918 | 38,011 | +8,093 | 0.00 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 68,563 | 37,871 | -30,692 | 0.02 | 0.01 | -0.00 | sell |
| Cinctive Capital Management LP | 0 | 35,935 | +35,935 | 0.00 | 0.07 | +0.07 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 26,448 | 35,144 | +8,696 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 34,051 | 34,051 | 0 | 0.06 | 0.08 | +0.03 | hold |
| STEMPOINT CAPITAL LP | 0 | 32,377 | +32,377 | 0.00 | 0.18 | +0.18 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 27,277 | +27,277 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 33,546 | 27,252 | -6,294 | 0.00 | 0.00 | +0.00 | sell |
| Waverly Advisors, LLC | 25,953 | 25,954 | +1 | 0.00 | 0.01 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 25,799 | 25,799 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Optimize Financial Inc | 24,967 | 25,331 | +364 | 0.22 | 0.42 | +0.20 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 18,500 | 24,950 | +6,450 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 23,343 | +23,343 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 22,136 | 22,136 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PROFUND ADVISORS LLC | 13,223 | 20,593 | +7,370 | 0.01 | 0.02 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,565 | 19,165 | +2,600 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 13,809 | 18,360 | +4,551 | 0.00 | 0.01 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 20,360 | 18,274 | -2,086 | 0.00 | 0.01 | +0.00 | sell |
| Neo Ivy Capital Management | 0 | 18,261 | +18,261 | 0.00 | 0.09 | +0.09 | buy |
| Global Endowment Management, LP | 18,184 | 18,184 | 0 | 0.04 | 0.07 | +0.04 | hold |
| AQR CAPITAL MANAGEMENT LLC | 17,047 | 17,820 | +773 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 16,698 | +16,698 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 10,678 | 15,989 | +5,311 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 10,693 | 13,797 | +3,104 | 0.00 | 0.00 | +0.00 | buy |