| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Prosight Management, LP | 0 | 983,200 | +983,200 | 0.00 | 0.83 | +0.83 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 222,893 | +222,893 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 147,339 | +147,339 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 145,965 | +145,965 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 144,500 | 259,500 | +115,000 | 0.01 | 0.02 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 51,200 | 156,800 | +105,600 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 243,295 | 342,169 | +98,874 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 11,381 | 68,343 | +56,962 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 40,669 | +40,669 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 78,479 | 114,265 | +35,786 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,120,347 | 1,155,647 | +35,300 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,232,923 | 1,260,079 | +27,156 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 25,555 | +25,555 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 4,383 | 24,135 | +19,752 | 0.00 | 0.00 | +0.00 | buy |
| FFT WEALTH MANAGEMENT LLC | 395,774 | 414,022 | +18,248 | 0.11 | 0.11 | -0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 14,086 | +14,086 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 18,406 | 32,162 | +13,756 | 0.00 | 0.00 | +0.00 | buy |
| Empowered Funds, LLC | 118,445 | 128,070 | +9,625 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,178 | 13,579 | +5,401 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 13,246 | 16,446 | +3,200 | 0.02 | 0.01 | -0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 14,251 | 17,396 | +3,145 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 81,175 | 84,233 | +3,058 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 79,666 | 82,584 | +2,918 | 0.00 | 0.00 | -0.00 | buy |
| BLAIR WILLIAM & CO/IL | 21,676 | 23,939 | +2,263 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 71,933 | 73,422 | +1,489 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 10,026 | 11,452 | +1,426 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 14,385 | 15,666 | +1,281 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,233 | +1,233 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,850 | 25,980 | +1,130 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 22,884 | 23,981 | +1,097 | 0.00 | 0.00 | -0.00 | buy |
| DCF Advisers, LLC | 18,730 | 19,730 | +1,000 | 0.04 | 0.04 | -0.00 | buy |
| FMR LLC | 85,225 | 86,207 | +982 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 54 | +54 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Financial Advisors, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Sound Income Strategies, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 5 | +5 | 0.00 | 0.00 | 0.00 | buy |
| Artal Group S.A. | 2,500,000 | 2,500,000 | 0 | 0.27 | 0.20 | -0.08 | hold |
| Ameritas Investment Partners, Inc. | 4,924 | 4,924 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TAKEDA PHARMACEUTICAL CO LTD | 7,531,996 | 7,531,996 | 0 | 7.41 | 7.95 | +0.54 | hold |
| EcoR1 Capital, LLC | 6,117,400 | 6,117,400 | 0 | 0.51 | 0.47 | -0.04 | hold |
| Rubric Capital Management LP | 5,315,969 | 5,315,969 | 0 | 0.64 | 0.48 | -0.16 | hold |
| TLS Advisors LLC | 1,319,679 | 1,319,679 | 0 | 14.10 | 9.37 | -4.73 | hold |
| Madison Avenue Partners, LP | 3,648,509 | 3,648,509 | 0 | 1.66 | 1.80 | +0.14 | hold |
| Blue Owl Capital Holdings LP | 864,822 | 864,822 | 0 | 0.67 | 0.53 | -0.14 | hold |
| Tejara Capital Ltd | 73,153 | 73,153 | 0 | 0.10 | 0.08 | -0.02 | hold |
| FIRST MANHATTAN CO. LLC. | 26,000 | 26,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAILARD, INC. | 12,600 | 12,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 5,201 | 5,201 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 62,341 | 62,341 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161,808 | 161,808 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 1,655,871 | 1,655,871 | 0 | 0.02 | 0.02 | -0.00 | hold |
| BANK OF NOVA SCOTIA | 44,152 | 44,152 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 29,639 | 29,386 | -253 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,982 | 18,675 | -307 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 29,885 | 29,554 | -331 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 3,287 | 977 | -2,310 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 61,795 | 58,984 | -2,811 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 5,202 | 2,011 | -3,191 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,815 | 5,995 | -3,820 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 39,792 | 35,938 | -3,854 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 26,797 | 22,819 | -3,978 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 78,267 | 71,264 | -7,003 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 490,672 | 480,867 | -9,805 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 2,989,777 | 2,976,308 | -13,469 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 448,591 | 433,872 | -14,719 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 31,717 | 16,796 | -14,921 | 0.00 | 0.00 | -0.00 | sell |
| Newman Dignan & Sheerar, Inc. | 16,522 | 0 | -16,522 | 0.02 | 0.00 | -0.02 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 17,230 | 0 | -17,230 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 248,809 | 229,553 | -19,256 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 24,264 | 0 | -24,264 | 0.01 | 0.00 | -0.01 | sell |
| Mirae Asset Global Investments Co., Ltd. | 33,996 | 0 | -33,996 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 82,060 | 42,136 | -39,924 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 1,631,742 | 1,578,061 | -53,681 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 439,345 | 357,870 | -81,475 | 0.03 | 0.02 | -0.01 | sell |
| Vestal Point Capital, LP | 85,429 | 0 | -85,429 | 0.03 | 0.00 | -0.03 | sell |
| BVF INC/IL | 6,851,051 | 3,853,818 | -2,997,233 | 0.55 | 0.32 | -0.23 | sell |