| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Sio Capital Management, LLC | 1,000,000 | 2,232,000 | +1,232,000 | 0.26 | 0.21 | -0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 107,700 | 1,023,800 | +916,100 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 667,516 | +667,516 | 0.00 | 0.03 | +0.03 | buy |
| Assenagon Asset Management S.A. | 70,114 | 560,830 | +490,716 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 123,583 | 440,103 | +316,520 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 265,491 | +265,491 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,850,601 | 2,088,046 | +237,445 | 0.01 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,545,387 | 1,732,865 | +187,478 | 0.03 | 0.01 | -0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,000 | 1,150,000 | +150,000 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 93,154 | +93,154 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 147,305 | 215,060 | +67,755 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 743,807 | 786,547 | +42,740 | 0.00 | 0.00 | -0.00 | buy |
| Velan Capital Investment Management LP | 70,000 | 97,000 | +27,000 | 0.06 | 0.03 | -0.03 | buy |
| HRT FINANCIAL LP | 0 | 25,592 | +25,592 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 23,724 | 44,010 | +20,286 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 15,681 | +15,681 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 9,840 | 23,846 | +14,006 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 13,068 | +13,068 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 0 | 10,238 | +10,238 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 37,636 | 43,028 | +5,392 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 10,639 | 15,450 | +4,811 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,329,435 | 1,330,993 | +1,558 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,530 | 37,012 | +1,482 | 0.00 | 0.00 | -0.00 | buy |
| SBI Securities Co., Ltd. | 84 | 884 | +800 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,924 | 4,924 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 3,853,818 | 3,853,818 | 0 | 0.12 | 0.05 | -0.07 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,267 | 4,267 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 47,780 | 47,780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 61 | 61 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 165,763 | 165,763 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TAKEDA PHARMACEUTICAL CO LTD | 7,531,996 | 7,531,996 | 0 | 26.40 | 14.51 | -11.89 | hold |
| Newman Dignan & Sheerar, Inc. | 16,522 | 16,522 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rubric Capital Management LP | 5,315,969 | 5,315,969 | 0 | 0.09 | 0.03 | -0.06 | hold |
| Sound Income Strategies, LLC | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TLS Advisors LLC | 680,967 | 680,967 | 0 | 1.45 | 0.48 | -0.97 | hold |
| TD Waterhouse Canada Inc. | 30 | 30 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Frazier Financial Advisors, LLC | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIRST MANHATTAN CO. LLC. | 26,000 | 26,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 6,579 | 6,579 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 17,396 | 17,396 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,986 | 18,986 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BLAIR WILLIAM & CO/IL | 23,039 | 23,039 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Invesco Ltd. | 27,207 | 27,207 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 2,011 | 2,011 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,400,191 | 1,400,191 | 0 | 0.01 | 0.00 | -0.01 | hold |
| DEUTSCHE BANK AG\ | 105,177 | 105,177 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 21 | 17 | -4 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 29,279 | 28,852 | -427 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 447 | 0 | -447 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 590 | 0 | -590 | 0.00 | 0.00 | 0.00 | sell |
| CWM, LLC | 1,540 | 0 | -1,540 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 2,073 | 400 | -1,673 | 0.00 | 0.00 | -0.00 | sell |
| Capital Advisors, Ltd. LLC | 1,710 | 0 | -1,710 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 84,078 | 80,917 | -3,161 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 16,584 | 12,754 | -3,830 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 34,916 | 30,897 | -4,019 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 48,551 | 43,197 | -5,354 | 0.00 | 0.00 | -0.00 | sell |
| DCF Advisers, LLC | 11,750 | 0 | -11,750 | 0.01 | 0.00 | -0.01 | sell |
| BBR PARTNERS, LLC | 12,495 | 0 | -12,495 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 130,532 | 115,867 | -14,665 | 0.03 | 0.01 | -0.02 | sell |
| STATE STREET CORP | 1,394,518 | 1,372,108 | -22,410 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161,808 | 135,487 | -26,321 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 93,307 | 63,918 | -29,389 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 104,712 | 66,953 | -37,759 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 3,148,082 | 3,108,781 | -39,301 | 0.00 | 0.00 | -0.00 | sell |
| Empowered Funds, LLC | 138,415 | 91,234 | -47,181 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 488,171 | 423,618 | -64,553 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 3,928,584 | 3,859,582 | -69,002 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 92,971 | 10,719 | -82,252 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 291,701 | 200,593 | -91,108 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 198,123 | 104,435 | -93,688 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 229,115 | 95,434 | -133,681 | 0.00 | 0.00 | -0.00 | sell |
| MONIMUS CAPITAL MANAGEMENT, LP | 138,266 | 0 | -138,266 | 0.12 | 0.00 | -0.12 | sell |
| JPMORGAN CHASE & CO | 1,418,306 | 1,208,624 | -209,682 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 943,416 | 0 | -943,416 | 0.02 | 0.00 | -0.02 | sell |
| Madison Avenue Partners, LP | 3,722,627 | 2,465,623 | -1,257,004 | 0.37 | 0.07 | -0.30 | sell |
| Siren, L.L.C. | 2,850,000 | 0 | -2,850,000 | 0.12 | 0.00 | -0.12 | sell |