| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 0 | 10,714,000 | +10,714,000 | 0.00 | 0.01 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 4,285,000 | 9,916,911 | +5,631,911 | 0.11 | 0.36 | +0.25 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 325,000 | 5,533,073 | +5,208,073 | 0.00 | 0.02 | +0.02 | buy |
| Affinity Asset Advisors, LLC | 7,150,000 | 10,636,318 | +3,486,318 | 0.84 | 1.38 | +0.55 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,492,000 | 6,163,781 | +2,671,781 | 0.01 | 0.02 | +0.01 | buy |
| Ikarian Capital, LLC | 247,558 | 2,894,704 | +2,647,146 | 0.05 | 0.92 | +0.87 | buy |
| Blue Owl Capital Holdings LP | 0 | 1,904,666 | +1,904,666 | 0.00 | 1.14 | +1.14 | buy |
| Saturn V Capital Management LP | 2,500,000 | 4,166,666 | +1,666,666 | 0.75 | 1.68 | +0.93 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 1,622,828 | +1,622,828 | 0.00 | 0.62 | +0.62 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 341,740 | 1,947,594 | +1,605,854 | 0.00 | 0.01 | +0.00 | buy |
| Rosalind Advisors, Inc. | 0 | 1,107,994 | +1,107,994 | 0.00 | 1.01 | +1.01 | buy |
| Ally Bridge Group (NY) LLC | 1,785,000 | 2,818,459 | +1,033,459 | 4.62 | 6.22 | +1.60 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.26 | +0.26 | buy |
| Propel Bio Management, LLC | 0 | 921,457 | +921,457 | 0.00 | 1.28 | +1.28 | buy |
| BlackRock, Inc. | 613,475 | 1,533,283 | +919,808 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 155,741 | 927,913 | +772,172 | 0.01 | 0.05 | +0.04 | buy |
| TWO SIGMA INVESTMENTS, LP | 598,869 | 1,256,869 | +658,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 672,004 | 1,318,091 | +646,087 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 328,924 | +328,924 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 290,432 | +290,432 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 277,656 | +277,656 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 270,298 | +270,298 | 0.00 | 0.07 | +0.07 | buy |
| ADAR1 Capital Management, LLC | 4,285,000 | 4,544,113 | +259,113 | 0.52 | 0.61 | +0.08 | buy |
| CIBC WORLD MARKET INC. | 0 | 249,351 | +249,351 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 276,533 | 520,283 | +243,750 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 39,034 | 197,971 | +158,937 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,339,465 | 1,496,518 | +157,053 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 0 | 130,813 | +130,813 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,721 | 114,242 | +109,521 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 101,759 | +101,759 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 166,631 | 254,804 | +88,173 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 85,411 | +85,411 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 72,000 | +72,000 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 33,308 | 101,581 | +68,273 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 43,262 | +43,262 | 0.00 | 0.03 | +0.03 | buy |
| Qube Research & Technologies Ltd | 53,951 | 94,301 | +40,350 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 27,294 | +27,294 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 25,324 | +25,324 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 87,874 | 111,804 | +23,930 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 22,171 | +22,171 | 0.00 | 0.01 | +0.01 | buy |
| Sovereign Financial Group, Inc. | 10,000 | 30,000 | +20,000 | 0.00 | 0.01 | +0.01 | buy |
| Focus Partners Advisor Solutions, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 192,496 | 212,211 | +19,715 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 108,334 | 123,969 | +15,635 | 0.02 | 0.02 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 13,246 | +13,246 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 13,166 | +13,166 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 10,951 | +10,951 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 201,036 | 208,205 | +7,169 | 0.03 | 0.05 | +0.02 | buy |
| TLS Advisors LLC | 13,600 | 18,858 | +5,258 | 0.98 | 0.10 | -0.88 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 4,384 | +4,384 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 2,925 | +2,925 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 26,339 | 28,839 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 312 | +312 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 219 | +219 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 980 | 992 | +12 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 3,571,000 | 3,571,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 95,434 | 95,434 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,714,000 | 10,714,000 | 0 | 0.18 | 0.25 | +0.07 | hold |
| Benin Management CORP | 19,000 | 19,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Arax Advisory Partners | 57 | 57 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Empowered Funds, LLC | 91,234 | 91,234 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sound Income Strategies, LLC | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 4,000 | 4,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Aaron Wealth Advisors LLC | 11,234 | 11,234 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TFC Financial Management, Inc. | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Velan Capital Investment Management LP | 160,000 | 160,000 | 0 | 0.15 | 0.22 | +0.07 | hold |
| Allspring Global Investments Holdings, LLC | 11,262 | 11,262 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD Waterhouse Canada Inc. | 30 | 30 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quadcap Wealth Management, LLC | 11,111 | 11,111 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIRST MANHATTAN CO. LLC. | 26,000 | 26,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearstead Advisors, LLC | 2,734 | 2,734 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Atlantic Union Bankshares Corp | 2,300 | 2,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 2,351 | 2,351 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cetera Investment Advisers | 17,001 | 17,000 | -1 | 0.00 | 0.00 | +0.00 | sell |
| SageView Advisory Group, LLC | 44 | 0 | -44 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 189 | 107 | -82 | 0.00 | 0.00 | -0.00 | sell |
| Tradewinds Capital Management, LLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| Abel Hall, LLC | 31,427 | 31,189 | -238 | 0.01 | 0.01 | +0.00 | sell |
| North Star Investment Management Corp. | 1,043 | 0 | -1,043 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 43,974 | 42,138 | -1,836 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 57,698 | 55,038 | -2,660 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 720,848 | 713,625 | -7,223 | 0.00 | 0.00 | +0.00 | sell |
| Total Clarity Wealth Management, Inc. | 28,600 | 20,975 | -7,625 | 0.01 | 0.01 | -0.00 | sell |
| Sepio Capital, LP | 10,145 | 0 | -10,145 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 10,676 | 0 | -10,676 | 0.00 | 0.00 | -0.00 | sell |
| NINE MASTS CAPITAL Ltd | 13,960 | 0 | -13,960 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 170,457 | 152,847 | -17,610 | 0.00 | 0.00 | +0.00 | sell |
| OMERS ADMINISTRATION Corp | 125,300 | 100,100 | -25,200 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 31,603 | 3,674 | -27,929 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 102,367 | 40,000 | -62,367 | 0.13 | 0.08 | -0.05 | sell |
| XTX Topco Ltd | 188,456 | 113,393 | -75,063 | 0.01 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 530,020 | 443,362 | -86,658 | 0.00 | 0.01 | +0.00 | sell |
| Graham Capital Management, L.P. | 127,459 | 0 | -127,459 | 0.01 | 0.00 | -0.01 | sell |
| JANE STREET GROUP, LLC | 883,867 | 735,429 | -148,438 | 0.00 | 0.00 | +0.00 | sell |
| Sio Capital Management, LLC | 1,427,495 | 1,252,381 | -175,114 | 0.39 | 0.40 | +0.01 | sell |
| TWO SIGMA ADVISERS, LP | 239,200 | 0 | -239,200 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 1,271,487 | 917,733 | -353,754 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,484,478 | 1,104,300 | -380,178 | 0.00 | 0.00 | +0.00 | sell |
| Assenagon Asset Management S.A. | 618,019 | 227,742 | -390,277 | 0.00 | 0.00 | -0.00 | sell |