| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 9,916,911 | 11,812,241 | +1,895,330 | 0.36 | 0.42 | +0.06 | buy |
| BlackRock, Inc. | 1,533,283 | 10,823,480 | +9,290,197 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 10,714,000 | 10,500,968 | -213,032 | 0.25 | 0.25 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 10,636,318 | 10,144,562 | -491,756 | 1.38 | 1.33 | -0.05 | sell |
| STATE STREET CORP | 520,283 | 7,900,765 | +7,380,482 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 4,544,113 | 7,417,479 | +2,873,366 | 0.61 | 0.94 | +0.33 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 5,533,073 | 6,719,076 | +1,186,003 | 0.02 | 0.03 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,163,781 | 6,163,781 | 0 | 0.02 | 0.02 | +0.00 | hold |
| FEDERATED HERMES, INC. | 3,571,000 | 5,951,666 | +2,380,666 | 0.01 | 0.02 | +0.01 | buy |
| BRAIDWELL LP | 0 | 5,919,464 | +5,919,464 | 0.00 | 0.59 | +0.59 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,318,091 | 4,072,653 | +2,754,562 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,000,000 | 3,101,129 | +2,101,129 | 0.26 | 0.93 | +0.67 | buy |
| STEMPOINT CAPITAL LP | 0 | 2,417,283 | +2,417,283 | 0.00 | 1.13 | +1.13 | buy |
| Ikarian Capital, LLC | 2,894,704 | 2,269,704 | -625,000 | 0.92 | 1.00 | +0.08 | sell |
| Point72 Asset Management, L.P. | 1,320,610 | 1,945,727 | +625,117 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,622,828 | 1,353,000 | -269,828 | 0.62 | 0.52 | -0.10 | sell |
| NORTHERN TRUST CORP | 254,804 | 1,246,139 | +991,335 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 921,457 | 1,115,538 | +194,081 | 1.28 | 1.57 | +0.29 | buy |
| Rosalind Advisors, Inc. | 1,107,994 | 1,107,994 | 0 | 1.01 | 1.12 | +0.11 | hold |
| Sio Capital Management, LLC | 1,252,381 | 1,005,334 | -247,047 | 0.40 | 0.46 | +0.06 | sell |
| Ensign Peak Advisors, Inc | 0 | 988,084 | +988,084 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 893,254 | +893,254 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,256,869 | 832,378 | -424,491 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 713,625 | 826,206 | +112,581 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 747,000 | +747,000 | 0.00 | 0.04 | +0.04 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 927,913 | 737,758 | -190,155 | 0.05 | 0.04 | -0.01 | sell |
| Saturn V Capital Management LP | 4,166,666 | 663,060 | -3,503,606 | 1.68 | 0.26 | -1.42 | sell |
| Ally Bridge Group (NY) LLC | 2,818,459 | 624,561 | -2,193,898 | 6.22 | 2.17 | -4.05 | sell |
| UBS Group AG | 277,656 | 458,917 | +181,261 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 444,042 | +444,042 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 72,000 | 444,042 | +372,042 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 55,038 | 416,318 | +361,280 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 290,432 | 409,490 | +119,058 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 387,767 | +387,767 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 152,847 | 332,692 | +179,845 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 270,298 | 259,631 | -10,667 | 0.07 | 0.06 | -0.01 | sell |
| Atom Investors LP | 0 | 251,836 | +251,836 | 0.00 | 0.06 | +0.06 | buy |
| CIBC WORLD MARKET INC. | 249,351 | 218,851 | -30,500 | 0.00 | 0.00 | +0.00 | sell |
| Parkman Healthcare Partners LLC | 208,205 | 197,947 | -10,258 | 0.05 | 0.05 | +0.01 | sell |
| SEI INVESTMENTS CO | 328,924 | 196,685 | -132,239 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 114,242 | 191,058 | +76,816 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 101,581 | 174,900 | +73,319 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 170,139 | +170,139 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 169,382 | +169,382 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 149,391 | +149,391 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 136,774 | +136,774 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 160,000 | 130,000 | -30,000 | 0.22 | 0.21 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 125,725 | +125,725 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,104,300 | 105,500 | -998,800 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 103,400 | +103,400 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 95,434 | 95,434 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Empowered Funds, LLC | 91,234 | 91,234 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 0 | 90,587 | +90,587 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 86,098 | +86,098 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 78,260 | +78,260 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 25,324 | 71,487 | +46,163 | 0.01 | 0.02 | +0.01 | buy |
| PROFUND ADVISORS LLC | 0 | 69,699 | +69,699 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 0 | 63,482 | +63,482 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 22,171 | 53,438 | +31,267 | 0.01 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 45,161 | +45,161 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 40,910 | +40,910 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 42,138 | 39,010 | -3,128 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 36,877 | +36,877 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 35,400 | +35,400 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 212,211 | 35,049 | -177,162 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 113,393 | 34,340 | -79,053 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 1 | 34,120 | +34,119 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,496,518 | 32,295 | -1,464,223 | 0.00 | 0.00 | -0.00 | sell |
| Spark Investment Management LLC | 0 | 31,800 | +31,800 | 0.00 | 0.17 | +0.17 | buy |
| Sovereign Financial Group, Inc. | 30,000 | 30,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 29,278 | +29,278 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 28,839 | 28,839 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 28,826 | +28,826 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 31,189 | 28,324 | -2,865 | 0.01 | 0.01 | -0.00 | sell |
| Total Clarity Wealth Management, Inc. | 20,975 | 27,411 | +6,436 | 0.01 | 0.01 | +0.00 | buy |
| FIRST MANHATTAN CO. LLC. | 26,000 | 26,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 992 | 23,876 | +22,884 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 23,095 | +23,095 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 40,000 | 21,300 | -18,700 | 0.08 | 0.04 | -0.03 | sell |
| Creative Planning | 0 | 20,998 | +20,998 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 20,049 | +20,049 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Advisor Solutions, LLC | 20,000 | 20,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 13,166 | 19,348 | +6,182 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 19,286 | +19,286 | 0.00 | 0.00 | +0.00 | buy |
| Benin Management CORP | 19,000 | 19,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Squarepoint Ops LLC | 197,971 | 18,937 | -179,034 | 0.00 | 0.00 | -0.00 | sell |
| TLS Advisors LLC | 18,858 | 18,858 | 0 | 0.10 | 0.15 | +0.05 | hold |
| GROUP ONE TRADING LLC | 13,246 | 18,663 | +5,417 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 227,742 | 17,544 | -210,198 | 0.00 | 0.00 | -0.00 | sell |
| Cetera Investment Advisers | 17,000 | 17,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 0 | 14,858 | +14,858 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 14,560 | +14,560 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 13,896 | +13,896 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 13,613 | +13,613 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 4,384 | 13,388 | +9,004 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 0 | 13,175 | +13,175 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 11,262 | 11,262 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Aaron Wealth Advisors LLC | 11,234 | 11,234 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quadcap Wealth Management, LLC | 11,111 | 11,111 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 0 | 6,164 | +6,164 | 0.00 | 0.00 | +0.00 | buy |