| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 288,290 | 628,290 | +340,000 | 0.01 | 0.02 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,212 | 220,401 | +215,189 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,664,552 | 1,847,334 | +182,782 | 0.00 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 119,507 | 260,509 | +141,002 | 0.01 | 0.02 | +0.02 | buy |
| Assenagon Asset Management S.A. | 0 | 86,289 | +86,289 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 74,875 | +74,875 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 20,473 | 84,175 | +63,702 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,089,393 | 3,142,439 | +53,046 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,502 | 50,225 | +47,723 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,488,571 | 1,527,985 | +39,414 | 0.02 | 0.04 | +0.02 | buy |
| Madison Avenue Partners, LP | 4,082,100 | 4,116,773 | +34,673 | 0.40 | 0.45 | +0.05 | buy |
| CITIGROUP INC | 14,316 | 43,952 | +29,636 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 20,464 | +20,464 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 19,190 | 37,743 | +18,553 | 0.00 | 0.01 | +0.00 | buy |
| Newman Dignan & Sheerar, Inc. | 0 | 16,522 | +16,522 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,302,514 | 1,317,330 | +14,816 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 465,532 | 480,225 | +14,693 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 26,154 | 38,230 | +12,076 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 11,431 | +11,431 | 0.00 | 0.00 | +0.00 | buy |
| Empowered Funds, LLC | 137,970 | 145,340 | +7,370 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,354,371 | 1,361,455 | +7,084 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,335 | 13,650 | +5,315 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 126,826 | 130,279 | +3,453 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,913 | 34,086 | +3,173 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 12,365 | 15,321 | +2,956 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 2,383 | 4,495 | +2,112 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 31,039 | 32,039 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 28,850 | 29,337 | +487 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,118 | 2,567 | +449 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 376 | 710 | +334 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 143 | 323 | +180 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,598 | 1,764 | +166 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 146 | +146 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,924 | 4,924 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 3,853,818 | 3,853,818 | 0 | 0.08 | 0.13 | +0.05 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,267 | 4,267 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 47,880 | 47,880 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BBR PARTNERS, LLC | 12,495 | 12,495 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TAKEDA PHARMACEUTICAL CO LTD | 7,531,996 | 7,531,996 | 0 | 2.49 | 23.42 | +20.93 | hold |
| Rubric Capital Management LP | 5,315,969 | 5,315,969 | 0 | 0.11 | 0.10 | -0.01 | hold |
| Sound Income Strategies, LLC | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Frazier Financial Advisors, LLC | 10 | 10 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FIRST MANHATTAN CO. LLC. | 26,000 | 26,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 6,579 | 6,579 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 17,396 | 17,396 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,986 | 18,986 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161,808 | 161,808 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 2,011 | 2,011 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,400,191 | 1,400,191 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 105,177 | 105,177 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Corebridge Financial, Inc. | 31,683 | 31,489 | -194 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 69,733 | 68,723 | -1,010 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 2,250 | 0 | -2,250 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 1,466,433 | 1,463,838 | -2,595 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 14,177 | 8,301 | -5,876 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 741,640 | 735,185 | -6,455 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 12,628 | 0 | -12,628 | 0.00 | 0.00 | -0.00 | sell |
| Baader Bank Aktiengesellschaft | 13,282 | 0 | -13,282 | 0.00 | 0.00 | -0.00 | sell |
| Knott David M Jr | 20,000 | 0 | -20,000 | 0.01 | 0.00 | -0.01 | sell |
| DCF Advisers, LLC | 41,750 | 14,750 | -27,000 | 0.02 | 0.01 | -0.01 | sell |
| Tejara Capital Ltd | 68,517 | 29,329 | -39,188 | 0.02 | 0.02 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 352,170 | 309,540 | -42,630 | 0.01 | 0.01 | +0.00 | sell |
| Bank of New York Mellon Corp | 218,163 | 165,763 | -52,400 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 78,024 | 0 | -78,024 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 141,200 | 44,500 | -96,700 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 115,832 | 0 | -115,832 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 274,982 | 104,011 | -170,971 | 0.00 | 0.00 | -0.00 | sell |
| Prosight Management, LP | 1,075,000 | 729,208 | -345,792 | 0.25 | 0.22 | -0.03 | sell |
| TLS Advisors LLC | 1,125,296 | 771,531 | -353,765 | 2.17 | 1.92 | -0.25 | sell |
| FFT WEALTH MANAGEMENT LLC | 489,552 | 0 | -489,552 | 0.03 | 0.00 | -0.03 | sell |
| Artal Group S.A. | 2,500,000 | 0 | -2,500,000 | 0.05 | 0.00 | -0.05 | sell |