| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Affinity Asset Advisors, LLC | 667,516 | 2,650,000 | +1,982,484 | 0.03 | 0.32 | +0.29 | buy |
| Ikarian Capital, LLC | 0 | 1,095,574 | +1,095,574 | 0.00 | 0.29 | +0.29 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 883,154 | +883,154 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 625,000 | +625,000 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 164,721 | 783,653 | +618,932 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 596,717 | +596,717 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 589,094 | +589,094 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 435,620 | 924,576 | +488,956 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 486,877 | +486,877 | 0.00 | 0.02 | +0.02 | buy |
| CITADEL ADVISORS LLC | 0 | 405,382 | +405,382 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 387,512 | +387,512 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 362,707 | +362,707 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 341,134 | +341,134 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 238,415 | +238,415 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 202,978 | +202,978 | 0.00 | 0.03 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,150,000 | 1,350,000 | +200,000 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 188,295 | +188,295 | 0.00 | 0.01 | +0.01 | buy |
| DIADEMA PARTNERS LP | 0 | 187,739 | +187,739 | 0.00 | 0.17 | +0.17 | buy |
| VANGUARD GROUP INC | 2,636,115 | 2,820,813 | +184,698 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 2,108,336 | 2,286,505 | +178,169 | 0.00 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 151,800 | +151,800 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 78,420 | 183,298 | +104,878 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 3,874 | 86,652 | +82,778 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 52,900 | +52,900 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 99,118 | 151,711 | +52,593 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 46,040 | +46,040 | 0.00 | 0.04 | +0.04 | buy |
| Quadrature Capital Ltd | 0 | 27,703 | +27,703 | 0.00 | 0.00 | +0.00 | buy |
| Apollon Wealth Management, LLC | 0 | 27,500 | +27,500 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 0 | 25,600 | +25,600 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 17,000 | +17,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 11,698 | +11,698 | 0.00 | 0.00 | +0.00 | buy |
| Quadcap Wealth Management, LLC | 0 | 11,111 | +11,111 | 0.00 | 0.00 | +0.00 | buy |
| Sovereign Financial Group, Inc. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 643,335 | 648,020 | +4,685 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 22,089 | 25,089 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| North Star Investment Management Corp. | 0 | 1,043 | +1,043 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 219 | +219 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 140 | +140 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 867 | 962 | +95 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 57,697 | 57,698 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 95,434 | 95,434 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TAKEDA PHARMACEUTICAL CO LTD | 7,531,996 | 7,531,996 | 0 | 12.71 | 59.82 | +47.11 | hold |
| Empowered Funds, LLC | 91,234 | 91,234 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sound Income Strategies, LLC | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Velan Capital Investment Management LP | 160,000 | 160,000 | 0 | 0.05 | 0.20 | +0.14 | hold |
| TD Waterhouse Canada Inc. | 30 | 30 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Abel Hall, LLC | 32,348 | 32,348 | 0 | 0.00 | 0.02 | +0.01 | hold |
| BARCLAYS PLC | 71 | 71 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FIRST MANHATTAN CO. LLC. | 26,000 | 26,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Atlantic Union Bankshares Corp | 2,300 | 2,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 227,033 | 227,033 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 2,351 | 2,351 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,400,191 | 1,400,191 | 0 | 0.00 | 0.01 | +0.01 | hold |
| FMR LLC | 46,988 | 46,987 | -1 | 0.00 | 0.00 | +0.00 | sell |
| True Wealth Design, LLC | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 24 | 0 | -24 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 884 | 425 | -459 | 0.00 | 0.00 | +0.00 | sell |
| Point72 (DIFC) Ltd | 1,301 | 197 | -1,104 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 11,411 | 808 | -10,603 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 12,664 | 0 | -12,664 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 13,718 | 0 | -13,718 | 0.00 | 0.00 | -0.00 | sell |
| PFG Investments, LLC | 13,975 | 0 | -13,975 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 15,705 | 0 | -15,705 | 0.00 | 0.00 | -0.00 | sell |
| Newman Dignan & Sheerar, Inc. | 16,522 | 0 | -16,522 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 38,382 | 19,173 | -19,209 | 0.00 | 0.00 | +0.00 | sell |
| HSBC HOLDINGS PLC | 19,220 | 0 | -19,220 | 0.00 | 0.00 | -0.00 | sell |
| Aaron Wealth Advisors LLC | 38,259 | 11,234 | -27,025 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 38,287 | 11,262 | -27,025 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 763,114 | 730,716 | -32,398 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 72,741 | 25,277 | -47,464 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 51,520 | 2,344 | -49,176 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,052,334 | 986,293 | -66,041 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 2,095,309 | 2,018,024 | -77,285 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 115,867 | 12,846 | -103,021 | 0.01 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 221,126 | 114,923 | -106,203 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 123,316 | 0 | -123,316 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 160,306 | 0 | -160,306 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 283,824 | 0 | -283,824 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,502,329 | 1,106,638 | -395,691 | 0.01 | 0.03 | +0.02 | sell |
| GSA CAPITAL PARTNERS LLP | 742,190 | 265,993 | -476,197 | 0.02 | 0.03 | +0.01 | sell |
| Rubric Capital Management LP | 478,533 | 0 | -478,533 | 0.00 | 0.00 | -0.00 | sell |
| Rosalind Advisors, Inc. | 500,000 | 0 | -500,000 | 0.08 | 0.00 | -0.08 | sell |
| TLS Advisors LLC | 680,967 | 18,858 | -662,109 | 0.70 | 0.08 | -0.63 | sell |
| BlackRock, Inc. | 1,369,010 | 611,315 | -757,695 | 0.00 | 0.00 | +0.00 | sell |
| Sio Capital Management, LLC | 2,232,000 | 1,427,495 | -804,505 | 0.30 | 0.47 | +0.17 | sell |
| Madison Avenue Partners, LP | 1,311,362 | 0 | -1,311,362 | 0.03 | 0.00 | -0.03 | sell |
| BVF INC/IL | 3,853,818 | 0 | -3,853,818 | 0.05 | 0.00 | -0.05 | sell |