| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.26 | +0.26 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 628,290 | 943,416 | +315,126 | 0.02 | 0.02 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 291,701 | +291,701 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 37,743 | 130,532 | +92,789 | 0.01 | 0.03 | +0.02 | buy |
| Verition Fund Management LLC | 74,875 | 147,305 | +72,430 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 70,000 | +70,000 | 0.00 | 0.06 | +0.06 | buy |
| GOLDMAN SACHS GROUP INC | 130,279 | 198,123 | +67,844 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 44,500 | 107,700 | +63,200 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,361,455 | 1,394,518 | +33,063 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 23,724 | +23,724 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,527,985 | 1,545,387 | +17,402 | 0.04 | 0.03 | -0.01 | buy |
| SG Americas Securities, LLC | 20,464 | 37,636 | +17,172 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 68,723 | 84,078 | +15,355 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,317,330 | 1,329,435 | +12,105 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 10,639 | +10,639 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 84,175 | 93,307 | +9,132 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 735,185 | 743,807 | +8,622 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 480,225 | 488,171 | +7,946 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 3,142,439 | 3,148,082 | +5,643 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 43,952 | 48,551 | +4,599 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,847,334 | 1,850,601 | +3,267 | 0.01 | 0.01 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 323 | 2,073 | +1,750 | 0.00 | 0.00 | +0.00 | buy |
| Capital Advisors, Ltd. LLC | 0 | 1,710 | +1,710 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 8,301 | 9,840 | +1,539 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 34,086 | 35,530 | +1,444 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 15,321 | 16,584 | +1,263 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 710 | 1,540 | +830 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,924 | 4,924 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 3,853,818 | 3,853,818 | 0 | 0.13 | 0.12 | -0.01 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,267 | 4,267 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 61 | 61 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BBR PARTNERS, LLC | 12,495 | 12,495 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 165,763 | 165,763 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TAKEDA PHARMACEUTICAL CO LTD | 7,531,996 | 7,531,996 | 0 | 23.42 | 26.40 | +2.98 | hold |
| Newman Dignan & Sheerar, Inc. | 16,522 | 16,522 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rubric Capital Management LP | 5,315,969 | 5,315,969 | 0 | 0.10 | 0.09 | -0.01 | hold |
| Sound Income Strategies, LLC | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD Waterhouse Canada Inc. | 30 | 30 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Frazier Financial Advisors, LLC | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Siren, L.L.C. | 2,850,000 | 2,850,000 | 0 | 0.17 | 0.12 | -0.05 | hold |
| FIRST MANHATTAN CO. LLC. | 26,000 | 26,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 6,579 | 6,579 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 17,396 | 17,396 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,986 | 18,986 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161,808 | 161,808 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 2,011 | 2,011 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,400,191 | 1,400,191 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 105,177 | 105,177 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 47,880 | 47,780 | -100 | 0.00 | 0.00 | -0.00 | sell |
| EARNED WEALTH ADVISORS, LLC | 146 | 0 | -146 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 1,764 | 447 | -1,317 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 29,337 | 27,207 | -2,130 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 31,489 | 29,279 | -2,210 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,567 | 0 | -2,567 | 0.00 | 0.00 | -0.00 | sell |
| DCF Advisers, LLC | 14,750 | 11,750 | -3,000 | 0.01 | 0.01 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 4,495 | 590 | -3,905 | 0.00 | 0.00 | -0.00 | sell |
| Empowered Funds, LLC | 145,340 | 138,415 | -6,925 | 0.00 | 0.00 | -0.00 | sell |
| BLAIR WILLIAM & CO/IL | 32,039 | 23,039 | -9,000 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 104,011 | 92,971 | -11,040 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 11,431 | 0 | -11,431 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,650 | 0 | -13,650 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 50,225 | 34,916 | -15,309 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 86,289 | 70,114 | -16,175 | 0.00 | 0.00 | -0.00 | sell |
| Tejara Capital Ltd | 29,329 | 0 | -29,329 | 0.02 | 0.00 | -0.02 | sell |
| XTX Topco Ltd | 38,230 | 0 | -38,230 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 1,463,838 | 1,418,306 | -45,532 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 309,540 | 229,115 | -80,425 | 0.01 | 0.00 | -0.00 | sell |
| TLS Advisors LLC | 771,531 | 680,967 | -90,564 | 1.92 | 1.45 | -0.47 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 220,401 | 104,712 | -115,689 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 260,509 | 123,583 | -136,926 | 0.02 | 0.01 | -0.01 | sell |
| BlackRock, Inc. | 4,314,437 | 3,928,584 | -385,853 | 0.00 | 0.00 | -0.00 | sell |
| Madison Avenue Partners, LP | 4,116,773 | 3,722,627 | -394,146 | 0.45 | 0.37 | -0.08 | sell |
| Prosight Management, LP | 729,208 | 0 | -729,208 | 0.22 | 0.00 | -0.22 | sell |