| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 10,714,000 | +10,714,000 | 0.00 | 0.18 | +0.18 | buy |
| Affinity Asset Advisors, LLC | 2,650,000 | 7,150,000 | +4,500,000 | 0.32 | 0.84 | +0.52 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 4,285,000 | +4,285,000 | 0.00 | 0.11 | +0.11 | buy |
| ADAR1 Capital Management, LLC | 12,846 | 4,285,000 | +4,272,154 | 0.00 | 0.52 | +0.52 | buy |
| FEDERATED HERMES, INC. | 0 | 3,571,000 | +3,571,000 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 3,551,129 | +3,551,129 | 0.00 | 0.01 | +0.01 | buy |
| Saturn V Capital Management LP | 0 | 2,500,000 | +2,500,000 | 0.00 | 0.75 | +0.75 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,350,000 | 3,492,000 | +2,142,000 | 0.00 | 0.01 | +0.01 | buy |
| Ally Bridge Group (NY) LLC | 0 | 1,785,000 | +1,785,000 | 0.00 | 4.62 | +4.62 | buy |
| AWM Investment Company, Inc. | 0 | 899,200 | +899,200 | 0.00 | 0.14 | +0.14 | buy |
| JANE STREET GROUP, LLC | 238,415 | 883,867 | +645,452 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 783,653 | 1,271,487 | +487,834 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 405,382 | 797,824 | +392,442 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 986,293 | 1,339,465 | +353,172 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 341,134 | 598,869 | +257,735 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,820,813 | 3,072,227 | +251,414 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 170,457 | +170,457 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 127,459 | +127,459 | 0.00 | 0.01 | +0.01 | buy |
| OMERS ADMINISTRATION Corp | 0 | 125,300 | +125,300 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 102,367 | +102,367 | 0.00 | 0.13 | +0.13 | buy |
| TWO SIGMA ADVISERS, LP | 151,800 | 239,200 | +87,400 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 27,703 | 87,874 | +60,171 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 227,033 | 276,533 | +49,500 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 33,308 | +33,308 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 25,277 | 53,951 | +28,674 | 0.00 | 0.00 | +0.00 | buy |
| Total Clarity Wealth Management, Inc. | 0 | 28,600 | +28,600 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 648,020 | 672,004 | +23,984 | 0.00 | 0.00 | +0.00 | buy |
| Benin Management CORP | 0 | 19,000 | +19,000 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 151,711 | 166,631 | +14,920 | 0.00 | 0.00 | +0.00 | buy |
| NINE MASTS CAPITAL Ltd | 0 | 13,960 | +13,960 | 0.00 | 0.00 | +0.00 | buy |
| Sepio Capital, LP | 0 | 10,145 | +10,145 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,344 | 10,676 | +8,332 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 183,298 | 188,456 | +5,158 | 0.01 | 0.01 | -0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 4,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 808 | 4,721 | +3,913 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 2,734 | +2,734 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 611,315 | 613,475 | +2,160 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 25,089 | 26,339 | +1,250 | 0.00 | 0.00 | +0.00 | buy |
| TFC Financial Management, Inc. | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Tradewinds Capital Management, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| SageView Advisory Group, LLC | 0 | 44 | +44 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 962 | 980 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 17,000 | 17,001 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 95,434 | 95,434 | 0 | 0.00 | 0.00 | +0.00 | hold |
| North Star Investment Management Corp. | 1,043 | 1,043 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bank of New York Mellon Corp | 57,698 | 57,698 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sio Capital Management, LLC | 1,427,495 | 1,427,495 | 0 | 0.47 | 0.39 | -0.08 | hold |
| Empowered Funds, LLC | 91,234 | 91,234 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sound Income Strategies, LLC | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aaron Wealth Advisors LLC | 11,234 | 11,234 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sovereign Financial Group, Inc. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Velan Capital Investment Management LP | 160,000 | 160,000 | 0 | 0.20 | 0.15 | -0.04 | hold |
| Allspring Global Investments Holdings, LLC | 11,262 | 11,262 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD Waterhouse Canada Inc. | 30 | 30 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quadcap Wealth Management, LLC | 11,111 | 11,111 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FIRST MANHATTAN CO. LLC. | 26,000 | 26,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Atlantic Union Bankshares Corp | 2,300 | 2,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 2,351 | 2,351 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 71 | 1 | -70 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 140 | 57 | -83 | 0.00 | 0.00 | +0.00 | sell |
| Advisory Services Network, LLC | 219 | 0 | -219 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 425 | 189 | -236 | 0.00 | 0.00 | -0.00 | sell |
| Abel Hall, LLC | 32,348 | 31,427 | -921 | 0.02 | 0.01 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 202,978 | 201,036 | -1,942 | 0.03 | 0.03 | +0.00 | sell |
| FMR LLC | 46,987 | 43,974 | -3,013 | 0.00 | 0.00 | +0.00 | sell |
| TLS Advisors LLC | 18,858 | 13,600 | -5,258 | 0.08 | 0.98 | +0.91 | sell |
| WELLS FARGO & COMPANY/MN | 730,716 | 720,848 | -9,868 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 11,698 | 0 | -11,698 | 0.00 | 0.00 | -0.00 | sell |
| Private Advisor Group, LLC | 25,600 | 0 | -25,600 | 0.00 | 0.00 | -0.00 | sell |
| Apollon Wealth Management, LLC | 27,500 | 0 | -27,500 | 0.00 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 46,040 | 0 | -46,040 | 0.04 | 0.00 | -0.04 | sell |
| Integrated Wealth Concepts LLC | 52,900 | 0 | -52,900 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 596,717 | 530,020 | -66,697 | 0.01 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 114,923 | 39,034 | -75,889 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 265,993 | 108,334 | -157,659 | 0.03 | 0.02 | -0.01 | sell |
| DIADEMA PARTNERS LP | 187,739 | 0 | -187,739 | 0.17 | 0.00 | -0.17 | sell |
| GROUP ONE TRADING LLC | 188,295 | 0 | -188,295 | 0.01 | 0.00 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 589,094 | 341,740 | -247,354 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 625,000 | 325,000 | -300,000 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 924,576 | 618,019 | -306,557 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 486,877 | 155,741 | -331,136 | 0.02 | 0.01 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 387,512 | 31,603 | -355,909 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 362,707 | 0 | -362,707 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 2,018,024 | 1,484,478 | -533,546 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 883,154 | 192,496 | -690,658 | 0.01 | 0.00 | -0.01 | sell |
| Ikarian Capital, LLC | 1,095,574 | 247,558 | -848,016 | 0.29 | 0.05 | -0.24 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 2,286,505 | 1,231,698 | -1,054,807 | 0.01 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,106,638 | 0 | -1,106,638 | 0.03 | 0.00 | -0.03 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,400,191 | 0 | -1,400,191 | 0.01 | 0.00 | -0.01 | sell |