| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Affinity Asset Advisors, LLC | 144,159 | 394,159 | +250,000 | 0.19 | 0.27 | +0.07 | buy |
| Shay Capital LLC | 15,016 | 151,038 | +136,022 | 0.03 | 0.19 | +0.16 | buy |
| Prosight Management, LP | 63,754 | 186,570 | +122,816 | 0.15 | 0.26 | +0.11 | buy |
| TANG CAPITAL MANAGEMENT LLC | 294,626 | 400,000 | +105,374 | 0.17 | 0.10 | -0.07 | buy |
| CANTOR FITZGERALD, L. P. | 35,700 | 130,700 | +95,000 | 0.01 | 0.02 | +0.01 | buy |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 399,743 | 438,797 | +39,054 | 0.13 | 0.08 | -0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 27,148 | +27,148 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 18,663 | +18,663 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 14,228 | 27,628 | +13,400 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 76,599 | 86,311 | +9,712 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 102 | 190 | +88 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 236 | 297 | +61 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 266 | 313 | +47 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,201 | 2,224 | +23 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 422 | 423 | +1 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 706,733 | 706,733 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MAI Capital Management | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 1,004,439 | 1,004,439 | 0 | 0.24 | 0.15 | -0.09 | hold |
| StepStone Group LP | 491,938 | 491,938 | 0 | 3.70 | 2.17 | -1.53 | hold |
| NEA Management Company, LLC | 478,548 | 478,548 | 0 | 0.23 | 0.16 | -0.07 | hold |
| Carlyle Group Inc. | 269,895 | 269,895 | 0 | 0.06 | 0.03 | -0.03 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 78,021 | 78,021 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Cormorant Asset Management, LP | 1,837,739 | 1,837,739 | 0 | 0.87 | 0.60 | -0.27 | hold |
| Samsara BioCapital, LLC | 824,155 | 824,155 | 0 | 0.97 | 0.63 | -0.34 | hold |
| Aisling Capital Management LP | 88,607 | 88,607 | 0 | 0.27 | 0.13 | -0.14 | hold |
| Ikarian Capital, LLC | 253,754 | 253,754 | 0 | 0.62 | 0.36 | -0.27 | hold |
| Deep Track Capital, LP | 523,989 | 523,989 | 0 | 0.17 | 0.07 | -0.10 | hold |
| Vestal Point Capital, LP | 635,000 | 635,000 | 0 | 0.32 | 0.19 | -0.13 | hold |
| ACORN CAPITAL ADVISORS, LLC | 1,439,674 | 1,439,674 | 0 | 5.51 | 3.42 | -2.10 | hold |
| NORTHERN TRUST CORP | 19,177 | 19,177 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 2,683 | 2,538 | -145 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 289 | 56 | -233 | 0.00 | 0.00 | -0.00 | sell |
| Aldebaran Capital, LLC | 45,572 | 45,048 | -524 | 0.37 | 0.18 | -0.19 | sell |
| Nantahala Capital Management, LLC | 54,777 | 54,208 | -569 | 0.03 | 0.02 | -0.01 | sell |
| BARCLAYS PLC | 8,741 | 6,765 | -1,976 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 94,017 | 88,981 | -5,036 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 47,450 | 41,863 | -5,587 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,074,314 | 1,068,104 | -6,210 | 0.01 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 87,354 | 80,454 | -6,900 | 0.14 | 0.09 | -0.05 | sell |
| OMERS ADMINISTRATION Corp | 12,100 | 0 | -12,100 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 13,495 | 0 | -13,495 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 18,633 | 0 | -18,633 | 0.01 | 0.00 | -0.01 | sell |
| Cubist Systematic Strategies, LLC | 20,549 | 0 | -20,549 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 43,371 | 0 | -43,371 | 0.04 | 0.00 | -0.04 | sell |
| MILLENNIUM MANAGEMENT LLC | 144,099 | 0 | -144,099 | 0.00 | 0.00 | -0.00 | sell |
| Altium Capital Management LLC | 218,386 | 0 | -218,386 | 0.58 | 0.00 | -0.58 | sell |
| BANK OF AMERICA CORP /DE/ | 249,642 | 0 | -249,642 | 0.00 | 0.00 | -0.00 | sell |