| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 3,998,333 | +3,998,333 | 0.00 | 0.18 | +0.18 | buy |
| ACORN CAPITAL ADVISORS, LLC | 2,839,674 | 2,839,674 | 0 | 2.79 | 3.34 | +0.55 | hold |
| StepStone Group LP | 491,938 | 2,660,612 | +2,168,674 | 0.72 | 5.31 | +4.59 | buy |
| ADAR1 Capital Management, LLC | 1,014,158 | 2,434,941 | +1,420,783 | 0.22 | 0.61 | +0.39 | buy |
| Prosight Management, LP | 816,909 | 2,154,381 | +1,337,472 | 0.49 | 1.46 | +0.97 | buy |
| BVF INC/IL | 0 | 1,978,972 | +1,978,972 | 0.00 | 0.26 | +0.26 | buy |
| Vivo Capital, LLC | 0 | 1,927,710 | +1,927,710 | 0.00 | 0.66 | +0.66 | buy |
| Vestal Point Capital, LP | 635,000 | 1,839,819 | +1,204,819 | 0.07 | 0.21 | +0.15 | buy |
| Foresite Capital Management VI LLC | 0 | 1,445,783 | +1,445,783 | 0.00 | 1.30 | +1.30 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,204,819 | +1,204,819 | 0.00 | 0.01 | +0.01 | buy |
| Sio Capital Management, LLC | 0 | 1,078,965 | +1,078,965 | 0.00 | 0.64 | +0.64 | buy |
| NEA Management Company, LLC | 478,548 | 478,548 | 0 | 0.07 | 0.11 | +0.04 | hold |
| Rosalind Advisors, Inc. | 730,488 | 443,763 | -286,725 | 0.77 | 0.75 | -0.02 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 247,350 | 377,250 | +129,900 | 0.00 | 0.00 | +0.00 | buy |
| Carlyle Group Inc. | 269,895 | 269,895 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Affinity Asset Advisors, LLC | 0 | 240,963 | +240,963 | 0.00 | 0.06 | +0.06 | buy |
| Sofinnova Investments, Inc. | 0 | 141,700 | +141,700 | 0.00 | 0.03 | +0.03 | buy |
| Stonepine Capital Management, LLC | 0 | 132,578 | +132,578 | 0.00 | 0.48 | +0.48 | buy |
| Shay Capital LLC | 780,861 | 132,219 | -648,642 | 0.37 | 0.08 | -0.29 | sell |
| CANTOR FITZGERALD, L. P. | 445,078 | 99,900 | -345,178 | 0.04 | 0.01 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 77,469 | 98,750 | +21,281 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 145,000 | 95,000 | -50,000 | 0.36 | 0.42 | +0.06 | sell |
| Aisling Capital Management LP | 88,607 | 88,607 | 0 | 0.05 | 0.08 | +0.02 | hold |
| BlackRock, Inc. | 52,678 | 49,587 | -3,091 | 0.00 | 0.00 | +0.00 | sell |
| NewEdge Advisors, LLC | 0 | 44,551 | +44,551 | 0.00 | 0.00 | +0.00 | buy |
| Aldebaran Capital, LLC | 41,284 | 40,419 | -865 | 0.11 | 0.13 | +0.02 | sell |
| HRT FINANCIAL LP | 0 | 37,055 | +37,055 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 36,444 | +36,444 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 17,801 | 34,129 | +16,328 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 30,499 | +30,499 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 27,242 | 25,000 | -2,242 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 11,320 | 24,262 | +12,942 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 45,948 | 22,224 | -23,724 | 0.01 | 0.01 | -0.01 | sell |
| NORTHERN TRUST CORP | 19,903 | 19,903 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 19,500 | 16,293 | -3,207 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 0 | 13,462 | +13,462 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 281 | 281 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TRUST CO OF TOLEDO NA /OH/ | 136 | 136 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 3,729 | 1 | -3,728 | 0.00 | 0.00 | -0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 223,125 | 0 | -223,125 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 26,608 | 0 | -26,608 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 60,454 | 0 | -60,454 | 0.04 | 0.00 | -0.04 | sell |
| HSBC HOLDINGS PLC | 19,973 | 0 | -19,973 | 0.00 | 0.00 | -0.00 | sell |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 542,361 | 0 | -542,361 | 0.07 | 0.00 | -0.07 | sell |
| GROUP ONE TRADING LLC | 56 | 0 | -56 | 0.00 | 0.00 | -0.00 | sell |