| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 49,587 | 1,499,845 | +1,450,258 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 1,978,972 | 3,235,778 | +1,256,806 | 0.26 | 0.38 | +0.12 | buy |
| CITADEL ADVISORS LLC | 0 | 1,187,047 | +1,187,047 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 963,855 | +963,855 | 0.00 | 0.19 | +0.19 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 98,750 | 724,438 | +625,688 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 13,462 | 463,662 | +450,200 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 431,631 | +431,631 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 141,700 | 321,692 | +179,992 | 0.03 | 0.08 | +0.05 | buy |
| NORTHERN TRUST CORP | 19,903 | 197,177 | +177,274 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 36,444 | 159,881 | +123,437 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 120,482 | +120,482 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 106,320 | +106,320 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 24,262 | 108,870 | +84,608 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 72,215 | +72,215 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 71,103 | +71,103 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 68,563 | +68,563 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 63,640 | +63,640 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 63,640 | +63,640 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 46,692 | +46,692 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 36,451 | +36,451 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 35,402 | +35,402 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 16,293 | 50,293 | +34,000 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 25,564 | +25,564 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 23,077 | +23,077 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 21,481 | +21,481 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 20,996 | +20,996 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 20,400 | +20,400 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 281 | 19,889 | +19,608 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 18,100 | +18,100 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 15,335 | +15,335 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 13,636 | +13,636 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1 | 12,190 | +12,189 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 12,069 | +12,069 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 11,288 | +11,288 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 10,323 | +10,323 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 25,000 | 31,720 | +6,720 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 2,555 | +2,555 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 2,379 | +2,379 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,611 | +1,611 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 528 | +528 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 99,900 | 100,014 | +114 | 0.01 | 0.01 | -0.01 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 136 | 136 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,204,819 | 1,204,819 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 3,998,333 | 3,998,333 | 0 | 0.18 | 0.16 | -0.02 | hold |
| Sio Capital Management, LLC | 1,078,965 | 1,078,965 | 0 | 0.64 | 0.84 | +0.20 | hold |
| StepStone Group LP | 2,660,612 | 2,660,612 | 0 | 5.31 | 0.56 | -4.75 | hold |
| NEA Management Company, LLC | 478,548 | 478,548 | 0 | 0.11 | 0.14 | +0.02 | hold |
| Rangeley Capital, LLC | 95,000 | 95,000 | 0 | 0.42 | 0.40 | -0.02 | hold |
| Carlyle Group Inc. | 269,895 | 269,895 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Vivo Capital, LLC | 1,927,710 | 1,927,710 | 0 | 0.66 | 0.80 | +0.14 | hold |
| Aisling Capital Management LP | 88,607 | 88,607 | 0 | 0.08 | 0.09 | +0.01 | hold |
| Affinity Asset Advisors, LLC | 240,963 | 240,963 | 0 | 0.06 | 0.05 | -0.00 | hold |
| ACORN CAPITAL ADVISORS, LLC | 2,839,674 | 2,839,674 | 0 | 3.34 | 3.53 | +0.19 | hold |
| Aldebaran Capital, LLC | 40,419 | 39,869 | -550 | 0.13 | 0.14 | +0.01 | sell |
| Stonepine Capital Management, LLC | 132,578 | 130,684 | -1,894 | 0.48 | 0.45 | -0.03 | sell |
| Vestal Point Capital, LP | 1,839,819 | 1,825,699 | -14,120 | 0.21 | 0.19 | -0.02 | sell |
| XTX Topco Ltd | 34,129 | 16,970 | -17,159 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 377,250 | 358,738 | -18,512 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 22,224 | 0 | -22,224 | 0.01 | 0.00 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 30,499 | 0 | -30,499 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 37,055 | 0 | -37,055 | 0.00 | 0.00 | -0.00 | sell |
| NewEdge Advisors, LLC | 44,551 | 0 | -44,551 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 132,219 | 50,000 | -82,219 | 0.08 | 0.03 | -0.05 | sell |
| ADAR1 Capital Management, LLC | 2,434,941 | 2,238,684 | -196,257 | 0.61 | 0.48 | -0.13 | sell |
| Rosalind Advisors, Inc. | 443,763 | 150,000 | -293,763 | 0.75 | 0.26 | -0.50 | sell |
| Prosight Management, LP | 2,154,381 | 978,992 | -1,175,389 | 1.46 | 0.77 | -0.69 | sell |
| Foresite Capital Management VI LLC | 1,445,783 | 0 | -1,445,783 | 1.30 | 0.00 | -1.30 | sell |