| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 0 | 1,837,739 | +1,837,739 | 0.00 | 0.87 | +0.87 | buy |
| CITADEL ADVISORS LLC | 0 | 1,074,314 | +1,074,314 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,004,439 | +1,004,439 | 0.00 | 0.24 | +0.24 | buy |
| Samsara BioCapital, LLC | 0 | 824,155 | +824,155 | 0.00 | 0.97 | +0.97 | buy |
| VANGUARD GROUP INC | 0 | 706,733 | +706,733 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 635,000 | +635,000 | 0.00 | 0.32 | +0.32 | buy |
| Deep Track Capital, LP | 0 | 523,989 | +523,989 | 0.00 | 0.17 | +0.17 | buy |
| StepStone Group LP | 0 | 491,938 | +491,938 | 0.00 | 3.70 | +3.70 | buy |
| NEA Management Company, LLC | 0 | 478,548 | +478,548 | 0.00 | 0.23 | +0.23 | buy |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 0 | 399,743 | +399,743 | 0.00 | 0.13 | +0.13 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 294,626 | +294,626 | 0.00 | 0.17 | +0.17 | buy |
| Carlyle Group Inc. | 0 | 269,895 | +269,895 | 0.00 | 0.06 | +0.06 | buy |
| Ikarian Capital, LLC | 0 | 253,754 | +253,754 | 0.00 | 0.62 | +0.62 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 249,642 | +249,642 | 0.00 | 0.00 | +0.00 | buy |
| Altium Capital Management LLC | 0 | 218,386 | +218,386 | 0.00 | 0.58 | +0.58 | buy |
| Affinity Asset Advisors, LLC | 0 | 144,159 | +144,159 | 0.00 | 0.19 | +0.19 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 144,099 | +144,099 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 0 | 94,017 | +94,017 | 0.00 | 0.00 | +0.00 | buy |
| Aisling Capital Management LP | 0 | 88,607 | +88,607 | 0.00 | 0.27 | +0.27 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 87,354 | +87,354 | 0.00 | 0.14 | +0.14 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 78,021 | +78,021 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 76,599 | +76,599 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 0 | 63,754 | +63,754 | 0.00 | 0.15 | +0.15 | buy |
| Nantahala Capital Management, LLC | 0 | 54,777 | +54,777 | 0.00 | 0.03 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 47,450 | +47,450 | 0.00 | 0.00 | +0.00 | buy |
| Aldebaran Capital, LLC | 0 | 45,572 | +45,572 | 0.00 | 0.37 | +0.37 | buy |
| 683 Capital Management, LLC | 0 | 43,371 | +43,371 | 0.00 | 0.04 | +0.04 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 35,700 | +35,700 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 20,549 | +20,549 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 19,177 | +19,177 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 18,633 | +18,633 | 0.00 | 0.01 | +0.01 | buy |
| Shay Capital LLC | 0 | 15,016 | +15,016 | 0.00 | 0.03 | +0.03 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 14,228 | +14,228 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 13,495 | +13,495 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 12,100 | +12,100 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 8,741 | +8,741 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 2,683 | +2,683 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 2,201 | +2,201 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 422 | +422 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 289 | +289 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 236 | +236 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 102 | +102 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 3,200 | 0 | -3,200 | 0.00 | 0.00 | -0.00 | sell |