| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 0 | 2,425,000 | +2,425,000 | 0.00 | 0.11 | +0.11 | buy |
| Siren, L.L.C. | 0 | 736,457 | +736,457 | 0.00 | 0.03 | +0.03 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 273,031 | +273,031 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 15,492 | 72,486 | +56,994 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 48,593 | +48,593 | 0.00 | 0.01 | +0.01 | buy |
| HighTower Advisors, LLC | 36,830 | 74,573 | +37,743 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 36,921 | +36,921 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 15,698 | +15,698 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 13,913 | +13,913 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 21,136 | 29,908 | +8,772 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 55,223 | 58,871 | +3,648 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATURE ESTATE & INVESTMENT ADVISORS LLC | 47,328 | 47,328 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Knoll Capital Management, LLC | 5,881,879 | 5,881,879 | 0 | 3.59 | 5.81 | +2.22 | hold |
| DIADEMA PARTNERS LP | 23,260 | 23,260 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Persistent Asset Partners Ltd | 5,881 | 5,881 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 51 | 51 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 20 | 0 | -20 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 12,382 | 0 | -12,382 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 288,670 | 274,497 | -14,173 | 0.03 | 0.05 | +0.02 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 473,442 | 368,847 | -104,595 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 131,622 | 20,559 | -111,063 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 146,854 | 0 | -146,854 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 195,780 | 0 | -195,780 | 0.00 | 0.00 | -0.00 | sell |