| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 5,607,271 | 5,618,365 | +11,094 | 0.00 | 0.00 | -0.00 | buy |
| EcoR1 Capital, LLC | 670,303 | 4,002,847 | +3,332,544 | 0.15 | 0.72 | +0.57 | buy |
| ARMISTICE CAPITAL, LLC | 4,200,000 | 4,000,000 | -200,000 | 0.62 | 0.38 | -0.23 | sell |
| VANGUARD GROUP INC | 3,250,066 | 3,266,484 | +16,418 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,292,703 | 1,880,760 | -411,943 | 0.01 | 0.01 | -0.00 | sell |
| Vestal Point Capital, LP | 1,475,000 | 1,475,000 | 0 | 0.31 | 0.21 | -0.10 | hold |
| Opaleye Management Inc. | 0 | 1,196,904 | +1,196,904 | 0.00 | 0.62 | +0.62 | buy |
| Erste Asset Management GmbH | 1,116,793 | 1,195,141 | +78,348 | 0.05 | 0.04 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,148,612 | 1,135,188 | -13,424 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,283,156 | 1,084,499 | -198,657 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 925,358 | 936,266 | +10,908 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 398,226 | 556,646 | +158,420 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 599,688 | 544,114 | -55,574 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 581,699 | 521,651 | -60,048 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 394,751 | 368,546 | -26,205 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 199,761 | 339,761 | +140,000 | 0.22 | 0.28 | +0.06 | buy |
| FIDUCIARY TRUST CO | 334,397 | 334,397 | 0 | 0.02 | 0.01 | -0.00 | hold |
| JPMORGAN CHASE & CO | 217,411 | 326,230 | +108,819 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 297,573 | 303,133 | +5,560 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 262,450 | 296,450 | +34,000 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 473,100 | 268,793 | -204,307 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 140,715 | 222,713 | +81,998 | 0.00 | 0.00 | +0.00 | buy |
| Altshuler Shaham Ltd | 0 | 203,740 | +203,740 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 427,430 | 176,097 | -251,333 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 158,109 | 162,112 | +4,003 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 176,216 | 160,037 | -16,179 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 146,457 | 150,405 | +3,948 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 160,492 | 149,747 | -10,745 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 118,705 | 141,737 | +23,032 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 193,415 | 139,332 | -54,083 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 137,892 | 137,888 | -4 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 104,699 | 132,663 | +27,964 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 90,478 | 116,000 | +25,522 | 0.00 | 0.00 | -0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 103,567 | 103,649 | +82 | 0.00 | 0.00 | -0.00 | buy |
| Patriot Financial Group Insurance Agency, LLC | 117,284 | 102,716 | -14,568 | 0.07 | 0.05 | -0.02 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 150,878 | 100,483 | -50,395 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 95,351 | +95,351 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 45,000 | 95,000 | +50,000 | 0.04 | 0.07 | +0.03 | buy |
| Nuveen, LLC | 93,161 | 93,161 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 94,190 | 91,746 | -2,444 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 87,459 | 87,459 | 0 | 0.01 | 0.01 | -0.00 | hold |
| OMERS ADMINISTRATION Corp | 71,950 | 83,012 | +11,062 | 0.00 | 0.00 | -0.00 | buy |
| Birchview Capital, LP | 134,918 | 74,918 | -60,000 | 0.48 | 0.17 | -0.30 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55,225 | 65,182 | +9,957 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 42,339 | 64,195 | +21,856 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 58,600 | 62,600 | +4,000 | 0.00 | 0.00 | -0.00 | buy |
| Allspring Global Investments Holdings, LLC | 56,353 | 61,775 | +5,422 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 69,991 | 58,921 | -11,070 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 58,830 | 58,830 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Walleye Capital LLC | 0 | 55,840 | +55,840 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 55,766 | 53,063 | -2,703 | 0.05 | 0.03 | -0.03 | sell |
| HSBC HOLDINGS PLC | 148,055 | 52,636 | -95,419 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 44,350 | 44,350 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Palumbo Wealth Management LLC | 0 | 38,487 | +38,487 | 0.00 | 0.04 | +0.04 | buy |
| Marex Group plc | 38,322 | 38,322 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 50,700 | 38,000 | -12,700 | 0.00 | 0.00 | -0.00 | sell |
| Ethic Inc. | 38,353 | 36,738 | -1,615 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 0 | 36,320 | +36,320 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 35,000 | 35,000 | 0 | 0.02 | 0.01 | -0.01 | hold |
| DEUTSCHE BANK AG\ | 0 | 31,669 | +31,669 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 31,298 | +31,298 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 30,425 | +30,425 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 28,577 | 25,067 | -3,510 | 0.00 | 0.00 | -0.00 | sell |
| Vestcor Inc | 22,874 | 22,874 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22,321 | 21,586 | -735 | 0.00 | 0.00 | -0.00 | sell |
| Hunter Perkins Capital Management, LLC | 53,840 | 20,965 | -32,875 | 0.06 | 0.02 | -0.04 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 21,245 | 18,972 | -2,273 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 0 | 16,381 | +16,381 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 37 | 15,729 | +15,692 | 0.00 | 0.02 | +0.02 | buy |
| HRT FINANCIAL LP | 37,345 | 15,508 | -21,837 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 26,753 | 15,208 | -11,545 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 23,002 | 14,417 | -8,585 | 0.01 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 14,195 | 14,195 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cetera Investment Advisers | 14,164 | 14,164 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,732 | 12,732 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COLDSTREAM CAPITAL MANAGEMENT INC | 11,775 | 11,749 | -26 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 11,499 | 11,499 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC Asset Management Inc | 0 | 11,335 | +11,335 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 16,477 | 11,254 | -5,223 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 0 | 11,116 | +11,116 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 28,104 | 10,669 | -17,435 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 9,723 | 9,603 | -120 | 0.00 | 0.00 | -0.00 | sell |
| Pinnacle Wealth Planning Services, Inc. | 0 | 9,446 | +9,446 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 8,135 | +8,135 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 5,952 | 5,957 | +5 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 4,054 | 4,054 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 3,969 | 3,969 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,923 | 3,923 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BESSEMER GROUP INC | 3,513 | 3,513 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,901 | 2,865 | -36 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,144 | 2,864 | +720 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 10,107 | 2,736 | -7,371 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 5,333 | 2,699 | -2,634 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 3,214 | 2,685 | -529 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 0 | 2,074 | +2,074 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,382 | 1,463 | +81 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 1,403 | 1,402 | -1 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,193 | 1,178 | -15 | 0.00 | 0.00 | -0.00 | sell |
| Versant Capital Management, Inc | 0 | 1,019 | +1,019 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 750 | 909 | +159 | 0.00 | 0.00 | -0.00 | buy |