| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 1,246,041 | 3,552,967 | +2,306,926 | 0.05 | 0.15 | +0.10 | buy |
| Darwin Global Management, Ltd. | 579,959 | 2,750,804 | +2,170,845 | 7.15 | 25.02 | +17.87 | buy |
| PERCEPTIVE ADVISORS LLC | 1,088,486 | 1,932,759 | +844,273 | 1.53 | 2.31 | +0.78 | buy |
| Capital Research Global Investors | 3,440,107 | 4,140,521 | +700,414 | 0.05 | 0.06 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 6,981,376 | 7,673,868 | +692,492 | 0.26 | 0.29 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,677,822 | 3,176,181 | +498,359 | 0.02 | 0.03 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,973,506 | 2,287,375 | +313,869 | 0.01 | 0.02 | 0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,674,368 | 1,867,807 | +193,439 | 1.27 | 1.27 | +0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,455,593 | 1,586,095 | +130,502 | 0.53 | 0.57 | +0.04 | buy |
| TD ASSET MANAGEMENT INC | 167,036 | 281,288 | +114,252 | 0.01 | 0.02 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 379,407 | 280,875 | +98,532 | 0.03 | 0.02 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 438,311 | 367,249 | +71,062 | 0.05 | 0.04 | 0.00 | sell |
| Monashee Investment Management LLC | 37,500 | 100,000 | +62,500 | 0.42 | 0.81 | +0.39 | buy |
| Affinity Asset Advisors, LLC | 25,000 | 80,000 | +55,000 | 0.31 | 0.89 | +0.58 | buy |
| AMERICAN CENTURY COMPANIES INC | 407,229 | 461,724 | +54,495 | 0.02 | 0.02 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 607,206 | 657,206 | +50,000 | 0.62 | 0.70 | +0.08 | buy |
| Artia Global Partners LP | 38,555 | 76,255 | +37,700 | 0.96 | 1.28 | +0.32 | buy |
| Swiss National Bank | 147,900 | 178,000 | +30,100 | 0.01 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 665,000 | 685,000 | +20,000 | 1.99 | 2.05 | +0.06 | buy |
| ALPS ADVISORS INC | 65,295 | 76,316 | +11,021 | 0.03 | 0.04 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 82,331 | 92,026 | +9,695 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 27,280 | 21,429 | +5,851 | 0.07 | 0.06 | 0.00 | sell |
| ProShare Advisors LLC | 21,607 | 26,667 | +5,060 | 0.00 | 0.00 | 0.00 | buy |
| Scientech Research LLC | 3,255 | 7,289 | +4,034 | 0.20 | 0.26 | +0.06 | buy |
| GUGGENHEIM CAPITAL LLC | 27,557 | 31,472 | +3,915 | 0.01 | 0.02 | 0.00 | buy |
| Bridgefront Capital, LLC | 3,209 | 6,594 | +3,385 | 0.15 | 0.34 | +0.19 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 8,030 | 6,007 | +2,023 | 0.04 | 0.03 | 0.00 | sell |
| ADAR1 Capital Management, LLC | 100 | 2,000 | +1,900 | 0.00 | 0.04 | +0.03 | buy |
| ALGERT GLOBAL LLC | 14,390 | 13,310 | +1,080 | 0.04 | 0.04 | 0.00 | sell |
| Ameritas Investment Partners, Inc. | 9,495 | 10,545 | +1,050 | 0.02 | 0.03 | +0.00 | buy |
| Banque Cantonale Vaudoise | 602 | 1,184 | +582 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 8,050 | 8,500 | +450 | 0.22 | 0.23 | +0.01 | buy |
| Woodline Partners LP | 393,351 | 393,704 | +353 | 0.27 | 0.25 | -0.02 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 4,336 | 4,202 | +134 | 0.00 | 0.00 | -0.00 | sell |
| Chicago Partners Investment Group LLC | 5,877 | 6,009 | +132 | 0.02 | 0.02 | -0.00 | buy |
| CALDWELL SUTTER CAPITAL, INC. | 359 | 379 | +20 | 0.01 | 0.01 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 15,843 | 15,840 | -3 | 0.02 | 0.02 | +0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 17,101 | 17,078 | -23 | 0.01 | 0.01 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 1,528 | 1,432 | -96 | 0.06 | 0.05 | -0.01 | sell |
| OLIVER LAGORE VANVALIN INVESTMENT GROUP | 284 | 174 | -110 | 0.01 | 0.00 | -0.00 | sell |
| Baker Avenue Asset Management, LP | 13,780 | 13,643 | -137 | 0.04 | 0.04 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 385,574 | 384,363 | -1,211 | 0.08 | 0.08 | -0.00 | sell |
| Parkwood LLC | 15,480 | 13,555 | -1,925 | 0.12 | 0.08 | -0.03 | sell |
| SEGALL BRYANT & HAMILL, LLC | 160,281 | 158,021 | -2,260 | 0.19 | 0.20 | +0.01 | sell |
| E Fund Management Co., Ltd. | 8,476 | 5,962 | -2,514 | 0.03 | 0.03 | -0.01 | sell |
| Bellevue Group AG | 15,800 | 13,244 | -2,556 | 0.02 | 0.01 | -0.00 | sell |
| ELEVATION POINT WEALTH PARTNERS, LLC | 8,208 | 5,004 | -3,204 | 0.05 | 0.03 | -0.02 | sell |
| Opaleye Management Inc. | 90,000 | 85,000 | -5,000 | 1.50 | 1.27 | -0.24 | sell |
| BANK OF HAWAII | 21,309 | 16,153 | -5,156 | 0.07 | 0.05 | -0.02 | sell |
| CASTLEARK MANAGEMENT LLC | 85,260 | 75,040 | -10,220 | 0.24 | 0.21 | -0.02 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 117,373 | 104,830 | -12,543 | 4.15 | 4.65 | +0.50 | sell |
| China Universal Asset Management Co., Ltd. | 42,167 | 20,840 | -21,327 | 0.52 | 0.18 | -0.33 | sell |
| Frazier Life Sciences Management, L.P. | 1,164,405 | 1,139,405 | -25,000 | 3.91 | 3.28 | -0.63 | sell |
| Nicholas Investment Partners, LP | 110,723 | 85,644 | -25,079 | 0.81 | 0.60 | -0.21 | sell |
| SAMLYN CAPITAL, LLC | 329,209 | 302,679 | -26,530 | 0.41 | 0.35 | -0.07 | sell |
| MOODY ALDRICH PARTNERS LLC | 147,927 | 118,602 | -29,325 | 1.67 | 1.38 | -0.29 | sell |
| Rafferty Asset Management, LLC | 158,413 | 126,164 | -32,249 | 0.04 | 0.03 | -0.01 | sell |
| Eversept Partners, LP | 233,839 | 197,331 | -36,508 | 1.29 | 0.90 | -0.39 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,088 | 85,088 | -65,000 | 0.02 | 0.01 | -0.01 | sell |
| Pier Capital, LLC | 201,562 | 127,384 | -74,178 | 1.81 | 1.20 | -0.61 | sell |
| BRAIDWELL LP | 1,289,965 | 1,212,703 | -77,262 | 2.98 | 2.67 | -0.31 | sell |
| ORBIMED ADVISORS LLC | 1,153,091 | 1,066,131 | -86,960 | 1.45 | 1.34 | -0.11 | sell |
| First Turn Management, LLC | 357,528 | 260,281 | -97,247 | 3.22 | 2.66 | -0.56 | sell |
| Parkman Healthcare Partners LLC | 267,594 | 149,956 | -117,638 | 2.38 | 1.26 | -1.12 | sell |
| Soleus Capital Management, L.P. | 415,450 | 207,750 | -207,700 | 2.89 | 1.25 | -1.65 | sell |
| JENNISON ASSOCIATES LLC | 1,476,154 | 1,256,883 | -219,271 | 0.07 | 0.06 | -0.01 | sell |
| Commodore Capital LP | 1,100,000 | 860,000 | -240,000 | 6.04 | 3.93 | -2.11 | sell |
| Kynam Capital Management, LP | 1,002,407 | 745,000 | -257,407 | 7.12 | 5.66 | -1.46 | sell |
| FRED ALGER MANAGEMENT, LLC | 1,670,189 | 1,396,711 | -273,478 | 0.57 | 0.47 | -0.09 | sell |
| Avidity Partners Management LP | 570,137 | 284,000 | -286,137 | 1.37 | 0.69 | -0.68 | sell |