| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 1,246,041 | 3,552,967 | +2,306,926 | 0.05 | 0.15 | +0.10 | buy |
| Darwin Global Management, Ltd. | 579,959 | 2,750,804 | +2,170,845 | 7.15 | 25.02 | +17.87 | buy |
| FMR LLC | 14,213,365 | 16,261,159 | +2,047,794 | 0.07 | 0.07 | +0.01 | buy |
| VANGUARD GROUP INC | 8,452,371 | 9,737,254 | +1,284,883 | 0.01 | 0.01 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,239,995 | +1,239,995 | 0.00 | 2.98 | +2.98 | buy |
| FRANKLIN RESOURCES INC | 1,076,920 | 2,147,656 | +1,070,736 | 0.03 | 0.05 | +0.01 | buy |
| Invesco Ltd. | 226,951 | 1,234,509 | +1,007,558 | 0.00 | 0.02 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 1,088,486 | 1,932,759 | +844,273 | 1.53 | 2.33 | +0.80 | buy |
| JPMORGAN CHASE & CO | 405,334 | 1,161,777 | +756,443 | 0.00 | 0.01 | +0.00 | buy |
| Capital Research Global Investors | 3,440,107 | 4,140,521 | +700,414 | 0.05 | 0.06 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 6,981,376 | 7,673,868 | +692,492 | 0.26 | 0.29 | +0.02 | buy |
| Avoro Capital Advisors LLC | 0 | 575,000 | +575,000 | 0.00 | 0.46 | +0.46 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,677,822 | 3,176,181 | +498,359 | 0.02 | 0.03 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,431,920 | 4,919,370 | +487,450 | 0.05 | 0.06 | +0.01 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 3,400 | 377,400 | +374,000 | 0.00 | 0.15 | +0.15 | buy |
| MAVERICK CAPITAL LTD | 0 | 355,131 | +355,131 | 0.00 | 0.47 | +0.47 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,973,506 | 2,287,375 | +313,869 | 0.01 | 0.01 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 7,891,254 | 8,203,754 | +312,500 | 7.74 | 7.13 | -0.61 | buy |
| EcoR1 Capital, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.52 | +0.52 | buy |
| Cercano Management LLC | 0 | 272,151 | +272,151 | 0.00 | 0.52 | +0.52 | buy |
| GOLDMAN SACHS GROUP INC | 481,119 | 698,492 | +217,373 | 0.01 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,674,368 | 1,867,807 | +193,439 | 1.27 | 1.27 | +0.00 | buy |
| Saturn V Capital Management LP | 0 | 185,175 | +185,175 | 0.00 | 5.07 | +5.07 | buy |
| NORGES BANK | 915,512 | 1,046,032 | +130,520 | 0.01 | 0.01 | +0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,455,593 | 1,586,095 | +130,502 | 0.53 | 0.57 | +0.04 | buy |
| Ensign Peak Advisors, Inc | 361,131 | 475,700 | +114,569 | 0.04 | 0.06 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 167,036 | 281,288 | +114,252 | 0.01 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 174,151 | 285,876 | +111,725 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 109,389 | +109,389 | 0.00 | 0.14 | +0.14 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 730,438 | 833,618 | +103,180 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 884,268 | 968,757 | +84,489 | 0.01 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 42,525 | 118,533 | +76,008 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 78,912 | 144,867 | +65,955 | 0.01 | 0.01 | +0.00 | buy |
| Monashee Investment Management LLC | 37,500 | 100,000 | +62,500 | 0.42 | 0.81 | +0.39 | buy |
| BANQUE PICTET & CIE SA | 0 | 60,887 | +60,887 | 0.00 | 0.04 | +0.04 | buy |
| First Light Asset Management, LLC | 0 | 60,284 | +60,284 | 0.00 | 0.32 | +0.32 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 59,400 | +59,400 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 98,135 | 156,986 | +58,851 | 0.00 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 25,000 | 80,000 | +55,000 | 0.31 | 0.89 | +0.58 | buy |
| AMERICAN CENTURY COMPANIES INC | 407,229 | 461,724 | +54,495 | 0.02 | 0.02 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 607,206 | 657,206 | +50,000 | 0.62 | 0.70 | +0.08 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 45,766 | +45,766 | 0.00 | 0.01 | +0.01 | buy |
| Informed Momentum Co LLC | 0 | 43,732 | +43,732 | 0.00 | 0.47 | +0.47 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 40,000 | +40,000 | 0.00 | 0.03 | +0.03 | buy |
| Artia Global Partners LP | 38,555 | 76,255 | +37,700 | 0.96 | 1.28 | +0.32 | buy |
| TWINBEECH CAPITAL LP | 0 | 31,647 | +31,647 | 0.00 | 0.04 | +0.04 | buy |
| FEDERATED HERMES, INC. | 394,192 | 425,750 | +31,558 | 0.06 | 0.07 | +0.01 | buy |
| Jump Financial, LLC | 0 | 30,224 | +30,224 | 0.00 | 0.06 | +0.06 | buy |
| Swiss National Bank | 147,900 | 178,000 | +30,100 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 81,473 | 108,012 | +26,539 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 22,603 | 47,388 | +24,785 | 0.00 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 665,000 | 685,000 | +20,000 | 2.00 | 2.06 | +0.06 | buy |
| Pathstone Holdings, LLC | 3,757 | 23,273 | +19,516 | 0.00 | 0.01 | +0.01 | buy |
| EFG Asset Management (North America) Corp. | 0 | 19,425 | +19,425 | 0.00 | 0.23 | +0.23 | buy |
| Russell Investments Group, Ltd. | 0 | 18,858 | +18,858 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 36,511 | 54,841 | +18,330 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 130,551 | 148,294 | +17,743 | 0.01 | 0.01 | +0.00 | buy |
| Neuberger Berman Group LLC | 86,167 | 102,311 | +16,144 | 0.00 | 0.01 | +0.00 | buy |
| Maven Securities LTD | 0 | 15,000 | +15,000 | 0.00 | 0.06 | +0.06 | buy |
| Legal & General Group Plc | 80,003 | 94,783 | +14,780 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 10,700 | 25,200 | +14,500 | 0.00 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 14,374 | +14,374 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 105,073 | 119,082 | +14,009 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 399,117 | 412,525 | +13,408 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,698 | 43,811 | +13,113 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 34,443 | 47,511 | +13,068 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 6,856 | 18,064 | +11,208 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 65,295 | 76,316 | +11,021 | 0.03 | 0.04 | +0.00 | buy |
| Calamos Advisors LLC | 0 | 10,165 | +10,165 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 166,034 | 176,078 | +10,044 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 82,331 | 92,026 | +9,695 | 0.01 | 0.01 | +0.00 | buy |
| Harvest Investment Services, LLC | 0 | 8,663 | +8,663 | 0.00 | 0.24 | +0.24 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 8,193 | +8,193 | 0.00 | 0.07 | +0.07 | buy |
| WELLS FARGO & COMPANY/MN | 35,813 | 43,055 | +7,242 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 6,028 | +6,028 | 0.00 | 0.04 | +0.04 | buy |
| Tidal Investments LLC | 0 | 5,928 | +5,928 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 183,877 | 189,668 | +5,791 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 46,627 | 52,313 | +5,686 | 0.01 | 0.01 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 5,554 | +5,554 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 21,607 | 26,667 | +5,060 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 48,381 | 53,429 | +5,048 | 0.01 | 0.01 | +0.00 | buy |
| Bank Pictet & Cie (Europe) AG | 0 | 4,846 | +4,846 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 49,271 | 53,997 | +4,726 | 0.02 | 0.02 | +0.00 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 0 | 4,703 | +4,703 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 11,950 | 16,638 | +4,688 | 0.00 | 0.00 | -0.00 | buy |
| Cetera Investment Advisers | 0 | 4,480 | +4,480 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 4,359 | +4,359 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 3,255 | 7,289 | +4,034 | 0.20 | 0.26 | +0.06 | buy |
| GUGGENHEIM CAPITAL LLC | 27,557 | 31,472 | +3,915 | 0.01 | 0.02 | +0.00 | buy |
| Arizona State Retirement System | 20,988 | 24,783 | +3,795 | 0.01 | 0.01 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 3,770 | +3,770 | 0.00 | 0.01 | +0.01 | buy |
| Mariner, LLC | 0 | 3,690 | +3,690 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 21,495 | 25,059 | +3,564 | 0.01 | 0.02 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 57,190 | 60,675 | +3,485 | 0.01 | 0.01 | +0.00 | buy |
| Bridgefront Capital, LLC | 3,209 | 6,594 | +3,385 | 0.15 | 0.34 | +0.19 | buy |
| Crossmark Global Holdings, Inc. | 0 | 3,137 | +3,137 | 0.00 | 0.00 | +0.00 | buy |
| CI INVESTMENTS INC. | 0 | 3,054 | +3,054 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 17,358 | 20,069 | +2,711 | 0.01 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 22,008 | 24,597 | +2,589 | 0.00 | 0.00 | +0.00 | buy |
| Belvedere Trading LLC | 0 | 2,585 | +2,585 | 0.00 | 0.01 | +0.01 | buy |