| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 14,213,365 | 16,261,159 | +2,047,794 | 0.07 | 0.07 | +0.01 | buy |
| VANGUARD GROUP INC | 8,452,371 | 9,737,254 | +1,284,883 | 0.01 | 0.01 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 7,891,254 | 8,203,754 | +312,500 | 7.74 | 7.13 | -0.61 | buy |
| JANUS HENDERSON GROUP PLC | 6,981,376 | 7,673,868 | +692,492 | 0.26 | 0.29 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,431,920 | 4,919,370 | +487,450 | 0.05 | 0.06 | +0.01 | buy |
| Capital Research Global Investors | 3,440,107 | 4,140,521 | +700,414 | 0.05 | 0.06 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 1,246,041 | 3,552,967 | +2,306,926 | 0.05 | 0.15 | +0.10 | buy |
| STATE STREET CORP | 3,389,528 | 3,337,092 | -52,436 | 0.01 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,677,822 | 3,176,181 | +498,359 | 0.02 | 0.03 | +0.00 | buy |
| Darwin Global Management, Ltd. | 579,959 | 2,750,804 | +2,170,845 | 7.15 | 25.02 | +17.87 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,973,506 | 2,287,375 | +313,869 | 0.01 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,076,920 | 2,147,656 | +1,070,736 | 0.03 | 0.05 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 1,088,486 | 1,932,759 | +844,273 | 1.53 | 2.33 | +0.80 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,674,368 | 1,867,807 | +193,439 | 1.27 | 1.27 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,915,047 | 1,780,703 | -134,344 | 0.05 | 0.04 | -0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,455,593 | 1,586,095 | +130,502 | 0.53 | 0.57 | +0.04 | buy |
| FRED ALGER MANAGEMENT, LLC | 1,670,189 | 1,396,711 | -273,478 | 0.57 | 0.47 | -0.09 | sell |
| JENNISON ASSOCIATES LLC | 1,476,154 | 1,256,883 | -219,271 | 0.07 | 0.06 | -0.01 | sell |
| Paradigm Biocapital Advisors LP | 0 | 1,239,995 | +1,239,995 | 0.00 | 2.98 | +2.98 | buy |
| Invesco Ltd. | 226,951 | 1,234,509 | +1,007,558 | 0.00 | 0.02 | +0.01 | buy |
| BRAIDWELL LP | 1,289,965 | 1,212,703 | -77,262 | 2.98 | 2.67 | -0.31 | sell |
| JPMORGAN CHASE & CO | 405,334 | 1,161,777 | +756,443 | 0.00 | 0.01 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 1,164,405 | 1,139,405 | -25,000 | 3.91 | 3.28 | -0.63 | sell |
| ORBIMED ADVISORS LLC | 1,153,091 | 1,066,131 | -86,960 | 1.45 | 1.34 | -0.11 | sell |
| NORGES BANK | 915,512 | 1,046,032 | +130,520 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 884,268 | 968,757 | +84,489 | 0.01 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,149,209 | 861,569 | -287,640 | 0.08 | 0.06 | -0.02 | sell |
| Commodore Capital LP | 1,100,000 | 860,000 | -240,000 | 6.04 | 3.93 | -2.11 | sell |
| Novo Holdings A/S | 845,000 | 845,000 | 0 | 3.28 | 3.98 | +0.70 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 730,438 | 833,618 | +103,180 | 0.01 | 0.01 | +0.00 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 793,036 | 793,036 | 0 | 12.63 | 34.82 | +22.19 | hold |
| Kynam Capital Management, LP | 1,002,407 | 745,000 | -257,407 | 7.12 | 5.66 | -1.46 | sell |
| GOLDMAN SACHS GROUP INC | 481,119 | 698,492 | +217,373 | 0.01 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 665,000 | 685,000 | +20,000 | 2.00 | 2.06 | +0.06 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 607,206 | 657,206 | +50,000 | 0.62 | 0.70 | +0.08 | buy |
| Avoro Capital Advisors LLC | 0 | 575,000 | +575,000 | 0.00 | 0.46 | +0.46 | buy |
| MORGAN STANLEY | 537,365 | 490,454 | -46,911 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 361,131 | 475,700 | +114,569 | 0.04 | 0.06 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 407,229 | 461,724 | +54,495 | 0.02 | 0.02 | +0.00 | buy |
| FEDERATED HERMES, INC. | 394,192 | 425,750 | +31,558 | 0.06 | 0.07 | +0.01 | buy |
| Bank of New York Mellon Corp | 399,117 | 412,525 | +13,408 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 393,351 | 393,704 | +353 | 0.27 | 0.25 | -0.02 | buy |
| LORD, ABBETT & CO. LLC | 385,574 | 384,363 | -1,211 | 0.08 | 0.08 | -0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 3,400 | 377,400 | +374,000 | 0.00 | 0.15 | +0.15 | buy |
| D. E. Shaw & Co., Inc. | 438,311 | 367,249 | -71,062 | 0.04 | 0.03 | -0.01 | sell |
| MAVERICK CAPITAL LTD | 0 | 355,131 | +355,131 | 0.00 | 0.47 | +0.47 | buy |
| SAMLYN CAPITAL, LLC | 329,209 | 302,679 | -26,530 | 0.45 | 0.36 | -0.09 | sell |
| Amundi | 329,788 | 302,357 | -27,431 | 0.01 | 0.01 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 300,000 | 300,000 | 0 | 1.74 | 2.13 | +0.39 | hold |
| EcoR1 Capital, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.52 | +0.52 | buy |
| BANK OF AMERICA CORP /DE/ | 174,151 | 285,876 | +111,725 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 570,137 | 284,000 | -286,137 | 1.37 | 0.69 | -0.68 | sell |
| TD ASSET MANAGEMENT INC | 167,036 | 281,288 | +114,252 | 0.01 | 0.02 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 379,407 | 280,875 | -98,532 | 0.03 | 0.02 | -0.01 | sell |
| Cercano Management LLC | 0 | 272,151 | +272,151 | 0.00 | 0.52 | +0.52 | buy |
| First Turn Management, LLC | 357,528 | 260,281 | -97,247 | 3.22 | 2.66 | -0.56 | sell |
| Soleus Capital Management, L.P. | 415,450 | 207,750 | -207,700 | 2.89 | 1.25 | -1.65 | sell |
| MILLENNIUM MANAGEMENT LLC | 691,432 | 206,982 | -484,450 | 0.04 | 0.01 | -0.03 | sell |
| Eversept Partners, LP | 233,839 | 197,331 | -36,508 | 1.44 | 1.01 | -0.43 | sell |
| Aberdeen Group plc | 194,232 | 194,232 | 0 | 0.03 | 0.03 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 183,877 | 189,668 | +5,791 | 0.01 | 0.01 | +0.00 | buy |
| COMERICA BANK | 187,838 | 188,084 | +246 | 0.05 | 0.06 | +0.00 | buy |
| Saturn V Capital Management LP | 0 | 185,175 | +185,175 | 0.00 | 5.07 | +5.07 | buy |
| Swiss National Bank | 147,900 | 178,000 | +30,100 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 166,034 | 176,078 | +10,044 | 0.00 | 0.00 | -0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 160,281 | 158,021 | -2,260 | 0.19 | 0.20 | +0.01 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 98,135 | 156,986 | +58,851 | 0.00 | 0.01 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 267,594 | 149,956 | -117,638 | 2.38 | 1.26 | -1.12 | sell |
| RHUMBLINE ADVISERS | 130,551 | 148,294 | +17,743 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 78,912 | 144,867 | +65,955 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 152,258 | 136,148 | -16,110 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 201,698 | 129,252 | -72,446 | 0.01 | 0.00 | -0.00 | sell |
| Pier Capital, LLC | 201,562 | 127,384 | -74,178 | 1.81 | 1.20 | -0.61 | sell |
| Rafferty Asset Management, LLC | 158,413 | 126,164 | -32,249 | 0.04 | 0.03 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 105,073 | 119,082 | +14,009 | 0.00 | 0.01 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 147,927 | 118,602 | -29,325 | 1.67 | 1.38 | -0.29 | sell |
| AMERIPRISE FINANCIAL INC | 42,525 | 118,533 | +76,008 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 109,389 | +109,389 | 0.00 | 0.14 | +0.14 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 81,473 | 108,012 | +26,539 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 117,373 | 104,830 | -12,543 | 4.15 | 4.65 | +0.50 | sell |
| Polar Asset Management Partners Inc. | 214,279 | 104,479 | -109,800 | 0.36 | 0.19 | -0.17 | sell |
| SEI INVESTMENTS CO | 103,348 | 103,403 | +55 | 0.01 | 0.01 | -0.00 | buy |
| Neuberger Berman Group LLC | 86,167 | 102,311 | +16,144 | 0.00 | 0.01 | +0.00 | buy |
| Monashee Investment Management LLC | 37,500 | 100,000 | +62,500 | 0.42 | 0.81 | +0.39 | buy |
| Legal & General Group Plc | 80,003 | 94,783 | +14,780 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 82,331 | 92,026 | +9,695 | 0.01 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 110,723 | 85,644 | -25,079 | 0.81 | 0.60 | -0.21 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,088 | 85,088 | -65,000 | 0.02 | 0.01 | -0.01 | sell |
| Opaleye Management Inc. | 90,000 | 85,000 | -5,000 | 1.50 | 1.27 | -0.24 | sell |
| Affinity Asset Advisors, LLC | 25,000 | 80,000 | +55,000 | 0.31 | 0.89 | +0.58 | buy |
| ALPS ADVISORS INC | 65,295 | 76,316 | +11,021 | 0.03 | 0.04 | +0.00 | buy |
| Artia Global Partners LP | 38,555 | 76,255 | +37,700 | 0.96 | 1.28 | +0.32 | buy |
| CASTLEARK MANAGEMENT LLC | 85,260 | 75,040 | -10,220 | 0.24 | 0.21 | -0.02 | sell |
| FIRST TRUST ADVISORS LP | 77,636 | 63,826 | -13,810 | 0.01 | 0.00 | -0.00 | sell |
| BANQUE PICTET & CIE SA | 0 | 60,887 | +60,887 | 0.00 | 0.04 | +0.04 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 57,190 | 60,675 | +3,485 | 0.01 | 0.01 | +0.00 | buy |
| First Light Asset Management, LLC | 0 | 60,284 | +60,284 | 0.00 | 0.32 | +0.32 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 59,400 | +59,400 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 36,511 | 54,841 | +18,330 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 54,604 | 54,136 | -468 | 0.00 | 0.00 | +0.00 | sell |