| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 8,689,190 | 12,189,149 | +3,499,959 | 9.47 | 7.69 | -1.78 | buy |
| JANUS HENDERSON GROUP PLC | 10,575,363 | 11,765,481 | +1,190,118 | 0.44 | 0.45 | 0.00 | buy |
| Kynam Capital Management, LP | 2,336,796 | 3,200,000 | +863,204 | 12.62 | 10.34 | -2.28 | buy |
| BAKER BROS. ADVISORS LP | 48,885 | 640,885 | +592,000 | 0.04 | 0.27 | +0.23 | buy |
| Eversept Partners, LP | 127,588 | 557,070 | +429,482 | 0.93 | 2.14 | +1.21 | buy |
| Hood River Capital Management LLC | 401,442 | 751,614 | +350,172 | 0.49 | 0.48 | -0.00 | buy |
| Paradigm Biocapital Advisors LP | 1,422,787 | 1,696,481 | +273,694 | 4.05 | 2.95 | -1.10 | buy |
| Allspring Global Investments Holdings, LLC | 593,523 | 335,990 | +257,533 | 0.08 | 0.02 | 0.00 | sell |
| Novo Holdings A/S | 750,000 | 915,000 | +165,000 | 3.72 | 2.63 | -1.09 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 308,939 | 469,561 | +160,622 | 0.01 | 0.01 | 0.00 | buy |
| TWINBEECH CAPITAL LP | 279,944 | 404,965 | +125,021 | 0.39 | 0.28 | -0.11 | buy |
| Clearbridge Investments, LLC | 1,102,486 | 1,220,455 | +117,969 | 0.07 | 0.04 | -0.03 | buy |
| Polar Capital Holdings Plc | 973,645 | 1,082,473 | +108,828 | 0.45 | 0.25 | -0.20 | buy |
| D. E. Shaw & Co., Inc. | 775,653 | 867,891 | +92,238 | 0.08 | 0.04 | 0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 383,454 | 470,230 | +86,776 | 0.57 | 0.35 | -0.22 | buy |
| DIADEMA PARTNERS LP | 10,000 | 92,385 | +82,385 | 0.92 | 2.79 | +1.87 | buy |
| LAZARD ASSET MANAGEMENT LLC | 486,764 | 557,794 | +71,030 | 0.06 | 0.03 | 0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,802,888 | 2,869,054 | +66,166 | 0.02 | 0.01 | 0.00 | buy |
| Walleye Capital LLC | 148,356 | 105,966 | +42,390 | 0.14 | 0.05 | 0.00 | sell |
| Aberdeen Group plc | 224,824 | 264,737 | +39,913 | 0.03 | 0.02 | -0.02 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 3,989 | 34,228 | +30,239 | 0.06 | 0.20 | +0.14 | buy |
| Saturn V Capital Management LP | 204,285 | 232,295 | +28,010 | 6.55 | 4.43 | -2.12 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 61,828 | 89,212 | +27,384 | 0.05 | 0.04 | -0.01 | buy |
| Commodore Capital LP | 1,625,000 | 1,650,000 | +25,000 | 9.75 | 4.59 | -5.16 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 44,818 | 66,116 | +21,298 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 73,069 | 56,179 | +16,890 | 0.14 | 0.05 | 0.00 | sell |
| CIBC WORLD MARKETS CORP | 11,620 | 27,554 | +15,934 | 0.01 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 100,307 | 116,229 | +15,922 | 0.72 | 0.45 | -0.27 | buy |
| ProShare Advisors LLC | 40,875 | 32,692 | +8,183 | 0.01 | 0.00 | 0.00 | sell |
| Pivotal bioVenture Partners Investment Advisor LLC | 703,834 | 710,734 | +6,900 | 38.91 | 21.72 | -17.19 | buy |
| MAVERICK CAPITAL LTD | 1,201,898 | 1,208,093 | +6,195 | 1.77 | 0.82 | -0.95 | buy |
| AGF MANAGEMENT LTD | 28,444 | 34,253 | +5,809 | 0.01 | 0.01 | -0.00 | buy |
| Curi Capital, LLC | 8,616 | 13,213 | +4,597 | 0.02 | 0.01 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 76,534 | 80,081 | +3,547 | 0.01 | 0.01 | -0.01 | buy |
| DnB Asset Management AS | 7,067 | 9,831 | +2,764 | 0.00 | 0.00 | -0.00 | buy |
| CenterBook Partners LP | 23,367 | 25,646 | +2,279 | 0.11 | 0.06 | -0.05 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 74,907 | 77,059 | +2,152 | 0.27 | 0.13 | 0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 18,950 | 21,040 | +2,090 | 1.04 | 0.62 | -0.42 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 105,052 | 107,050 | +1,998 | 0.01 | 0.01 | -0.01 | buy |
| Persistent Asset Partners Ltd | 19,151 | 21,139 | +1,988 | 1.45 | 0.70 | -0.74 | buy |
| E Fund Management Co., Ltd. | 10,479 | 12,319 | +1,840 | 0.04 | 0.02 | -0.02 | buy |
| ZACKS INVESTMENT MANAGEMENT | 12,194 | 13,879 | +1,685 | 0.01 | 0.00 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 26,450 | 28,006 | +1,556 | 0.02 | 0.01 | 0.00 | buy |
| J.Safra Asset Management Corp | 1,907 | 3,403 | +1,496 | 0.01 | 0.01 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 127,771 | 126,416 | +1,355 | 0.01 | 0.01 | 0.00 | sell |
| CI INVESTMENTS INC. | 3,067 | 1,956 | +1,111 | 0.00 | 0.00 | 0.00 | sell |
| Corebridge Financial, Inc. | 61,736 | 60,834 | +902 | 0.03 | 0.01 | 0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 2,617 | 3,192 | +575 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 12,469 | 12,967 | +498 | 0.01 | 0.00 | -0.00 | buy |
| Avior Wealth Management, LLC | 6,456 | 6,799 | +343 | 0.02 | 0.01 | -0.01 | buy |
| SIERRA OCEAN, LLC | 21 | 33 | +12 | 0.00 | 0.00 | -0.00 | buy |
| Baker Avenue Asset Management, LP | 13,143 | 13,144 | +1 | 0.03 | 0.02 | -0.02 | buy |
| MCF Advisors LLC | 100 | 97 | -3 | 0.00 | 0.00 | -0.00 | sell |
| Riverview Trust Co | 236 | 230 | -6 | 0.02 | 0.01 | -0.01 | sell |
| MEEDER ASSET MANAGEMENT INC | 52 | 42 | -10 | 0.00 | 0.00 | -0.00 | sell |
| Everhart Financial Group, Inc. | 6,164 | 6,149 | -15 | 0.10 | 0.03 | -0.07 | sell |
| GILDER GAGNON HOWE & CO LLC | 16,550 | 16,359 | -191 | 0.01 | 0.01 | -0.01 | sell |
| Ameritas Investment Partners, Inc. | 12,768 | 12,562 | -206 | 0.04 | 0.02 | -0.02 | sell |
| Whipplewood Advisors, LLC | 345 | 6 | -339 | 0.02 | 0.01 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 26,428 | 25,827 | -601 | 0.20 | 0.09 | -0.11 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 72,094 | 71,477 | -617 | 0.01 | 0.01 | -0.00 | sell |
| Candriam S.C.A. | 114,110 | 113,390 | -720 | 0.05 | 0.03 | -0.03 | sell |
| Bellevue Group AG | 12,038 | 11,290 | -748 | 0.02 | 0.01 | -0.01 | sell |
| BANQUE PICTET & CIE SA | 59,315 | 57,977 | -1,338 | 0.03 | 0.02 | -0.01 | sell |
| PROFUND ADVISORS LLC | 29,854 | 28,396 | -1,458 | 0.09 | 0.05 | -0.04 | sell |
| MOODY ALDRICH PARTNERS LLC | 52,686 | 51,157 | -1,529 | 0.80 | 0.40 | -0.39 | sell |
| Swiss National Bank | 219,000 | 217,300 | -1,700 | 0.01 | 0.01 | -0.01 | sell |
| Calamos Advisors LLC | 9,995 | 6,794 | -3,201 | 0.00 | 0.00 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 153,988 | 149,762 | -4,226 | 0.17 | 0.09 | -0.09 | sell |
| Siren, L.L.C. | 299,991 | 295,543 | -4,448 | 1.09 | 0.63 | -0.46 | sell |
| Woodline Partners LP | 1,120,922 | 1,111,777 | -9,145 | 0.62 | 0.27 | -0.35 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 16,526 | 6,506 | -10,020 | 0.03 | 0.01 | -0.02 | sell |
| HighVista Strategies LLC | 44,661 | 33,102 | -11,559 | 1.36 | 0.48 | -0.88 | sell |
| Rafferty Asset Management, LLC | 147,436 | 131,812 | -15,624 | 0.04 | 0.02 | -0.02 | sell |
| AMERICAN CENTURY COMPANIES INC | 605,267 | 587,054 | -18,213 | 0.03 | 0.01 | -0.02 | sell |
| Parkman Healthcare Partners LLC | 116,138 | 93,431 | -22,707 | 1.27 | 0.42 | -0.85 | sell |
| TD ASSET MANAGEMENT INC | 333,756 | 303,596 | -30,160 | 0.02 | 0.01 | -0.01 | sell |
| Alyeska Investment Group, L.P. | 197,585 | 164,640 | -32,945 | 0.06 | 0.02 | -0.04 | sell |
| Capital Research Global Investors | 6,210,523 | 6,110,108 | -100,415 | 0.10 | 0.05 | -0.05 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,166,833 | 1,060,863 | -105,970 | 0.79 | 0.39 | -0.40 | sell |
| JENNISON ASSOCIATES LLC | 1,246,551 | 1,125,720 | -120,831 | 0.06 | 0.03 | -0.03 | sell |
| TimesSquare Capital Management, LLC | 413,637 | 281,863 | -131,774 | 100.00 | 100.00 | 0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 2,860,717 | 2,702,691 | -158,026 | 0.14 | 0.07 | -0.08 | sell |
| Avoro Capital Advisors LLC | 1,175,000 | 1,000,000 | -175,000 | 1.36 | 0.59 | -0.77 | sell |
| Cormorant Asset Management, LP | 425,000 | 175,000 | -250,000 | 1.91 | 0.50 | -1.41 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 2,566,759 | 2,155,137 | -411,622 | 0.91 | 0.40 | -0.52 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,966,956 | 3,542,007 | -424,949 | 0.04 | 0.02 | -0.02 | sell |
| FRED ALGER MANAGEMENT, LLC | 523,007 | 22,360 | -500,647 | 0.20 | 0.00 | -0.20 | sell |
| PERCEPTIVE ADVISORS LLC | 1,718,417 | 706,567 | -1,011,850 | 3.88 | 0.94 | -2.93 | sell |