| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 8,689,190 | 12,189,149 | +3,499,959 | 9.47 | 7.69 | -1.78 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,444,012 | 6,416,930 | +1,972,918 | 0.07 | 0.05 | -0.02 | buy |
| JANUS HENDERSON GROUP PLC | 10,575,363 | 11,765,481 | +1,190,118 | 0.44 | 0.45 | +0.01 | buy |
| Kynam Capital Management, LP | 2,336,796 | 3,200,000 | +863,204 | 12.62 | 10.34 | -2.28 | buy |
| Deep Track Capital, LP | 0 | 750,000 | +750,000 | 0.00 | 0.92 | +0.92 | buy |
| BAKER BROS. ADVISORS LP | 48,885 | 640,885 | +592,000 | 0.04 | 0.27 | +0.23 | buy |
| Eversept Partners, LP | 127,588 | 557,070 | +429,482 | 1.08 | 2.38 | +1.30 | buy |
| Fiera Capital Corp | 0 | 359,202 | +359,202 | 0.00 | 0.05 | +0.05 | buy |
| Hood River Capital Management LLC | 401,442 | 751,614 | +350,172 | 0.49 | 0.48 | -0.00 | buy |
| UBS Group AG | 736,561 | 1,080,396 | +343,835 | 0.01 | 0.01 | -0.00 | buy |
| Assenagon Asset Management S.A. | 0 | 323,565 | +323,565 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 469,911 | 790,812 | +320,901 | 0.00 | 0.00 | -0.00 | buy |
| Paradigm Biocapital Advisors LP | 1,422,787 | 1,696,481 | +273,694 | 4.05 | 2.95 | -1.10 | buy |
| CITIGROUP INC | 379,208 | 621,079 | +241,871 | 0.03 | 0.02 | -0.01 | buy |
| FRANKLIN RESOURCES INC | 2,869,332 | 3,089,032 | +219,700 | 0.07 | 0.03 | -0.03 | buy |
| Ikarian Capital, LLC | 0 | 200,000 | +200,000 | 0.00 | 2.46 | +2.46 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 125,396 | 318,338 | +192,942 | 0.02 | 0.02 | +0.00 | buy |
| Novo Holdings A/S | 750,000 | 915,000 | +165,000 | 3.72 | 2.63 | -1.09 | buy |
| JPMORGAN CHASE & CO | 1,735,663 | 1,900,179 | +164,516 | 0.01 | 0.01 | -0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 308,939 | 469,561 | +160,622 | 0.01 | 0.01 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 586,128 | 744,160 | +158,032 | 0.09 | 0.05 | -0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 54,077 | 196,277 | +142,200 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 276,578 | 413,429 | +136,851 | 0.02 | 0.02 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 279,944 | 404,965 | +125,021 | 0.39 | 0.28 | -0.11 | buy |
| Clearbridge Investments, LLC | 1,102,486 | 1,220,455 | +117,969 | 0.07 | 0.04 | -0.03 | buy |
| GREAT POINT PARTNERS LLC | 0 | 115,517 | +115,517 | 0.00 | 2.37 | +2.37 | buy |
| Polar Capital Holdings Plc | 973,645 | 1,082,473 | +108,828 | 0.45 | 0.25 | -0.20 | buy |
| Jump Financial, LLC | 0 | 100,100 | +100,100 | 0.00 | 0.06 | +0.06 | buy |
| C WorldWide Group Holding A/S | 0 | 95,000 | +95,000 | 0.00 | 0.04 | +0.04 | buy |
| First Light Asset Management, LLC | 0 | 94,420 | +94,420 | 0.00 | 0.41 | +0.41 | buy |
| D. E. Shaw & Co., Inc. | 775,653 | 867,891 | +92,238 | 0.07 | 0.04 | -0.03 | buy |
| Russell Investments Group, Ltd. | 108,389 | 199,590 | +91,201 | 0.01 | 0.01 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 47,295 | 137,440 | +90,145 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 1,166,054 | 1,255,827 | +89,773 | 0.02 | 0.01 | -0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 383,454 | 470,230 | +86,776 | 0.57 | 0.35 | -0.22 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 86,244 | +86,244 | 0.00 | 0.11 | +0.11 | buy |
| DIADEMA PARTNERS LP | 10,000 | 92,385 | +82,385 | 0.92 | 2.79 | +1.87 | buy |
| VANGUARD GROUP INC | 11,961,687 | 12,043,805 | +82,118 | 0.02 | 0.01 | -0.01 | buy |
| LAZARD ASSET MANAGEMENT LLC | 486,764 | 557,794 | +71,030 | 0.06 | 0.03 | -0.03 | buy |
| Verition Fund Management LLC | 6,073 | 74,274 | +68,201 | 0.00 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,802,888 | 2,869,054 | +66,166 | 0.02 | 0.01 | -0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 65,158 | +65,158 | 0.00 | 0.08 | +0.08 | buy |
| Nebula Research & Development LLC | 0 | 48,760 | +48,760 | 0.00 | 0.17 | +0.17 | buy |
| Hudson Bay Capital Management LP | 98,739 | 144,309 | +45,570 | 0.05 | 0.03 | -0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 55,083 | 96,600 | +41,517 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 472,964 | 513,998 | +41,034 | 0.01 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 224,824 | 264,737 | +39,913 | 0.03 | 0.02 | -0.02 | buy |
| Engineers Gate Manager LP | 58,689 | 96,697 | +38,008 | 0.08 | 0.06 | -0.02 | buy |
| WELLS FARGO & COMPANY/MN | 72,275 | 106,735 | +34,460 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,017,845 | 1,050,678 | +32,833 | 0.09 | 0.05 | -0.04 | buy |
| Allostery Investments LP | 0 | 32,000 | +32,000 | 0.00 | 1.74 | +1.74 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 3,989 | 34,228 | +30,239 | 0.06 | 0.20 | +0.14 | buy |
| RAYMOND JAMES FINANCIAL INC | 264,704 | 293,134 | +28,430 | 0.01 | 0.00 | -0.00 | buy |
| Saturn V Capital Management LP | 204,285 | 232,295 | +28,010 | 6.55 | 4.43 | -2.12 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 61,828 | 89,212 | +27,384 | 0.05 | 0.03 | -0.01 | buy |
| Commodore Capital LP | 1,625,000 | 1,650,000 | +25,000 | 9.75 | 4.59 | -5.16 | buy |
| Avidity Partners Management LP | 0 | 23,000 | +23,000 | 0.00 | 0.18 | +0.18 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 44,818 | 66,116 | +21,298 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 339,095 | 360,186 | +21,091 | 0.11 | 0.06 | -0.05 | buy |
| Caitong International Asset Management Co., Ltd | 295 | 21,015 | +20,720 | 0.02 | 0.59 | +0.57 | buy |
| SEI INVESTMENTS CO | 161,682 | 181,903 | +20,221 | 0.02 | 0.01 | -0.01 | buy |
| DIMENSION CAPITAL MANAGEMENT LLC | 0 | 17,580 | +17,580 | 0.00 | 0.10 | +0.10 | buy |
| CIBC WORLD MARKETS CORP | 11,620 | 27,554 | +15,934 | 0.01 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 100,307 | 116,229 | +15,922 | 0.72 | 0.45 | -0.27 | buy |
| ROYAL BANK OF CANADA | 13,697 | 29,471 | +15,774 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 30,000 | 44,200 | +14,200 | 0.10 | 0.08 | -0.03 | buy |
| BROWN ADVISORY INC | 556,209 | 570,258 | +14,049 | 0.06 | 0.03 | -0.03 | buy |
| ASSETMARK, INC | 776 | 14,424 | +13,648 | 0.00 | 0.00 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 0 | 12,905 | +12,905 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 12,800 | +12,800 | 0.00 | 0.09 | +0.09 | buy |
| J. Safra Sarasin Holding AG | 0 | 12,436 | +12,436 | 0.00 | 0.01 | +0.01 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 11,264 | +11,264 | 0.00 | 0.51 | +0.51 | buy |
| XTX Topco Ltd | 3,026 | 13,796 | +10,770 | 0.02 | 0.03 | +0.01 | buy |
| Polar Asset Management Partners Inc. | 0 | 10,004 | +10,004 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 171,814 | 181,230 | +9,416 | 0.01 | 0.01 | -0.01 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 9,350 | +9,350 | 0.00 | 0.00 | +0.00 | buy |
| SIH Partners, LLLP | 0 | 8,109 | +8,109 | 0.00 | 0.03 | +0.03 | buy |
| STIFEL FINANCIAL CORP | 0 | 7,435 | +7,435 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 7,400 | +7,400 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 18,831 | 25,760 | +6,929 | 0.01 | 0.01 | -0.00 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 703,834 | 710,734 | +6,900 | 38.91 | 21.72 | -17.19 | buy |
| BANK OF MONTREAL /CAN/ | 23,873 | 30,273 | +6,400 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 123,664 | 129,872 | +6,208 | 0.00 | 0.00 | -0.00 | buy |
| MAVERICK CAPITAL LTD | 1,201,898 | 1,208,093 | +6,195 | 1.77 | 0.82 | -0.95 | buy |
| FORA Capital, LLC | 0 | 5,907 | +5,907 | 0.00 | 0.02 | +0.02 | buy |
| Dauntless Investment Group, LLC | 0 | 5,825 | +5,825 | 0.00 | 0.81 | +0.81 | buy |
| AGF MANAGEMENT LTD | 28,444 | 34,253 | +5,809 | 0.01 | 0.01 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 5,800 | +5,800 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 9,000 | 14,520 | +5,520 | 0.00 | 0.00 | -0.00 | buy |
| Magnetar Financial LLC | 0 | 5,498 | +5,498 | 0.00 | 0.00 | +0.00 | buy |
| Farringdon Capital, Ltd. | 0 | 5,372 | +5,372 | 0.00 | 0.10 | +0.10 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 301,560 | 306,729 | +5,169 | 0.03 | 0.01 | -0.01 | buy |
| Curi Capital, LLC | 8,616 | 13,213 | +4,597 | 0.02 | 0.01 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 88,705 | 92,732 | +4,027 | 0.02 | 0.01 | -0.01 | buy |
| Ethic Inc. | 5,643 | 9,380 | +3,737 | 0.01 | 0.01 | -0.00 | buy |
| Atria Investments, Inc | 2,496 | 6,133 | +3,637 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 103,683 | 107,317 | +3,634 | 0.02 | 0.01 | -0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 76,534 | 80,081 | +3,547 | 0.01 | 0.01 | -0.01 | buy |
| Handelsbanken Fonder AB | 31,500 | 34,900 | +3,400 | 0.01 | 0.01 | -0.00 | buy |
| DnB Asset Management AS | 7,067 | 9,831 | +2,764 | 0.00 | 0.00 | -0.00 | buy |