| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 13,387,188 | 16,575,875 | +3,188,687 | 0.28 | 0.46 | +0.18 | buy |
| FMR LLC | 13,834,514 | 16,492,861 | +2,658,347 | 0.03 | 0.05 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 11,296,333 | 12,126,017 | +829,684 | 0.33 | 0.49 | +0.16 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 10,724,599 | 11,474,599 | +750,000 | 5.07 | 7.07 | +2.00 | buy |
| BlackRock, Inc. | 10,246,378 | 10,971,816 | +725,438 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 5,966,310 | 5,614,597 | -351,713 | 0.05 | 0.06 | +0.01 | sell |
| Paradigm Biocapital Advisors LP | 4,068,020 | 4,793,020 | +725,000 | 5.03 | 5.69 | +0.67 | buy |
| STATE STREET CORP | 4,980,005 | 4,440,519 | -539,486 | 0.01 | 0.01 | +0.00 | sell |
| Deep Track Capital, LP | 4,000,000 | 4,300,000 | +300,000 | 4.21 | 5.16 | +0.95 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,539,717 | 3,646,138 | +106,421 | 0.68 | 0.89 | +0.21 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,866,305 | 3,201,283 | +334,978 | 0.01 | 0.01 | +0.00 | buy |
| Kynam Capital Management, LP | 2,922,335 | 2,922,335 | 0 | 8.78 | 10.78 | +2.00 | hold |
| D. E. Shaw & Co., Inc. | 3,631,053 | 2,865,318 | -765,735 | 0.13 | 0.13 | +0.00 | sell |
| Caligan Partners LP | 1,704,815 | 2,060,719 | +355,904 | 7.20 | 8.47 | +1.27 | buy |
| JENNISON ASSOCIATES LLC | 677,553 | 1,698,011 | +1,020,458 | 0.02 | 0.07 | +0.05 | buy |
| Polar Capital Holdings Plc | 1,672,783 | 1,425,788 | -246,995 | 0.35 | 0.36 | +0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,293,830 | 1,403,948 | +110,118 | 0.01 | 0.01 | +0.00 | buy |
| MAVERICK CAPITAL LTD | 1,354,237 | 1,377,738 | +23,501 | 0.67 | 0.93 | +0.26 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 917,115 | 1,374,292 | +457,177 | 0.66 | 1.32 | +0.66 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,372,425 | 1,372,425 | 0 | 24.48 | 28.51 | +4.02 | hold |
| UBS Group AG | 1,093,593 | 1,337,390 | +243,797 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,078,120 | 1,275,036 | +196,916 | 0.01 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 5,000 | 1,261,000 | +1,256,000 | 0.00 | 0.43 | +0.43 | buy |
| BANK OF AMERICA CORP /DE/ | 701,634 | 1,216,843 | +515,209 | 0.00 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 0 | 1,190,697 | +1,190,697 | 0.00 | 1.65 | +1.65 | buy |
| Assenagon Asset Management S.A. | 544,728 | 1,164,813 | +620,085 | 0.04 | 0.11 | +0.07 | buy |
| NORTHERN TRUST CORP | 1,034,180 | 1,144,469 | +110,289 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,085,519 | 1,008,314 | -77,205 | 0.00 | 0.00 | +0.00 | sell |
| Aberdeen Group plc | 979,765 | 978,969 | -796 | 0.07 | 0.09 | +0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,175,339 | 976,429 | -198,910 | 0.01 | 0.01 | +0.00 | sell |
| Eversept Partners, LP | 1,197,722 | 924,193 | -273,529 | 3.10 | 3.54 | +0.44 | sell |
| Capital Research Global Investors | 842,978 | 912,688 | +69,710 | 0.01 | 0.01 | +0.00 | buy |
| Novo Holdings A/S | 916,160 | 860,000 | -56,160 | 3.28 | 4.05 | +0.77 | sell |
| Saturn V Capital Management LP | 798,940 | 824,532 | +25,592 | 6.77 | 8.68 | +1.91 | buy |
| BAUPOST GROUP LLC/MA | 0 | 800,000 | +800,000 | 0.00 | 0.91 | +0.91 | buy |
| MORGAN STANLEY | 835,387 | 735,907 | -99,480 | 0.00 | 0.00 | +0.00 | sell |
| Pictet Asset Management Holding SA | 881,435 | 700,311 | -181,124 | 0.04 | 0.04 | +0.00 | sell |
| Point72 Asset Management, L.P. | 161,614 | 620,401 | +458,787 | 0.01 | 0.06 | +0.05 | buy |
| FEDERATED HERMES, INC. | 523,489 | 566,828 | +43,339 | 0.04 | 0.05 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 497,740 | 522,019 | +24,279 | 0.59 | 0.70 | +0.11 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 26,865 | 514,577 | +487,712 | 0.00 | 0.06 | +0.06 | buy |
| BROWN ADVISORY INC | 566,925 | 511,701 | -55,224 | 0.04 | 0.05 | +0.01 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 549,514 | 501,857 | -47,657 | 0.01 | 0.02 | +0.00 | sell |
| Bank of New York Mellon Corp | 449,363 | 474,526 | +25,163 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 336,143 | 473,363 | +137,220 | 0.00 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 527,688 | 445,903 | -81,785 | 0.04 | 0.05 | +0.01 | sell |
| Alyeska Investment Group, L.P. | 244,775 | 435,581 | +190,806 | 0.03 | 0.07 | +0.04 | buy |
| Ikarian Capital, LLC | 378,682 | 428,682 | +50,000 | 2.26 | 3.56 | +1.30 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 389,010 | 410,605 | +21,595 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 608,958 | 385,472 | -223,486 | 1.19 | 0.91 | -0.28 | sell |
| DIMENSIONAL FUND ADVISORS LP | 191,786 | 375,772 | +183,986 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 67,439 | 363,984 | +296,545 | 0.05 | 0.32 | +0.27 | buy |
| AMERICAN CENTURY COMPANIES INC | 357,300 | 355,854 | -1,446 | 0.01 | 0.01 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,725,000 | 350,000 | -1,375,000 | 0.12 | 0.03 | -0.09 | sell |
| Boxer Capital Management, LLC | 0 | 325,000 | +325,000 | 0.00 | 2.48 | +2.48 | buy |
| Nuveen, LLC | 307,202 | 320,789 | +13,587 | 0.00 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 0 | 315,022 | +315,022 | 0.00 | 0.10 | +0.10 | buy |
| TD ASSET MANAGEMENT INC | 363,734 | 312,762 | -50,972 | 0.01 | 0.01 | +0.00 | sell |
| Logos Global Management LP | 650,000 | 300,000 | -350,000 | 2.00 | 0.90 | -1.10 | sell |
| DEUTSCHE BANK AG\ | 342,894 | 299,693 | -43,201 | 0.01 | 0.01 | +0.00 | sell |
| Artisan Partners Limited Partnership | 304,049 | 297,432 | -6,617 | 0.02 | 0.03 | +0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 424,294 | 293,695 | -130,599 | 0.01 | 0.01 | -0.00 | sell |
| Rosalind Advisors, Inc. | 0 | 290,000 | +290,000 | 0.00 | 6.90 | +6.90 | buy |
| Woodline Partners LP | 274,740 | 274,740 | 0 | 0.05 | 0.06 | +0.01 | hold |
| FRED ALGER MANAGEMENT, LLC | 57,808 | 270,115 | +212,307 | 0.01 | 0.07 | +0.06 | buy |
| RAYMOND JAMES FINANCIAL INC | 185,851 | 260,395 | +74,544 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 315,642 | 259,137 | -56,505 | 1.09 | 0.90 | -0.18 | sell |
| JANE STREET GROUP, LLC | 279,604 | 252,877 | -26,727 | 0.02 | 0.02 | +0.00 | sell |
| University of Wisconsin Foundation | 247,000 | 239,749 | -7,251 | 9.58 | 12.37 | +2.79 | sell |
| Nantahala Capital Management, LLC | 0 | 238,746 | +238,746 | 0.00 | 0.87 | +0.87 | buy |
| Swiss National Bank | 230,400 | 233,100 | +2,700 | 0.01 | 0.01 | +0.00 | buy |
| Freestone Grove Partners LP | 0 | 224,731 | +224,731 | 0.00 | 0.09 | +0.09 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 50,762 | 224,518 | +173,756 | 0.00 | 0.01 | +0.01 | buy |
| C WorldWide Group Holding A/S | 195,000 | 195,000 | 0 | 0.16 | 0.24 | +0.09 | hold |
| Invesco Ltd. | 141,220 | 184,043 | +42,823 | 0.00 | 0.00 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 193,423 | 183,935 | -9,488 | 0.12 | 0.11 | -0.01 | sell |
| RHUMBLINE ADVISERS | 150,919 | 158,841 | +7,922 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 144,603 | 151,555 | +6,952 | 0.00 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 207,090 | 145,371 | -61,719 | 0.01 | 0.01 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 148,787 | 144,981 | -3,806 | 0.99 | 0.99 | -0.00 | sell |
| First Light Asset Management, LLC | 0 | 141,784 | +141,784 | 0.00 | 0.74 | +0.74 | buy |
| Creative Planning | 102,686 | 140,177 | +37,491 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 133,882 | 137,082 | +3,200 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 110,862 | 136,100 | +25,238 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 241,880 | 132,178 | -109,702 | 0.01 | 0.00 | -0.00 | sell |
| Clearbridge Investments, LLC | 0 | 128,377 | +128,377 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 125,827 | +125,827 | 0.00 | 0.07 | +0.07 | buy |
| HighVista Strategies LLC | 114,049 | 124,647 | +10,598 | 1.36 | 2.00 | +0.64 | buy |
| NAN FUNG TRINITY (HK) Ltd | 142,930 | 122,930 | -20,000 | 0.52 | 0.78 | +0.26 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 116,817 | 121,320 | +4,503 | 0.01 | 0.01 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 112,631 | +112,631 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 111,310 | 111,310 | 0 | 0.01 | 0.01 | -0.00 | hold |
| AMERIPRISE FINANCIAL INC | 305,194 | 110,986 | -194,208 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 110,454 | +110,454 | 0.00 | 4.59 | +4.59 | buy |
| Cormorant Asset Management, LP | 125,000 | 100,000 | -25,000 | 0.33 | 0.29 | -0.03 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 50,798 | 98,155 | +47,357 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 120,301 | 97,337 | -22,964 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 108,445 | 86,366 | -22,079 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 133,764 | 78,402 | -55,362 | 0.02 | 0.02 | -0.00 | sell |
| SummitTX Capital, L.P. | 14,869 | 74,842 | +59,973 | 0.02 | 0.14 | +0.12 | buy |