| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital Research Global Investors | 2,853,006 | 3,364,127 | +511,121 | 0.03 | 0.05 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 1,170,000 | 1,614,122 | +444,122 | 1.14 | 2.35 | 0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 435,000 | 60,088 | +374,912 | 0.04 | 0.01 | 0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 420,877 | 215,477 | +205,400 | 0.02 | 0.02 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,313,642 | 1,214,072 | +99,570 | 0.07 | 0.08 | 0.00 | sell |
| GREAT POINT PARTNERS LLC | 659,211 | 589,211 | +70,000 | 4.88 | 5.89 | 0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 393,249 | 462,304 | +69,055 | 0.02 | 0.03 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 7,127,611 | 7,059,751 | +67,860 | 0.18 | 0.22 | 0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 60,000 | 108,977 | +48,977 | 0.43 | 0.91 | 0.00 | buy |
| Affinity Asset Advisors, LLC | 62,223 | 13,923 | +48,300 | 0.90 | 0.27 | 0.00 | sell |
| Parkman Healthcare Partners LLC | 186,097 | 228,505 | +42,408 | 1.52 | 1.98 | 0.00 | buy |
| D. E. Shaw & Co., Inc. | 794,907 | 812,912 | +18,005 | 0.06 | 0.07 | 0.00 | buy |
| ALPS ADVISORS INC | 52,726 | 68,879 | +16,153 | 0.02 | 0.03 | 0.00 | buy |
| ProShare Advisors LLC | 13,990 | 18,020 | +4,030 | 0.00 | 0.00 | 0.00 | buy |
| PROFUND ADVISORS LLC | 34,086 | 31,004 | +3,082 | 0.08 | 0.08 | 0.00 | sell |
| ALGERT GLOBAL LLC | 21,837 | 22,000 | +163 | 0.04 | 0.05 | 0.00 | buy |