| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 7,673,868 | 8,868,907 | +1,195,039 | 0.29 | 0.36 | 0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 3,552,967 | 4,022,589 | +469,622 | 0.15 | 0.19 | +0.04 | buy |
| Commodore Capital LP | 860,000 | 1,305,000 | +445,000 | 3.93 | 6.73 | +2.80 | buy |
| Cormorant Asset Management, LP | 685,000 | 1,100,000 | +415,000 | 2.05 | 4.80 | +2.75 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,586,095 | 1,929,348 | +343,253 | 0.57 | 0.72 | +0.15 | buy |
| MAVERICK CAPITAL LTD | 355,131 | 687,908 | +332,777 | 0.47 | 0.99 | +0.52 | buy |
| Woodline Partners LP | 393,704 | 706,903 | +313,199 | 0.25 | 0.51 | +0.26 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,287,375 | 2,441,772 | +154,397 | 0.02 | 0.02 | 0.00 | buy |
| D. E. Shaw & Co., Inc. | 367,249 | 230,207 | +137,042 | 0.04 | 0.03 | 0.00 | sell |
| JENNISON ASSOCIATES LLC | 1,256,883 | 1,383,131 | +126,248 | 0.06 | 0.07 | +0.01 | buy |
| Novo Holdings A/S | 845,000 | 950,000 | +105,000 | 3.98 | 3.87 | -0.11 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 657,206 | 739,153 | +81,947 | 0.70 | 0.96 | +0.25 | buy |
| First Light Asset Management, LLC | 60,284 | 139,729 | +79,445 | 0.32 | 0.92 | +0.61 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,867,807 | 1,934,747 | +66,940 | 1.27 | 1.41 | +0.14 | buy |
| AMERICAN CENTURY COMPANIES INC | 461,724 | 527,594 | +65,870 | 0.02 | 0.03 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 8,193 | 40,342 | +32,149 | 0.07 | 0.23 | +0.16 | buy |
| TD ASSET MANAGEMENT INC | 281,288 | 312,426 | +31,138 | 0.02 | 0.02 | +0.00 | buy |
| Saturn V Capital Management LP | 185,175 | 215,680 | +30,505 | 5.07 | 6.15 | +1.08 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 280,875 | 307,516 | +26,641 | 0.02 | 0.02 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 8,500 | 33,730 | +25,230 | 0.23 | 1.04 | +0.81 | buy |
| HighVista Strategies LLC | 9,321 | 32,313 | +22,992 | 0.23 | 0.89 | +0.66 | buy |
| ALGERT GLOBAL LLC | 13,310 | 34,752 | +21,442 | 0.04 | 0.09 | 0.00 | buy |
| EFG Asset Management (North America) Corp. | 19,425 | 30,442 | +11,017 | 0.23 | 0.40 | +0.17 | buy |
| ADAR1 Capital Management, LLC | 2,000 | 12,250 | +10,250 | 0.04 | 0.19 | +0.15 | buy |
| Kynam Capital Management, LP | 745,000 | 753,240 | +8,240 | 5.66 | 5.95 | +0.29 | buy |
| ProShare Advisors LLC | 26,667 | 20,934 | +5,733 | 0.00 | 0.00 | 0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 104,830 | 110,400 | +5,570 | 4.65 | 7.02 | +2.37 | buy |
| SEGALL BRYANT & HAMILL, LLC | 158,021 | 162,432 | +4,411 | 0.20 | 0.22 | +0.02 | buy |
| Swiss National Bank | 178,000 | 181,300 | +3,300 | 0.01 | 0.01 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 17,358 | 20,230 | +2,872 | 0.01 | 0.01 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 3,770 | 6,252 | +2,482 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 21,429 | 18,987 | +2,442 | 0.06 | 0.05 | 0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,346 | 20,485 | +2,139 | 0.00 | 0.01 | 0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 45,766 | 43,941 | +1,825 | 0.01 | 0.01 | +0.00 | sell |
| Nicholas Investment Partners, LP | 85,644 | 87,230 | +1,586 | 0.60 | 0.68 | +0.08 | buy |
| Cercano Management LLC | 272,151 | 273,608 | +1,457 | 0.52 | 0.55 | +0.03 | buy |
| GUGGENHEIM CAPITAL LLC | 31,472 | 30,024 | +1,448 | 0.02 | 0.02 | 0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 15,840 | 17,269 | +1,429 | 0.02 | 0.03 | +0.01 | buy |
| Calamos Advisors LLC | 10,165 | 11,533 | +1,368 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 13,244 | 14,210 | +966 | 0.01 | 0.02 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 92,026 | 91,279 | +747 | 0.01 | 0.01 | +0.00 | sell |
| J.Safra Asset Management Corp | 81 | 607 | +526 | 0.00 | 0.00 | +0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 4,202 | 4,620 | +418 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 6,007 | 6,307 | +300 | 0.03 | 0.03 | 0.00 | buy |
| Parkman Healthcare Partners LLC | 149,956 | 150,191 | +235 | 1.26 | 1.52 | +0.26 | buy |
| Ameritas Investment Partners, Inc. | 10,545 | 10,696 | +151 | 0.03 | 0.03 | +0.00 | buy |
| Bell Investment Advisors, Inc | 69 | 79 | +10 | 0.00 | 0.00 | 0.00 | buy |
| Fortitude Family Office, LLC | 17 | 26 | +9 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 62 | 63 | +1 | 0.00 | 0.00 | +0.00 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 5,004 | 4,971 | -33 | 0.03 | 0.03 | +0.00 | sell |
| OLIVER LAGORE VANVALIN INVESTMENT GROUP | 174 | 121 | -53 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 1,432 | 1,223 | -209 | 0.05 | 0.05 | -0.01 | sell |
| E Fund Management Co., Ltd. | 5,962 | 5,751 | -211 | 0.03 | 0.02 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 17,078 | 16,831 | -247 | 0.01 | 0.02 | +0.00 | sell |
| Belvedere Trading LLC | 2,585 | 2,098 | -487 | 0.00 | 0.00 | -0.00 | sell |
| Chicago Partners Investment Group LLC | 6,009 | 5,066 | -943 | 0.02 | 0.02 | +0.00 | sell |
| Bank Pictet & Cie (Europe) AG | 4,846 | 3,894 | -952 | 0.01 | 0.01 | -0.00 | sell |
| BANK OF HAWAII | 16,153 | 15,178 | -975 | 0.05 | 0.05 | -0.00 | sell |
| STRS OHIO | 25,200 | 23,700 | -1,500 | 0.01 | 0.01 | +0.00 | sell |
| BANQUE PICTET & CIE SA | 60,887 | 59,077 | -1,810 | 0.04 | 0.04 | +0.00 | sell |
| Parkwood LLC | 13,555 | 11,702 | -1,853 | 0.08 | 0.11 | +0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,176,181 | 3,173,167 | -3,014 | 0.03 | 0.03 | +0.00 | sell |
| Aberdeen Group plc | 194,232 | 190,401 | -3,831 | 0.03 | 0.03 | +0.00 | sell |
| Polar Asset Management Partners Inc. | 104,479 | 98,200 | -6,279 | 0.12 | 0.15 | +0.03 | sell |
| Capital Research Global Investors | 4,140,521 | 4,133,544 | -6,977 | 0.06 | 0.07 | +0.00 | sell |
| Informed Momentum Co LLC | 43,732 | 36,522 | -7,210 | 0.47 | 0.45 | -0.02 | sell |
| China Universal Asset Management Co., Ltd. | 20,840 | 12,781 | -8,059 | 0.18 | 0.14 | -0.04 | sell |
| Pier Capital, LLC | 127,384 | 114,969 | -12,415 | 1.20 | 1.29 | +0.09 | sell |
| MOODY ALDRICH PARTNERS LLC | 118,602 | 100,286 | -18,316 | 1.38 | 1.48 | +0.10 | sell |
| Affinity Asset Advisors, LLC | 80,000 | 60,000 | -20,000 | 0.68 | 0.52 | -0.15 | sell |
| Soleus Capital Management, L.P. | 207,750 | 185,250 | -22,500 | 1.25 | 1.23 | -0.01 | sell |
| CASTLEARK MANAGEMENT LLC | 75,040 | 43,690 | -31,350 | 0.21 | 0.13 | -0.08 | sell |
| Rafferty Asset Management, LLC | 126,164 | 94,683 | -31,481 | 0.03 | 0.03 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 1,932,759 | 1,862,608 | -70,151 | 2.31 | 3.39 | +1.08 | sell |
| FRED ALGER MANAGEMENT, LLC | 1,396,711 | 1,310,436 | -86,275 | 0.47 | 0.48 | +0.01 | sell |
| Frazier Life Sciences Management, L.P. | 1,139,405 | 1,039,405 | -100,000 | 3.28 | 3.67 | +0.39 | sell |
| Eversept Partners, LP | 197,331 | 96,089 | -101,242 | 0.90 | 0.50 | -0.40 | sell |
| LORD, ABBETT & CO. LLC | 384,363 | 246,242 | -138,121 | 0.08 | 0.06 | -0.02 | sell |
| ORBIMED ADVISORS LLC | 1,066,131 | 795,900 | -270,231 | 1.34 | 1.19 | -0.14 | sell |
| BRAIDWELL LP | 1,212,703 | 808,303 | -404,400 | 2.67 | 1.91 | -0.76 | sell |
| Paradigm Biocapital Advisors LP | 1,239,995 | 627,202 | -612,793 | 2.98 | 1.81 | -1.17 | sell |
| Darwin Global Management, Ltd. | 2,750,804 | 2,080,946 | -669,858 | 25.02 | 19.07 | -5.94 | sell |