| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 11,765,481 | 14,691,344 | +2,925,863 | 0.45 | 0.23 | -0.21 | buy |
| FMR LLC | 12,512,234 | 12,151,050 | -361,184 | 0.03 | 0.02 | -0.01 | sell |
| VANGUARD GROUP INC | 12,043,805 | 11,997,085 | -46,720 | 0.01 | 0.01 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 12,189,149 | 11,965,991 | -223,158 | 7.69 | 6.55 | -1.13 | sell |
| BlackRock, Inc. | 10,579,477 | 10,642,243 | +62,766 | 0.01 | 0.01 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 2,702,691 | 6,001,124 | +3,298,433 | 0.07 | 0.12 | +0.06 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 6,416,930 | 4,954,804 | -1,462,126 | 0.05 | 0.03 | -0.02 | sell |
| STATE STREET CORP | 4,407,683 | 4,942,235 | +534,552 | 0.01 | 0.01 | -0.00 | buy |
| Capital Research Global Investors | 6,110,108 | 4,771,786 | -1,338,322 | 0.05 | 0.03 | -0.02 | sell |
| Paradigm Biocapital Advisors LP | 1,696,481 | 3,372,837 | +1,676,356 | 2.95 | 4.68 | +1.73 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,542,007 | 3,170,247 | -371,760 | 0.02 | 0.01 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 867,891 | 3,088,450 | +2,220,559 | 0.04 | 0.10 | +0.06 | buy |
| Kynam Capital Management, LP | 3,200,000 | 3,071,588 | -128,412 | 10.34 | 10.75 | +0.41 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 2,155,137 | 3,068,898 | +913,761 | 0.40 | 0.42 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,869,054 | 3,011,140 | +142,086 | 0.01 | 0.01 | -0.00 | buy |
| Deep Track Capital, LP | 750,000 | 2,150,000 | +1,400,000 | 0.92 | 2.25 | +1.33 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,333,382 | 1,417,711 | +84,329 | 0.01 | 0.01 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,125,720 | 1,399,299 | +273,579 | 0.03 | 0.03 | -0.00 | buy |
| UBS Group AG | 1,080,396 | 1,380,853 | +300,457 | 0.01 | 0.01 | +0.00 | buy |
| MAVERICK CAPITAL LTD | 1,208,093 | 1,310,605 | +102,512 | 0.82 | 0.65 | -0.17 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 710,734 | 1,305,125 | +594,391 | 21.72 | 26.30 | +4.58 | buy |
| Eversept Partners, LP | 557,070 | 1,298,514 | +741,444 | 2.38 | 4.25 | +1.87 | buy |
| JPMORGAN CHASE & CO | 1,900,179 | 1,198,770 | -701,409 | 0.01 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 1,050,678 | 1,175,661 | +124,983 | 0.05 | 0.04 | -0.01 | buy |
| NORTHERN TRUST CORP | 1,122,956 | 1,121,892 | -1,064 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 413,429 | 1,104,839 | +691,410 | 0.02 | 0.03 | +0.02 | buy |
| CITADEL ADVISORS LLC | 96,387 | 1,090,738 | +994,351 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 790,812 | 1,082,671 | +291,859 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 899,842 | 987,674 | +87,832 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 3,089,032 | 939,275 | -2,149,757 | 0.03 | 0.01 | -0.03 | sell |
| GOLDMAN SACHS GROUP INC | 1,147,302 | 934,668 | -212,634 | 0.01 | 0.00 | -0.00 | sell |
| Novo Holdings A/S | 915,000 | 916,160 | +1,160 | 2.63 | 2.10 | -0.53 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 470,230 | 848,141 | +377,911 | 0.35 | 0.48 | +0.13 | buy |
| MORGAN STANLEY | 606,951 | 841,922 | +234,971 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 1,082,473 | 825,795 | -256,678 | 0.25 | 0.14 | -0.11 | sell |
| Qube Research & Technologies Ltd | 0 | 809,530 | +809,530 | 0.00 | 0.04 | +0.04 | buy |
| ROYAL BANK OF CANADA | 29,471 | 749,392 | +719,921 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 1,220,455 | 646,055 | -574,400 | 0.04 | 0.02 | -0.02 | sell |
| BAKER BROS. ADVISORS LP | 640,885 | 640,885 | 0 | 0.27 | 0.20 | -0.07 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 633,204 | +633,204 | 0.00 | 0.08 | +0.08 | buy |
| BROWN ADVISORY INC | 570,258 | 571,939 | +1,681 | 0.03 | 0.02 | -0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 513,998 | 555,008 | +41,010 | 0.00 | 0.00 | -0.00 | buy |
| Saturn V Capital Management LP | 232,295 | 544,221 | +311,926 | 4.43 | 7.17 | +2.74 | buy |
| TD ASSET MANAGEMENT INC | 303,596 | 539,784 | +236,188 | 0.01 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 744,160 | 532,203 | -211,957 | 0.05 | 0.03 | -0.02 | sell |
| LAZARD ASSET MANAGEMENT LLC | 557,794 | 512,135 | -45,659 | 0.03 | 0.02 | -0.01 | sell |
| TWINBEECH CAPITAL LP | 404,965 | 503,248 | +98,283 | 0.28 | 0.37 | +0.09 | buy |
| Nuveen, LLC | 555,832 | 487,769 | -68,063 | 0.01 | 0.00 | -0.00 | sell |
| COMERICA BANK | 360,186 | 479,510 | +119,324 | 0.06 | 0.06 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 539,405 | 474,405 | -65,000 | 0.93 | 0.62 | -0.31 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 220,819 | 450,619 | +229,800 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 418,014 | 449,694 | +31,680 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 226,122 | 438,409 | +212,287 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 621,079 | 429,284 | -191,795 | 0.02 | 0.01 | -0.01 | sell |
| Aberdeen Group plc | 264,737 | 424,907 | +160,170 | 0.02 | 0.02 | +0.00 | buy |
| Jump Financial, LLC | 100,100 | 403,597 | +303,497 | 0.06 | 0.17 | +0.11 | buy |
| Walleye Capital LLC | 105,966 | 362,610 | +256,644 | 0.04 | 0.11 | +0.06 | buy |
| Fiera Capital Corp | 359,202 | 353,842 | -5,360 | 0.05 | 0.04 | -0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 587,054 | 351,052 | -236,002 | 0.01 | 0.01 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 678,581 | 330,671 | -347,910 | 0.01 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 200,000 | 305,000 | +105,000 | 2.46 | 3.28 | +0.82 | buy |
| TANG CAPITAL MANAGEMENT LLC | 300,000 | 300,000 | 0 | 0.63 | 0.49 | -0.13 | hold |
| RAYMOND JAMES FINANCIAL INC | 293,134 | 299,582 | +6,448 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 145,389 | 297,748 | +152,359 | 0.01 | 0.02 | +0.01 | buy |
| Siren, L.L.C. | 295,543 | 295,543 | 0 | 0.63 | 0.50 | -0.13 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 287,796 | +287,796 | 0.00 | 1.91 | +1.91 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 196,277 | 269,077 | +72,800 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,197,688 | 262,957 | -934,731 | 0.02 | 0.00 | -0.01 | sell |
| Alyeska Investment Group, L.P. | 164,640 | 244,775 | +80,135 | 0.02 | 0.03 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 225,000 | 225,000 | 0 | 0.17 | 0.13 | -0.04 | hold |
| Swiss National Bank | 217,300 | 221,300 | +4,000 | 0.01 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 153,152 | 208,010 | +54,858 | 0.01 | 0.01 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 206,171 | +206,171 | 0.00 | 0.14 | +0.14 | buy |
| Woodline Partners LP | 1,111,777 | 200,078 | -911,699 | 0.27 | 0.03 | -0.24 | sell |
| RHUMBLINE ADVISERS | 181,230 | 198,487 | +17,257 | 0.01 | 0.01 | -0.00 | buy |
| DIADEMA PARTNERS LP | 92,385 | 198,285 | +105,900 | 2.79 | 4.01 | +1.22 | buy |
| C WorldWide Group Holding A/S | 95,000 | 195,000 | +100,000 | 0.04 | 0.09 | +0.04 | buy |
| SEGALL BRYANT & HAMILL, LLC | 149,762 | 180,239 | +30,477 | 0.09 | 0.08 | -0.00 | buy |
| Cormorant Asset Management, LP | 175,000 | 175,000 | 0 | 0.50 | 0.42 | -0.08 | hold |
| Rafferty Asset Management, LLC | 131,812 | 164,823 | +33,011 | 0.02 | 0.02 | -0.00 | buy |
| Invesco Ltd. | 1,255,827 | 161,636 | -1,094,191 | 0.01 | 0.00 | -0.01 | sell |
| Engineers Gate Manager LP | 96,697 | 160,808 | +64,111 | 0.06 | 0.07 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 318,338 | 152,852 | -165,486 | 0.02 | 0.01 | -0.01 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 142,737 | 152,077 | +9,340 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 56,179 | 149,579 | +93,400 | 0.05 | 0.10 | +0.05 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,704,211 | 141,486 | -1,562,725 | 0.02 | 0.00 | -0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 50,432 | 139,124 | +88,692 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 126,416 | 134,451 | +8,035 | 0.01 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 129,872 | 133,562 | +3,690 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 137,440 | 125,087 | -12,353 | 0.01 | 0.01 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 25,000 | 125,000 | +100,000 | 0.15 | 0.60 | +0.45 | buy |
| WELLS FARGO & COMPANY/MN | 106,735 | 121,285 | +14,550 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 227,431 | 109,880 | -117,551 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 107,050 | 107,050 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Trexquant Investment LP | 0 | 106,281 | +106,281 | 0.00 | 0.04 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 104,836 | +104,836 | 0.00 | 0.01 | +0.01 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 104,250 | +104,250 | 0.00 | 0.41 | +0.41 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 65,158 | 103,267 | +38,109 | 0.08 | 0.10 | +0.02 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 77,059 | 102,362 | +25,303 | 0.13 | 0.14 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 12,800 | 98,032 | +85,232 | 0.09 | 0.52 | +0.42 | buy |