| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 2,702,691 | 6,001,124 | +3,298,433 | 0.07 | 0.12 | +0.06 | buy |
| JANUS HENDERSON GROUP PLC | 11,765,481 | 14,691,344 | +2,925,863 | 0.45 | 0.24 | 0.00 | buy |
| D. E. Shaw & Co., Inc. | 867,891 | 3,088,450 | +2,220,559 | 0.04 | 0.11 | 0.00 | buy |
| Paradigm Biocapital Advisors LP | 1,696,481 | 3,372,837 | +1,676,356 | 2.95 | 4.68 | +1.73 | buy |
| Deep Track Capital, LP | 750,000 | 2,150,000 | +1,400,000 | 0.92 | 2.25 | +1.33 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 2,155,137 | 3,068,898 | +913,761 | 0.40 | 0.42 | +0.02 | buy |
| Eversept Partners, LP | 557,070 | 1,298,514 | +741,444 | 2.14 | 3.88 | +1.75 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 710,734 | 1,305,125 | +594,391 | 21.72 | 26.30 | +4.58 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 470,230 | 848,141 | +377,911 | 0.35 | 0.48 | +0.13 | buy |
| Saturn V Capital Management LP | 232,295 | 544,221 | +311,926 | 4.43 | 7.17 | +2.74 | buy |
| JENNISON ASSOCIATES LLC | 1,125,720 | 1,399,299 | +273,579 | 0.03 | 0.03 | -0.00 | buy |
| Walleye Capital LLC | 105,966 | 362,610 | +256,644 | 0.05 | 0.12 | 0.00 | buy |
| TD ASSET MANAGEMENT INC | 303,596 | 539,784 | +236,188 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 264,737 | 424,907 | +160,170 | 0.02 | 0.02 | +0.00 | buy |
| DIADEMA PARTNERS LP | 92,385 | 198,285 | +105,900 | 2.79 | 4.01 | +1.22 | buy |
| Ikarian Capital, LLC | 200,000 | 305,000 | +105,000 | 2.46 | 3.28 | +0.82 | buy |
| MAVERICK CAPITAL LTD | 1,208,093 | 1,310,605 | +102,512 | 0.82 | 0.65 | -0.17 | buy |
| Affinity Asset Advisors, LLC | 25,000 | 125,000 | +100,000 | 0.15 | 0.60 | +0.45 | buy |
| C WorldWide Group Holding A/S | 95,000 | 195,000 | +100,000 | 0.04 | 0.09 | +0.04 | buy |
| TWINBEECH CAPITAL LP | 404,965 | 503,248 | +98,283 | 0.28 | 0.37 | +0.09 | buy |
| ALGERT GLOBAL LLC | 56,179 | 149,579 | +93,400 | 0.05 | 0.10 | 0.00 | buy |
| ADAR1 Capital Management, LLC | 12,800 | 98,032 | +85,232 | 0.09 | 0.52 | +0.42 | buy |
| Alyeska Investment Group, L.P. | 164,640 | 244,775 | +80,135 | 0.02 | 0.03 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 557,794 | 512,135 | +45,659 | 0.03 | 0.02 | 0.00 | sell |
| Rafferty Asset Management, LLC | 131,812 | 164,823 | +33,011 | 0.02 | 0.02 | -0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 149,762 | 180,239 | +30,477 | 0.09 | 0.08 | -0.00 | buy |
| BANQUE PICTET & CIE SA | 57,977 | 83,372 | +25,395 | 0.02 | 0.02 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 77,059 | 102,362 | +25,303 | 0.13 | 0.14 | 0.00 | buy |
| Persistent Asset Partners Ltd | 21,139 | 45,499 | +24,360 | 0.70 | 1.30 | +0.59 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 89,212 | 69,769 | +19,443 | 0.04 | 0.02 | -0.01 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 66,116 | 79,126 | +13,010 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 126,416 | 134,451 | +8,035 | 0.01 | 0.01 | 0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 28,006 | 35,542 | +7,536 | 0.01 | 0.01 | 0.00 | buy |
| DnB Asset Management AS | 9,831 | 16,755 | +6,924 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 28,396 | 35,088 | +6,692 | 0.05 | 0.04 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 25,827 | 31,910 | +6,083 | 0.09 | 0.10 | +0.01 | buy |
| E Fund Management Co., Ltd. | 12,319 | 18,398 | +6,079 | 0.02 | 0.03 | +0.01 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 7,400 | 10,500 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 32,692 | 30,609 | +2,083 | 0.00 | 0.00 | 0.00 | sell |
| Avior Wealth Management, LLC | 6,799 | 8,529 | +1,730 | 0.01 | 0.01 | -0.00 | buy |
| Novo Holdings A/S | 915,000 | 916,160 | +1,160 | 2.63 | 2.10 | -0.53 | buy |
| Nebula Research & Development LLC | 48,760 | 49,873 | +1,113 | 0.17 | 0.14 | -0.03 | buy |
| Virtus Investment Advisers, LLC | 1,872 | 2,729 | +857 | 0.02 | 0.03 | +0.01 | buy |
| J.Safra Asset Management Corp | 3,403 | 4,072 | +669 | 0.01 | 0.01 | -0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 13,879 | 14,250 | +371 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 33,102 | 33,457 | +355 | 0.48 | 0.40 | -0.08 | buy |
| Ameritas Investment Partners, Inc. | 12,562 | 12,842 | +280 | 0.02 | 0.01 | -0.00 | buy |
| Optiver Holding B.V. | 336 | 546 | +210 | 0.00 | 0.00 | 0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 6,506 | 6,671 | +165 | 0.01 | 0.01 | -0.00 | buy |
| CI INVESTMENTS INC. | 1,956 | 2,115 | +159 | 0.00 | 0.00 | 0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 42 | 44 | +2 | 0.00 | 0.00 | -0.00 | buy |
| Baker Avenue Asset Management, LP | 13,144 | 13,143 | -1 | 0.02 | 0.01 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 16,359 | 16,285 | -74 | 0.01 | 0.01 | -0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 71,477 | 70,372 | -1,105 | 0.01 | 0.01 | -0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 80,081 | 76,994 | -3,087 | 0.01 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 22,360 | 18,271 | -4,089 | 0.00 | 0.00 | -0.00 | sell |
| Fiera Capital Corp | 359,202 | 353,842 | -5,360 | 0.05 | 0.04 | -0.01 | sell |
| CIBC WORLD MARKETS CORP | 27,554 | 15,498 | -12,056 | 0.01 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 21,040 | 4,205 | -16,835 | 0.62 | 0.09 | -0.53 | sell |
| Candriam S.C.A. | 113,390 | 74,717 | -38,673 | 0.03 | 0.01 | -0.01 | sell |
| Frazier Life Sciences Management, L.P. | 539,405 | 474,405 | -65,000 | 0.93 | 0.62 | -0.31 | sell |
| Kynam Capital Management, LP | 3,200,000 | 3,071,588 | -128,412 | 10.34 | 10.75 | +0.41 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 12,189,149 | 11,965,991 | -223,158 | 7.69 | 6.55 | -1.13 | sell |
| Polar Capital Holdings Plc | 1,082,473 | 825,795 | -256,678 | 0.25 | 0.14 | -0.11 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,542,007 | 3,170,247 | -371,760 | 0.02 | 0.01 | -0.00 | sell |
| Clearbridge Investments, LLC | 1,220,455 | 646,055 | -574,400 | 0.04 | 0.02 | -0.02 | sell |
| Woodline Partners LP | 1,111,777 | 200,078 | -911,699 | 0.27 | 0.03 | -0.24 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,060,863 | 73,376 | -987,487 | 0.39 | 0.02 | -0.37 | sell |
| Capital Research Global Investors | 6,110,108 | 4,771,786 | -1,338,322 | 0.05 | 0.03 | -0.02 | sell |