| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 16,492,861 | 20,852,907 | +4,360,046 | 0.05 | 0.05 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 12,126,017 | 12,207,450 | +81,433 | 0.49 | 0.47 | -0.02 | buy |
| BlackRock, Inc. | 10,971,816 | 12,068,129 | +1,096,313 | 0.01 | 0.01 | -0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 11,474,599 | 11,474,599 | 0 | 7.07 | 5.80 | -1.27 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 5,614,597 | 7,001,565 | +1,386,968 | 0.06 | 0.07 | +0.01 | buy |
| STATE STREET CORP | 4,440,519 | 5,351,698 | +911,179 | 0.01 | 0.01 | +0.00 | buy |
| Deep Track Capital, LP | 4,300,000 | 4,300,000 | 0 | 5.16 | 3.68 | -1.47 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 3,201,283 | 3,459,363 | +258,080 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 976,429 | 2,988,999 | +2,012,570 | 0.01 | 0.02 | +0.01 | buy |
| Kynam Capital Management, LP | 2,922,335 | 2,922,335 | 0 | 10.78 | 9.39 | -1.39 | hold |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,646,138 | 2,472,428 | -1,173,710 | 0.89 | 0.47 | -0.42 | sell |
| Caligan Partners LP | 2,060,719 | 2,188,636 | +127,917 | 8.47 | 6.14 | -2.33 | buy |
| Paradigm Biocapital Advisors LP | 4,793,020 | 2,127,852 | -2,665,168 | 5.69 | 2.32 | -3.37 | sell |
| Bellevue Group AG | 1,190,697 | 1,971,935 | +781,238 | 1.65 | 2.41 | +0.77 | buy |
| D. E. Shaw & Co., Inc. | 2,865,318 | 1,901,872 | -963,446 | 0.13 | 0.07 | -0.06 | sell |
| MAVERICK CAPITAL LTD | 1,377,738 | 1,613,242 | +235,504 | 0.93 | 0.85 | -0.08 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,464,812 | +1,464,812 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,403,948 | 1,464,812 | +60,864 | 0.01 | 0.01 | -0.00 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,372,425 | 1,425,470 | +53,045 | 28.51 | 26.92 | -1.58 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,374,292 | 1,380,219 | +5,927 | 1.32 | 1.07 | -0.25 | buy |
| GOLDMAN SACHS GROUP INC | 1,275,036 | 1,350,760 | +75,724 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 1,144,469 | 1,280,172 | +135,703 | 0.01 | 0.01 | -0.00 | buy |
| NORGES BANK | 0 | 1,245,805 | +1,245,805 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 1,008,314 | 1,227,346 | +219,032 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 375,772 | 1,194,754 | +818,982 | 0.00 | 0.01 | +0.01 | buy |
| Polar Capital Holdings Plc | 1,425,788 | 1,185,943 | -239,845 | 0.36 | 0.20 | -0.17 | sell |
| BANK OF AMERICA CORP /DE/ | 1,216,843 | 1,078,798 | -138,045 | 0.01 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 350,000 | 880,000 | +530,000 | 0.03 | 0.07 | +0.04 | buy |
| Saturn V Capital Management LP | 824,532 | 852,914 | +28,382 | 8.68 | 7.11 | -1.57 | buy |
| Capital Research Global Investors | 912,688 | 836,761 | -75,927 | 0.01 | 0.01 | -0.00 | sell |
| Novo Holdings A/S | 860,000 | 800,000 | -60,000 | 4.05 | 2.70 | -1.35 | sell |
| MORGAN STANLEY | 735,907 | 797,718 | +61,811 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 355,854 | 782,184 | +426,330 | 0.01 | 0.02 | +0.01 | buy |
| UBS Group AG | 1,337,390 | 776,511 | -560,879 | 0.01 | 0.01 | -0.01 | sell |
| Clearbridge Investments, LLC | 128,377 | 751,999 | +623,622 | 0.01 | 0.04 | +0.03 | buy |
| Pictet Asset Management Holding SA | 700,311 | 694,719 | -5,592 | 0.04 | 0.04 | -0.00 | sell |
| Eversept Partners, LP | 924,193 | 629,952 | -294,241 | 3.54 | 2.00 | -1.54 | sell |
| FEDERATED HERMES, INC. | 566,828 | 601,161 | +34,333 | 0.05 | 0.05 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 522,019 | 534,163 | +12,144 | 0.70 | 0.58 | -0.12 | buy |
| ALGERT GLOBAL LLC | 363,984 | 515,343 | +151,359 | 0.32 | 0.36 | +0.04 | buy |
| Bank of New York Mellon Corp | 474,526 | 502,135 | +27,609 | 0.01 | 0.00 | -0.00 | buy |
| BROWN ADVISORY INC | 511,701 | 487,017 | -24,684 | 0.05 | 0.04 | -0.01 | sell |
| JENNISON ASSOCIATES LLC | 1,698,011 | 476,216 | -1,221,795 | 0.07 | 0.02 | -0.05 | sell |
| FRANKLIN RESOURCES INC | 473,363 | 476,004 | +2,641 | 0.01 | 0.01 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 224,518 | 465,477 | +240,959 | 0.01 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 501,857 | 452,723 | -49,134 | 0.02 | 0.01 | -0.00 | sell |
| First Turn Management, LLC | 0 | 443,836 | +443,836 | 0.00 | 2.76 | +2.76 | buy |
| AMERIPRISE FINANCIAL INC | 110,986 | 440,505 | +329,519 | 0.00 | 0.01 | +0.00 | buy |
| Ikarian Capital, LLC | 428,682 | 388,682 | -40,000 | 3.56 | 3.70 | +0.13 | sell |
| Ensign Peak Advisors, Inc | 445,903 | 381,686 | -64,217 | 0.05 | 0.04 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 410,605 | 371,550 | -39,055 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 260,395 | 369,406 | +109,011 | 0.00 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 145,371 | 363,205 | +217,834 | 0.01 | 0.02 | +0.01 | buy |
| Aberdeen Group plc | 978,969 | 362,756 | -616,213 | 0.09 | 0.03 | -0.06 | sell |
| Alyeska Investment Group, L.P. | 435,581 | 362,272 | -73,309 | 0.07 | 0.05 | -0.02 | sell |
| First Light Asset Management, LLC | 141,784 | 345,157 | +203,373 | 0.74 | 1.22 | +0.48 | buy |
| Boxer Capital Management, LLC | 325,000 | 325,000 | 0 | 2.48 | 1.42 | -1.06 | hold |
| Nuveen, LLC | 320,789 | 324,762 | +3,973 | 0.01 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 274,740 | 274,740 | 0 | 0.06 | 0.05 | -0.01 | hold |
| TD ASSET MANAGEMENT INC | 312,762 | 274,640 | -38,122 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 111,310 | 273,876 | +162,566 | 0.01 | 0.01 | +0.01 | buy |
| Artisan Partners Limited Partnership | 297,432 | 270,590 | -26,842 | 0.03 | 0.03 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 299,693 | 258,338 | -41,355 | 0.01 | 0.00 | -0.00 | sell |
| Swiss National Bank | 233,100 | 245,500 | +12,400 | 0.01 | 0.01 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 112,631 | 243,502 | +130,871 | 0.01 | 0.03 | +0.01 | buy |
| University of Wisconsin Foundation | 239,749 | 239,749 | 0 | 12.37 | 11.03 | -1.33 | hold |
| Nantahala Capital Management, LLC | 238,746 | 222,146 | -16,600 | 0.87 | 0.78 | -0.09 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 151,555 | 212,472 | +60,917 | 0.01 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 315,022 | 208,054 | -106,968 | 0.10 | 0.05 | -0.04 | sell |
| CITIGROUP INC | 132,178 | 202,673 | +70,495 | 0.00 | 0.01 | +0.00 | buy |
| Rosalind Advisors, Inc. | 290,000 | 200,000 | -90,000 | 6.90 | 4.37 | -2.54 | sell |
| C WorldWide Group Holding A/S | 195,000 | 195,000 | 0 | 0.24 | 0.27 | +0.03 | hold |
| SEGALL BRYANT & HAMILL, LLC | 183,935 | 187,269 | +3,334 | 0.11 | 0.13 | +0.02 | buy |
| Invesco Ltd. | 184,043 | 173,439 | -10,604 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 158,841 | 168,517 | +9,676 | 0.01 | 0.01 | -0.00 | buy |
| Russell Investments Group, Ltd. | 38,179 | 162,784 | +124,605 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 137,082 | 159,909 | +22,827 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 36,090 | 156,090 | +120,000 | 0.12 | 0.37 | +0.25 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 121,320 | 150,159 | +28,839 | 0.01 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 124,647 | 149,739 | +25,092 | 2.00 | 1.98 | -0.02 | buy |
| HRT FINANCIAL LP | 53,300 | 147,300 | +94,000 | 0.01 | 0.02 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 259,137 | 146,034 | -113,103 | 0.90 | 0.40 | -0.51 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 144,981 | 145,000 | +19 | 0.99 | 0.94 | -0.05 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 136,100 | 140,833 | +4,733 | 0.01 | 0.01 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 293,695 | 136,625 | -157,070 | 0.01 | 0.01 | -0.01 | sell |
| Jump Financial, LLC | 0 | 135,000 | +135,000 | 0.00 | 0.07 | +0.07 | buy |
| WELLS FARGO & COMPANY/MN | 53,106 | 132,513 | +79,407 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 131,133 | +131,133 | 0.00 | 0.43 | +0.43 | buy |
| Edgestream Partners, L.P. | 0 | 131,115 | +131,115 | 0.00 | 0.23 | +0.23 | buy |
| Trexquant Investment LP | 49,212 | 128,333 | +79,121 | 0.02 | 0.05 | +0.03 | buy |
| NAN FUNG TRINITY (HK) Ltd | 122,930 | 122,930 | 0 | 0.78 | 0.71 | -0.08 | hold |
| Creative Planning | 140,177 | 120,771 | -19,406 | 0.01 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 270,115 | 116,965 | -153,150 | 0.07 | 0.02 | -0.05 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 86,366 | 108,504 | +22,138 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 1,164,813 | 101,433 | -1,063,380 | 0.11 | 0.01 | -0.10 | sell |
| Legal & General Group Plc | 97,337 | 97,451 | +114 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 19,257 | 81,632 | +62,375 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 67,854 | 76,628 | +8,774 | 0.02 | 0.02 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 75,000 | +75,000 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 72,902 | 71,772 | -1,130 | 0.01 | 0.01 | -0.00 | sell |