| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 1,454,502 | 1,754,691 | +300,189 | 0.06 | 0.08 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 812,912 | 538,384 | +274,528 | 0.07 | 0.05 | 0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,192,382 | 2,417,652 | +225,270 | 0.02 | 0.02 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,685,214 | 1,875,114 | +189,900 | 0.01 | 0.01 | 0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,189,857 | 1,323,884 | +134,027 | 0.75 | 0.88 | +0.13 | buy |
| MOODY ALDRICH PARTNERS LLC | 24,665 | 140,170 | +115,505 | 0.24 | 1.35 | +1.11 | buy |
| Commodore Capital LP | 1,015,000 | 1,100,000 | +85,000 | 5.70 | 6.55 | +0.86 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 60,088 | 132,088 | +72,000 | 0.01 | 0.02 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 89,045 | 151,146 | +62,101 | 0.01 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,142,918 | 1,204,628 | +61,710 | 0.04 | 0.04 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 462,304 | 430,949 | +31,355 | 0.03 | 0.03 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 108,977 | 121,230 | +12,253 | 0.91 | 1.20 | +0.30 | buy |
| Affinity Asset Advisors, LLC | 13,923 | 25,000 | +11,077 | 0.27 | 0.42 | +0.14 | buy |
| Parkman Healthcare Partners LLC | 228,505 | 238,132 | +9,627 | 1.98 | 2.22 | +0.25 | buy |
| ADVISORY RESEARCH INC | 34,718 | 41,255 | +6,537 | 0.22 | 0.29 | +0.07 | buy |
| Campbell & CO Investment Adviser LLC | 20,748 | 26,342 | +5,594 | 0.18 | 0.16 | -0.02 | buy |
| Bellevue Group AG | 26,000 | 30,500 | +4,500 | 0.02 | 0.03 | +0.01 | buy |
| READYSTATE ASSET MANAGEMENT LP | 55,520 | 58,472 | +2,952 | 0.27 | 0.25 | -0.03 | buy |
| ALGERT GLOBAL LLC | 22,000 | 24,790 | +2,790 | 0.05 | 0.06 | 0.00 | buy |
| Ikarian Capital, LLC | 140,000 | 142,417 | +2,417 | 2.47 | 2.70 | +0.23 | buy |
| Kynam Capital Management, LP | 1,300,000 | 1,302,407 | +2,407 | 9.95 | 11.04 | +1.09 | buy |
| Parkwood LLC | 14,778 | 16,641 | +1,863 | 0.13 | 0.15 | +0.02 | buy |
| Ameritas Investment Partners, Inc. | 7,592 | 9,217 | +1,625 | 0.02 | 0.02 | +0.00 | buy |
| BANK OF HAWAII | 19,574 | 21,166 | +1,592 | 0.05 | 0.06 | +0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 29,061 | 30,286 | +1,225 | 0.01 | 0.01 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 41,228 | 42,410 | +1,182 | 0.64 | 0.63 | -0.01 | buy |
| Chicago Partners Investment Group LLC | 6,157 | 7,162 | +1,005 | 0.02 | 0.02 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 7,059,751 | 7,060,588 | +837 | 0.22 | 0.24 | 0.00 | buy |
| ALPS ADVISORS INC | 68,879 | 69,305 | +426 | 0.03 | 0.03 | -0.00 | buy |
| ProShare Advisors LLC | 18,020 | 18,322 | +302 | 0.00 | 0.00 | 0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 17,022 | 17,106 | +84 | 0.01 | 0.01 | +0.00 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 8,157 | 8,146 | -11 | 0.04 | 0.05 | +0.00 | sell |
| OLIVER LAGORE VANVALIN INVESTMENT GROUP | 185 | 161 | -24 | 0.00 | 0.00 | -0.00 | sell |
| Nicholas Investment Partners, LP | 460,164 | 460,008 | -156 | 1.57 | 1.75 | +0.18 | sell |
| VIRTUS ADVISERS, LLC | 2,075 | 1,883 | -192 | 0.06 | 0.06 | -0.00 | sell |
| J. Goldman & Co LP | 9,051 | 8,684 | -367 | 0.03 | 0.02 | -0.00 | sell |
| Rafferty Asset Management, LLC | 164,309 | 163,894 | -415 | 0.05 | 0.05 | +0.00 | sell |
| E Fund Management Co., Ltd. | 8,834 | 8,416 | -418 | 0.03 | 0.03 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 122,166 | 121,022 | -1,144 | 4.13 | 4.49 | +0.35 | sell |
| PROFUND ADVISORS LLC | 31,004 | 28,882 | -2,122 | 0.08 | 0.08 | -0.00 | sell |
| Pier Capital, LLC | 206,196 | 203,728 | -2,468 | 1.48 | 1.67 | +0.20 | sell |
| HighVista Strategies LLC | 14,561 | 11,248 | -3,313 | 0.33 | 0.27 | -0.07 | sell |
| Graham Capital Management, L.P. | 10,549 | 7,082 | -3,467 | 0.02 | 0.01 | -0.01 | sell |
| Eversept Partners, LP | 195,691 | 190,430 | -5,261 | 1.03 | 1.08 | +0.05 | sell |
| Woodline Partners LP | 390,456 | 380,613 | -9,843 | 0.23 | 0.23 | -0.00 | sell |
| CASTLEARK MANAGEMENT LLC | 69,000 | 56,630 | -12,370 | 0.16 | 0.15 | -0.01 | sell |
| Informed Momentum Co LLC | 60,554 | 17,289 | -43,265 | 0.56 | 0.17 | -0.39 | sell |
| GREAT POINT PARTNERS LLC | 589,211 | 531,211 | -58,000 | 5.89 | 5.09 | -0.80 | sell |
| Soleus Capital Management, L.P. | 571,250 | 499,650 | -71,600 | 3.17 | 2.57 | -0.61 | sell |
| Opaleye Management Inc. | 177,000 | 90,000 | -87,000 | 2.11 | 1.49 | -0.62 | sell |
| Lisanti Capital Growth, LLC | 132,735 | 34,970 | -97,765 | 0.92 | 0.28 | -0.64 | sell |
| BRAIDWELL LP | 1,722,353 | 1,619,553 | -102,800 | 2.81 | 2.61 | -0.20 | sell |
| Avidity Partners Management LP | 875,000 | 756,165 | -118,835 | 1.53 | 1.55 | +0.03 | sell |
| Medicxi Ventures Management (Jersey) Ltd | 1,315,435 | 1,049,893 | -265,542 | 18.41 | 17.09 | -1.32 | sell |
| PERCEPTIVE ADVISORS LLC | 1,614,122 | 1,342,751 | -271,371 | 2.34 | 2.30 | -0.04 | sell |
| FRED ALGER MANAGEMENT, LLC | 2,371,218 | 2,093,305 | -277,913 | 0.60 | 0.61 | +0.01 | sell |