| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 8,868,907 | 10,921,896 | +2,052,989 | 0.36 | 0.64 | +0.28 | buy |
| VANGUARD GROUP INC | 9,796,995 | 11,440,483 | +1,643,488 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,173,167 | 4,466,137 | +1,292,970 | 0.03 | 0.06 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 130,062 | 1,148,184 | +1,018,122 | 0.00 | 0.05 | +0.05 | buy |
| Polar Capital Holdings Plc | 0 | 995,779 | +995,779 | 0.00 | 0.54 | +0.54 | buy |
| Clearbridge Investments, LLC | 186,141 | 1,159,280 | +973,139 | 0.01 | 0.10 | +0.09 | buy |
| Capital Research Global Investors | 4,133,544 | 4,898,221 | +764,677 | 0.07 | 0.12 | +0.05 | buy |
| Avoro Capital Advisors LLC | 575,000 | 1,175,000 | +600,000 | 0.58 | 1.96 | +1.38 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 8,203,754 | 8,689,190 | +485,436 | 8.19 | 11.45 | +3.25 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 876,237 | 1,295,837 | +419,600 | 0.01 | 0.03 | +0.02 | buy |
| Woodline Partners LP | 706,903 | 1,103,945 | +397,042 | 0.51 | 1.07 | +0.55 | buy |
| Point72 Asset Management, L.P. | 0 | 359,796 | +359,796 | 0.00 | 0.14 | +0.14 | buy |
| FRANKLIN RESOURCES INC | 2,461,775 | 2,786,335 | +324,560 | 0.06 | 0.09 | +0.03 | buy |
| Logos Global Management LP | 0 | 300,000 | +300,000 | 0.00 | 3.84 | +3.84 | buy |
| MAVERICK CAPITAL LTD | 687,908 | 976,249 | +288,341 | 0.99 | 2.18 | +1.19 | buy |
| Kynam Capital Management, LP | 753,240 | 1,039,288 | +286,048 | 5.95 | 9.20 | +3.25 | buy |
| MORGAN STANLEY | 409,692 | 694,869 | +285,177 | 0.00 | 0.01 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 0 | 269,121 | +269,121 | 0.00 | 0.46 | +0.46 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,441,772 | 2,700,782 | +259,010 | 0.02 | 0.02 | +0.01 | buy |
| Pictet Asset Management Holding SA | 532,904 | 780,905 | +248,001 | 0.05 | 0.10 | +0.05 | buy |
| Invesco Ltd. | 1,078,720 | 1,312,096 | +233,376 | 0.02 | 0.03 | +0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 225,000 | +225,000 | 0.00 | 0.38 | +0.38 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 224,446 | +224,446 | 0.00 | 0.09 | +0.09 | buy |
| Alyeska Investment Group, L.P. | 0 | 218,831 | +218,831 | 0.00 | 0.13 | +0.13 | buy |
| JPMORGAN CHASE & CO | 1,212,443 | 1,427,760 | +215,317 | 0.01 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 736,739 | 949,251 | +212,512 | 0.01 | 0.02 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 230,207 | 423,498 | +193,291 | 0.02 | 0.06 | +0.04 | buy |
| PERCEPTIVE ADVISORS LLC | 1,862,608 | 2,027,608 | +165,000 | 3.39 | 4.97 | +1.58 | buy |
| Tri Locum Partners LP | 113,344 | 271,922 | +158,578 | 2.16 | 7.44 | +5.28 | buy |
| Maven Securities LTD | 0 | 129,700 | +129,700 | 0.00 | 1.67 | +1.67 | buy |
| NORGES BANK | 984,464 | 1,112,535 | +128,071 | 0.01 | 0.02 | +0.01 | buy |
| Darwin Global Management, Ltd. | 2,080,946 | 2,198,187 | +117,241 | 19.07 | 20.43 | +1.35 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 295,762 | 408,274 | +112,512 | 0.01 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 35,642 | 136,429 | +100,787 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 471,281 | 569,890 | +98,609 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 939,726 | 1,036,417 | +96,691 | 0.01 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 203,731 | 298,435 | +94,704 | 0.01 | 0.03 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 462,682 | 546,835 | +84,153 | 0.06 | 0.11 | +0.05 | buy |
| BARCLAYS PLC | 127,952 | 209,753 | +81,801 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 0 | 79,938 | +79,938 | 0.00 | 0.12 | +0.12 | buy |
| BROWN ADVISORY INC | 367,217 | 444,039 | +76,822 | 0.04 | 0.06 | +0.03 | buy |
| FEDERATED HERMES, INC. | 425,640 | 501,050 | +75,410 | 0.08 | 0.13 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 277,764 | 350,151 | +72,387 | 0.01 | 0.01 | +0.00 | buy |
| Altium Capital Management LLC | 0 | 72,000 | +72,000 | 0.00 | 2.45 | +2.45 | buy |
| LORD, ABBETT & CO. LLC | 246,242 | 312,425 | +66,183 | 0.06 | 0.11 | +0.05 | buy |
| Russell Investments Group, Ltd. | 18,959 | 78,947 | +59,988 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 58,216 | +58,216 | 0.00 | 0.07 | +0.07 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,500 | 60,500 | +58,000 | 0.05 | 1.56 | +1.51 | buy |
| Schonfeld Strategic Advisors LLC | 24,788 | 81,010 | +56,222 | 0.01 | 0.08 | +0.06 | buy |
| CITIGROUP INC | 165,795 | 220,543 | +54,748 | 0.01 | 0.02 | +0.01 | buy |
| Caption Management, LLC | 0 | 54,735 | +54,735 | 0.00 | 0.67 | +0.67 | buy |
| Cercano Management LLC | 273,608 | 327,742 | +54,134 | 0.55 | 0.90 | +0.34 | buy |
| TD ASSET MANAGEMENT INC | 312,426 | 366,156 | +53,730 | 0.02 | 0.04 | +0.01 | buy |
| Crestline Management, LP | 0 | 53,583 | +53,583 | 0.00 | 0.35 | +0.35 | buy |
| EcoR1 Capital, LLC | 300,000 | 352,464 | +52,464 | 0.69 | 1.38 | +0.69 | buy |
| Jump Financial, LLC | 0 | 51,516 | +51,516 | 0.00 | 0.12 | +0.12 | buy |
| MACQUARIE GROUP LTD | 159,012 | 208,875 | +49,863 | 0.01 | 0.03 | +0.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 92,304 | 140,847 | +48,543 | 0.02 | 0.04 | +0.02 | buy |
| Duquesne Family Office LLC | 0 | 42,965 | +42,965 | 0.00 | 0.17 | +0.17 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 152,778 | 195,086 | +42,308 | 0.01 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 23,356 | 63,492 | +40,136 | 0.01 | 0.02 | +0.02 | buy |
| Monashee Investment Management LLC | 0 | 40,000 | +40,000 | 0.00 | 0.49 | +0.49 | buy |
| Global IMC LLC | 0 | 39,032 | +39,032 | 0.00 | 0.90 | +0.90 | buy |
| FIRST TRUST ADVISORS LP | 78,926 | 117,864 | +38,938 | 0.01 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 3,367,147 | 3,405,743 | +38,596 | 0.01 | 0.02 | +0.00 | buy |
| Informed Momentum Co LLC | 36,522 | 72,995 | +36,473 | 0.45 | 1.25 | +0.80 | buy |
| FORA Capital, LLC | 0 | 34,379 | +34,379 | 0.00 | 0.46 | +0.46 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 18,415 | 52,702 | +34,287 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 32,494 | +32,494 | 0.00 | 0.21 | +0.21 | buy |
| T. Rowe Price Investment Management, Inc. | 4,022,589 | 4,053,828 | +31,239 | 0.19 | 0.28 | +0.09 | buy |
| BAMCO INC /NY/ | 0 | 31,000 | +31,000 | 0.00 | 0.01 | +0.01 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 29,272 | 60,272 | +31,000 | 0.00 | 0.01 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 28,228 | +28,228 | 0.00 | 0.04 | +0.04 | buy |
| Headlands Technologies LLC | 0 | 27,782 | +27,782 | 0.00 | 0.37 | +0.37 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 27,433 | +27,433 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 43,941 | 70,037 | +26,096 | 0.01 | 0.04 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 131,749 | 157,024 | +25,275 | 0.01 | 0.02 | +0.01 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 110,400 | 135,400 | +25,000 | 7.03 | 12.53 | +5.50 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 40,342 | 64,664 | +24,322 | 0.23 | 0.32 | +0.09 | buy |
| Windsor Advisory Group, LLC | 0 | 22,744 | +22,744 | 0.00 | 2.93 | +2.93 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,127 | 44,470 | +20,343 | 0.00 | 0.01 | +0.01 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 18,100 | +18,100 | 0.00 | 0.45 | +0.45 | buy |
| UBS Group AG | 95,676 | 111,573 | +15,897 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 288,006 | 303,879 | +15,873 | 0.02 | 0.04 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 10,463 | 26,019 | +15,556 | 0.04 | 0.18 | +0.14 | buy |
| PRUDENTIAL FINANCIAL INC | 81,338 | 96,653 | +15,315 | 0.01 | 0.02 | +0.01 | buy |
| Calamos Advisors LLC | 11,533 | 26,831 | +15,298 | 0.00 | 0.01 | +0.01 | buy |
| Man Group plc | 0 | 14,551 | +14,551 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 13,645 | +13,645 | 0.00 | 0.01 | +0.01 | buy |
| Lisanti Capital Growth, LLC | 19,340 | 32,515 | +13,175 | 0.35 | 0.94 | +0.59 | buy |
| Scientech Research LLC | 0 | 12,888 | +12,888 | 0.00 | 0.29 | +0.29 | buy |
| HighVista Strategies LLC | 32,313 | 44,661 | +12,348 | 0.89 | 1.76 | +0.87 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 60,367 | 72,316 | +11,949 | 0.01 | 0.02 | +0.01 | buy |
| CASTLEARK MANAGEMENT LLC | 43,690 | 54,620 | +10,930 | 0.13 | 0.25 | +0.12 | buy |
| HAP Trading, LLC | 0 | 10,920 | +10,920 | 0.00 | 0.63 | +0.63 | buy |
| Creative Planning | 27,280 | 37,525 | +10,245 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 170,149 | 179,217 | +9,068 | 0.02 | 0.03 | +0.01 | buy |
| TORNO CAPITAL, LLC | 0 | 9,000 | +9,000 | 0.00 | 1.33 | +1.33 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 8,895 | +8,895 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,781 | 21,466 | +8,685 | 0.14 | 0.27 | +0.13 | buy |