| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 16,167,340 | 15,800,667 | -366,673 | 0.08 | 0.11 | +0.03 | sell |
| VANGUARD GROUP INC | 9,796,995 | 11,440,483 | +1,643,488 | 0.01 | 0.02 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 8,868,907 | 10,921,896 | +2,052,989 | 0.36 | 0.64 | +0.28 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 8,203,754 | 8,689,190 | +485,436 | 8.19 | 11.45 | +3.25 | buy |
| Capital Research Global Investors | 4,133,544 | 4,898,221 | +764,677 | 0.07 | 0.12 | +0.05 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,593,066 | 4,513,756 | -79,310 | 0.06 | 0.09 | +0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,173,167 | 4,466,137 | +1,292,970 | 0.03 | 0.06 | +0.03 | buy |
| T. Rowe Price Investment Management, Inc. | 4,022,589 | 4,053,828 | +31,239 | 0.19 | 0.28 | +0.09 | buy |
| STATE STREET CORP | 3,367,147 | 3,405,743 | +38,596 | 0.01 | 0.02 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 2,461,775 | 2,786,335 | +324,560 | 0.06 | 0.09 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,441,772 | 2,700,782 | +259,010 | 0.02 | 0.02 | +0.01 | buy |
| Darwin Global Management, Ltd. | 2,080,946 | 2,198,187 | +117,241 | 19.07 | 20.43 | +1.35 | buy |
| PERCEPTIVE ADVISORS LLC | 1,862,608 | 2,027,608 | +165,000 | 3.39 | 4.97 | +1.58 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,929,348 | 1,739,874 | -189,474 | 0.72 | 0.90 | +0.18 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,934,747 | 1,721,296 | -213,451 | 1.41 | 1.69 | +0.28 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,734,821 | 1,645,914 | -88,907 | 0.05 | 0.06 | +0.02 | sell |
| JPMORGAN CHASE & CO | 1,212,443 | 1,427,760 | +215,317 | 0.01 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 1,078,720 | 1,312,096 | +233,376 | 0.02 | 0.03 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 876,237 | 1,295,837 | +419,600 | 0.01 | 0.03 | +0.02 | buy |
| FRED ALGER MANAGEMENT, LLC | 1,310,436 | 1,243,717 | -66,719 | 0.48 | 0.69 | +0.21 | sell |
| JENNISON ASSOCIATES LLC | 1,383,131 | 1,237,430 | -145,701 | 0.07 | 0.09 | +0.02 | sell |
| Avoro Capital Advisors LLC | 575,000 | 1,175,000 | +600,000 | 0.58 | 1.96 | +1.38 | buy |
| Clearbridge Investments, LLC | 186,141 | 1,159,280 | +973,139 | 0.01 | 0.10 | +0.09 | buy |
| DEUTSCHE BANK AG\ | 130,062 | 1,148,184 | +1,018,122 | 0.00 | 0.05 | +0.05 | buy |
| NORGES BANK | 984,464 | 1,112,535 | +128,071 | 0.01 | 0.02 | +0.01 | buy |
| Woodline Partners LP | 706,903 | 1,103,945 | +397,042 | 0.51 | 1.07 | +0.55 | buy |
| Kynam Capital Management, LP | 753,240 | 1,039,288 | +286,048 | 5.95 | 9.20 | +3.25 | buy |
| NORTHERN TRUST CORP | 939,726 | 1,036,417 | +96,691 | 0.01 | 0.02 | +0.01 | buy |
| Cormorant Asset Management, LP | 1,100,000 | 1,000,000 | -100,000 | 4.83 | 6.06 | +1.23 | sell |
| Polar Capital Holdings Plc | 0 | 995,779 | +995,779 | 0.00 | 0.54 | +0.54 | buy |
| MAVERICK CAPITAL LTD | 687,908 | 976,249 | +288,341 | 0.99 | 2.18 | +1.19 | buy |
| GOLDMAN SACHS GROUP INC | 736,739 | 949,251 | +212,512 | 0.01 | 0.02 | +0.01 | buy |
| Commodore Capital LP | 1,305,000 | 920,000 | -385,000 | 6.73 | 6.57 | -0.16 | sell |
| Frazier Life Sciences Management, L.P. | 1,039,405 | 879,405 | -160,000 | 3.67 | 4.03 | +0.36 | sell |
| Pictet Asset Management Holding SA | 532,904 | 780,905 | +248,001 | 0.05 | 0.10 | +0.05 | buy |
| Novo Holdings A/S | 950,000 | 750,000 | -200,000 | 3.87 | 4.26 | +0.39 | sell |
| MORGAN STANLEY | 409,692 | 694,869 | +285,177 | 0.00 | 0.01 | +0.00 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 793,036 | 639,539 | -153,497 | 46.04 | 43.38 | -2.66 | sell |
| Paradigm Biocapital Advisors LP | 627,202 | 627,732 | +530 | 1.81 | 2.51 | +0.70 | buy |
| BANK OF AMERICA CORP /DE/ | 471,281 | 569,890 | +98,609 | 0.00 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 462,682 | 546,835 | +84,153 | 0.06 | 0.11 | +0.05 | buy |
| AMERICAN CENTURY COMPANIES INC | 527,594 | 529,005 | +1,411 | 0.02 | 0.04 | +0.01 | buy |
| FEDERATED HERMES, INC. | 425,640 | 501,050 | +75,410 | 0.08 | 0.13 | +0.05 | buy |
| BROWN ADVISORY INC | 367,217 | 444,039 | +76,822 | 0.04 | 0.06 | +0.03 | buy |
| Amundi | 442,308 | 434,792 | -7,516 | 0.01 | 0.02 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 230,207 | 423,498 | +193,291 | 0.02 | 0.06 | +0.04 | buy |
| Bank of New York Mellon Corp | 468,579 | 412,050 | -56,529 | 0.01 | 0.01 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 295,762 | 408,274 | +112,512 | 0.01 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 795,900 | 387,000 | -408,900 | 1.19 | 0.81 | -0.39 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 739,153 | 383,454 | -355,699 | 0.96 | 0.76 | -0.20 | sell |
| TD ASSET MANAGEMENT INC | 312,426 | 366,156 | +53,730 | 0.02 | 0.04 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 359,796 | +359,796 | 0.00 | 0.14 | +0.14 | buy |
| EcoR1 Capital, LLC | 300,000 | 352,464 | +52,464 | 0.69 | 1.38 | +0.69 | buy |
| AMERIPRISE FINANCIAL INC | 277,764 | 350,151 | +72,387 | 0.01 | 0.01 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 343,552 | 347,474 | +3,922 | 0.04 | 0.06 | +0.02 | buy |
| Cercano Management LLC | 273,608 | 327,742 | +54,134 | 0.55 | 0.90 | +0.34 | buy |
| LORD, ABBETT & CO. LLC | 246,242 | 312,425 | +66,183 | 0.06 | 0.11 | +0.05 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 288,006 | 303,879 | +15,873 | 0.02 | 0.04 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 300,000 | 300,000 | 0 | 2.31 | 2.45 | +0.14 | hold |
| Logos Global Management LP | 0 | 300,000 | +300,000 | 0.00 | 3.84 | +3.84 | buy |
| MILLENNIUM MANAGEMENT LLC | 203,731 | 298,435 | +94,704 | 0.01 | 0.03 | +0.02 | buy |
| BRAIDWELL LP | 808,303 | 297,568 | -510,735 | 1.91 | 0.96 | -0.95 | sell |
| COMERICA BANK | 273,025 | 273,022 | -3 | 0.09 | 0.12 | +0.04 | sell |
| Tri Locum Partners LP | 113,344 | 271,922 | +158,578 | 2.16 | 7.44 | +5.28 | buy |
| TimesSquare Capital Management, LLC | 0 | 269,121 | +269,121 | 0.00 | 0.46 | +0.46 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 307,516 | 255,040 | -52,476 | 0.02 | 0.03 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 225,000 | +225,000 | 0.00 | 0.38 | +0.38 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 224,446 | +224,446 | 0.00 | 0.09 | +0.09 | buy |
| CITIGROUP INC | 165,795 | 220,543 | +54,748 | 0.01 | 0.02 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 0 | 218,831 | +218,831 | 0.00 | 0.13 | +0.13 | buy |
| First Turn Management, LLC | 260,281 | 211,985 | -48,296 | 3.20 | 3.84 | +0.64 | sell |
| BARCLAYS PLC | 127,952 | 209,753 | +81,801 | 0.00 | 0.01 | +0.01 | buy |
| MACQUARIE GROUP LTD | 159,012 | 208,875 | +49,863 | 0.01 | 0.03 | +0.01 | buy |
| Saturn V Capital Management LP | 215,680 | 204,987 | -10,693 | 6.15 | 8.37 | +2.22 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 152,778 | 195,086 | +42,308 | 0.01 | 0.02 | +0.01 | buy |
| Swiss National Bank | 181,300 | 180,600 | -700 | 0.01 | 0.01 | +0.00 | sell |
| SEI INVESTMENTS CO | 170,149 | 179,217 | +9,068 | 0.02 | 0.03 | +0.01 | buy |
| RHUMBLINE ADVISERS | 159,295 | 164,103 | +4,808 | 0.01 | 0.02 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 131,749 | 157,024 | +25,275 | 0.01 | 0.02 | +0.01 | buy |
| SEGALL BRYANT & HAMILL, LLC | 162,432 | 156,056 | -6,376 | 0.22 | 0.24 | +0.03 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 92,304 | 140,847 | +48,543 | 0.02 | 0.04 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 35,642 | 136,429 | +100,787 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 110,400 | 135,400 | +25,000 | 7.03 | 12.53 | +5.50 | buy |
| Parkman Healthcare Partners LLC | 150,191 | 130,249 | -19,942 | 1.54 | 1.90 | +0.36 | sell |
| Maven Securities LTD | 0 | 129,700 | +129,700 | 0.00 | 1.67 | +1.67 | buy |
| FIRST TRUST ADVISORS LP | 78,926 | 117,864 | +38,938 | 0.01 | 0.01 | +0.01 | buy |
| UBS Group AG | 95,676 | 111,573 | +15,897 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 96,310 | 99,528 | +3,218 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 81,338 | 96,653 | +15,315 | 0.01 | 0.02 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 91,279 | 89,436 | -1,843 | 0.01 | 0.01 | +0.00 | sell |
| JANE STREET GROUP, LLC | 106,611 | 85,543 | -21,068 | 0.01 | 0.02 | +0.01 | sell |
| Opaleye Management Inc. | 85,000 | 85,000 | 0 | 1.47 | 1.62 | +0.15 | hold |
| Aberdeen Group plc | 190,401 | 82,830 | -107,571 | 0.03 | 0.02 | -0.01 | sell |
| Neuberger Berman Group LLC | 108,092 | 82,733 | -25,359 | 0.01 | 0.01 | +0.00 | sell |
| Nicholas Investment Partners, LP | 87,230 | 81,883 | -5,347 | 0.68 | 0.86 | +0.18 | sell |
| Schonfeld Strategic Advisors LLC | 24,788 | 81,010 | +56,222 | 0.01 | 0.08 | +0.06 | buy |
| Trexquant Investment LP | 0 | 79,938 | +79,938 | 0.00 | 0.12 | +0.12 | buy |
| Russell Investments Group, Ltd. | 18,959 | 78,947 | +59,988 | 0.00 | 0.01 | +0.01 | buy |
| Artia Global Partners LP | 76,255 | 76,255 | 0 | 1.48 | 2.46 | +0.99 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 418,715 | 74,167 | -344,548 | 0.08 | 0.02 | -0.06 | sell |