| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 8,868,907 | 10,921,896 | +2,052,989 | 0.36 | 0.64 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,173,167 | 4,466,137 | +1,292,970 | 0.03 | 0.06 | +0.03 | buy |
| Clearbridge Investments, LLC | 186,141 | 1,159,280 | +973,139 | 0.01 | 0.10 | +0.09 | buy |
| Capital Research Global Investors | 4,133,544 | 4,898,221 | +764,677 | 0.07 | 0.12 | +0.05 | buy |
| Avoro Capital Advisors LLC | 575,000 | 1,175,000 | +600,000 | 0.58 | 1.96 | +1.38 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 8,203,754 | 8,689,190 | +485,436 | 8.19 | 11.45 | +3.25 | buy |
| Woodline Partners LP | 706,903 | 1,103,945 | +397,042 | 0.51 | 1.07 | +0.55 | buy |
| MAVERICK CAPITAL LTD | 687,908 | 976,249 | +288,341 | 0.99 | 2.18 | +1.19 | buy |
| Kynam Capital Management, LP | 753,240 | 1,039,288 | +286,048 | 5.95 | 9.20 | +3.25 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,441,772 | 2,700,782 | +259,010 | 0.02 | 0.03 | 0.00 | buy |
| D. E. Shaw & Co., Inc. | 230,207 | 423,498 | +193,291 | 0.03 | 0.07 | 0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,862,608 | 2,027,608 | +165,000 | 3.39 | 4.90 | +1.51 | buy |
| Tri Locum Partners LP | 113,344 | 271,922 | +158,578 | 2.16 | 7.44 | +5.28 | buy |
| Darwin Global Management, Ltd. | 2,080,946 | 2,198,187 | +117,241 | 19.07 | 20.43 | +1.35 | buy |
| LORD, ABBETT & CO. LLC | 246,242 | 312,425 | +66,183 | 0.06 | 0.11 | +0.05 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,500 | 60,500 | +58,000 | 0.05 | 1.56 | +1.51 | buy |
| Cercano Management LLC | 273,608 | 327,742 | +54,134 | 0.55 | 0.90 | +0.34 | buy |
| TD ASSET MANAGEMENT INC | 312,426 | 366,156 | +53,730 | 0.02 | 0.04 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 307,516 | 255,040 | +52,476 | 0.02 | 0.03 | +0.01 | sell |
| EcoR1 Capital, LLC | 300,000 | 352,464 | +52,464 | 0.69 | 1.38 | +0.69 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 92,304 | 140,847 | +48,543 | 0.02 | 0.04 | +0.02 | buy |
| Informed Momentum Co LLC | 36,522 | 72,995 | +36,473 | 0.45 | 1.25 | +0.80 | buy |
| T. Rowe Price Investment Management, Inc. | 4,022,589 | 4,053,828 | +31,239 | 0.19 | 0.28 | +0.09 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 43,941 | 70,037 | +26,096 | 0.01 | 0.04 | +0.03 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 110,400 | 135,400 | +25,000 | 7.02 | 12.53 | +5.51 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 40,342 | 64,664 | +24,322 | 0.23 | 0.32 | 0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 10,463 | 26,019 | +15,556 | 0.04 | 0.19 | 0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 81,338 | 96,653 | +15,315 | 0.01 | 0.02 | 0.00 | buy |
| Calamos Advisors LLC | 11,533 | 26,831 | +15,298 | 0.00 | 0.01 | +0.01 | buy |
| Lisanti Capital Growth, LLC | 19,340 | 32,515 | +13,175 | 0.35 | 0.94 | +0.59 | buy |
| HighVista Strategies LLC | 32,313 | 44,661 | +12,348 | 0.89 | 1.76 | +0.87 | buy |
| CASTLEARK MANAGEMENT LLC | 43,690 | 54,620 | +10,930 | 0.13 | 0.25 | +0.12 | buy |
| China Universal Asset Management Co., Ltd. | 12,781 | 21,466 | +8,685 | 0.14 | 0.27 | +0.13 | buy |
| ProShare Advisors LLC | 20,934 | 29,146 | +8,212 | 0.00 | 0.01 | 0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 57,256 | 65,311 | +8,055 | 0.01 | 0.02 | +0.01 | buy |
| BANQUE PICTET & CIE SA | 59,077 | 64,772 | +5,695 | 0.04 | 0.06 | +0.02 | buy |
| Corebridge Financial, Inc. | 58,737 | 63,850 | +5,113 | 0.03 | 0.04 | 0.00 | buy |
| RHUMBLINE ADVISERS | 159,295 | 164,103 | +4,808 | 0.01 | 0.02 | 0.00 | buy |
| ALGERT GLOBAL LLC | 34,752 | 39,292 | +4,540 | 0.09 | 0.12 | 0.00 | buy |
| PROFUND ADVISORS LLC | 18,987 | 14,697 | +4,290 | 0.05 | 0.06 | 0.00 | sell |
| Allspring Global Investments Holdings, LLC | 343,552 | 347,474 | +3,922 | 0.04 | 0.06 | 0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 20,230 | 23,194 | +2,964 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 91,279 | 89,436 | +1,843 | 0.01 | 0.01 | +0.00 | sell |
| STRS OHIO | 23,700 | 25,500 | +1,800 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 527,594 | 529,005 | +1,411 | 0.03 | 0.04 | +0.01 | buy |
| Everhart Financial Group, Inc. | 5,464 | 6,723 | +1,259 | 0.11 | 0.17 | +0.06 | buy |
| Ameritas Investment Partners, Inc. | 10,696 | 11,882 | +1,186 | 0.03 | 0.05 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 6,307 | 5,307 | +1,000 | 0.03 | 0.05 | 0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20,485 | 21,311 | +826 | 0.01 | 0.01 | 0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 63 | 698 | +635 | 0.00 | 0.01 | +0.00 | buy |
| J.Safra Asset Management Corp | 607 | 1,171 | +564 | 0.00 | 0.01 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 627,202 | 627,732 | +530 | 1.81 | 2.51 | +0.70 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 3,667 | 3,274 | +393 | 0.00 | 0.00 | 0.00 | sell |
| Belvedere Trading LLC | 2,098 | 2,466 | +368 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 30,024 | 29,800 | +224 | 0.02 | 0.02 | 0.00 | sell |
| CIBC Asset Management Inc | 3,026 | 3,136 | +110 | 0.00 | 0.00 | 0.00 | buy |
| VIRTUS ADVISERS, LLC | 1,223 | 1,244 | +21 | 0.05 | 0.07 | +0.02 | buy |
| OLIVER LAGORE VANVALIN INVESTMENT GROUP | 121 | 80 | -41 | 0.00 | 0.00 | -0.00 | sell |
| Bank Pictet & Cie (Europe) AG | 3,894 | 3,805 | -89 | 0.01 | 0.01 | +0.00 | sell |
| Chicago Partners Investment Group LLC | 5,066 | 4,973 | -93 | 0.02 | 0.02 | +0.00 | sell |
| BANK OF HAWAII | 15,178 | 15,023 | -155 | 0.05 | 0.07 | +0.02 | sell |
| Corton Capital Inc. | 3,838 | 3,548 | -290 | 0.15 | 0.20 | +0.05 | sell |
| GILDER GAGNON HOWE & CO LLC | 16,831 | 16,508 | -323 | 0.02 | 0.02 | +0.01 | sell |
| Baker Avenue Asset Management, LP | 13,643 | 13,143 | -500 | 0.04 | 0.05 | +0.01 | sell |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 12,661 | 11,975 | -686 | 0.01 | 0.01 | +0.00 | sell |
| Swiss National Bank | 181,300 | 180,600 | -700 | 0.01 | 0.01 | +0.00 | sell |
| ELEVATION POINT WEALTH PARTNERS, LLC | 4,971 | 4,000 | -971 | 0.03 | 0.04 | +0.01 | sell |
| E Fund Management Co., Ltd. | 5,751 | 4,144 | -1,607 | 0.02 | 0.02 | +0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 17,269 | 15,605 | -1,664 | 0.03 | 0.04 | +0.01 | sell |
| ADAR1 Capital Management, LLC | 12,250 | 10,097 | -2,153 | 0.19 | 0.19 | +0.01 | sell |
| Bellevue Group AG | 14,210 | 11,981 | -2,229 | 0.02 | 0.02 | +0.00 | sell |
| Nicholas Investment Partners, LP | 87,230 | 81,883 | -5,347 | 0.68 | 0.86 | +0.18 | sell |
| SEGALL BRYANT & HAMILL, LLC | 162,432 | 156,056 | -6,376 | 0.22 | 0.24 | +0.03 | sell |
| EFG Asset Management (North America) Corp. | 30,442 | 22,818 | -7,624 | 0.40 | 0.44 | +0.04 | sell |
| Affinity Asset Advisors, LLC | 60,000 | 50,000 | -10,000 | 0.71 | 0.89 | +0.17 | sell |
| Saturn V Capital Management LP | 215,680 | 204,987 | -10,693 | 6.15 | 8.37 | +2.22 | sell |
| SECTORAL ASSET MANAGEMENT INC | 33,730 | 14,540 | -19,190 | 1.04 | 0.98 | -0.05 | sell |
| Parkman Healthcare Partners LLC | 150,191 | 130,249 | -19,942 | 1.54 | 1.90 | +0.36 | sell |
| Rafferty Asset Management, LLC | 94,683 | 64,496 | -30,187 | 0.03 | 0.03 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 98,200 | 54,000 | -44,200 | 0.15 | 0.13 | -0.02 | sell |
| MOODY ALDRICH PARTNERS LLC | 100,286 | 54,169 | -46,117 | 1.48 | 1.13 | -0.35 | sell |
| First Turn Management, LLC | 260,281 | 211,985 | -48,296 | 3.20 | 3.84 | +0.64 | sell |
| FRED ALGER MANAGEMENT, LLC | 1,310,436 | 1,243,717 | -66,719 | 0.48 | 0.69 | +0.21 | sell |
| Pier Capital, LLC | 114,969 | 47,567 | -67,402 | 1.29 | 0.77 | -0.53 | sell |
| Cormorant Asset Management, LP | 1,100,000 | 1,000,000 | -100,000 | 4.80 | 6.06 | +1.26 | sell |
| Aberdeen Group plc | 190,401 | 82,830 | -107,571 | 0.03 | 0.02 | -0.01 | sell |
| JENNISON ASSOCIATES LLC | 1,383,131 | 1,237,430 | -145,701 | 0.07 | 0.09 | +0.02 | sell |
| Pivotal bioVenture Partners Investment Advisor LLC | 793,036 | 639,539 | -153,497 | 46.04 | 43.38 | -2.66 | sell |
| Soleus Capital Management, L.P. | 185,250 | 27,050 | -158,200 | 1.23 | 0.26 | -0.98 | sell |
| Frazier Life Sciences Management, L.P. | 1,039,405 | 879,405 | -160,000 | 3.67 | 4.03 | +0.36 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,929,348 | 1,739,874 | -189,474 | 0.72 | 0.90 | +0.18 | sell |
| Novo Holdings A/S | 950,000 | 750,000 | -200,000 | 3.87 | 4.26 | +0.39 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,934,747 | 1,721,296 | -213,451 | 1.41 | 1.69 | +0.28 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 739,153 | 383,454 | -355,699 | 0.96 | 0.76 | -0.20 | sell |
| Commodore Capital LP | 1,305,000 | 920,000 | -385,000 | 6.73 | 6.57 | -0.16 | sell |
| ORBIMED ADVISORS LLC | 795,900 | 387,000 | -408,900 | 1.19 | 0.81 | -0.39 | sell |
| BRAIDWELL LP | 808,303 | 297,568 | -510,735 | 1.91 | 0.96 | -0.95 | sell |