| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 6,001,124 | 8,315,295 | +2,314,171 | 0.12 | 0.18 | +0.06 | buy |
| D. E. Shaw & Co., Inc. | 3,088,450 | 4,290,790 | +1,202,340 | 0.10 | 0.12 | +0.02 | buy |
| Deep Track Capital, LP | 2,150,000 | 3,000,000 | +850,000 | 2.25 | 3.02 | +0.77 | buy |
| Point72 Asset Management, L.P. | 0 | 696,843 | +696,843 | 0.00 | 0.05 | +0.05 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,068,898 | 3,732,715 | +663,817 | 0.42 | 0.56 | +0.15 | buy |
| Logos Global Management LP | 0 | 625,000 | +625,000 | 0.00 | 2.22 | +2.22 | buy |
| Paradigm Biocapital Advisors LP | 3,372,837 | 3,784,755 | +411,918 | 4.68 | 4.03 | -0.65 | buy |
| JPMORGAN CHASE & CO | 1,198,770 | 1,565,036 | +366,266 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 12,151,050 | 12,509,933 | +358,883 | 0.02 | 0.02 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 333,000 | +333,000 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 11,997,085 | 12,320,453 | +323,368 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 424,907 | 722,793 | +297,886 | 0.02 | 0.04 | +0.02 | buy |
| Saturn V Capital Management LP | 544,221 | 788,441 | +244,220 | 7.17 | 6.23 | -0.94 | buy |
| Man Group plc | 29,495 | 244,897 | +215,402 | 0.00 | 0.02 | +0.01 | buy |
| ROYAL BANK OF CANADA | 749,392 | 949,049 | +199,657 | 0.00 | 0.01 | +0.00 | buy |
| COMERICA BANK | 479,510 | 654,369 | +174,859 | 0.06 | 0.09 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 104,836 | 278,133 | +173,297 | 0.01 | 0.02 | +0.01 | buy |
| Assenagon Asset Management S.A. | 47,976 | 219,950 | +171,974 | 0.00 | 0.01 | +0.01 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 134,877 | +134,877 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 262,957 | 397,789 | +134,832 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 1,298,514 | 1,421,983 | +123,469 | 4.25 | 3.92 | -0.33 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 139,124 | 257,667 | +118,543 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 98,032 | 213,064 | +115,032 | 0.52 | 0.76 | +0.24 | buy |
| HRT FINANCIAL LP | 0 | 114,034 | +114,034 | 0.00 | 0.02 | +0.02 | buy |
| BROWN ADVISORY INC | 571,939 | 676,985 | +105,046 | 0.02 | 0.03 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 100,561 | +100,561 | 0.00 | 0.05 | +0.05 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 84,380 | +84,380 | 0.00 | 0.01 | +0.01 | buy |
| Voleon Capital Management LP | 0 | 78,927 | +78,927 | 0.00 | 0.07 | +0.07 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,954,804 | 5,032,771 | +77,967 | 0.03 | 0.03 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 73,283 | +73,283 | 0.00 | 0.06 | +0.06 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,305,125 | 1,372,425 | +67,300 | 26.30 | 28.58 | +2.28 | buy |
| Neo Ivy Capital Management | 24,241 | 83,110 | +58,869 | 0.25 | 0.73 | +0.48 | buy |
| HighVista Strategies LLC | 33,457 | 86,802 | +53,345 | 0.40 | 0.77 | +0.37 | buy |
| SEI INVESTMENTS CO | 39,709 | 89,948 | +50,239 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 50,000 | +50,000 | 0.00 | 0.43 | +0.43 | buy |
| Woodline Partners LP | 200,078 | 246,986 | +46,908 | 0.03 | 0.04 | +0.01 | buy |
| JANE STREET GROUP, LLC | 297,748 | 343,697 | +45,949 | 0.02 | 0.01 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 330,671 | 374,902 | +44,231 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 934,668 | 975,377 | +40,709 | 0.00 | 0.01 | +0.00 | buy |
| Weiss Asset Management LP | 0 | 39,189 | +39,189 | 0.00 | 0.02 | +0.02 | buy |
| HSBC HOLDINGS PLC | 19,216 | 50,625 | +31,409 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 18,271 | 45,414 | +27,143 | 0.00 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 287,796 | 314,339 | +26,543 | 1.91 | 1.64 | -0.28 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 103,267 | 128,731 | +25,464 | 0.10 | 0.12 | +0.01 | buy |
| ALGERT GLOBAL LLC | 149,579 | 172,149 | +22,570 | 0.10 | 0.10 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 19,099 | 40,101 | +21,002 | 0.02 | 0.04 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 87,562 | 107,587 | +20,025 | 0.01 | 0.01 | +0.00 | buy |
| DIADEMA PARTNERS LP | 198,285 | 218,285 | +20,000 | 4.01 | 5.48 | +1.47 | buy |
| TUDOR INVESTMENT CORP ET AL | 53,082 | 73,035 | +19,953 | 0.01 | 0.02 | +0.00 | buy |
| FEDERATED HERMES, INC. | 261 | 18,156 | +17,895 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 161,636 | 179,081 | +17,445 | 0.00 | 0.00 | +0.00 | buy |
| Perbak Capital Partners LLP | 26,419 | 40,931 | +14,512 | 0.19 | 0.26 | +0.07 | buy |
| SG Americas Securities, LLC | 11,137 | 25,558 | +14,421 | 0.00 | 0.00 | +0.00 | buy |
| Bridgefront Capital, LLC | 10,708 | 24,325 | +13,617 | 0.09 | 0.26 | +0.17 | buy |
| Trexquant Investment LP | 106,281 | 119,850 | +13,569 | 0.04 | 0.04 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 12,195 | +12,195 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 54,995 | 67,133 | +12,138 | 0.02 | 0.03 | +0.02 | buy |
| Bridgewater Associates, LP | 0 | 11,855 | +11,855 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 12,139 | 23,591 | +11,452 | 0.01 | 0.02 | +0.01 | buy |
| State of New Jersey Common Pension Fund D | 55,477 | 66,658 | +11,181 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 17,624 | 28,761 | +11,137 | 0.00 | 0.01 | +0.00 | buy |
| Handelsbanken Fonder AB | 34,900 | 45,000 | +10,100 | 0.00 | 0.01 | +0.00 | buy |
| Limestone Investment Advisors LP | 0 | 9,600 | +9,600 | 0.00 | 0.16 | +0.16 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 9,433 | +9,433 | 0.00 | 0.05 | +0.05 | buy |
| Mirae Asset Global Investments Co., Ltd. | 14,110 | 23,184 | +9,074 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 25,758 | 34,150 | +8,392 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 0 | 8,346 | +8,346 | 0.00 | 0.00 | +0.00 | buy |
| Quantessence Capital LLC | 0 | 7,846 | +7,846 | 0.00 | 0.09 | +0.09 | buy |
| Mariner, LLC | 0 | 7,755 | +7,755 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 305,000 | 311,682 | +6,682 | 3.28 | 2.27 | -1.01 | buy |
| SummitTX Capital, L.P. | 0 | 6,659 | +6,659 | 0.00 | 0.01 | +0.01 | buy |
| LPL Financial LLC | 12,735 | 19,317 | +6,582 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 4,429 | 10,946 | +6,517 | 0.01 | 0.03 | +0.01 | buy |
| Meeder Advisory Services, Inc. | 0 | 5,818 | +5,818 | 0.00 | 0.01 | +0.01 | buy |
| Headlands Technologies LLC | 26,993 | 32,731 | +5,738 | 0.11 | 0.09 | -0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 5,699 | +5,699 | 0.00 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 121,285 | 126,048 | +4,763 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 45,499 | 50,076 | +4,577 | 1.30 | 1.31 | +0.01 | buy |
| SEGALL BRYANT & HAMILL, LLC | 180,239 | 184,795 | +4,556 | 0.08 | 0.09 | +0.01 | buy |
| Sterling Capital Management LLC | 3,396 | 7,928 | +4,532 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 28,032 | 32,030 | +3,998 | 0.01 | 0.01 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 3,930 | +3,930 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 221,300 | 225,100 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 12,375 | 15,638 | +3,263 | 0.03 | 0.04 | +0.01 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 11,067 | 14,258 | +3,191 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 12,722 | 15,855 | +3,133 | 0.00 | 0.01 | +0.00 | buy |
| Avior Wealth Management, LLC | 8,529 | 11,031 | +2,502 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 107,050 | 109,444 | +2,394 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 2,000 | +2,000 | 0.00 | 0.02 | +0.02 | buy |
| Lombard Odier Asset Management (USA) Corp | 13,446 | 15,427 | +1,981 | 0.11 | 0.13 | +0.02 | buy |
| J.Safra Asset Management Corp | 4,072 | 5,984 | +1,912 | 0.01 | 0.01 | +0.00 | buy |
| SIGNATUREFD, LLC | 3,266 | 5,139 | +1,873 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 1,856 | +1,856 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 78,470 | 80,323 | +1,853 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,658 | 3,254 | +1,596 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 20,630 | 22,089 | +1,459 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 6 | 1,356 | +1,350 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 1,252 | +1,252 | 0.00 | 0.02 | +0.02 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 79,126 | 80,238 | +1,112 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,680 | 2,606 | +926 | 0.00 | 0.00 | +0.00 | buy |