| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 14,691,344 | 13,104,203 | -1,587,141 | 0.23 | 0.22 | -0.02 | sell |
| FMR LLC | 12,151,050 | 12,509,933 | +358,883 | 0.02 | 0.02 | +0.00 | buy |
| VANGUARD GROUP INC | 11,997,085 | 12,320,453 | +323,368 | 0.01 | 0.01 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 11,965,991 | 11,965,991 | 0 | 6.55 | 5.31 | -1.24 | hold |
| BlackRock, Inc. | 10,642,243 | 9,955,978 | -686,265 | 0.01 | 0.01 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 6,001,124 | 8,315,295 | +2,314,171 | 0.12 | 0.18 | +0.06 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,954,804 | 5,032,771 | +77,967 | 0.03 | 0.03 | +0.00 | buy |
| STATE STREET CORP | 4,942,235 | 4,785,889 | -156,346 | 0.01 | 0.01 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 3,088,450 | 4,290,790 | +1,202,340 | 0.10 | 0.12 | +0.02 | buy |
| Paradigm Biocapital Advisors LP | 3,372,837 | 3,784,755 | +411,918 | 4.68 | 4.03 | -0.65 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,068,898 | 3,732,715 | +663,817 | 0.42 | 0.56 | +0.15 | buy |
| Kynam Capital Management, LP | 3,071,588 | 3,071,588 | 0 | 10.75 | 8.24 | -2.51 | hold |
| Deep Track Capital, LP | 2,150,000 | 3,000,000 | +850,000 | 2.25 | 3.02 | +0.77 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,011,140 | 2,884,040 | -127,100 | 0.01 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,170,247 | 1,688,483 | -1,481,764 | 0.01 | 0.01 | -0.01 | sell |
| JPMORGAN CHASE & CO | 1,198,770 | 1,565,036 | +366,266 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 1,298,514 | 1,421,983 | +123,469 | 4.25 | 3.92 | -0.33 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,305,125 | 1,372,425 | +67,300 | 26.30 | 28.58 | +2.28 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,417,711 | 1,293,407 | -124,304 | 0.01 | 0.01 | -0.00 | sell |
| MAVERICK CAPITAL LTD | 1,310,605 | 1,289,567 | -21,038 | 0.65 | 0.62 | -0.03 | sell |
| JENNISON ASSOCIATES LLC | 1,399,299 | 1,170,899 | -228,400 | 0.03 | 0.02 | -0.00 | sell |
| NORTHERN TRUST CORP | 1,121,892 | 1,073,346 | -48,546 | 0.01 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 1,175,661 | 1,029,629 | -146,032 | 0.04 | 0.04 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 934,668 | 975,377 | +40,709 | 0.00 | 0.01 | +0.00 | buy |
| ROYAL BANK OF CANADA | 749,392 | 949,049 | +199,657 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,104,839 | 948,967 | -155,872 | 0.03 | 0.03 | -0.01 | sell |
| Novo Holdings A/S | 916,160 | 916,160 | 0 | 2.10 | 2.13 | +0.02 | hold |
| UBS Group AG | 1,380,853 | 847,573 | -533,280 | 0.01 | 0.01 | -0.00 | sell |
| Capital Research Global Investors | 4,771,786 | 842,978 | -3,928,808 | 0.03 | 0.01 | -0.03 | sell |
| Saturn V Capital Management LP | 544,221 | 788,441 | +244,220 | 7.17 | 6.23 | -0.94 | buy |
| MORGAN STANLEY | 841,922 | 784,483 | -57,439 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 424,907 | 722,793 | +297,886 | 0.02 | 0.04 | +0.02 | buy |
| Point72 Asset Management, L.P. | 0 | 696,843 | +696,843 | 0.00 | 0.05 | +0.05 | buy |
| BROWN ADVISORY INC | 571,939 | 676,985 | +105,046 | 0.02 | 0.03 | +0.01 | buy |
| COMERICA BANK | 479,510 | 654,369 | +174,859 | 0.06 | 0.09 | +0.03 | buy |
| BAKER BROS. ADVISORS LP | 640,885 | 640,885 | 0 | 0.20 | 0.17 | -0.04 | hold |
| BANK OF AMERICA CORP /DE/ | 1,082,671 | 635,070 | -447,601 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 0 | 625,000 | +625,000 | 0.00 | 2.22 | +2.22 | buy |
| Qube Research & Technologies Ltd | 809,530 | 553,849 | -255,681 | 0.04 | 0.03 | -0.01 | sell |
| Ensign Peak Advisors, Inc | 532,203 | 528,853 | -3,350 | 0.03 | 0.03 | +0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 633,204 | 519,734 | -113,470 | 0.08 | 0.06 | -0.01 | sell |
| Nuveen, LLC | 487,769 | 484,638 | -3,131 | 0.00 | 0.00 | +0.00 | sell |
| Frazier Life Sciences Management, L.P. | 474,405 | 474,405 | 0 | 0.62 | 0.51 | -0.10 | hold |
| Bank of New York Mellon Corp | 449,694 | 439,612 | -10,082 | 0.00 | 0.00 | +0.00 | sell |
| Polar Capital Holdings Plc | 825,795 | 415,530 | -410,265 | 0.14 | 0.07 | -0.07 | sell |
| TD ASSET MANAGEMENT INC | 539,784 | 398,480 | -141,304 | 0.01 | 0.01 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 555,008 | 398,144 | -156,864 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 262,957 | 397,789 | +134,832 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 438,409 | 393,914 | -44,495 | 0.01 | 0.01 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 848,141 | 379,330 | -468,811 | 0.48 | 0.22 | -0.26 | sell |
| AMERIPRISE FINANCIAL INC | 330,671 | 374,902 | +44,231 | 0.00 | 0.00 | +0.00 | buy |
| Fiera Capital Corp | 353,842 | 345,852 | -7,990 | 0.04 | 0.04 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 351,052 | 344,027 | -7,025 | 0.01 | 0.01 | +0.00 | sell |
| JANE STREET GROUP, LLC | 297,748 | 343,697 | +45,949 | 0.02 | 0.01 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 939,275 | 336,106 | -603,169 | 0.01 | 0.00 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 333,000 | +333,000 | 0.00 | 0.02 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 450,619 | 314,892 | -135,727 | 0.01 | 0.01 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 287,796 | 314,339 | +26,543 | 1.91 | 1.64 | -0.28 | buy |
| CITIGROUP INC | 429,284 | 313,078 | -116,206 | 0.01 | 0.01 | -0.00 | sell |
| Ikarian Capital, LLC | 305,000 | 311,682 | +6,682 | 3.28 | 2.27 | -1.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 300,000 | 300,000 | 0 | 0.49 | 0.42 | -0.08 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 104,836 | 278,133 | +173,297 | 0.01 | 0.02 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 139,124 | 257,667 | +118,543 | 0.00 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 200,078 | 246,986 | +46,908 | 0.03 | 0.04 | +0.01 | buy |
| Man Group plc | 29,495 | 244,897 | +215,402 | 0.00 | 0.02 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 244,775 | 244,775 | 0 | 0.03 | 0.03 | -0.00 | hold |
| TWINBEECH CAPITAL LP | 503,248 | 228,087 | -275,161 | 0.37 | 0.32 | -0.05 | sell |
| Swiss National Bank | 221,300 | 225,100 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 47,976 | 219,950 | +171,974 | 0.00 | 0.01 | +0.01 | buy |
| DIADEMA PARTNERS LP | 198,285 | 218,285 | +20,000 | 4.01 | 5.48 | +1.47 | buy |
| ADAR1 Capital Management, LLC | 98,032 | 213,064 | +115,032 | 0.52 | 0.76 | +0.24 | buy |
| CITADEL ADVISORS LLC | 1,090,738 | 205,799 | -884,939 | 0.03 | 0.01 | -0.02 | sell |
| C WorldWide Group Holding A/S | 195,000 | 195,000 | 0 | 0.09 | 0.11 | +0.02 | hold |
| Jump Financial, LLC | 403,597 | 191,700 | -211,897 | 0.17 | 0.10 | -0.07 | sell |
| RAYMOND JAMES FINANCIAL INC | 299,582 | 189,293 | -110,289 | 0.00 | 0.00 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 180,239 | 184,795 | +4,556 | 0.08 | 0.09 | +0.01 | buy |
| RHUMBLINE ADVISERS | 198,487 | 183,212 | -15,275 | 0.01 | 0.01 | -0.00 | sell |
| Invesco Ltd. | 161,636 | 179,081 | +17,445 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 175,000 | 175,000 | 0 | 0.42 | 0.43 | +0.01 | hold |
| ALGERT GLOBAL LLC | 149,579 | 172,149 | +22,570 | 0.10 | 0.10 | +0.00 | buy |
| Rafferty Asset Management, LLC | 164,823 | 149,414 | -15,409 | 0.02 | 0.02 | -0.00 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 152,077 | 144,614 | -7,463 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 208,010 | 136,870 | -71,140 | 0.01 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 141,486 | 135,226 | -6,260 | 0.00 | 0.00 | +0.00 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 134,877 | +134,877 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 133,562 | 130,401 | -3,161 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 103,267 | 128,731 | +25,464 | 0.10 | 0.12 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 121,285 | 126,048 | +4,763 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 206,171 | 125,785 | -80,386 | 0.14 | 0.08 | -0.05 | sell |
| Affinity Asset Advisors, LLC | 125,000 | 125,000 | 0 | 0.60 | 0.42 | -0.18 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 125,087 | 121,787 | -3,300 | 0.01 | 0.01 | +0.00 | sell |
| Trexquant Investment LP | 106,281 | 119,850 | +13,569 | 0.04 | 0.04 | +0.01 | buy |
| LAZARD ASSET MANAGEMENT LLC | 512,135 | 119,092 | -393,043 | 0.02 | 0.01 | -0.02 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 152,852 | 118,734 | -34,118 | 0.01 | 0.01 | -0.00 | sell |
| Engineers Gate Manager LP | 160,808 | 114,660 | -46,148 | 0.07 | 0.05 | -0.02 | sell |
| HRT FINANCIAL LP | 0 | 114,034 | +114,034 | 0.00 | 0.02 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 107,050 | 109,444 | +2,394 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 87,562 | 107,587 | +20,025 | 0.01 | 0.01 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 104,250 | 104,250 | 0 | 0.41 | 0.37 | -0.03 | hold |
| Cubist Systematic Strategies, LLC | 0 | 100,561 | +100,561 | 0.00 | 0.05 | +0.05 | buy |