| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,003,916 | 1,455,593 | +451,677 | 0.35 | 0.53 | +0.18 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,323,884 | 1,674,368 | +350,484 | 0.88 | 1.27 | +0.39 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,417,652 | 2,677,822 | +260,170 | 0.02 | 0.02 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 393,000 | 607,206 | +214,206 | 0.36 | 0.62 | +0.26 | buy |
| ORBIMED ADVISORS LLC | 1,007,148 | 1,153,091 | +145,943 | 1.10 | 1.45 | +0.35 | buy |
| D. E. Shaw & Co., Inc. | 538,384 | 438,311 | +100,073 | 0.05 | 0.05 | 0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,875,114 | 1,973,506 | +98,392 | 0.01 | 0.01 | 0.00 | buy |
| JANUS HENDERSON GROUP PLC | 7,060,588 | 6,981,376 | +79,212 | 0.24 | 0.26 | 0.00 | sell |
| Capital Research Global Investors | 3,364,127 | 3,440,107 | +75,980 | 0.05 | 0.05 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 430,949 | 379,407 | +51,542 | 0.03 | 0.03 | -0.00 | sell |
| Eversept Partners, LP | 190,430 | 233,839 | +43,409 | 0.82 | 1.29 | +0.47 | buy |
| T. Rowe Price Investment Management, Inc. | 1,204,628 | 1,246,041 | +41,413 | 0.04 | 0.05 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 238,132 | 267,594 | +29,462 | 2.22 | 2.38 | +0.15 | buy |
| CASTLEARK MANAGEMENT LLC | 56,630 | 85,260 | +28,630 | 0.15 | 0.24 | +0.09 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 132,088 | 150,088 | +18,000 | 0.02 | 0.02 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 151,146 | 167,036 | +15,890 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 380,613 | 393,351 | +12,738 | 0.23 | 0.27 | +0.04 | buy |
| ALGERT GLOBAL LLC | 24,790 | 14,390 | +10,400 | 0.06 | 0.04 | 0.00 | sell |
| J. Goldman & Co LP | 8,684 | 17,694 | +9,010 | 0.02 | 0.04 | +0.03 | buy |
| MOODY ALDRICH PARTNERS LLC | 140,170 | 147,927 | +7,757 | 1.35 | 1.67 | +0.32 | buy |
| Erste Asset Management GmbH | 29,000 | 33,600 | +4,600 | 0.03 | 0.03 | +0.01 | buy |
| ProShare Advisors LLC | 18,322 | 21,607 | +3,285 | 0.00 | 0.00 | 0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 30,286 | 27,557 | +2,729 | 0.01 | 0.01 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 10,000 | 8,030 | +1,970 | 0.01 | 0.04 | 0.00 | sell |
| PROFUND ADVISORS LLC | 28,882 | 27,280 | +1,602 | 0.08 | 0.07 | 0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 82,868 | 82,331 | +537 | 0.01 | 0.01 | +0.00 | sell |
| Ameritas Investment Partners, Inc. | 9,217 | 9,495 | +278 | 0.02 | 0.02 | +0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 4,565 | 4,336 | +229 | 0.00 | 0.00 | +0.00 | sell |
| Ellsworth Advisors, LLC | 7,853 | 8,060 | +207 | 0.13 | 0.16 | +0.03 | buy |
| BANK OF HAWAII | 21,166 | 21,309 | +143 | 0.06 | 0.07 | +0.01 | buy |
| OLIVER LAGORE VANVALIN INVESTMENT GROUP | 161 | 284 | +123 | 0.00 | 0.01 | +0.00 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 8,146 | 8,208 | +62 | 0.05 | 0.05 | +0.00 | buy |
| E Fund Management Co., Ltd. | 8,416 | 8,476 | +60 | 0.03 | 0.03 | +0.00 | buy |
| Washington Trust Advisors, Inc. | 32 | 61 | +29 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 17,106 | 17,101 | -5 | 0.01 | 0.01 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 42,410 | 42,167 | -243 | 0.63 | 0.52 | -0.11 | sell |
| VIRTUS ADVISERS, LLC | 1,883 | 1,528 | -355 | 0.06 | 0.06 | +0.00 | sell |
| Parkwood LLC | 16,641 | 15,480 | -1,161 | 0.09 | 0.12 | +0.02 | sell |
| Chicago Partners Investment Group LLC | 7,162 | 5,877 | -1,285 | 0.02 | 0.02 | -0.00 | sell |
| HighVista Strategies LLC | 11,248 | 9,321 | -1,927 | 0.27 | 0.21 | -0.05 | sell |
| Pier Capital, LLC | 203,728 | 201,562 | -2,166 | 1.67 | 1.81 | +0.14 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 121,022 | 117,373 | -3,649 | 4.13 | 4.15 | +0.01 | sell |
| ALPS ADVISORS INC | 69,305 | 65,295 | -4,010 | 0.03 | 0.03 | +0.00 | sell |
| Rafferty Asset Management, LLC | 163,894 | 158,413 | -5,481 | 0.05 | 0.04 | -0.01 | sell |
| Bellevue Group AG | 30,500 | 15,800 | -14,700 | 0.03 | 0.02 | -0.01 | sell |
| ADVISORY RESEARCH INC | 41,255 | 17,461 | -23,794 | 0.29 | 0.17 | -0.12 | sell |
| Soleus Capital Management, L.P. | 499,650 | 415,450 | -84,200 | 2.57 | 2.89 | +0.33 | sell |
| SECTORAL ASSET MANAGEMENT INC | 121,230 | 8,050 | -113,180 | 1.20 | 0.22 | -0.99 | sell |
| GREAT POINT PARTNERS LLC | 531,211 | 360,000 | -171,211 | 4.93 | 3.85 | -1.08 | sell |
| Avidity Partners Management LP | 756,165 | 570,137 | -186,028 | 1.55 | 1.37 | -0.18 | sell |
| PERCEPTIVE ADVISORS LLC | 1,342,751 | 1,088,486 | -254,265 | 2.28 | 1.53 | -0.76 | sell |
| JENNISON ASSOCIATES LLC | 1,754,691 | 1,476,154 | -278,537 | 0.08 | 0.07 | -0.01 | sell |
| Kynam Capital Management, LP | 1,302,407 | 1,002,407 | -300,000 | 11.04 | 7.12 | -3.91 | sell |
| BRAIDWELL LP | 1,619,553 | 1,289,965 | -329,588 | 2.61 | 2.98 | +0.37 | sell |
| Nicholas Investment Partners, LP | 460,008 | 110,723 | -349,285 | 1.75 | 0.81 | -0.94 | sell |
| FRED ALGER MANAGEMENT, LLC | 2,093,305 | 1,670,189 | -423,116 | 0.61 | 0.57 | -0.05 | sell |