| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital Research Global Investors | 4,898,221 | 6,210,523 | +1,312,302 | 0.12 | 0.10 | -0.01 | buy |
| Kynam Capital Management, LP | 1,039,288 | 2,336,796 | +1,297,508 | 9.20 | 12.62 | +3.42 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,739,874 | 2,566,759 | +826,885 | 0.90 | 0.91 | +0.02 | buy |
| Paradigm Biocapital Advisors LP | 627,732 | 1,422,787 | +795,055 | 2.51 | 4.05 | +1.54 | buy |
| Commodore Capital LP | 920,000 | 1,625,000 | +705,000 | 6.57 | 9.75 | +3.18 | buy |
| AMERIPRISE FINANCIAL INC | 350,151 | 716,773 | +366,622 | 0.01 | 0.02 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 423,498 | 775,653 | +352,155 | 0.07 | 0.08 | 0.00 | buy |
| JANUS HENDERSON GROUP PLC | 10,921,896 | 10,575,363 | +346,533 | 0.64 | 0.44 | 0.00 | sell |
| Allspring Global Investments Holdings, LLC | 347,474 | 593,523 | +246,049 | 0.06 | 0.08 | 0.00 | buy |
| MAVERICK CAPITAL LTD | 976,249 | 1,201,898 | +225,649 | 2.18 | 1.77 | -0.40 | buy |
| TimesSquare Capital Management, LLC | 269,121 | 413,637 | +144,516 | 0.46 | 100.00 | +99.54 | buy |
| Aberdeen Group plc | 82,830 | 224,824 | +141,994 | 0.02 | 0.03 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,700,782 | 2,802,888 | +102,106 | 0.03 | 0.02 | 0.00 | buy |
| Walleye Capital LLC | 58,216 | 148,356 | +90,140 | 0.09 | 0.14 | 0.00 | buy |
| Artia Global Partners LP | 76,255 | 162,255 | +86,000 | 2.46 | 5.36 | +2.89 | buy |
| Rafferty Asset Management, LLC | 64,496 | 147,436 | +82,940 | 0.03 | 0.04 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 529,005 | 605,267 | +76,262 | 0.04 | 0.03 | -0.01 | buy |
| Soleus Capital Management, L.P. | 27,050 | 99,050 | +72,000 | 0.26 | 0.61 | +0.36 | buy |
| First Turn Management, LLC | 211,985 | 276,905 | +64,920 | 3.84 | 4.06 | +0.22 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 639,539 | 703,834 | +64,295 | 43.38 | 38.91 | -4.47 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 255,040 | 303,556 | +48,516 | 0.03 | 0.03 | -0.00 | buy |
| Crestline Management, LP | 53,583 | 101,035 | +47,452 | 0.32 | 0.27 | -0.04 | buy |
| Duquesne Family Office LLC | 42,965 | 86,265 | +43,300 | 0.17 | 0.19 | +0.02 | buy |
| Swiss National Bank | 180,600 | 219,000 | +38,400 | 0.01 | 0.01 | -0.00 | buy |
| ALGERT GLOBAL LLC | 39,292 | 73,069 | +33,777 | 0.12 | 0.14 | 0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 28,228 | 61,828 | +33,600 | 0.04 | 0.05 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 96,653 | 127,771 | +31,118 | 0.02 | 0.01 | 0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 14,374 | 44,818 | +30,444 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 81,883 | 100,307 | +18,424 | 0.86 | 0.72 | -0.14 | buy |
| Woodline Partners LP | 1,103,945 | 1,120,922 | +16,977 | 1.07 | 0.62 | -0.44 | buy |
| Windsor Advisory Group, LLC | 22,744 | 39,223 | +16,479 | 2.93 | 3.73 | +0.80 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 89,436 | 105,052 | +15,616 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 14,697 | 29,854 | +15,157 | 0.06 | 0.09 | 0.00 | buy |
| ProShare Advisors LLC | 29,146 | 40,875 | +11,729 | 0.01 | 0.01 | 0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 65,311 | 76,534 | +11,223 | 0.02 | 0.01 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 64,664 | 74,907 | +10,243 | 0.32 | 0.27 | 0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 23,194 | 32,963 | +9,769 | 0.01 | 0.01 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,237,430 | 1,246,551 | +9,121 | 0.09 | 0.06 | -0.03 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 21,311 | 29,199 | +7,888 | 0.01 | 0.01 | 0.00 | buy |
| RHUMBLINE ADVISERS | 164,103 | 171,814 | +7,711 | 0.02 | 0.01 | 0.00 | buy |
| E Fund Management Co., Ltd. | 4,144 | 10,479 | +6,335 | 0.02 | 0.04 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 21,466 | 26,428 | +4,962 | 0.27 | 0.20 | -0.07 | buy |
| SECTORAL ASSET MANAGEMENT INC | 14,540 | 18,950 | +4,410 | 0.98 | 1.04 | +0.05 | buy |
| GUGGENHEIM CAPITAL LLC | 29,800 | 26,450 | +3,350 | 0.02 | 0.02 | 0.00 | sell |
| Brevan Howard Capital Management LP | 1,847 | 4,393 | +2,546 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 12,888 | 15,273 | +2,385 | 0.29 | 0.35 | +0.06 | buy |
| Corebridge Financial, Inc. | 63,850 | 61,736 | +2,114 | 0.04 | 0.03 | 0.00 | sell |
| DnB Asset Management AS | 5,812 | 7,067 | +1,255 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 11,882 | 12,768 | +886 | 0.05 | 0.04 | -0.01 | buy |
| J.Safra Asset Management Corp | 1,171 | 1,907 | +736 | 0.01 | 0.01 | +0.00 | buy |
| Curi Capital, LLC | 7,901 | 8,616 | +715 | 0.02 | 0.02 | -0.00 | buy |
| CI INVESTMENTS INC. | 2,460 | 3,067 | +607 | 0.00 | 0.00 | 0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 11,975 | 12,469 | +494 | 0.01 | 0.01 | -0.00 | buy |
| Chicago Partners Investment Group LLC | 4,973 | 5,431 | +458 | 0.02 | 0.01 | -0.01 | buy |
| Catalyst Funds Management Pty Ltd | 18,100 | 18,400 | +300 | 0.45 | 0.37 | -0.08 | buy |
| Bridgefront Capital, LLC | 4,072 | 4,244 | +172 | 0.18 | 0.12 | -0.06 | buy |
| CIBC Asset Management Inc | 3,136 | 3,307 | +171 | 0.00 | 0.00 | 0.00 | buy |
| Bellevue Group AG | 11,981 | 12,038 | +57 | 0.02 | 0.02 | -0.00 | buy |
| CALDWELL SUTTER CAPITAL, INC. | 379 | 432 | +53 | 0.02 | 0.02 | -0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 16,508 | 16,550 | +42 | 0.02 | 0.01 | -0.01 | buy |
| VIRTUS ADVISERS, LLC | 1,244 | 809 | -435 | 0.07 | 0.03 | -0.04 | sell |
| Bank Pictet & Cie (Europe) AG | 3,805 | 3,363 | -442 | 0.01 | 0.01 | -0.00 | sell |
| Everhart Financial Group, Inc. | 6,723 | 6,164 | -559 | 0.17 | 0.10 | -0.07 | sell |
| MEEDER ASSET MANAGEMENT INC | 698 | 52 | -646 | 0.01 | 0.00 | -0.01 | sell |
| Saturn V Capital Management LP | 204,987 | 204,285 | -702 | 8.37 | 6.55 | -1.82 | sell |
| ZACKS INVESTMENT MANAGEMENT | 13,645 | 12,194 | -1,451 | 0.01 | 0.01 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 54,169 | 52,686 | -1,483 | 1.13 | 0.80 | -0.33 | sell |
| TORNO CAPITAL, LLC | 9,000 | 7,000 | -2,000 | 1.33 | 0.11 | -1.22 | sell |
| SEGALL BRYANT & HAMILL, LLC | 156,056 | 153,988 | -2,068 | 0.24 | 0.17 | -0.07 | sell |
| CASTLEARK MANAGEMENT LLC | 54,620 | 52,360 | -2,260 | 0.25 | 0.15 | -0.10 | sell |
| Sandia Investment Management LP | 5,000 | 2,500 | -2,500 | 0.93 | 0.39 | -0.54 | sell |
| BANQUE PICTET & CIE SA | 64,772 | 59,315 | -5,457 | 0.06 | 0.03 | -0.02 | sell |
| BAMCO INC /NY/ | 31,000 | 25,000 | -6,000 | 0.01 | 0.01 | -0.00 | sell |
| STRS OHIO | 25,500 | 18,400 | -7,100 | 0.01 | 0.01 | -0.01 | sell |
| Opaleye Management Inc. | 85,000 | 75,000 | -10,000 | 1.62 | 1.07 | -0.55 | sell |
| Parkman Healthcare Partners LLC | 130,249 | 116,138 | -14,111 | 1.90 | 1.27 | -0.63 | sell |
| Calamos Advisors LLC | 26,831 | 9,995 | -16,836 | 0.01 | 0.00 | -0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 60,500 | 40,788 | -19,712 | 1.56 | 0.75 | -0.81 | sell |
| Alyeska Investment Group, L.P. | 218,831 | 197,585 | -21,246 | 0.13 | 0.06 | -0.07 | sell |
| Polar Capital Holdings Plc | 995,779 | 973,645 | -22,134 | 0.54 | 0.45 | -0.10 | sell |
| Affinity Asset Advisors, LLC | 50,000 | 25,000 | -25,000 | 0.78 | 0.27 | -0.51 | sell |
| TD ASSET MANAGEMENT INC | 366,156 | 333,756 | -32,400 | 0.04 | 0.02 | -0.01 | sell |
| Clearbridge Investments, LLC | 1,159,280 | 1,102,486 | -56,794 | 0.10 | 0.07 | -0.03 | sell |
| LORD, ABBETT & CO. LLC | 312,425 | 245,891 | -66,534 | 0.11 | 0.06 | -0.05 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 140,847 | 72,094 | -68,753 | 0.04 | 0.01 | -0.02 | sell |
| BRAIDWELL LP | 297,568 | 222,424 | -75,144 | 0.96 | 0.54 | -0.42 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 135,400 | 45,000 | -90,400 | 12.53 | 3.71 | -8.83 | sell |
| PERCEPTIVE ADVISORS LLC | 2,027,608 | 1,718,417 | -309,191 | 4.90 | 3.88 | -1.03 | sell |
| Frazier Life Sciences Management, L.P. | 879,405 | 539,405 | -340,000 | 4.03 | 1.83 | -2.19 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,466,137 | 3,966,956 | -499,181 | 0.06 | 0.04 | -0.02 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,721,296 | 1,166,833 | -554,463 | 1.69 | 0.79 | -0.90 | sell |
| Cormorant Asset Management, LP | 1,000,000 | 425,000 | -575,000 | 6.06 | 1.91 | -4.15 | sell |
| FRED ALGER MANAGEMENT, LLC | 1,243,717 | 523,007 | -720,710 | 0.69 | 0.20 | -0.48 | sell |
| T. Rowe Price Investment Management, Inc. | 4,053,828 | 2,860,717 | -1,193,111 | 0.28 | 0.14 | -0.13 | sell |