| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GOLDMAN SACHS GROUP INC | 949,251 | 3,129,604 | +2,180,353 | 0.02 | 0.05 | +0.03 | buy |
| Capital Research Global Investors | 4,898,221 | 6,210,523 | +1,312,302 | 0.12 | 0.10 | -0.01 | buy |
| Kynam Capital Management, LP | 1,039,288 | 2,336,796 | +1,297,508 | 9.20 | 12.62 | +3.42 | buy |
| STATE STREET CORP | 3,405,743 | 4,539,406 | +1,133,663 | 0.02 | 0.01 | -0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,739,874 | 2,566,759 | +826,885 | 0.90 | 0.91 | +0.02 | buy |
| Paradigm Biocapital Advisors LP | 627,732 | 1,422,787 | +795,055 | 2.51 | 4.05 | +1.54 | buy |
| Commodore Capital LP | 920,000 | 1,625,000 | +705,000 | 6.57 | 9.75 | +3.18 | buy |
| UBS Group AG | 111,573 | 736,561 | +624,988 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 11,440,483 | 11,961,687 | +521,204 | 0.02 | 0.02 | -0.01 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 486,764 | +486,764 | 0.00 | 0.06 | +0.06 | buy |
| BlackRock, Inc. | 10,666,437 | 11,106,069 | +439,632 | 0.03 | 0.02 | -0.01 | buy |
| Hood River Capital Management LLC | 0 | 401,442 | +401,442 | 0.00 | 0.49 | +0.49 | buy |
| AMERIPRISE FINANCIAL INC | 350,151 | 716,773 | +366,622 | 0.01 | 0.02 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 423,498 | 775,653 | +352,155 | 0.06 | 0.07 | +0.01 | buy |
| Squarepoint Ops LLC | 63,492 | 376,846 | +313,354 | 0.02 | 0.08 | +0.06 | buy |
| JPMORGAN CHASE & CO | 1,427,760 | 1,735,663 | +307,903 | 0.01 | 0.01 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 279,944 | +279,944 | 0.00 | 0.39 | +0.39 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 52,702 | 308,939 | +256,237 | 0.00 | 0.01 | +0.01 | buy |
| Allspring Global Investments Holdings, LLC | 347,474 | 593,523 | +246,049 | 0.06 | 0.08 | +0.02 | buy |
| Pictet Asset Management Holding SA | 780,905 | 1,017,845 | +236,940 | 0.10 | 0.09 | -0.01 | buy |
| MAVERICK CAPITAL LTD | 976,249 | 1,201,898 | +225,649 | 2.18 | 1.77 | -0.40 | buy |
| JANE STREET GROUP, LLC | 85,543 | 299,292 | +213,749 | 0.02 | 0.04 | +0.02 | buy |
| CITIGROUP INC | 220,543 | 379,208 | +158,665 | 0.02 | 0.03 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 136,429 | 293,706 | +157,277 | 0.00 | 0.01 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 269,121 | 413,637 | +144,516 | 0.46 | 0.49 | +0.03 | buy |
| Aberdeen Group plc | 82,830 | 224,824 | +141,994 | 0.02 | 0.03 | +0.02 | buy |
| CITADEL ADVISORS LLC | 5,867 | 141,781 | +135,914 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,645,914 | 1,779,362 | +133,448 | 0.06 | 0.05 | -0.01 | buy |
| Man Group plc | 14,551 | 142,426 | +127,875 | 0.00 | 0.04 | +0.03 | buy |
| Eversept Partners, LP | 0 | 127,588 | +127,588 | 0.00 | 1.08 | +1.08 | buy |
| NORTHERN TRUST CORP | 1,036,417 | 1,160,001 | +123,584 | 0.02 | 0.01 | -0.01 | buy |
| Candriam S.C.A. | 0 | 114,110 | +114,110 | 0.00 | 0.05 | +0.05 | buy |
| BROWN ADVISORY INC | 444,039 | 556,209 | +112,170 | 0.06 | 0.06 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,700,782 | 2,802,888 | +102,106 | 0.02 | 0.02 | -0.01 | buy |
| Hudson Bay Capital Management LP | 0 | 98,739 | +98,739 | 0.00 | 0.05 | +0.05 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 91,265 | +91,265 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 58,216 | 148,356 | +90,140 | 0.07 | 0.12 | +0.05 | buy |
| Artia Global Partners LP | 76,255 | 162,255 | +86,000 | 2.46 | 5.36 | +2.89 | buy |
| FRANKLIN RESOURCES INC | 2,786,335 | 2,869,332 | +82,997 | 0.09 | 0.07 | -0.02 | buy |
| Rafferty Asset Management, LLC | 64,496 | 147,436 | +82,940 | 0.03 | 0.04 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 44,470 | 125,396 | +80,926 | 0.01 | 0.02 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 77,274 | +77,274 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 529,005 | 605,267 | +76,262 | 0.04 | 0.03 | -0.01 | buy |
| Soleus Capital Management, L.P. | 27,050 | 99,050 | +72,000 | 0.26 | 0.61 | +0.36 | buy |
| COMERICA BANK | 273,022 | 339,095 | +66,073 | 0.12 | 0.11 | -0.01 | buy |
| First Turn Management, LLC | 211,985 | 276,905 | +64,920 | 3.84 | 4.06 | +0.22 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 408,274 | 472,964 | +64,690 | 0.01 | 0.01 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 1,148,184 | 1,212,706 | +64,522 | 0.05 | 0.04 | -0.01 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 639,539 | 703,834 | +64,295 | 43.38 | 38.91 | -4.47 | buy |
| Engineers Gate Manager LP | 4,490 | 58,689 | +54,199 | 0.01 | 0.08 | +0.07 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 54,077 | +54,077 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 255,040 | 303,556 | +48,516 | 0.03 | 0.02 | -0.00 | buy |
| Crestline Management, LP | 53,583 | 101,035 | +47,452 | 0.35 | 0.29 | -0.06 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,295,837 | 1,341,773 | +45,936 | 0.03 | 0.02 | -0.01 | buy |
| BARCLAYS PLC | 209,753 | 254,885 | +45,132 | 0.01 | 0.01 | -0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 43,466 | +43,466 | 0.00 | 0.03 | +0.03 | buy |
| Duquesne Family Office LLC | 42,965 | 86,265 | +43,300 | 0.17 | 0.20 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 546,835 | 586,128 | +39,293 | 0.11 | 0.09 | -0.02 | buy |
| MACQUARIE GROUP LTD | 208,875 | 248,034 | +39,159 | 0.03 | 0.02 | -0.00 | buy |
| Swiss National Bank | 180,600 | 219,000 | +38,400 | 0.01 | 0.01 | -0.00 | buy |
| Proficio Capital Partners LLC | 0 | 35,609 | +35,609 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 39,292 | 73,069 | +33,777 | 0.12 | 0.14 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 28,228 | 61,828 | +33,600 | 0.04 | 0.05 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 96,653 | 127,771 | +31,118 | 0.02 | 0.01 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 14,374 | 44,818 | +30,444 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 78,947 | 108,389 | +29,442 | 0.01 | 0.01 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 28,501 | +28,501 | 0.00 | 0.06 | +0.06 | buy |
| AGF MANAGEMENT LTD | 0 | 28,444 | +28,444 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 47,018 | 72,275 | +25,257 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 99,528 | 123,664 | +24,136 | 0.00 | 0.00 | -0.00 | buy |
| CenterBook Partners LP | 0 | 23,367 | +23,367 | 0.00 | 0.11 | +0.11 | buy |
| Bayesian Capital Management, LP | 0 | 20,204 | +20,204 | 0.00 | 0.20 | +0.20 | buy |
| Nicholas Investment Partners, LP | 81,883 | 100,307 | +18,424 | 0.86 | 0.72 | -0.14 | buy |
| Diversified Trust Co | 0 | 17,502 | +17,502 | 0.00 | 0.03 | +0.03 | buy |
| Woodline Partners LP | 1,103,945 | 1,120,922 | +16,977 | 1.07 | 0.62 | -0.44 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 16,526 | +16,526 | 0.00 | 0.03 | +0.03 | buy |
| Windsor Advisory Group, LLC | 22,744 | 39,223 | +16,479 | 2.93 | 3.73 | +0.80 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 72,316 | 88,705 | +16,389 | 0.02 | 0.02 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 89,436 | 105,052 | +15,616 | 0.01 | 0.01 | -0.00 | buy |
| Twin Tree Management, LP | 3,737 | 19,325 | +15,588 | 0.01 | 0.04 | +0.03 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 60,272 | 75,472 | +15,200 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 14,697 | 29,854 | +15,157 | 0.06 | 0.09 | +0.03 | buy |
| Tower Research Capital LLC (TRC) | 978 | 14,436 | +13,458 | 0.00 | 0.02 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 11,113 | 24,516 | +13,403 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 333 | 12,818 | +12,485 | 0.00 | 0.03 | +0.03 | buy |
| ProShare Advisors LLC | 29,146 | 40,875 | +11,729 | 0.01 | 0.01 | -0.00 | buy |
| Headlands Technologies LLC | 27,782 | 39,417 | +11,635 | 0.37 | 0.32 | -0.04 | buy |
| CIBC WORLD MARKETS CORP | 0 | 11,620 | +11,620 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 65,311 | 76,534 | +11,223 | 0.02 | 0.01 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 64,664 | 74,907 | +10,243 | 0.32 | 0.27 | -0.05 | buy |
| Bank of New York Mellon Corp | 412,050 | 421,938 | +9,888 | 0.01 | 0.01 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 23,194 | 32,963 | +9,769 | 0.01 | 0.01 | -0.00 | buy |
| Creative Planning | 37,525 | 46,821 | +9,296 | 0.00 | 0.00 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,237,430 | 1,246,551 | +9,121 | 0.09 | 0.06 | -0.03 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 21,311 | 29,199 | +7,888 | 0.01 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 164,103 | 171,814 | +7,711 | 0.02 | 0.01 | -0.00 | buy |
| SYON CAPITAL LLC | 0 | 6,671 | +6,671 | 0.00 | 0.05 | +0.05 | buy |
| MetLife Investment Management, LLC | 67,833 | 74,503 | +6,670 | 0.04 | 0.03 | -0.01 | buy |
| E Fund Management Co., Ltd. | 4,144 | 10,479 | +6,335 | 0.02 | 0.04 | +0.02 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 48,962 | 55,083 | +6,121 | 0.00 | 0.00 | -0.00 | buy |