| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 8,315,295 | 11,296,333 | +2,981,038 | 0.18 | 0.33 | +0.15 | buy |
| Caligan Partners LP | 0 | 1,704,815 | +1,704,815 | 0.00 | 7.20 | +7.20 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 333,000 | 1,725,000 | +1,392,000 | 0.02 | 0.12 | +0.10 | buy |
| FMR LLC | 12,509,933 | 13,834,514 | +1,324,581 | 0.02 | 0.03 | +0.01 | buy |
| Polar Capital Holdings Plc | 415,530 | 1,672,783 | +1,257,253 | 0.07 | 0.35 | +0.28 | buy |
| NORGES BANK | 0 | 1,228,939 | +1,228,939 | 0.00 | 0.01 | +0.01 | buy |
| Deep Track Capital, LP | 3,000,000 | 4,000,000 | +1,000,000 | 3.02 | 4.21 | +1.19 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 5,032,771 | 5,966,310 | +933,539 | 0.03 | 0.05 | +0.02 | buy |
| Soleus Capital Management, L.P. | 0 | 608,958 | +608,958 | 0.00 | 1.19 | +1.19 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 379,330 | 917,115 | +537,785 | 0.22 | 0.66 | +0.44 | buy |
| FEDERATED HERMES, INC. | 18,156 | 523,489 | +505,333 | 0.00 | 0.04 | +0.04 | buy |
| EcoR1 Capital, LLC | 0 | 450,000 | +450,000 | 0.00 | 0.95 | +0.95 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 128,731 | 497,740 | +369,009 | 0.12 | 0.59 | +0.47 | buy |
| Assenagon Asset Management S.A. | 219,950 | 544,728 | +324,778 | 0.01 | 0.04 | +0.03 | buy |
| Artisan Partners Limited Partnership | 0 | 304,049 | +304,049 | 0.00 | 0.02 | +0.02 | buy |
| BlackRock, Inc. | 9,955,978 | 10,246,378 | +290,400 | 0.01 | 0.01 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 3,784,755 | 4,068,020 | +283,265 | 4.03 | 5.03 | +0.99 | buy |
| JANUS HENDERSON GROUP PLC | 13,104,203 | 13,387,188 | +282,985 | 0.22 | 0.28 | +0.06 | buy |
| Aberdeen Group plc | 722,793 | 979,765 | +256,972 | 0.04 | 0.07 | +0.03 | buy |
| University of Wisconsin Foundation | 0 | 247,000 | +247,000 | 0.00 | 9.58 | +9.58 | buy |
| UBS Group AG | 847,573 | 1,093,593 | +246,020 | 0.01 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 314,892 | 549,514 | +234,622 | 0.01 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 4,785,889 | 4,980,005 | +194,116 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 28,367 | 191,786 | +163,419 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 131,637 | +131,637 | 0.00 | 0.27 | +0.27 | buy |
| CITADEL ADVISORS LLC | 205,799 | 326,574 | +120,775 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 975,377 | 1,078,120 | +102,743 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 213,064 | 315,642 | +102,578 | 0.76 | 1.09 | +0.33 | buy |
| Ikarian Capital, LLC | 311,682 | 378,682 | +67,000 | 2.27 | 2.26 | -0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 635,070 | 701,634 | +66,564 | 0.00 | 0.00 | +0.00 | buy |
| MAVERICK CAPITAL LTD | 1,289,567 | 1,354,237 | +64,670 | 0.62 | 0.67 | +0.05 | buy |
| MORGAN STANLEY | 784,483 | 835,387 | +50,904 | 0.00 | 0.00 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 104,250 | 142,930 | +38,680 | 0.37 | 0.52 | +0.15 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 34,150 | 70,124 | +35,974 | 0.00 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 11,100 | 47,000 | +35,900 | 0.02 | 0.11 | +0.09 | buy |
| Alberta Investment Management Corp | 0 | 30,100 | +30,100 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 246,986 | 274,740 | +27,754 | 0.04 | 0.05 | +0.01 | buy |
| HighVista Strategies LLC | 86,802 | 114,049 | +27,247 | 0.77 | 1.36 | +0.59 | buy |
| Logos Global Management LP | 625,000 | 650,000 | +25,000 | 2.22 | 2.00 | -0.23 | buy |
| Progeny 3, Inc. | 0 | 23,300 | +23,300 | 0.00 | 0.06 | +0.06 | buy |
| Creative Planning | 80,323 | 102,686 | +22,363 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 32,922 | 50,447 | +17,525 | 0.04 | 0.07 | +0.03 | buy |
| XTX Topco Ltd | 0 | 15,261 | +15,261 | 0.00 | 0.02 | +0.02 | buy |
| Walleye Capital LLC | 0 | 14,805 | +14,805 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 14,762 | +14,762 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 33,791 | 47,755 | +13,964 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 344,027 | 357,300 | +13,273 | 0.01 | 0.01 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 45,414 | 57,808 | +12,394 | 0.01 | 0.01 | +0.00 | buy |
| Saturn V Capital Management LP | 788,441 | 798,940 | +10,499 | 6.23 | 6.77 | +0.54 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 10,400 | +10,400 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 439,612 | 449,363 | +9,751 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 15,855 | 25,224 | +9,369 | 0.01 | 0.01 | +0.01 | buy |
| SEGALL BRYANT & HAMILL, LLC | 184,795 | 193,423 | +8,628 | 0.09 | 0.12 | +0.03 | buy |
| Quantitative Investment Management, LLC | 0 | 8,222 | +8,222 | 0.00 | 0.04 | +0.04 | buy |
| SummitTX Capital, L.P. | 6,659 | 14,869 | +8,210 | 0.01 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 126,048 | 134,075 | +8,027 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 7,100 | +7,100 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 1,356 | 7,756 | +6,400 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 5,850 | +5,850 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 5,399 | +5,399 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 225,100 | 230,400 | +5,300 | 0.00 | 0.01 | +0.00 | buy |
| DnB Asset Management AS | 11,236 | 16,471 | +5,235 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 5,090 | +5,090 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 5,025 | +5,025 | 0.00 | 0.03 | +0.03 | buy |
| Quarry LP | 0 | 5,000 | +5,000 | 0.00 | 0.04 | +0.04 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 5,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 0 | 4,680 | +4,680 | 0.00 | 0.11 | +0.11 | buy |
| Empowered Funds, LLC | 0 | 4,576 | +4,576 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 7,184 | 11,742 | +4,558 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Asset Management Inc | 0 | 4,516 | +4,516 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 4,399 | +4,399 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 107,587 | 111,310 | +3,723 | 0.01 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 3,500 | +3,500 | 0.00 | 0.08 | +0.08 | buy |
| Virtus Investment Advisers, LLC | 3,302 | 5,979 | +2,677 | 0.03 | 0.07 | +0.04 | buy |
| ProShare Advisors LLC | 24,201 | 26,725 | +2,524 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 1,126 | 3,635 | +2,509 | 0.00 | 0.00 | +0.00 | buy |
| Meeder Advisory Services, Inc. | 5,818 | 8,104 | +2,286 | 0.01 | 0.02 | +0.01 | buy |
| Pathstone Holdings, LLC | 22,089 | 24,229 | +2,140 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 12,363 | 14,501 | +2,138 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 11,364 | 13,403 | +2,039 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 1,636 | +1,636 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,549 | +1,549 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 109,444 | 110,862 | +1,418 | 0.00 | 0.01 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 23,184 | 24,579 | +1,395 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 38,749 | 40,002 | +1,253 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 19,317 | 20,489 | +1,172 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 5,992 | 7,158 | +1,166 | 0.01 | 0.01 | +0.00 | buy |
| J.Safra Asset Management Corp | 5,984 | 7,054 | +1,070 | 0.01 | 0.02 | +0.00 | buy |
| SIGNATUREFD, LLC | 5,139 | 6,167 | +1,028 | 0.00 | 0.00 | +0.00 | buy |
| Vident Advisory, LLC | 7,814 | 8,821 | +1,007 | 0.00 | 0.00 | +0.00 | buy |
| Pinnacle Wealth Planning Services, Inc. | 0 | 890 | +890 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 831 | +831 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 41 | 830 | +789 | 0.00 | 0.01 | +0.01 | buy |
| Mariner, LLC | 7,755 | 8,539 | +784 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 14,258 | 14,842 | +584 | 0.00 | 0.00 | +0.00 | buy |
| Kemnay Advisory Services Inc. | 0 | 460 | +460 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,293,407 | 1,293,830 | +423 | 0.01 | 0.01 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 23,591 | 23,992 | +401 | 0.02 | 0.03 | +0.01 | buy |
| KLP KAPITALFORVALTNING AS | 24,600 | 25,000 | +400 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 9,714 | 10,083 | +369 | 0.00 | 0.00 | +0.00 | buy |