| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 8,315,295 | 11,296,333 | +2,981,038 | 0.18 | 0.33 | +0.15 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 333,000 | 1,725,000 | +1,392,000 | 0.02 | 0.12 | +0.10 | buy |
| Polar Capital Holdings Plc | 415,530 | 1,672,783 | +1,257,253 | 0.07 | 0.35 | +0.28 | buy |
| Deep Track Capital, LP | 3,000,000 | 4,000,000 | +1,000,000 | 3.02 | 4.21 | +1.19 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 379,330 | 917,115 | +537,785 | 0.22 | 0.66 | +0.44 | buy |
| Paradigm Biocapital Advisors LP | 3,784,755 | 4,068,020 | +283,265 | 4.03 | 5.03 | +0.99 | buy |
| Aberdeen Group plc | 722,793 | 979,765 | +256,972 | 0.04 | 0.07 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 213,064 | 315,642 | +102,578 | 0.76 | 1.09 | +0.33 | buy |
| Ikarian Capital, LLC | 311,682 | 378,682 | +67,000 | 2.27 | 2.26 | -0.01 | buy |
| MAVERICK CAPITAL LTD | 1,289,567 | 1,354,237 | +64,670 | 0.62 | 0.67 | +0.05 | buy |
| NAN FUNG TRINITY (HK) Ltd | 104,250 | 142,930 | +38,680 | 0.37 | 0.52 | +0.15 | buy |
| Rock Springs Capital Management LP | 11,100 | 47,000 | +35,900 | 0.02 | 0.11 | +0.09 | buy |
| HighVista Strategies LLC | 86,802 | 114,049 | +27,247 | 0.77 | 1.36 | +0.59 | buy |
| Logos Global Management LP | 625,000 | 650,000 | +25,000 | 2.22 | 2.00 | -0.23 | buy |
| PROFUND ADVISORS LLC | 32,922 | 50,447 | +17,525 | 0.04 | 0.07 | 0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 45,414 | 57,808 | +12,394 | 0.01 | 0.01 | +0.00 | buy |
| Saturn V Capital Management LP | 788,441 | 798,940 | +10,499 | 6.23 | 6.77 | +0.54 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 67,956 | 58,234 | +9,722 | 0.02 | 0.03 | +0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 184,795 | 193,423 | +8,628 | 4.30 | 0.12 | -4.18 | buy |
| SummitTX Capital, L.P. | 6,659 | 14,869 | +8,210 | 0.01 | 0.02 | +0.01 | buy |
| DnB Asset Management AS | 11,236 | 16,471 | +5,235 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 26,903 | 22,007 | +4,896 | 0.00 | 0.00 | 0.00 | sell |
| Virtus Investment Advisers, LLC | 3,302 | 5,979 | +2,677 | 0.03 | 0.07 | +0.04 | buy |
| ProShare Advisors LLC | 24,201 | 26,725 | +2,524 | 0.00 | 0.00 | 0.00 | buy |
| Meeder Advisory Services, Inc. | 5,818 | 8,104 | +2,286 | 0.01 | 0.02 | +0.01 | buy |
| J.Safra Asset Management Corp | 5,984 | 7,054 | +1,070 | 0.01 | 0.02 | +0.00 | buy |
| AlphaQuest LLC | 10,946 | 10,513 | +433 | 0.03 | 0.03 | 0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 23,591 | 23,992 | +401 | 0.02 | 0.03 | +0.01 | buy |
| Qsemble Capital Management, LP | 6,346 | 6,701 | +355 | 0.02 | 0.03 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 31,022 | 31,274 | +252 | 0.09 | 0.11 | 0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 16,141 | 16,109 | -32 | 0.01 | 0.01 | +0.00 | sell |
| Dynamic Wealth Strategies, LLC | 250 | 86 | -164 | 0.01 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 2,793 | 2,572 | -221 | 0.00 | 0.00 | +0.00 | sell |
| Ameritas Investment Partners, Inc. | 9,565 | 9,294 | -271 | 0.01 | 0.01 | +0.00 | sell |
| Headlands Technologies LLC | 32,731 | 31,706 | -1,025 | 0.09 | 0.12 | +0.03 | sell |
| China Universal Asset Management Co., Ltd. | 22,756 | 21,331 | -1,425 | 0.07 | 0.08 | +0.01 | sell |
| Avior Wealth Management, LLC | 11,031 | 9,487 | -1,544 | 0.01 | 0.01 | +0.00 | sell |
| BANQUE PICTET & CIE SA | 74,864 | 71,815 | -3,049 | 0.02 | 0.02 | +0.00 | sell |
| CIBC WORLD MARKETS CORP | 15,498 | 7,575 | -7,923 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 149,414 | 133,764 | -15,650 | 0.02 | 0.02 | +0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 300,000 | 275,000 | -25,000 | 0.42 | 0.63 | +0.21 | sell |
| Perbak Capital Partners LLP | 40,931 | 8,899 | -32,032 | 0.26 | 0.13 | -0.13 | sell |
| TD ASSET MANAGEMENT INC | 398,480 | 363,734 | -34,746 | 0.01 | 0.01 | +0.00 | sell |
| Persistent Asset Partners Ltd | 50,076 | 5,334 | -44,742 | 1.31 | 0.12 | -1.19 | sell |
| Voleon Capital Management LP | 78,927 | 31,779 | -47,148 | 0.07 | 0.03 | -0.04 | sell |
| Cormorant Asset Management, LP | 175,000 | 125,000 | -50,000 | 0.43 | 0.27 | -0.17 | sell |
| Neo Ivy Capital Management | 83,110 | 4,803 | -78,307 | 0.73 | 0.04 | -0.69 | sell |
| Kynam Capital Management, LP | 3,071,588 | 2,922,335 | -149,253 | 8.24 | 8.78 | +0.54 | sell |
| TWINBEECH CAPITAL LP | 228,087 | 78,239 | -149,848 | 0.32 | 0.26 | -0.07 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 314,339 | 148,787 | -165,552 | 1.64 | 0.99 | -0.65 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,732,715 | 3,539,717 | -192,998 | 0.56 | 0.68 | +0.12 | sell |
| DIADEMA PARTNERS LP | 218,285 | 22,972 | -195,313 | 5.48 | 0.63 | -4.85 | sell |
| Eversept Partners, LP | 1,421,983 | 1,197,722 | -224,261 | 3.53 | 2.78 | -0.75 | sell |
| JENNISON ASSOCIATES LLC | 1,170,899 | 677,553 | -493,346 | 0.02 | 0.02 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,688,483 | 1,175,339 | -513,144 | 0.01 | 0.01 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 11,965,991 | 10,724,599 | -1,241,392 | 5.31 | 5.07 | -0.24 | sell |