| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital Research Global Investors | 1,115,460 | 1,532,303 | +416,843 | 0.02 | 0.02 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 2,373,795 | 2,586,295 | +212,500 | 4.03 | 4.31 | +0.28 | buy |
| Capital World Investors | 115,693 | 221,450 | +105,757 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 609,437 | 696,473 | +87,036 | 0.05 | 0.06 | +0.02 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 46,887 | 73,432 | +26,545 | 0.03 | 0.05 | +0.02 | buy |
| Granahan Investment Management, LLC | 77,709 | 83,270 | +5,561 | 0.33 | 0.33 | +0.00 | buy |
| Rock Springs Capital Management LP | 689,748 | 692,598 | +2,850 | 3.54 | 3.75 | +0.22 | buy |
| E. Ohman J:or Asset Management AB | 4,409 | 5,523 | +1,114 | 0.01 | 0.01 | +0.00 | buy |
| Avior Wealth Management, LLC | 4,650 | 5,440 | +790 | 0.01 | 0.02 | +0.00 | buy |
| Abel Hall, LLC | 4,015 | 4,258 | +243 | 0.07 | 0.08 | +0.01 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 154 | 209 | +55 | 0.01 | 0.01 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 80,620 | 80,552 | -68 | 0.01 | 0.02 | +0.00 | sell |
| Opaleye Management Inc. | 123,000 | 122,500 | -500 | 4.65 | 1.23 | -3.42 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 24,535 | 23,422 | -1,113 | 0.04 | 0.04 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 12,118 | 10,917 | -1,201 | 0.08 | 0.07 | -0.01 | sell |
| First Light Asset Management, LLC | 87,181 | 85,765 | -1,416 | 0.68 | 0.58 | -0.10 | sell |
| TOTH FINANCIAL ADVISORY CORP | 10,000 | 7,800 | -2,200 | 0.10 | 0.08 | -0.01 | sell |
| HighVista Strategies LLC | 16,796 | 13,657 | -3,139 | 0.40 | 0.35 | -0.06 | sell |
| ASPIRIANT, LLC | 33,007 | 27,960 | -5,047 | 0.08 | 0.08 | -0.01 | sell |
| Liberty Mutual Group Asset Management Inc. | 20,514 | 880 | -19,634 | 0.14 | 0.01 | -0.13 | sell |
| Candriam S.C.A. | 464,340 | 433,025 | -31,315 | 0.21 | 0.22 | +0.01 | sell |
| PFM Health Sciences, LP | 136,621 | 101,550 | -35,071 | 1.08 | 0.97 | -0.12 | sell |
| Artisan Partners Limited Partnership | 390,669 | 354,816 | -35,853 | 0.05 | 0.06 | +0.01 | sell |
| SummitTX Capital, L.P. | 165,599 | 126,401 | -39,198 | 0.45 | 0.36 | -0.09 | sell |
| Sofinnova Investments, Inc. | 450,096 | 408,027 | -42,069 | 1.49 | 2.34 | +0.85 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 3,417,509 | 3,168,853 | -248,656 | 0.23 | 0.21 | -0.03 | sell |