| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 2,154,110 | 3,268,579 | +1,114,469 | 2.21 | 2.48 | +0.27 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 151,843 | 730,643 | +578,800 | 0.02 | 0.11 | +0.08 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 267,000 | 577,000 | +310,000 | 0.02 | 0.03 | 0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 598,905 | 855,505 | +256,600 | 0.33 | 0.37 | +0.04 | buy |
| ORBIMED ADVISORS LLC | 536,642 | 704,842 | +168,200 | 0.49 | 0.56 | +0.07 | buy |
| JGP Global Gestao de Recursos Ltda. | 5,688 | 105,814 | +100,126 | 0.16 | 2.95 | +2.79 | buy |
| Woodline Partners LP | 74,850 | 172,207 | +97,357 | 0.04 | 0.07 | +0.03 | buy |
| Rafferty Asset Management, LLC | 121,654 | 218,657 | +97,003 | 0.02 | 0.04 | +0.01 | buy |
| Checkpoint Capital L.P. | 730,000 | 825,500 | +95,500 | 23.42 | 23.91 | +0.49 | buy |
| Altium Capital Management LLC | 6,485 | 57,271 | +50,786 | 0.21 | 1.11 | +0.90 | buy |
| ALGERT GLOBAL LLC | 28,803 | 69,048 | +40,245 | 0.05 | 0.12 | 0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 66,708 | 86,967 | +20,259 | 0.18 | 0.20 | +0.03 | buy |
| Atom Investors LP | 24,931 | 41,276 | +16,345 | 0.20 | 0.22 | +0.02 | buy |
| PROFUND ADVISORS LLC | 20,491 | 34,281 | +13,790 | 0.04 | 0.06 | 0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 174,248 | 183,776 | +9,528 | 2.47 | 2.23 | -0.24 | buy |
| Nan Fung Group Holdings Ltd | 40,070 | 49,120 | +9,050 | 1.15 | 1.97 | +0.82 | buy |
| Parkwood LLC | 10,198 | 15,033 | +4,835 | 0.06 | 0.06 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,837 | 11,561 | +4,724 | 0.06 | 0.06 | +0.00 | buy |
| E Fund Management Co., Ltd. | 6,533 | 10,333 | +3,800 | 0.02 | 0.03 | +0.01 | buy |
| ALPS ADVISORS INC | 40,215 | 42,419 | +2,204 | 0.01 | 0.01 | -0.00 | buy |
| ELEVATION WEALTH PARTNERS, LLC | 400 | 1,971 | +1,571 | 0.01 | 0.04 | +0.04 | buy |
| ProShare Advisors LLC | 12,281 | 13,808 | +1,527 | 0.00 | 0.00 | 0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,597 | 8,874 | +1,277 | 0.22 | 0.20 | -0.02 | buy |
| JANUS HENDERSON GROUP PLC | 621,892 | 621,427 | +465 | 0.02 | 0.01 | 0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 89,605 | 89,726 | +121 | 0.24 | 0.22 | -0.02 | buy |
| Clearbridge Investments, LLC | 91,158 | 90,004 | -1,154 | 0.00 | 0.00 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 283,518 | 281,157 | -2,361 | 0.05 | 0.04 | -0.01 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 76,507 | 73,873 | -2,634 | 0.06 | 0.05 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 17,406 | 10,706 | -6,700 | 0.07 | 0.03 | -0.04 | sell |
| Bellevue Group AG | 32,869 | 12,500 | -20,369 | 0.02 | 0.01 | -0.01 | sell |
| Exome Asset Management LLC | 72,203 | 45,603 | -26,600 | 3.28 | 1.69 | -1.59 | sell |
| NATIXIS | 80,500 | 6,050 | -74,450 | 0.03 | 0.00 | -0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 572,297 | 481,533 | -90,764 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 610,000 | 515,000 | -95,000 | 7.46 | 4.86 | -2.59 | sell |
| Frazier Life Sciences Management, L.P. | 2,371,304 | 2,190,179 | -181,125 | 5.83 | 4.00 | -1.82 | sell |
| Polar Capital Holdings Plc | 1,750,000 | 1,500,000 | -250,000 | 0.50 | 0.34 | -0.15 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 8,052,648 | 7,747,591 | -305,057 | 0.29 | 0.25 | -0.04 | sell |
| Commodore Capital LP | 1,550,000 | 1,050,000 | -500,000 | 6.23 | 3.04 | -3.18 | sell |