| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRIMECAP MANAGEMENT CO/CA/ | 8,052,648 | 7,747,591 | -305,057 | 0.29 | 0.25 | -0.04 | sell |
| BAKER BROS. ADVISORS LP | 6,398,365 | 6,398,365 | 0 | 3.35 | 3.48 | +0.13 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 5,330,412 | 5,330,412 | 0 | 3.83 | 2.94 | -0.89 | hold |
| GOLDMAN SACHS GROUP INC | 5,047,934 | 5,111,601 | +63,667 | 0.05 | 0.05 | -0.00 | buy |
| VANGUARD GROUP INC | 3,226,938 | 3,304,146 | +77,208 | 0.00 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 2,154,110 | 3,268,579 | +1,114,469 | 2.21 | 2.50 | +0.28 | buy |
| STATE STREET CORP | 2,206,018 | 3,013,838 | +807,820 | 0.00 | 0.01 | +0.00 | buy |
| NEA Management Company, LLC | 2,909,956 | 2,909,956 | 0 | 8.92 | 7.83 | -1.09 | hold |
| Frazier Life Sciences Management, L.P. | 2,371,304 | 2,190,179 | -181,125 | 5.83 | 4.00 | -1.82 | sell |
| FEDERATED HERMES, INC. | 2,310,955 | 1,661,097 | -649,858 | 0.26 | 0.17 | -0.10 | sell |
| Rock Springs Capital Management LP | 1,522,893 | 1,522,893 | 0 | 1.73 | 1.68 | -0.05 | hold |
| Polar Capital Holdings Plc | 1,750,000 | 1,500,000 | -250,000 | 0.50 | 0.34 | -0.15 | sell |
| Pictet Asset Management Holding SA | 1,163,961 | 1,211,679 | +47,718 | 0.06 | 0.06 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,119,129 | 1,180,705 | +61,576 | 0.01 | 0.00 | -0.00 | buy |
| Commodore Capital LP | 1,550,000 | 1,050,000 | -500,000 | 6.23 | 3.04 | -3.18 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 598,905 | 855,505 | +256,600 | 0.33 | 0.37 | +0.04 | buy |
| Checkpoint Capital L.P. | 730,000 | 825,500 | +95,500 | 23.42 | 23.91 | +0.49 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 151,843 | 730,643 | +578,800 | 0.02 | 0.11 | +0.09 | buy |
| ORBIMED ADVISORS LLC | 536,642 | 704,842 | +168,200 | 0.49 | 0.56 | +0.07 | buy |
| JANUS HENDERSON GROUP PLC | 621,892 | 621,427 | -465 | 0.02 | 0.01 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 267,000 | 577,000 | +310,000 | 0.02 | 0.03 | +0.01 | buy |
| Cormorant Asset Management, LP | 550,000 | 550,000 | 0 | 1.21 | 1.05 | -0.16 | hold |
| Opaleye Management Inc. | 610,000 | 515,000 | -95,000 | 7.46 | 4.86 | -2.59 | sell |
| NORTHERN TRUST CORP | 501,094 | 502,855 | +1,761 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 572,297 | 481,533 | -90,764 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 362,717 | 473,455 | +110,738 | 0.07 | 0.07 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 397,685 | 406,745 | +9,060 | 0.00 | 0.00 | -0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 239,000 | 367,517 | +128,517 | 0.02 | 0.02 | +0.01 | buy |
| Assenagon Asset Management S.A. | 301,636 | 285,651 | -15,985 | 0.04 | 0.03 | -0.01 | sell |
| LORD, ABBETT & CO. LLC | 283,518 | 281,157 | -2,361 | 0.05 | 0.04 | -0.01 | sell |
| Artisan Partners Limited Partnership | 271,421 | 271,421 | 0 | 0.02 | 0.02 | -0.00 | hold |
| FRANKLIN RESOURCES INC | 5,876 | 220,905 | +215,029 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 121,654 | 218,657 | +97,003 | 0.02 | 0.04 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 209,938 | 206,980 | -2,958 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 139,802 | 193,523 | +53,721 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 54,300 | 190,520 | +136,220 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 174,248 | 183,776 | +9,528 | 2.47 | 2.23 | -0.24 | buy |
| MORGAN STANLEY | 231,656 | 182,870 | -48,786 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 64,991 | 172,752 | +107,761 | 0.00 | 0.01 | +0.00 | buy |
| Samsara BioCapital, LLC | 172,647 | 172,647 | 0 | 1.23 | 1.16 | -0.08 | hold |
| Woodline Partners LP | 74,850 | 172,207 | +97,357 | 0.04 | 0.07 | +0.03 | buy |
| UBS Group AG | 85,955 | 171,565 | +85,610 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 180,222 | 167,838 | -12,384 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 1,256 | 145,291 | +144,035 | 0.00 | 0.04 | +0.04 | buy |
| BARCLAYS PLC | 251,415 | 127,536 | -123,879 | 0.01 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 69,870 | 111,114 | +41,244 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 15,350 | 108,755 | +93,405 | 0.00 | 0.02 | +0.02 | buy |
| JGP Global Gestao de Recursos Ltda. | 5,688 | 105,814 | +100,126 | 0.16 | 2.95 | +2.79 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 32,232 | 103,253 | +71,021 | 0.00 | 0.01 | +0.00 | buy |
| Swiss National Bank | 89,700 | 93,300 | +3,600 | 0.00 | 0.00 | -0.00 | buy |
| Clearbridge Investments, LLC | 91,158 | 90,004 | -1,154 | 0.00 | 0.00 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 89,605 | 89,726 | +121 | 0.24 | 0.22 | -0.02 | buy |
| Invesco Ltd. | 135,731 | 88,205 | -47,526 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 66,708 | 86,967 | +20,259 | 0.18 | 0.20 | +0.03 | buy |
| RHUMBLINE ADVISERS | 73,172 | 76,724 | +3,552 | 0.00 | 0.00 | -0.00 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 76,507 | 73,873 | -2,634 | 0.06 | 0.05 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 14,982 | 70,999 | +56,017 | 0.00 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 28,803 | 69,048 | +40,245 | 0.05 | 0.12 | +0.06 | buy |
| Jefferies Financial Group Inc. | 82,061 | 68,566 | -13,495 | 0.06 | 0.06 | +0.00 | sell |
| CASTLEARK MANAGEMENT LLC | 0 | 63,900 | +63,900 | 0.00 | 0.12 | +0.12 | buy |
| Altium Capital Management LLC | 6,485 | 57,271 | +50,786 | 0.21 | 1.11 | +0.90 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 63,085 | 56,009 | -7,076 | 0.01 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 77,599 | 54,504 | -23,095 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 54,390 | 53,430 | -960 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 0 | 50,870 | +50,870 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 40,070 | 49,120 | +9,050 | 1.15 | 1.97 | +0.82 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,997 | 47,894 | -1,103 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 39,238 | 47,624 | +8,386 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 46,828 | 47,416 | +588 | 0.00 | 0.00 | -0.00 | buy |
| Exome Asset Management LLC | 72,203 | 45,603 | -26,600 | 3.28 | 1.69 | -1.59 | sell |
| ALPS ADVISORS INC | 40,215 | 42,419 | +2,204 | 0.01 | 0.01 | -0.00 | buy |
| Atom Investors LP | 24,931 | 41,276 | +16,345 | 0.20 | 0.22 | +0.02 | buy |
| PROFUND ADVISORS LLC | 20,491 | 34,281 | +13,790 | 0.04 | 0.06 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 37,414 | 33,304 | -4,110 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 34,051 | 33,118 | -933 | 0.01 | 0.01 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 32,874 | 32,811 | -63 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 529,130 | 29,020 | -500,110 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 27,048 | 28,159 | +1,111 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 30,625 | 27,937 | -2,688 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 37,800 | 27,600 | -10,200 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 27,123 | 27,123 | 0 | 0.01 | 0.01 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 39,759 | 26,985 | -12,774 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 0 | 26,436 | +26,436 | 0.00 | 0.03 | +0.03 | buy |
| JANE STREET GROUP, LLC | 184,359 | 26,318 | -158,041 | 0.01 | 0.00 | -0.01 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 25,537 | 26,318 | +781 | 0.00 | 0.00 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 22,781 | +22,781 | 0.00 | 0.13 | +0.13 | buy |
| TWINBEECH CAPITAL LP | 0 | 22,714 | +22,714 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 20,980 | 20,980 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIDUCIARY TRUST CO | 20,000 | 20,000 | 0 | 0.02 | 0.01 | -0.00 | hold |
| MARSHALL WACE, LLP | 0 | 19,750 | +19,750 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 18,550 | 17,659 | -891 | 0.00 | 0.00 | -0.00 | sell |
| Campbell & CO Investment Adviser LLC | 10,742 | 16,331 | +5,589 | 0.04 | 0.06 | +0.02 | buy |
| Handelsbanken Fonder AB | 12,321 | 15,921 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 15,355 | +15,355 | 0.00 | 0.06 | +0.06 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 182,297 | 15,085 | -167,212 | 0.01 | 0.00 | -0.01 | sell |
| Parkwood LLC | 10,198 | 15,033 | +4,835 | 0.07 | 0.07 | -0.01 | buy |
| HighVista Strategies LLC | 14,362 | 14,362 | 0 | 0.24 | 0.22 | -0.02 | hold |
| ProShare Advisors LLC | 12,281 | 13,808 | +1,527 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 3,000 | 13,600 | +10,600 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 4,900 | 13,355 | +8,455 | 0.00 | 0.01 | +0.00 | buy |