| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 685,152 | 1,199,053 | +513,901 | 0.00 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,219,554 | 1,655,350 | +435,796 | 0.04 | 0.05 | 0.00 | buy |
| Checkpoint Capital L.P. | 727,982 | 907,240 | +179,258 | 20.74 | 26.37 | +5.63 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,290,975 | 1,458,022 | +167,047 | 0.60 | 0.74 | +0.15 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 273,896 | 337,605 | +63,709 | 3.43 | 3.74 | +0.31 | buy |
| PDT Partners, LLC | 43,583 | 102,195 | +58,612 | 0.22 | 0.38 | +0.17 | buy |
| Sofinnova Investments, Inc. | 397,428 | 446,839 | +49,411 | 1.62 | 1.55 | -0.07 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 30,252 | 77,297 | +47,045 | 0.07 | 0.19 | 0.00 | buy |
| Aberdeen Group plc | 80,517 | 108,129 | +27,612 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 41,551 | 61,461 | +19,910 | 0.06 | 0.08 | 0.00 | buy |
| Hood River Capital Management LLC | 643,691 | 659,431 | +15,740 | 0.53 | 0.60 | +0.06 | buy |
| Rafferty Asset Management, LLC | 50,394 | 57,732 | +7,338 | 0.01 | 0.01 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 5,123 | 12,148 | +7,025 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 30,941 | 36,890 | +5,949 | 0.36 | 0.38 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 28,092 | 33,893 | +5,801 | 0.02 | 0.02 | +0.00 | buy |
| ProShare Advisors LLC | 18,328 | 14,704 | +3,624 | 0.00 | 0.00 | 0.00 | sell |
| Atom Investors LP | 11,605 | 14,962 | +3,357 | 0.08 | 0.10 | +0.02 | buy |
| Advisors Asset Management, Inc. | 7,074 | 10,250 | +3,176 | 0.01 | 0.01 | 0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 106,261 | 103,202 | +3,059 | 0.01 | 0.01 | 0.00 | sell |
| TD ASSET MANAGEMENT INC | 47,800 | 50,200 | +2,400 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 16,400 | 18,500 | +2,100 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 10,481 | 12,444 | +1,963 | 0.02 | 0.03 | +0.01 | buy |
| Bridgefront Capital, LLC | 4,604 | 6,414 | +1,810 | 0.09 | 0.10 | +0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,290 | 1,573 | +283 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 5,866 | 5,966 | +100 | 0.02 | 0.02 | 0.00 | buy |
| Chicago Partners Investment Group LLC | 3,696 | 3,510 | -186 | 0.01 | 0.01 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,031 | 12,682 | -349 | 0.07 | 0.06 | -0.01 | sell |
| JGP Global Gestao de Recursos Ltda. | 5,378 | 3,824 | -1,554 | 0.69 | 0.15 | -0.53 | sell |
| HighVista Strategies LLC | 37,426 | 35,039 | -2,387 | 0.78 | 0.72 | -0.06 | sell |
| ALPS ADVISORS INC | 49,700 | 46,207 | -3,493 | 0.02 | 0.01 | -0.00 | sell |
| FIDUCIARY TRUST CO | 20,000 | 15,000 | -5,000 | 0.01 | 0.01 | -0.00 | sell |
| Persistent Asset Partners Ltd | 18,312 | 11,501 | -6,811 | 0.93 | 0.54 | -0.39 | sell |
| Bellevue Group AG | 23,596 | 15,550 | -8,046 | 0.03 | 0.02 | -0.01 | sell |
| Hennion & Walsh Asset Management, Inc. | 99,447 | 89,622 | -9,825 | 0.25 | 0.21 | -0.04 | sell |
| Opaleye Management Inc. | 500,000 | 490,000 | -10,000 | 4.90 | 5.78 | +0.88 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 48,411 | 36,984 | -11,427 | 0.05 | 0.04 | -0.01 | sell |
| LOOMIS SAYLES & CO L P | 618,485 | 605,764 | -12,721 | 0.04 | 0.05 | +0.00 | sell |
| Informed Momentum Co LLC | 63,078 | 45,108 | -17,970 | 0.50 | 0.41 | -0.09 | sell |
| ORBIMED ADVISORS LLC | 400,000 | 380,000 | -20,000 | 0.46 | 0.48 | +0.02 | sell |
| DIADEMA PARTNERS LP | 75,000 | 50,000 | -25,000 | 4.73 | 2.12 | -2.61 | sell |
| LORD, ABBETT & CO. LLC | 160,651 | 135,360 | -25,291 | 0.03 | 0.03 | -0.00 | sell |
| Samsara BioCapital, LLC | 172,647 | 138,118 | -34,529 | 1.33 | 1.30 | -0.02 | sell |
| Candriam S.C.A. | 332,392 | 291,469 | -40,923 | 0.11 | 0.10 | -0.01 | sell |
| Cinctive Capital Management LP | 82,755 | 4,356 | -78,399 | 0.25 | 0.02 | -0.23 | sell |
| STEMPOINT CAPITAL LP | 208,016 | 33,816 | -174,200 | 2.92 | 0.57 | -2.35 | sell |
| Cormorant Asset Management, LP | 400,000 | 150,000 | -250,000 | 1.23 | 0.60 | -0.63 | sell |
| Rock Springs Capital Management LP | 1,162,718 | 834,188 | -328,530 | 2.48 | 2.53 | +0.05 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 1,167,700 | 817,700 | -350,000 | 0.13 | 0.09 | -0.04 | sell |
| BAKER BROS. ADVISORS LP | 6,084,249 | 5,604,483 | -479,766 | 3.64 | 3.29 | -0.35 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 6,571,190 | 5,787,322 | -783,868 | 0.28 | 0.25 | -0.03 | sell |
| Polar Capital Holdings Plc | 1,500,000 | 500,000 | -1,000,000 | 0.47 | 0.16 | -0.31 | sell |
| PERCEPTIVE ADVISORS LLC | 3,680,473 | 2,548,445 | -1,132,028 | 5.68 | 4.77 | -0.91 | sell |
| Frazier Life Sciences Management, L.P. | 1,869,808 | 678,760 | -1,191,048 | 4.34 | 1.64 | -2.70 | sell |