| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 6,666,837 | 6,666,837 | 0 | 7.31 | 6.14 | -1.17 | hold |
| BlackRock, Inc. | 6,297,334 | 6,237,151 | -60,183 | 0.01 | 0.01 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 5,604,483 | 5,604,483 | 0 | 3.51 | 2.80 | -0.71 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 3,478,669 | 3,417,509 | -61,160 | 0.28 | 0.23 | -0.05 | sell |
| PERCEPTIVE ADVISORS LLC | 2,546,391 | 2,373,795 | -172,596 | 4.99 | 4.08 | -0.92 | sell |
| STATE STREET CORP | 2,198,615 | 2,271,851 | +73,236 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,830,866 | 1,965,432 | +134,566 | 0.03 | 0.02 | -0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,267,158 | 1,929,123 | +661,965 | 0.57 | 0.70 | +0.14 | buy |
| FMR LLC | 1,706,317 | 1,689,671 | -16,646 | 0.01 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,560,847 | 1,654,876 | +94,029 | 0.02 | 0.02 | -0.00 | buy |
| Polar Capital Holdings Plc | 1,185,392 | 1,615,586 | +430,194 | 0.58 | 0.61 | +0.03 | buy |
| JPMORGAN CHASE & CO | 1,423,989 | 1,553,644 | +129,655 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 153,322 | 1,418,619 | +1,265,297 | 0.01 | 0.09 | +0.08 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,375,729 | 1,416,269 | +40,540 | 0.01 | 0.01 | -0.00 | buy |
| FEDERATED HERMES, INC. | 1,623,841 | 1,286,303 | -337,538 | 0.29 | 0.18 | -0.11 | sell |
| Checkpoint Capital L.P. | 992,200 | 1,227,200 | +235,000 | 33.65 | 38.30 | +4.65 | buy |
| Capital Research Global Investors | 985,086 | 1,115,460 | +130,374 | 0.02 | 0.02 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,126,125 | 918,153 | -207,972 | 0.05 | 0.04 | -0.02 | sell |
| ALLIANCEBERNSTEIN L.P. | 930,233 | 910,413 | -19,820 | 0.03 | 0.03 | +0.00 | sell |
| Point72 Asset Management, L.P. | 429,420 | 846,801 | +417,381 | 0.07 | 0.13 | +0.06 | buy |
| Woodline Partners LP | 688,779 | 758,891 | +70,112 | 0.29 | 0.25 | -0.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 621,585 | 725,744 | +104,159 | 0.10 | 0.10 | -0.00 | buy |
| Siren, L.L.C. | 499,975 | 725,511 | +225,536 | 1.60 | 1.75 | +0.15 | buy |
| MORGAN STANLEY | 651,402 | 703,978 | +52,576 | 0.00 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 695,010 | 689,748 | -5,262 | 3.82 | 3.54 | -0.28 | sell |
| Pictet Asset Management Holding SA | 614,663 | 667,046 | +52,383 | 0.06 | 0.06 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 224,484 | 628,667 | +404,183 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 695,735 | 626,845 | -68,890 | 0.02 | 0.01 | -0.00 | sell |
| Clearbridge Investments, LLC | 506,109 | 609,437 | +103,328 | 0.04 | 0.05 | +0.00 | buy |
| Integral Health Asset Management, LLC | 475,000 | 600,000 | +125,000 | 2.58 | 2.76 | +0.18 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 549,020 | 541,450 | -7,570 | 0.01 | 0.01 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 532,447 | 526,459 | -5,988 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 488,216 | 498,514 | +10,298 | 0.01 | 0.01 | -0.00 | buy |
| LOOMIS SAYLES & CO L P | 503,901 | 465,102 | -38,799 | 0.07 | 0.05 | -0.01 | sell |
| Candriam S.C.A. | 287,907 | 464,340 | +176,433 | 0.15 | 0.21 | +0.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 186,709 | 451,825 | +265,116 | 0.01 | 0.03 | +0.02 | buy |
| Sofinnova Investments, Inc. | 271,394 | 450,096 | +178,702 | 1.25 | 1.96 | +0.71 | buy |
| Logos Global Management LP | 190,000 | 450,000 | +260,000 | 1.36 | 2.02 | +0.66 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,285,222 | 436,546 | -848,676 | 0.93 | 0.28 | -0.66 | sell |
| Artisan Partners Limited Partnership | 263,591 | 390,669 | +127,078 | 0.04 | 0.06 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 261,160 | 383,957 | +122,797 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 291,150 | 364,306 | +73,156 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 619,542 | 348,953 | -270,589 | 0.20 | 0.10 | -0.10 | sell |
| ORBIMED ADVISORS LLC | 239,800 | 314,100 | +74,300 | 0.53 | 0.60 | +0.07 | buy |
| BRAIDWELL LP | 0 | 310,628 | +310,628 | 0.00 | 0.90 | +0.90 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 135,950 | 306,000 | +170,050 | 2.11 | 3.14 | +1.03 | buy |
| Bank of New York Mellon Corp | 301,080 | 293,298 | -7,782 | 0.01 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 310,919 | 277,943 | -32,976 | 0.05 | 0.03 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 250,156 | 273,757 | +23,601 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 32,829 | 262,968 | +230,139 | 0.01 | 0.05 | +0.04 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 341,193 | 258,011 | -83,182 | 0.06 | 0.04 | -0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 164,563 | 247,876 | +83,313 | 0.01 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 237,043 | 239,912 | +2,869 | 0.28 | 0.21 | -0.07 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 249,874 | 233,810 | -16,064 | 0.03 | 0.02 | -0.01 | sell |
| UBS Group AG | 427,236 | 231,650 | -195,586 | 0.01 | 0.00 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 51,349 | 211,450 | +160,101 | 0.41 | 1.11 | +0.69 | buy |
| SummitTX Capital, L.P. | 80,729 | 165,599 | +84,870 | 0.26 | 0.46 | +0.20 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 149,373 | 151,842 | +2,469 | 0.04 | 0.03 | -0.01 | buy |
| DEUTSCHE BANK AG\ | 129,123 | 141,601 | +12,478 | 0.00 | 0.00 | -0.00 | buy |
| M&G Plc | 137,074 | 138,567 | +1,493 | 0.08 | 0.06 | -0.01 | buy |
| PFM Health Sciences, LP | 40,210 | 136,621 | +96,411 | 0.44 | 1.25 | +0.81 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 131,674 | +131,674 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 93,677 | 125,207 | +31,530 | 0.01 | 0.02 | +0.00 | buy |
| Opaleye Management Inc. | 330,000 | 123,000 | -207,000 | 4.66 | 4.65 | -0.01 | sell |
| Nuveen, LLC | 115,934 | 117,376 | +1,442 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 134,180 | 115,712 | -18,468 | 0.02 | 0.01 | -0.00 | sell |
| Capital World Investors | 115,693 | 115,693 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Swiss National Bank | 111,300 | 112,200 | +900 | 0.01 | 0.01 | -0.00 | buy |
| AXIOM INVESTORS LLC /DE | 83,554 | 91,749 | +8,195 | 0.08 | 0.09 | +0.01 | buy |
| First Light Asset Management, LLC | 295,844 | 87,181 | -208,663 | 2.42 | 0.68 | -1.74 | sell |
| FIRST TRUST ADVISORS LP | 88,505 | 85,506 | -2,999 | 0.01 | 0.01 | -0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 44,805 | 80,620 | +35,815 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 0 | 79,357 | +79,357 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 53,452 | 77,709 | +24,257 | 0.24 | 0.33 | +0.08 | buy |
| Neuberger Berman Group LLC | 73,572 | 73,434 | -138 | 0.01 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 71,212 | 69,858 | -1,354 | 0.01 | 0.01 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 39,887 | 65,818 | +25,931 | 0.09 | 0.12 | +0.03 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,537 | 65,806 | +12,269 | 0.01 | 0.01 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 123,537 | 62,936 | -60,601 | 0.02 | 0.01 | -0.01 | sell |
| Blue Owl Capital Holdings LP | 0 | 61,455 | +61,455 | 0.00 | 1.44 | +1.44 | buy |
| XTX Topco Ltd | 10,433 | 59,502 | +49,069 | 0.03 | 0.09 | +0.06 | buy |
| AQR CAPITAL MANAGEMENT LLC | 70,046 | 59,279 | -10,767 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 88,250 | 58,513 | -29,737 | 0.15 | 0.08 | -0.07 | sell |
| Atom Investors LP | 22,929 | 57,000 | +34,071 | 0.19 | 0.35 | +0.16 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 72,282 | 52,967 | -19,315 | 0.01 | 0.01 | -0.01 | sell |
| CASTLEARK MANAGEMENT LLC | 64,479 | 52,279 | -12,200 | 0.20 | 0.15 | -0.05 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 4,097 | 50,784 | +46,687 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 59,609 | 50,769 | -8,840 | 0.01 | 0.00 | -0.00 | sell |
| PICTON MAHONEY ASSET MANAGEMENT | 0 | 50,372 | +50,372 | 0.00 | 0.05 | +0.05 | buy |
| Rafferty Asset Management, LLC | 55,526 | 50,105 | -5,421 | 0.02 | 0.02 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 41,115 | 49,920 | +8,805 | 0.00 | 0.00 | -0.00 | buy |
| Nan Fung Group Holdings Ltd | 49,120 | 49,120 | 0 | 4.71 | 3.52 | -1.18 | hold |
| Harvest Investment Services, LLC | 43,953 | 48,468 | +4,515 | 0.89 | 0.77 | -0.12 | buy |
| Legal & General Group Plc | 55,075 | 47,032 | -8,043 | 0.00 | 0.00 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 34,127 | 46,887 | +12,760 | 0.03 | 0.03 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 2,415 | 43,872 | +41,457 | 0.00 | 0.00 | +0.00 | buy |
| Utah Retirement Systems | 0 | 42,177 | +42,177 | 0.00 | 0.04 | +0.04 | buy |
| SEI INVESTMENTS CO | 37,432 | 40,685 | +3,253 | 0.00 | 0.00 | -0.00 | buy |
| Exome Asset Management LLC | 0 | 40,581 | +40,581 | 0.00 | 2.08 | +2.08 | buy |
| Hillsdale Investment Management Inc. | 42,300 | 40,300 | -2,000 | 0.12 | 0.10 | -0.03 | sell |