| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ALKEON CAPITAL MANAGEMENT LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.21 | +0.21 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 5,330,412 | 6,084,412 | +754,000 | 2.94 | 3.30 | +0.37 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 855,505 | 1,182,370 | +326,865 | 0.37 | 0.47 | +0.10 | buy |
| MORGAN STANLEY | 182,870 | 475,651 | +292,781 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 271,398 | +271,398 | 0.00 | 0.07 | +0.07 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 730,643 | 967,243 | +236,600 | 0.11 | 0.12 | +0.01 | buy |
| NISA INVESTMENT ADVISORS, LLC | 145,291 | 374,347 | +229,056 | 0.04 | 0.10 | +0.06 | buy |
| Invesco Ltd. | 88,205 | 276,700 | +188,495 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 2,190,179 | 2,371,304 | +181,125 | 4.00 | 4.55 | +0.55 | buy |
| PERCEPTIVE ADVISORS LLC | 3,268,579 | 3,446,579 | +178,000 | 2.50 | 3.42 | +0.92 | buy |
| GOLDMAN SACHS GROUP INC | 5,111,601 | 5,288,635 | +177,034 | 0.05 | 0.04 | -0.00 | buy |
| Commodore Capital LP | 1,050,000 | 1,225,000 | +175,000 | 3.04 | 3.43 | +0.39 | buy |
| JANE STREET GROUP, LLC | 26,318 | 146,500 | +120,182 | 0.00 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 0 | 112,804 | +112,804 | 0.00 | 0.01 | +0.01 | buy |
| Checkpoint Capital L.P. | 825,500 | 922,100 | +96,600 | 23.91 | 22.82 | -1.08 | buy |
| FIRST TRUST ADVISORS LP | 0 | 91,010 | +91,010 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 19,750 | 106,809 | +87,059 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 54,504 | 140,146 | +85,642 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,180,705 | 1,252,689 | +71,984 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 3,304,146 | 3,360,695 | +56,549 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 0 | 44,984 | +44,984 | 0.00 | 0.20 | +0.20 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 481,533 | 525,942 | +44,409 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 6,050 | 43,951 | +37,901 | 0.00 | 0.01 | +0.01 | buy |
| NATIONAL BANK OF CANADA /FI/ | 367,517 | 404,242 | +36,725 | 0.02 | 0.03 | +0.00 | buy |
| ALGERT GLOBAL LLC | 69,048 | 104,132 | +35,084 | 0.12 | 0.14 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 70,999 | 103,830 | +32,831 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 206,980 | 236,431 | +29,451 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 7,513 | 33,727 | +26,214 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 167,838 | 191,871 | +24,033 | 0.00 | 0.00 | +0.00 | buy |
| GTS SECURITIES LLC | 0 | 23,136 | +23,136 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 406,745 | 427,958 | +21,213 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 20,980 | 40,415 | +19,435 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 18,120 | +18,120 | 0.00 | 0.01 | +0.01 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 14,670 | +14,670 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 0 | 11,920 | +11,920 | 0.00 | 0.01 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 22,781 | 34,627 | +11,846 | 0.13 | 0.11 | -0.02 | buy |
| FRANKLIN RESOURCES INC | 220,905 | 232,677 | +11,772 | 0.00 | 0.00 | -0.00 | buy |
| PDT Partners, LLC | 0 | 11,510 | +11,510 | 0.00 | 0.04 | +0.04 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 11,154 | +11,154 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 10,921 | +10,921 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 86,967 | 96,378 | +9,411 | 0.20 | 0.20 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 539 | 9,925 | +9,386 | 0.00 | 0.01 | +0.01 | buy |
| Tidal Investments LLC | 0 | 9,011 | +9,011 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 8,900 | +8,900 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 193,523 | 202,326 | +8,803 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 53,430 | 61,070 | +7,640 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 4,796 | 11,578 | +6,782 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 76,724 | 83,063 | +6,339 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 33,304 | 39,427 | +6,123 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 27,123 | 31,652 | +4,529 | 0.01 | 0.01 | -0.00 | buy |
| ROYAL BANK OF CANADA | 1,444 | 5,449 | +4,005 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 27,600 | 31,000 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 89,726 | 93,081 | +3,355 | 0.22 | 0.23 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 26,985 | 29,535 | +2,550 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 47,416 | 49,771 | +2,355 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 7,180 | 9,532 | +2,352 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,820 | +1,820 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 47,624 | 49,291 | +1,667 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 385 | 2,010 | +1,625 | 0.00 | 0.00 | +0.00 | buy |
| Gotham Asset Management, LLC | 11,103 | 12,627 | +1,524 | 0.01 | 0.01 | -0.00 | buy |
| AlphaQuest LLC | 271 | 1,662 | +1,391 | 0.00 | 0.01 | +0.01 | buy |
| Parkwood LLC | 15,033 | 16,387 | +1,354 | 0.07 | 0.08 | +0.02 | buy |
| ORG Partners LLC | 0 | 1,206 | +1,206 | 0.00 | 0.01 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 0 | 1,160 | +1,160 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 183,776 | 184,662 | +886 | 2.23 | 1.87 | -0.36 | buy |
| GROUP ONE TRADING LLC | 4,275 | 4,991 | +716 | 0.01 | 0.01 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 12,400 | 13,000 | +600 | 0.15 | 0.11 | -0.04 | buy |
| Bellevue Group AG | 12,500 | 13,000 | +500 | 0.01 | 0.01 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 20 | 379 | +359 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 404 | 657 | +253 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 231 | +231 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 27,937 | 28,058 | +121 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 62 | 141 | +79 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 6,807 | 6,878 | +71 | 0.00 | 0.00 | -0.00 | buy |
| MATHER GROUP, LLC. | 0 | 65 | +65 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,815 | 1,875 | +60 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 54 | +54 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 28 | 82 | +54 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 32,811 | 32,855 | +44 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| CVA Family Office, LLC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 704,842 | 704,842 | 0 | 0.56 | 0.58 | +0.01 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 5,318 | 5,318 | 0 | 0.01 | 0.01 | -0.00 | hold |
| WHITTIER TRUST CO | 2,000 | 2,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TEXAS TREASURY SAFEKEEPING TRUST CO | 4,230 | 4,230 | 0 | 0.00 | 0.01 | +0.01 | hold |
| BAKER BROS. ADVISORS LP | 6,398,365 | 6,398,365 | 0 | 3.48 | 3.36 | -0.12 | hold |
| HighVista Strategies LLC | 14,362 | 14,362 | 0 | 0.22 | 0.22 | -0.01 | hold |
| Handelsbanken Fonder AB | 15,921 | 15,921 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KBC Group NV | 1,263 | 1,263 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jasper Ridge Partners, L.P. | 5,639 | 5,639 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 17,659 | 17,659 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 213 | 213 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 227 | 227 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEA Management Company, LLC | 2,909,956 | 2,909,956 | 0 | 7.83 | 8.99 | +1.16 | hold |
| Opaleye Management Inc. | 515,000 | 515,000 | 0 | 4.86 | 4.83 | -0.03 | hold |
| Parallel Advisors, LLC | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 172,647 | 172,647 | 0 | 1.16 | 1.48 | +0.33 | hold |
| Global Retirement Partners, LLC | 35 | 35 | 0 | 0.00 | 0.00 | -0.00 | hold |