| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 855,505 | 1,182,370 | +326,865 | 0.37 | 0.47 | +0.10 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 730,643 | 967,243 | +236,600 | 0.11 | 0.11 | +0.01 | buy |
| Frazier Life Sciences Management, L.P. | 2,190,179 | 2,371,304 | +181,125 | 4.00 | 4.55 | +0.55 | buy |
| PERCEPTIVE ADVISORS LLC | 3,268,579 | 3,446,579 | +178,000 | 2.48 | 3.41 | +0.93 | buy |
| Commodore Capital LP | 1,050,000 | 1,225,000 | +175,000 | 3.04 | 3.43 | +0.39 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 577,000 | 417,000 | +160,000 | 0.03 | 0.02 | 0.00 | sell |
| Checkpoint Capital L.P. | 825,500 | 922,100 | +96,600 | 23.91 | 22.82 | -1.08 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 481,533 | 525,942 | +44,409 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 6,050 | 43,951 | +37,901 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 69,048 | 104,132 | +35,084 | 0.12 | 0.15 | 0.00 | buy |
| JANUS HENDERSON GROUP PLC | 621,427 | 593,642 | +27,785 | 0.01 | 0.01 | 0.00 | sell |
| PROFUND ADVISORS LLC | 34,281 | 13,975 | +20,306 | 0.06 | 0.02 | 0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 22,781 | 34,627 | +11,846 | 0.13 | 0.11 | -0.02 | buy |
| Hennion & Walsh Asset Management, Inc. | 86,967 | 96,378 | +9,411 | 0.20 | 0.20 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 89,726 | 93,081 | +3,355 | 0.22 | 0.23 | +0.01 | buy |
| Parkwood LLC | 15,033 | 16,387 | +1,354 | 0.06 | 0.08 | +0.03 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 183,776 | 184,662 | +886 | 2.23 | 1.87 | -0.36 | buy |
| ADAR1 Capital Management, LLC | 12,400 | 13,000 | +600 | 0.15 | 0.11 | -0.04 | buy |
| Bellevue Group AG | 12,500 | 13,000 | +500 | 0.01 | 0.01 | +0.00 | buy |
| Artisan Partners Limited Partnership | 271,421 | 271,267 | -154 | 0.02 | 0.02 | -0.00 | sell |
| Chicago Partners Investment Group LLC | 5,445 | 4,797 | -648 | 0.01 | 0.01 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 8,874 | 7,423 | -1,451 | 0.20 | 0.15 | -0.05 | sell |
| Clearbridge Investments, LLC | 90,004 | 88,108 | -1,896 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 11,561 | 7,163 | -4,398 | 0.06 | 0.04 | -0.02 | sell |
| ALLIANZ SE | 9,080 | 1,350 | -7,730 | 0.01 | 0.00 | -0.01 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 73,873 | 63,197 | -10,676 | 0.05 | 0.05 | -0.01 | sell |
| Atom Investors LP | 41,276 | 26,629 | -14,647 | 0.22 | 0.11 | -0.11 | sell |
| CASTLEARK MANAGEMENT LLC | 63,900 | 19,010 | -44,890 | 0.12 | 0.03 | -0.08 | sell |
| Cormorant Asset Management, LP | 550,000 | 475,000 | -75,000 | 1.05 | 1.13 | +0.08 | sell |
| JGP Global Gestao de Recursos Ltda. | 105,814 | 5,814 | -100,000 | 2.95 | 0.30 | -2.64 | sell |
| Woodline Partners LP | 172,207 | 44,247 | -127,960 | 0.07 | 0.02 | -0.05 | sell |
| Rafferty Asset Management, LLC | 218,657 | 72,562 | -146,095 | 0.04 | 0.01 | -0.02 | sell |
| LORD, ABBETT & CO. LLC | 281,157 | 102,591 | -178,566 | 0.04 | 0.01 | -0.03 | sell |
| Rock Springs Capital Management LP | 1,522,893 | 1,280,493 | -242,400 | 1.68 | 1.58 | -0.09 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 7,747,591 | 7,312,391 | -435,200 | 0.25 | 0.22 | -0.03 | sell |