| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 6,854,755 | 6,267,538 | -587,217 | 0.01 | 0.01 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 5,604,483 | 5,604,483 | 0 | 3.29 | 3.44 | +0.15 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,084,412 | 5,561,359 | -523,053 | 5.38 | 5.92 | +0.54 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 5,787,322 | 4,878,037 | -909,285 | 0.25 | 0.24 | -0.01 | sell |
| VANGUARD GROUP INC | 3,444,926 | 3,589,114 | +144,188 | 0.00 | 0.00 | +0.00 | buy |
| NEA Management Company, LLC | 2,909,956 | 2,909,956 | 0 | 11.87 | 13.84 | +1.97 | hold |
| PERCEPTIVE ADVISORS LLC | 2,548,445 | 2,418,299 | -130,146 | 4.79 | 5.73 | +0.95 | sell |
| FMR LLC | 1,688,375 | 1,953,441 | +265,066 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,970,733 | 1,907,601 | -63,132 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,637,908 | 1,733,722 | +95,814 | 0.02 | 0.02 | +0.00 | buy |
| FEDERATED HERMES, INC. | 1,591,871 | 1,686,494 | +94,623 | 0.18 | 0.20 | +0.02 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,341,092 | 1,629,468 | +288,376 | 0.35 | 0.43 | +0.09 | buy |
| JANUS HENDERSON GROUP PLC | 1,655,350 | 1,411,902 | -243,448 | 0.05 | 0.04 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,199,053 | 1,341,392 | +142,339 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,287,168 | 1,311,253 | +24,085 | 0.01 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,458,022 | 1,269,952 | -188,070 | 0.74 | 0.64 | -0.10 | sell |
| Polar Capital Holdings Plc | 500,000 | 1,250,870 | +750,870 | 0.16 | 0.41 | +0.25 | buy |
| Checkpoint Capital L.P. | 907,240 | 1,060,000 | +152,760 | 26.37 | 31.21 | +4.85 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 817,700 | 1,017,700 | +200,000 | 0.26 | 0.31 | +0.06 | buy |
| Rock Springs Capital Management LP | 834,188 | 861,153 | +26,965 | 2.53 | 3.39 | +0.86 | buy |
| JPMORGAN CHASE & CO | 143,640 | 783,559 | +639,919 | 0.00 | 0.00 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 605,764 | 591,454 | -14,310 | 0.05 | 0.05 | +0.00 | sell |
| Sofinnova Investments, Inc. | 446,839 | 586,010 | +139,171 | 1.78 | 2.52 | +0.73 | buy |
| FRANKLIN RESOURCES INC | 326,160 | 543,802 | +217,642 | 0.01 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 659,431 | 543,688 | -115,743 | 0.60 | 0.48 | -0.12 | sell |
| MORGAN STANLEY | 504,049 | 524,480 | +20,431 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 514,381 | +514,381 | 0.00 | 0.17 | +0.17 | buy |
| NORTHERN TRUST CORP | 536,206 | 510,246 | -25,960 | 0.00 | 0.00 | +0.00 | sell |
| Opaleye Management Inc. | 490,000 | 475,000 | -15,000 | 5.78 | 6.07 | +0.30 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 445,429 | 461,438 | +16,009 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 259,346 | 416,115 | +156,769 | 0.02 | 0.03 | +0.01 | buy |
| Siren, L.L.C. | 277,533 | 409,742 | +132,209 | 0.83 | 1.34 | +0.51 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 337,605 | 400,772 | +63,167 | 3.74 | 5.18 | +1.45 | buy |
| MARSHALL WACE, LLP | 535,103 | 376,242 | -158,861 | 0.04 | 0.03 | -0.01 | sell |
| BARCLAYS PLC | 101,217 | 351,198 | +249,981 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 341,000 | +341,000 | 0.00 | 0.04 | +0.04 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 422,868 | 338,804 | -84,064 | 0.08 | 0.08 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 14,112 | 314,893 | +300,781 | 0.00 | 0.03 | +0.03 | buy |
| Candriam S.C.A. | 291,469 | 312,452 | +20,983 | 0.10 | 0.11 | +0.02 | buy |
| Clearbridge Investments, LLC | 0 | 312,445 | +312,445 | 0.00 | 0.02 | +0.02 | buy |
| COMERICA BANK | 244,754 | 301,661 | +56,907 | 0.05 | 0.07 | +0.02 | buy |
| UBS Group AG | 272,108 | 252,582 | -19,526 | 0.00 | 0.00 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 380,000 | 248,512 | -131,488 | 0.48 | 0.39 | -0.09 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 85,849 | 244,003 | +158,154 | 0.01 | 0.02 | +0.01 | buy |
| Qube Research & Technologies Ltd | 216,193 | 240,345 | +24,152 | 0.02 | 0.02 | +0.00 | buy |
| Assenagon Asset Management S.A. | 22,192 | 237,998 | +215,806 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 125,782 | 227,627 | +101,845 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 111,752 | 222,152 | +110,400 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 223,484 | 207,389 | -16,095 | 0.00 | 0.00 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 135,360 | 204,275 | +68,915 | 0.03 | 0.04 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 217,379 | 198,110 | -19,269 | 0.01 | 0.01 | +0.00 | sell |
| ROYAL BANK OF CANADA | 0 | 196,236 | +196,236 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 146,585 | 184,109 | +37,524 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 33,816 | 176,752 | +142,936 | 0.57 | 3.60 | +3.02 | buy |
| Artisan Partners Limited Partnership | 0 | 174,479 | +174,479 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 98,281 | 173,069 | +74,788 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 63,842 | 170,832 | +106,990 | 0.01 | 0.03 | +0.02 | buy |
| Russell Investments Group, Ltd. | 114,778 | 130,998 | +16,220 | 0.01 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 0 | 130,000 | +130,000 | 0.00 | 1.10 | +1.10 | buy |
| Nuveen, LLC | 147,301 | 121,855 | -25,446 | 0.00 | 0.00 | -0.00 | sell |
| Integral Health Asset Management, LLC | 0 | 120,000 | +120,000 | 0.00 | 0.71 | +0.71 | buy |
| PANAGORA ASSET MANAGEMENT INC | 141,162 | 119,466 | -21,696 | 0.04 | 0.03 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 50,557 | 115,118 | +64,561 | 0.01 | 0.03 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 86,066 | 102,239 | +16,173 | 0.00 | 0.01 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 103,202 | 99,445 | -3,757 | 0.01 | 0.01 | +0.00 | sell |
| PDT Partners, LLC | 102,195 | 97,638 | -4,557 | 0.38 | 0.35 | -0.04 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 93,105 | 95,517 | +2,412 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 89,300 | 90,600 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 85,719 | 87,526 | +1,807 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 77,297 | 86,546 | +9,249 | 0.19 | 0.23 | +0.04 | buy |
| Neuberger Berman Group LLC | 67,939 | 86,139 | +18,200 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 57,150 | 77,983 | +20,833 | 0.02 | 0.04 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 82,980 | 77,262 | -5,718 | 0.01 | 0.01 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 89,779 | 73,714 | -16,065 | 0.00 | 0.00 | -0.00 | sell |
| Cinctive Capital Management LP | 4,356 | 70,937 | +66,581 | 0.02 | 0.25 | +0.23 | buy |
| Invesco Ltd. | 261,902 | 68,924 | -192,978 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 64,386 | 68,132 | +3,746 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 108,129 | 67,657 | -40,472 | 0.01 | 0.01 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 173,822 | 64,577 | -109,245 | 0.12 | 0.04 | -0.08 | sell |
| ALLIANCEBERNSTEIN L.P. | 61,470 | 61,470 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALGERT GLOBAL LLC | 61,461 | 60,219 | -1,242 | 0.08 | 0.08 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,850 | 58,618 | +41,768 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 54,930 | 57,217 | +2,287 | 0.07 | 0.09 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 50,200 | 56,000 | +5,800 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 355,712 | 54,088 | -301,624 | 0.05 | 0.01 | -0.04 | sell |
| Legal & General Group Plc | 51,158 | 52,681 | +1,523 | 0.00 | 0.00 | +0.00 | buy |
| AXIOM INVESTORS LLC /DE | 0 | 52,460 | +52,460 | 0.00 | 0.03 | +0.03 | buy |
| Rafferty Asset Management, LLC | 57,732 | 51,611 | -6,121 | 0.01 | 0.01 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 89,622 | 51,079 | -38,543 | 0.21 | 0.13 | -0.08 | sell |
| Samsara BioCapital, LLC | 138,118 | 50,476 | -87,642 | 1.30 | 0.65 | -0.65 | sell |
| Nan Fung Group Holdings Ltd | 49,120 | 49,120 | 0 | 2.12 | 4.89 | +2.77 | hold |
| AQR CAPITAL MANAGEMENT LLC | 39,363 | 49,040 | +9,677 | 0.00 | 0.00 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 0 | 48,775 | +48,775 | 0.00 | 0.02 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 36,890 | 45,390 | +8,500 | 0.38 | 0.47 | +0.09 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,721 | 42,917 | +196 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 70,638 | 42,368 | -28,270 | 0.00 | 0.00 | -0.00 | sell |
| Granahan Investment Management, LLC | 0 | 41,172 | +41,172 | 0.00 | 0.11 | +0.11 | buy |
| DEUTSCHE BANK AG\ | 43,779 | 36,779 | -7,000 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 33,025 | 35,708 | +2,683 | 0.00 | 0.01 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 25,409 | 34,829 | +9,420 | 0.06 | 0.09 | +0.03 | buy |