| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Polar Capital Holdings Plc | 500,000 | 1,250,870 | +750,870 | 0.16 | 0.41 | +0.25 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,341,092 | 1,629,468 | +288,376 | 0.35 | 0.43 | +0.09 | buy |
| JANUS HENDERSON GROUP PLC | 1,655,350 | 1,411,902 | +243,448 | 0.05 | 0.04 | 0.00 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 817,700 | 1,017,700 | +200,000 | 0.09 | 0.11 | +0.02 | buy |
| Checkpoint Capital L.P. | 907,240 | 1,060,000 | +152,760 | 26.37 | 31.21 | +4.85 | buy |
| STEMPOINT CAPITAL LP | 33,816 | 176,752 | +142,936 | 0.57 | 3.60 | +3.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,199,053 | 1,341,392 | +142,339 | 0.01 | 0.01 | +0.00 | buy |
| Sofinnova Investments, Inc. | 446,839 | 586,010 | +139,171 | 1.55 | 2.26 | +0.72 | buy |
| Siren, L.L.C. | 277,533 | 409,742 | +132,209 | 0.83 | 1.34 | +0.51 | buy |
| LORD, ABBETT & CO. LLC | 135,360 | 204,275 | +68,915 | 0.03 | 0.04 | +0.02 | buy |
| Cinctive Capital Management LP | 4,356 | 70,937 | +66,581 | 0.02 | 0.25 | +0.23 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 50,557 | 115,118 | +64,561 | 0.01 | 0.03 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 337,605 | 400,772 | +63,167 | 3.74 | 5.18 | +1.45 | buy |
| Rock Springs Capital Management LP | 834,188 | 861,153 | +26,965 | 2.53 | 3.39 | +0.86 | buy |
| Candriam S.C.A. | 291,469 | 312,452 | +20,983 | 0.10 | 0.11 | +0.02 | buy |
| ALPS ADVISORS INC | 46,207 | 34,178 | +12,029 | 0.01 | 0.01 | 0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 77,297 | 86,546 | +9,249 | 0.19 | 0.23 | 0.00 | buy |
| ADAR1 Capital Management, LLC | 36,890 | 45,390 | +8,500 | 0.38 | 0.47 | +0.09 | buy |
| SummitTX Capital, L.P. | 17,343 | 25,452 | +8,109 | 0.04 | 0.07 | +0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 33,893 | 27,443 | +6,450 | 0.02 | 0.02 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 50,200 | 56,000 | +5,800 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 15,550 | 20,906 | +5,356 | 0.02 | 0.03 | +0.01 | buy |
| LAZARD ASSET MANAGEMENT LLC | 103,202 | 99,445 | +3,757 | 0.01 | 0.01 | 0.00 | sell |
| Advisors Asset Management, Inc. | 10,250 | 13,596 | +3,346 | 0.01 | 0.02 | 0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 54,930 | 57,217 | +2,287 | 0.07 | 0.09 | +0.02 | buy |
| ALGERT GLOBAL LLC | 61,461 | 60,219 | +1,242 | 0.08 | 0.08 | 0.00 | sell |
| ProShare Advisors LLC | 14,704 | 13,536 | +1,168 | 0.00 | 0.00 | 0.00 | sell |
| Avior Wealth Management, LLC | 4,589 | 5,635 | +1,046 | 0.01 | 0.01 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 6,446 | 7,052 | +606 | 0.09 | 0.15 | +0.06 | buy |
| E Fund Management Co., Ltd. | 5,396 | 5,761 | +365 | 0.01 | 0.02 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,682 | 12,778 | +96 | 0.06 | 0.08 | +0.01 | buy |
| Optiver Holding B.V. | 155 | 221 | +66 | 0.00 | 0.00 | 0.00 | buy |
| Atom Investors LP | 14,962 | 14,866 | -96 | 0.10 | 0.08 | -0.01 | sell |
| STRS OHIO | 18,500 | 17,400 | -1,100 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 12,444 | 11,254 | -1,190 | 0.03 | 0.03 | -0.00 | sell |
| Leo Wealth, LLC | 16,000 | 13,445 | -2,555 | 0.12 | 0.07 | -0.06 | sell |
| Bayforest Capital Ltd | 3,134 | 116 | -3,018 | 0.07 | 0.00 | -0.07 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 7,701 | 4,214 | -3,487 | 0.07 | 0.04 | -0.03 | sell |
| PDT Partners, LLC | 102,195 | 97,638 | -4,557 | 0.38 | 0.35 | -0.04 | sell |
| FIDUCIARY TRUST CO | 15,000 | 10,000 | -5,000 | 0.01 | 0.01 | -0.00 | sell |
| CIBC WORLD MARKETS CORP | 12,148 | 6,706 | -5,442 | 0.01 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 57,732 | 51,611 | -6,121 | 0.01 | 0.01 | -0.00 | sell |
| HighVista Strategies LLC | 35,039 | 28,068 | -6,971 | 0.72 | 0.65 | -0.06 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 36,984 | 29,991 | -6,993 | 0.04 | 0.03 | -0.00 | sell |
| LOOMIS SAYLES & CO L P | 605,764 | 591,454 | -14,310 | 0.05 | 0.05 | +0.00 | sell |
| Opaleye Management Inc. | 490,000 | 475,000 | -15,000 | 5.78 | 6.07 | +0.30 | sell |
| Hennion & Walsh Asset Management, Inc. | 89,622 | 51,079 | -38,543 | 0.21 | 0.13 | -0.08 | sell |
| Aberdeen Group plc | 108,129 | 67,657 | -40,472 | 0.01 | 0.01 | -0.00 | sell |
| Samsara BioCapital, LLC | 138,118 | 50,476 | -87,642 | 1.30 | 0.65 | -0.65 | sell |
| Hood River Capital Management LLC | 659,431 | 543,688 | -115,743 | 0.60 | 0.48 | -0.12 | sell |
| PERCEPTIVE ADVISORS LLC | 2,548,445 | 2,418,299 | -130,146 | 4.77 | 5.67 | +0.90 | sell |
| ORBIMED ADVISORS LLC | 380,000 | 248,512 | -131,488 | 0.48 | 0.39 | -0.09 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,458,022 | 1,269,952 | -188,070 | 0.74 | 0.64 | -0.10 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 6,084,412 | 5,561,359 | -523,053 | 5.38 | 5.92 | +0.54 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 5,787,322 | 4,878,037 | -909,285 | 0.25 | 0.24 | -0.01 | sell |