| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Polar Capital Holdings Plc | 500,000 | 1,250,870 | +750,870 | 0.16 | 0.41 | +0.25 | buy |
| JPMORGAN CHASE & CO | 143,640 | 783,559 | +639,919 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 514,381 | +514,381 | 0.00 | 0.17 | +0.17 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 341,000 | +341,000 | 0.00 | 0.04 | +0.04 | buy |
| Clearbridge Investments, LLC | 0 | 312,445 | +312,445 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 14,112 | 314,893 | +300,781 | 0.00 | 0.03 | +0.03 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,341,092 | 1,629,468 | +288,376 | 0.35 | 0.43 | +0.09 | buy |
| FMR LLC | 1,688,375 | 1,953,441 | +265,066 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 101,217 | 351,198 | +249,981 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 326,160 | 543,802 | +217,642 | 0.01 | 0.01 | +0.00 | buy |
| Assenagon Asset Management S.A. | 22,192 | 237,998 | +215,806 | 0.00 | 0.02 | +0.02 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 817,700 | 1,017,700 | +200,000 | 0.26 | 0.31 | +0.06 | buy |
| ROYAL BANK OF CANADA | 0 | 196,236 | +196,236 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 0 | 174,479 | +174,479 | 0.00 | 0.02 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 85,849 | 244,003 | +158,154 | 0.01 | 0.02 | +0.01 | buy |
| Pictet Asset Management Holding SA | 259,346 | 416,115 | +156,769 | 0.02 | 0.03 | +0.01 | buy |
| Checkpoint Capital L.P. | 907,240 | 1,060,000 | +152,760 | 26.37 | 31.21 | +4.85 | buy |
| VANGUARD GROUP INC | 3,444,926 | 3,589,114 | +144,188 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 33,816 | 176,752 | +142,936 | 0.57 | 3.60 | +3.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,199,053 | 1,341,392 | +142,339 | 0.01 | 0.01 | +0.00 | buy |
| Sofinnova Investments, Inc. | 446,839 | 586,010 | +139,171 | 1.78 | 2.52 | +0.73 | buy |
| Siren, L.L.C. | 277,533 | 409,742 | +132,209 | 0.83 | 1.34 | +0.51 | buy |
| Logos Global Management LP | 0 | 130,000 | +130,000 | 0.00 | 1.10 | +1.10 | buy |
| Integral Health Asset Management, LLC | 0 | 120,000 | +120,000 | 0.00 | 0.71 | +0.71 | buy |
| BANK OF AMERICA CORP /DE/ | 111,752 | 222,152 | +110,400 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 63,842 | 170,832 | +106,990 | 0.01 | 0.03 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 125,782 | 227,627 | +101,845 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,637,908 | 1,733,722 | +95,814 | 0.02 | 0.02 | +0.00 | buy |
| FEDERATED HERMES, INC. | 1,591,871 | 1,686,494 | +94,623 | 0.18 | 0.20 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 98,281 | 173,069 | +74,788 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 135,360 | 204,275 | +68,915 | 0.03 | 0.04 | +0.02 | buy |
| Cinctive Capital Management LP | 4,356 | 70,937 | +66,581 | 0.02 | 0.25 | +0.23 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 50,557 | 115,118 | +64,561 | 0.01 | 0.03 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 337,605 | 400,772 | +63,167 | 3.74 | 5.18 | +1.45 | buy |
| COMERICA BANK | 244,754 | 301,661 | +56,907 | 0.05 | 0.07 | +0.02 | buy |
| AXIOM INVESTORS LLC /DE | 0 | 52,460 | +52,460 | 0.00 | 0.03 | +0.03 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 0 | 48,775 | +48,775 | 0.00 | 0.02 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,850 | 58,618 | +41,768 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 0 | 41,172 | +41,172 | 0.00 | 0.11 | +0.11 | buy |
| Bank of New York Mellon Corp | 146,585 | 184,109 | +37,524 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 834,188 | 861,153 | +26,965 | 2.53 | 3.39 | +0.86 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 24,666 | +24,666 | 0.00 | 0.06 | +0.06 | buy |
| Qube Research & Technologies Ltd | 216,193 | 240,345 | +24,152 | 0.02 | 0.02 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,287,168 | 1,311,253 | +24,085 | 0.01 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 291,469 | 312,452 | +20,983 | 0.10 | 0.11 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 57,150 | 77,983 | +20,833 | 0.02 | 0.04 | +0.02 | buy |
| MORGAN STANLEY | 504,049 | 524,480 | +20,431 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 67,939 | 86,139 | +18,200 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 114,778 | 130,998 | +16,220 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 86,066 | 102,239 | +16,173 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 445,429 | 461,438 | +16,009 | 0.00 | 0.01 | +0.00 | buy |
| Harvest Investment Services, LLC | 0 | 15,466 | +15,466 | 0.00 | 0.22 | +0.22 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 10,546 | +10,546 | 0.00 | 0.00 | +0.00 | buy |
| TOTH FINANCIAL ADVISORY CORP | 0 | 10,000 | +10,000 | 0.00 | 0.07 | +0.07 | buy |
| AQR CAPITAL MANAGEMENT LLC | 39,363 | 49,040 | +9,677 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 25,409 | 34,829 | +9,420 | 0.06 | 0.09 | +0.03 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 77,297 | 86,546 | +9,249 | 0.19 | 0.23 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 36,890 | 45,390 | +8,500 | 0.38 | 0.47 | +0.09 | buy |
| E. Ohman J:or Asset Management AB | 0 | 8,213 | +8,213 | 0.00 | 0.01 | +0.01 | buy |
| SummitTX Capital, L.P. | 17,343 | 25,452 | +8,109 | 0.04 | 0.07 | +0.03 | buy |
| Caption Management, LLC | 0 | 7,540 | +7,540 | 0.00 | 0.04 | +0.04 | buy |
| Point72 (DIFC) Ltd | 6,653 | 13,149 | +6,496 | 0.03 | 0.07 | +0.03 | buy |
| Allianz Asset Management GmbH | 6,100 | 12,100 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 50,200 | 56,000 | +5,800 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 15,550 | 20,906 | +5,356 | 0.02 | 0.03 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 1,058 | 6,111 | +5,053 | 0.00 | 0.01 | +0.01 | buy |
| Creative Planning | 12,333 | 17,222 | +4,889 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 4,560 | +4,560 | 0.00 | 0.09 | +0.09 | buy |
| Savant Capital, LLC | 0 | 4,382 | +4,382 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 3,908 | +3,908 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 3,872 | +3,872 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 64,386 | 68,132 | +3,746 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Capital Holdings, LLC | 0 | 3,700 | +3,700 | 0.00 | 0.01 | +0.01 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 0 | 3,476 | +3,476 | 0.00 | 0.00 | +0.00 | buy |
| Advisors Asset Management, Inc. | 10,250 | 13,596 | +3,346 | 0.01 | 0.02 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 4,355 | 7,095 | +2,740 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 33,025 | 35,708 | +2,683 | 0.00 | 0.01 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 93,105 | 95,517 | +2,412 | 0.01 | 0.01 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 54,930 | 57,217 | +2,287 | 0.07 | 0.09 | +0.02 | buy |
| RHUMBLINE ADVISERS | 85,719 | 87,526 | +1,807 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 51,158 | 52,681 | +1,523 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 89,300 | 90,600 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 1,065 | +1,065 | 0.00 | 0.01 | +0.01 | buy |
| Avior Wealth Management, LLC | 4,589 | 5,635 | +1,046 | 0.01 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 5,069 | 6,097 | +1,028 | 0.02 | 0.03 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 4,518 | 5,540 | +1,022 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 979 | +979 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 9,300 | 10,200 | +900 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 32,381 | 33,145 | +764 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,926 | 9,652 | +726 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 11,655 | 12,359 | +704 | 0.01 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 13,181 | 13,834 | +653 | 0.00 | 0.01 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 6,446 | 7,052 | +606 | 0.09 | 0.15 | +0.06 | buy |
| LPL Financial LLC | 4,214 | 4,805 | +591 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 590 | +590 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 2,584 | 3,091 | +507 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 421 | +421 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 12,404 | 12,772 | +368 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 5,396 | 5,761 | +365 | 0.01 | 0.02 | +0.00 | buy |