| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 6,666,837 | 6,666,837 | 0 | 6.14 | 6.43 | +0.29 | hold |
| BlackRock, Inc. | 6,237,151 | 6,156,902 | -80,249 | 0.01 | 0.01 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 5,604,483 | 5,604,483 | 0 | 2.80 | 3.12 | +0.32 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 3,417,509 | 3,168,853 | -248,656 | 0.23 | 0.21 | -0.03 | sell |
| JPMORGAN CHASE & CO | 1,553,644 | 2,652,746 | +1,099,102 | 0.01 | 0.02 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 2,373,795 | 2,586,295 | +212,500 | 4.08 | 4.46 | +0.38 | buy |
| STATE STREET CORP | 2,271,851 | 2,573,529 | +301,678 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,654,876 | 2,566,171 | +911,295 | 0.02 | 0.03 | +0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,929,123 | 2,208,595 | +279,472 | 0.70 | 0.80 | +0.10 | buy |
| GOLDMAN SACHS GROUP INC | 1,965,432 | 2,126,502 | +161,070 | 0.02 | 0.02 | +0.00 | buy |
| FEDERATED HERMES, INC. | 1,286,303 | 1,785,716 | +499,413 | 0.18 | 0.29 | +0.10 | buy |
| Polar Capital Holdings Plc | 1,615,586 | 1,663,632 | +48,046 | 0.61 | 0.52 | -0.09 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,416,269 | 1,533,698 | +117,429 | 0.01 | 0.01 | +0.00 | buy |
| Capital Research Global Investors | 1,115,460 | 1,532,303 | +416,843 | 0.02 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 1,418,619 | 1,263,652 | -154,967 | 0.09 | 0.08 | -0.01 | sell |
| Checkpoint Capital L.P. | 1,227,200 | 1,186,000 | -41,200 | 38.30 | 33.79 | -4.52 | sell |
| Siren, L.L.C. | 725,511 | 1,136,275 | +410,764 | 1.75 | 2.56 | +0.81 | buy |
| MORGAN STANLEY | 703,978 | 1,112,240 | +408,262 | 0.00 | 0.01 | +0.00 | buy |
| FMR LLC | 1,689,671 | 1,025,840 | -663,831 | 0.01 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 667,046 | 957,785 | +290,739 | 0.06 | 0.10 | +0.04 | buy |
| ALLIANCEBERNSTEIN L.P. | 910,413 | 894,723 | -15,690 | 0.03 | 0.03 | -0.01 | sell |
| Woodline Partners LP | 758,891 | 758,891 | 0 | 0.25 | 0.26 | +0.01 | hold |
| Clearbridge Investments, LLC | 609,437 | 696,473 | +87,036 | 0.05 | 0.06 | +0.02 | buy |
| Rock Springs Capital Management LP | 689,748 | 692,598 | +2,850 | 3.54 | 3.75 | +0.22 | buy |
| NORGES BANK | 0 | 685,844 | +685,844 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 626,845 | 577,033 | -49,812 | 0.01 | 0.01 | +0.00 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 552,738 | +552,738 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 526,459 | 552,738 | +26,279 | 0.01 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 600,000 | 550,000 | -50,000 | 2.76 | 2.51 | -0.26 | sell |
| Invesco Ltd. | 364,306 | 543,271 | +178,965 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 498,514 | 540,332 | +41,818 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 541,450 | 514,850 | -26,600 | 0.01 | 0.01 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 273,757 | 488,747 | +214,990 | 0.00 | 0.01 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 465,102 | 434,102 | -31,000 | 0.05 | 0.06 | +0.01 | sell |
| Candriam S.C.A. | 464,340 | 433,025 | -31,315 | 0.21 | 0.22 | +0.01 | sell |
| Squarepoint Ops LLC | 262,968 | 422,921 | +159,953 | 0.05 | 0.09 | +0.04 | buy |
| Point72 Asset Management, L.P. | 846,801 | 414,210 | -432,591 | 0.13 | 0.07 | -0.06 | sell |
| Sofinnova Investments, Inc. | 450,096 | 408,027 | -42,069 | 1.96 | 2.42 | +0.46 | sell |
| AMERIPRISE FINANCIAL INC | 383,957 | 401,634 | +17,677 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 725,744 | 397,000 | -328,744 | 0.10 | 0.06 | -0.04 | sell |
| Bank of New York Mellon Corp | 293,298 | 394,044 | +100,746 | 0.00 | 0.01 | +0.00 | buy |
| BRAIDWELL LP | 310,628 | 381,128 | +70,500 | 0.90 | 1.57 | +0.66 | buy |
| Artisan Partners Limited Partnership | 390,669 | 354,816 | -35,853 | 0.06 | 0.06 | +0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 628,667 | 325,470 | -303,197 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 314,100 | 322,900 | +8,800 | 0.60 | 0.68 | +0.08 | buy |
| MILLENNIUM MANAGEMENT LLC | 451,825 | 316,719 | -135,106 | 0.03 | 0.02 | -0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 306,000 | 311,461 | +5,461 | 3.14 | 3.85 | +0.71 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 233,810 | 272,974 | +39,164 | 0.02 | 0.03 | +0.01 | buy |
| Capital World Investors | 115,693 | 221,450 | +105,757 | 0.00 | 0.00 | +0.00 | buy |
| Duquesne Family Office LLC | 0 | 203,618 | +203,618 | 0.00 | 0.52 | +0.52 | buy |
| Nuveen, LLC | 117,376 | 203,078 | +85,702 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 247,876 | 197,374 | -50,502 | 0.01 | 0.01 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 65,818 | 193,215 | +127,397 | 0.12 | 0.38 | +0.26 | buy |
| Assenagon Asset Management S.A. | 0 | 186,491 | +186,491 | 0.00 | 0.03 | +0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 131,674 | 160,518 | +28,844 | 0.01 | 0.01 | +0.00 | buy |
| First Turn Management, LLC | 0 | 154,018 | +154,018 | 0.00 | 1.83 | +1.83 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 125,207 | 148,152 | +22,945 | 0.02 | 0.02 | +0.01 | buy |
| UBS Group AG | 231,650 | 144,378 | -87,272 | 0.00 | 0.00 | -0.00 | sell |
| Nicholas Investment Partners, LP | 0 | 139,270 | +139,270 | 0.00 | 0.87 | +0.87 | buy |
| ADAR1 Capital Management, LLC | 211,450 | 136,158 | -75,292 | 1.11 | 0.71 | -0.39 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 151,842 | 135,867 | -15,975 | 0.03 | 0.03 | -0.00 | sell |
| Qube Research & Technologies Ltd | 277,943 | 134,410 | -143,533 | 0.03 | 0.02 | -0.02 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 436,546 | 129,285 | -307,261 | 0.28 | 0.08 | -0.20 | sell |
| SummitTX Capital, L.P. | 165,599 | 126,401 | -39,198 | 0.46 | 0.37 | -0.09 | sell |
| Logos Global Management LP | 450,000 | 125,000 | -325,000 | 2.02 | 0.60 | -1.42 | sell |
| Opaleye Management Inc. | 123,000 | 122,500 | -500 | 4.65 | 1.23 | -3.42 | sell |
| SEGALL BRYANT & HAMILL, LLC | 0 | 121,866 | +121,866 | 0.00 | 0.16 | +0.16 | buy |
| DEUTSCHE BANK AG\ | 141,601 | 115,232 | -26,369 | 0.00 | 0.00 | -0.00 | sell |
| Longaeva Partners L.P. | 0 | 110,074 | +110,074 | 0.00 | 0.35 | +0.35 | buy |
| Swiss National Bank | 112,200 | 109,700 | -2,500 | 0.01 | 0.01 | +0.00 | sell |
| PFM Health Sciences, LP | 136,621 | 101,550 | -35,071 | 1.25 | 0.98 | -0.27 | sell |
| Aberdeen Group plc | 79,357 | 94,946 | +15,589 | 0.01 | 0.01 | +0.00 | buy |
| AXIOM INVESTORS LLC /DE | 91,749 | 86,880 | -4,869 | 0.09 | 0.08 | -0.01 | sell |
| Russell Investments Group, Ltd. | 115,712 | 86,548 | -29,164 | 0.01 | 0.01 | -0.00 | sell |
| First Light Asset Management, LLC | 87,181 | 85,765 | -1,416 | 0.68 | 0.58 | -0.10 | sell |
| ALGERT GLOBAL LLC | 58,513 | 83,431 | +24,918 | 0.08 | 0.11 | +0.03 | buy |
| Granahan Investment Management, LLC | 77,709 | 83,270 | +5,561 | 0.33 | 0.33 | +0.00 | buy |
| Neuberger Berman Group LLC | 73,434 | 83,035 | +9,601 | 0.00 | 0.01 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 80,620 | 80,552 | -68 | 0.01 | 0.02 | +0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 80,400 | +80,400 | 0.00 | 1.28 | +1.28 | buy |
| Atom Investors LP | 57,000 | 73,465 | +16,465 | 0.35 | 0.73 | +0.37 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 46,887 | 73,432 | +26,545 | 0.03 | 0.05 | +0.02 | buy |
| RHUMBLINE ADVISERS | 69,858 | 73,333 | +3,475 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 34,108 | 72,147 | +38,039 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 30,190 | 69,145 | +38,955 | 0.00 | 0.01 | +0.01 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 68,548 | +68,548 | 0.00 | 0.05 | +0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 258,011 | 68,281 | -189,730 | 0.04 | 0.01 | -0.02 | sell |
| PICTON MAHONEY ASSET MANAGEMENT | 50,372 | 65,880 | +15,508 | 0.05 | 0.07 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 65,806 | 64,031 | -1,775 | 0.01 | 0.01 | +0.00 | sell |
| Blue Owl Capital Holdings LP | 61,455 | 61,455 | 0 | 1.44 | 1.04 | -0.40 | hold |
| ExodusPoint Capital Management, LP | 17,775 | 61,147 | +43,372 | 0.02 | 0.06 | +0.05 | buy |
| AQR CAPITAL MANAGEMENT LLC | 59,279 | 59,208 | -71 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 12,336 | 58,347 | +46,011 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 49,920 | 58,069 | +8,149 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 50,769 | 57,170 | +6,401 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 56,248 | +56,248 | 0.00 | 0.04 | +0.04 | buy |
| Man Group plc | 4,022 | 50,788 | +46,766 | 0.00 | 0.01 | +0.01 | buy |
| Nan Fung Group Holdings Ltd | 49,120 | 49,120 | 0 | 3.52 | 4.15 | +0.62 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 47,400 | +47,400 | 0.00 | 0.00 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 40,300 | 44,000 | +3,700 | 0.10 | 0.11 | +0.02 | buy |