| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 22,993 | 274,524 | +251,531 | 0.00 | 0.08 | +0.08 | buy |
| Cormorant Asset Management, LP | 600,000 | 850,000 | +250,000 | 0.56 | 1.14 | +0.57 | buy |
| Polar Capital Holdings Plc | 2,250,000 | 2,500,000 | +250,000 | 0.25 | 0.43 | +0.17 | buy |
| BAKER BROS. ADVISORS LP | 6,498,267 | 6,702,349 | +204,082 | 0.62 | 0.89 | +0.27 | buy |
| Frazier Life Sciences Management, L.P. | 2,167,222 | 2,371,304 | +204,082 | 2.13 | 3.61 | +1.48 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 116,168 | 260,537 | +144,369 | 0.65 | 2.23 | +1.58 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 58,119 | 131,662 | +73,543 | 0.00 | 0.02 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 68,564 | 16,465 | +52,099 | 0.12 | 0.04 | 0.00 | sell |
| ALGERT GLOBAL LLC | 59,093 | 33,413 | +25,680 | 0.04 | 0.04 | 0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 21,183 | 40,146 | +18,963 | 0.02 | 0.06 | +0.04 | buy |
| JANUS HENDERSON GROUP PLC | 1,078,207 | 1,065,745 | +12,462 | 0.01 | 0.02 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 745 | 1,458 | +713 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 41,793 | 41,951 | +158 | 0.01 | 0.01 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 158,959 | 157,426 | -1,533 | 0.15 | 0.23 | +0.08 | sell |
| VIRTUS ADVISERS, LLC | 19,414 | 17,193 | -2,221 | 0.19 | 0.24 | +0.05 | sell |
| PROFUND ADVISORS LLC | 47,080 | 27,818 | -19,262 | 0.04 | 0.04 | -0.01 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 8,299,317 | 8,267,421 | -31,896 | 0.11 | 0.16 | +0.05 | sell |
| Opaleye Management Inc. | 735,000 | 653,000 | -82,000 | 2.90 | 4.87 | +1.97 | sell |
| Rafferty Asset Management, LLC | 259,344 | 162,804 | -96,540 | 0.02 | 0.02 | -0.00 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 218,425 | 104,720 | -113,705 | 0.06 | 0.05 | -0.01 | sell |