| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CANADA PENSION PLAN INVESTMENT BOARD | 417,000 | 67,000 | +350,000 | 0.02 | 0.00 | 0.00 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 1,000,000 | 1,167,700 | +167,700 | 0.07 | 0.10 | +0.04 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 967,243 | 1,111,043 | +143,800 | 0.11 | 0.14 | +0.02 | buy |
| Candriam S.C.A. | 271,398 | 395,377 | +123,979 | 0.07 | 0.12 | +0.05 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,182,370 | 1,299,490 | +117,120 | 0.47 | 0.58 | +0.11 | buy |
| PERCEPTIVE ADVISORS LLC | 3,446,579 | 3,560,214 | +113,635 | 3.41 | 3.95 | +0.54 | buy |
| Woodline Partners LP | 44,247 | 143,823 | +99,576 | 0.02 | 0.06 | +0.05 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 184,662 | 255,578 | +70,916 | 1.87 | 3.02 | +1.15 | buy |
| JGP Global Gestao de Recursos Ltda. | 5,814 | 56,378 | +50,564 | 0.30 | 5.76 | +5.46 | buy |
| ALGERT GLOBAL LLC | 104,132 | 54,171 | +49,961 | 0.15 | 0.08 | 0.00 | sell |
| Frazier Life Sciences Management, L.P. | 2,371,304 | 2,416,952 | +45,648 | 4.55 | 5.08 | +0.52 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 525,942 | 550,530 | +24,588 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 14,362 | 37,426 | +23,064 | 0.22 | 0.68 | +0.46 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 34,627 | 41,368 | +6,741 | 0.11 | 0.09 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,163 | 11,758 | +4,595 | 0.04 | 0.07 | +0.03 | buy |
| Hennion & Walsh Asset Management, Inc. | 96,378 | 100,961 | +4,583 | 0.20 | 0.25 | +0.04 | buy |
| JANUS HENDERSON GROUP PLC | 593,642 | 598,122 | +4,480 | 0.01 | 0.02 | 0.00 | buy |
| Bellevue Group AG | 13,000 | 15,700 | +2,700 | 0.01 | 0.01 | +0.00 | buy |
| Quantinno Capital Management LP | 18,120 | 16,120 | +2,000 | 0.01 | 0.01 | 0.00 | sell |
| PROFUND ADVISORS LLC | 13,975 | 13,358 | +617 | 0.02 | 0.03 | 0.00 | sell |
| CASTLEARK MANAGEMENT LLC | 19,010 | 19,260 | +250 | 0.03 | 0.04 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 102,591 | 102,646 | +55 | 0.01 | 0.02 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 6,398,365 | 6,398,366 | +1 | 3.36 | 3.47 | +0.12 | buy |
| PDT Partners, LLC | 11,510 | 11,500 | -10 | 0.04 | 0.05 | +0.01 | sell |
| Chicago Partners Investment Group LLC | 4,797 | 4,725 | -72 | 0.01 | 0.01 | -0.00 | sell |
| Clearbridge Investments, LLC | 88,108 | 87,424 | -684 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 72,562 | 64,576 | -7,986 | 0.01 | 0.01 | +0.00 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 63,197 | 48,844 | -14,353 | 0.05 | 0.04 | -0.00 | sell |
| Opaleye Management Inc. | 515,000 | 500,000 | -15,000 | 4.83 | 4.37 | -0.46 | sell |
| NATIXIS | 43,951 | 11,187 | -32,764 | 0.01 | 0.00 | -0.01 | sell |
| Rock Springs Capital Management LP | 1,280,493 | 1,228,093 | -52,400 | 1.58 | 2.09 | +0.51 | sell |
| Cormorant Asset Management, LP | 475,000 | 400,000 | -75,000 | 1.13 | 1.11 | -0.02 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 7,312,391 | 7,216,911 | -95,480 | 0.22 | 0.28 | +0.06 | sell |
| Checkpoint Capital L.P. | 922,100 | 663,381 | -258,719 | 22.82 | 17.24 | -5.58 | sell |
| ORBIMED ADVISORS LLC | 704,842 | 435,900 | -268,942 | 0.58 | 0.42 | -0.16 | sell |
| Commodore Capital LP | 1,225,000 | 650,000 | -575,000 | 3.43 | 2.13 | -1.31 | sell |