| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRIMECAP MANAGEMENT CO/CA/ | 7,312,391 | 7,216,911 | -95,480 | 0.22 | 0.28 | +0.06 | sell |
| BAKER BROS. ADVISORS LP | 6,398,365 | 6,398,366 | +1 | 3.36 | 3.47 | +0.12 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 6,084,412 | 6,084,412 | 0 | 3.30 | 3.68 | +0.37 | hold |
| GOLDMAN SACHS GROUP INC | 5,288,635 | 3,879,796 | -1,408,839 | 0.04 | 0.04 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 3,446,579 | 3,560,214 | +113,635 | 3.42 | 4.00 | +0.59 | buy |
| VANGUARD GROUP INC | 3,360,695 | 3,447,911 | +87,216 | 0.00 | 0.00 | +0.00 | buy |
| NEA Management Company, LLC | 2,909,956 | 2,909,956 | 0 | 8.99 | 8.31 | -0.68 | hold |
| Frazier Life Sciences Management, L.P. | 2,371,304 | 2,416,952 | +45,648 | 4.55 | 5.08 | +0.52 | buy |
| STATE STREET CORP | 2,003,882 | 1,993,166 | -10,716 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 1,660,784 | 1,663,900 | +3,116 | 0.16 | 0.19 | +0.03 | buy |
| Polar Capital Holdings Plc | 1,500,000 | 1,500,000 | 0 | 0.36 | 0.38 | +0.01 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,182,370 | 1,299,490 | +117,120 | 0.47 | 0.58 | +0.11 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,252,689 | 1,256,188 | +3,499 | 0.00 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,280,493 | 1,228,093 | -52,400 | 1.59 | 2.09 | +0.51 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 1,000,000 | 1,167,700 | +167,700 | 0.21 | 0.34 | +0.12 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 967,243 | 1,111,043 | +143,800 | 0.12 | 0.14 | +0.02 | buy |
| Checkpoint Capital L.P. | 922,100 | 663,381 | -258,719 | 22.82 | 17.24 | -5.58 | sell |
| Commodore Capital LP | 1,225,000 | 650,000 | -575,000 | 3.43 | 2.13 | -1.31 | sell |
| LOOMIS SAYLES & CO L P | 0 | 636,628 | +636,628 | 0.00 | 0.04 | +0.04 | buy |
| Hood River Capital Management LLC | 0 | 614,598 | +614,598 | 0.00 | 0.52 | +0.52 | buy |
| JANUS HENDERSON GROUP PLC | 593,642 | 598,122 | +4,480 | 0.01 | 0.02 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 525,942 | 550,530 | +24,588 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 515,000 | 500,000 | -15,000 | 4.83 | 4.37 | -0.46 | sell |
| NORTHERN TRUST CORP | 499,448 | 498,466 | -982 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 475,651 | 464,604 | -11,047 | 0.00 | 0.00 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 704,842 | 435,900 | -268,942 | 0.58 | 0.42 | -0.16 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 427,958 | 433,866 | +5,908 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 106,809 | 406,615 | +299,806 | 0.01 | 0.03 | +0.02 | buy |
| Cormorant Asset Management, LP | 475,000 | 400,000 | -75,000 | 1.13 | 1.11 | -0.02 | sell |
| Candriam S.C.A. | 271,398 | 395,377 | +123,979 | 0.07 | 0.12 | +0.05 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 462,188 | 353,323 | -108,865 | 0.07 | 0.07 | -0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 404,242 | 341,507 | -62,735 | 0.03 | 0.02 | -0.00 | sell |
| Pictet Asset Management Holding SA | 801,796 | 329,339 | -472,457 | 0.04 | 0.02 | -0.02 | sell |
| Sofinnova Investments, Inc. | 0 | 276,678 | +276,678 | 0.00 | 1.20 | +1.20 | buy |
| Invesco Ltd. | 276,700 | 264,417 | -12,283 | 0.00 | 0.00 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 232,677 | 259,416 | +26,739 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 184,662 | 255,578 | +70,916 | 1.87 | 3.02 | +1.15 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 236,431 | 225,373 | -11,058 | 0.00 | 0.00 | +0.00 | sell |
| Samsara BioCapital, LLC | 172,647 | 172,647 | 0 | 1.48 | 1.74 | +0.25 | hold |
| Bank of New York Mellon Corp | 191,871 | 148,926 | -42,945 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 44,247 | 143,823 | +99,576 | 0.02 | 0.06 | +0.05 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 136,950 | +136,950 | 0.00 | 0.06 | +0.06 | buy |
| Aberdeen Group plc | 112,804 | 112,804 | 0 | 0.01 | 0.01 | +0.00 | hold |
| JANE STREET GROUP, LLC | 146,500 | 109,186 | -37,314 | 0.01 | 0.01 | +0.00 | sell |
| BARCLAYS PLC | 53,631 | 106,397 | +52,766 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 92,043 | 106,250 | +14,207 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 37,811 | 102,832 | +65,021 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 102,778 | +102,778 | 0.00 | 0.01 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 102,591 | 102,646 | +55 | 0.01 | 0.02 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 96,378 | 100,961 | +4,583 | 0.20 | 0.25 | +0.04 | buy |
| Swiss National Bank | 88,700 | 89,300 | +600 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 88,108 | 87,424 | -684 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 140,146 | 81,592 | -58,554 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 83,063 | 80,714 | -2,349 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 65,942 | 76,634 | +10,692 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 91,010 | 70,762 | -20,248 | 0.00 | 0.00 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 417,000 | 67,000 | -350,000 | 0.02 | 0.00 | -0.01 | sell |
| NORGES BANK | 43,238 | 66,276 | +23,038 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 374,347 | 66,240 | -308,107 | 0.10 | 0.02 | -0.08 | sell |
| Rafferty Asset Management, LLC | 72,562 | 64,576 | -7,986 | 0.01 | 0.01 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 61,070 | 59,570 | -1,500 | 0.00 | 0.00 | +0.00 | sell |
| JGP Global Gestao de Recursos Ltda. | 5,814 | 56,378 | +50,564 | 0.30 | 5.78 | +5.48 | buy |
| ALGERT GLOBAL LLC | 104,132 | 54,171 | -49,961 | 0.14 | 0.08 | -0.07 | sell |
| Legal & General Group Plc | 49,771 | 50,852 | +1,081 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 27,989 | 50,295 | +22,306 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 49,120 | 49,120 | 0 | 2.15 | 2.22 | +0.07 | hold |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 63,197 | 48,844 | -14,353 | 0.05 | 0.04 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 49,291 | 48,703 | -588 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,757 | 43,916 | -841 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 40,415 | 41,887 | +1,472 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 34,627 | 41,368 | +6,741 | 0.11 | 0.09 | -0.01 | buy |
| STEMPOINT CAPITAL LP | 0 | 41,268 | +41,268 | 0.00 | 0.65 | +0.65 | buy |
| CITIGROUP INC | 19,992 | 41,197 | +21,205 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 14,362 | 37,426 | +23,064 | 0.22 | 0.68 | +0.46 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 36,977 | +36,977 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 26,060 | 33,264 | +7,204 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 103,830 | 32,809 | -71,021 | 0.01 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 9,532 | 32,586 | +23,054 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,391 | 32,502 | +2,111 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 39,427 | 32,453 | -6,974 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 31,000 | 31,800 | +800 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 31,652 | 31,652 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Schonfeld Strategic Advisors LLC | 10,921 | 30,535 | +19,614 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 29,535 | 29,474 | -61 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 29,454 | 29,274 | -180 | 0.01 | 0.01 | +0.00 | sell |
| SEI INVESTMENTS CO | 7,370 | 29,021 | +21,651 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 202,326 | 27,716 | -174,610 | 0.00 | 0.00 | -0.00 | sell |
| Penserra Capital Management LLC | 0 | 25,063 | +25,063 | 0.00 | 0.03 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,125 | 21,481 | -2,644 | 0.00 | 0.00 | +0.00 | sell |
| Assenagon Asset Management S.A. | 229,491 | 20,052 | -209,439 | 0.02 | 0.00 | -0.02 | sell |
| FIDUCIARY TRUST CO | 20,000 | 20,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| STIFEL FINANCIAL CORP | 28,058 | 19,842 | -8,216 | 0.00 | 0.00 | -0.00 | sell |
| Handelsbanken Fonder AB | 15,921 | 19,321 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 19,010 | 19,260 | +250 | 0.03 | 0.04 | +0.01 | buy |
| Crestline Management, LP | 0 | 18,998 | +18,998 | 0.00 | 0.06 | +0.06 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 7,049 | 18,186 | +11,137 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 18,000 | +18,000 | 0.00 | 0.02 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 17,659 | 17,659 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 20,399 | 17,560 | -2,839 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 32,855 | 16,850 | -16,005 | 0.00 | 0.00 | -0.00 | sell |