| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LOOMIS SAYLES & CO L P | 0 | 636,628 | +636,628 | 0.00 | 0.04 | +0.04 | buy |
| Hood River Capital Management LLC | 0 | 614,598 | +614,598 | 0.00 | 0.52 | +0.52 | buy |
| MARSHALL WACE, LLP | 106,809 | 406,615 | +299,806 | 0.01 | 0.03 | +0.02 | buy |
| Sofinnova Investments, Inc. | 0 | 276,678 | +276,678 | 0.00 | 1.20 | +1.20 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 1,000,000 | 1,167,700 | +167,700 | 0.21 | 0.34 | +0.12 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 967,243 | 1,111,043 | +143,800 | 0.12 | 0.14 | +0.02 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 136,950 | +136,950 | 0.00 | 0.06 | +0.06 | buy |
| Candriam S.C.A. | 271,398 | 395,377 | +123,979 | 0.07 | 0.12 | +0.05 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,182,370 | 1,299,490 | +117,120 | 0.47 | 0.58 | +0.11 | buy |
| PERCEPTIVE ADVISORS LLC | 3,446,579 | 3,560,214 | +113,635 | 3.42 | 4.00 | +0.59 | buy |
| CITADEL ADVISORS LLC | 0 | 102,778 | +102,778 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 44,247 | 143,823 | +99,576 | 0.02 | 0.06 | +0.05 | buy |
| VANGUARD GROUP INC | 3,360,695 | 3,447,911 | +87,216 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 184,662 | 255,578 | +70,916 | 1.87 | 3.02 | +1.15 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 37,811 | 102,832 | +65,021 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 53,631 | 106,397 | +52,766 | 0.00 | 0.00 | +0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 5,814 | 56,378 | +50,564 | 0.30 | 5.78 | +5.48 | buy |
| Frazier Life Sciences Management, L.P. | 2,371,304 | 2,416,952 | +45,648 | 4.55 | 5.08 | +0.52 | buy |
| STEMPOINT CAPITAL LP | 0 | 41,268 | +41,268 | 0.00 | 0.65 | +0.65 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 36,977 | +36,977 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 232,677 | 259,416 | +26,739 | 0.00 | 0.00 | +0.00 | buy |
| Penserra Capital Management LLC | 0 | 25,063 | +25,063 | 0.00 | 0.03 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 525,942 | 550,530 | +24,588 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 14,362 | 37,426 | +23,064 | 0.22 | 0.68 | +0.46 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 9,532 | 32,586 | +23,054 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 43,238 | 66,276 | +23,038 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 27,989 | 50,295 | +22,306 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 7,370 | 29,021 | +21,651 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 19,992 | 41,197 | +21,205 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 10,921 | 30,535 | +19,614 | 0.00 | 0.01 | +0.01 | buy |
| Crestline Management, LP | 0 | 18,998 | +18,998 | 0.00 | 0.06 | +0.06 | buy |
| Jefferies Financial Group Inc. | 0 | 18,000 | +18,000 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 92,043 | 106,250 | +14,207 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 13,716 | +13,716 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 12,386 | +12,386 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 7,049 | 18,186 | +11,137 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,543 | 14,425 | +10,882 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 65,942 | 76,634 | +10,692 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 8,594 | +8,594 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 1,662 | 9,167 | +7,505 | 0.01 | 0.04 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 26,060 | 33,264 | +7,204 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 34,627 | 41,368 | +6,741 | 0.11 | 0.09 | -0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 427,958 | 433,866 | +5,908 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 4,858 | +4,858 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,163 | 11,758 | +4,595 | 0.04 | 0.07 | +0.03 | buy |
| Hennion & Walsh Asset Management, Inc. | 96,378 | 100,961 | +4,583 | 0.20 | 0.25 | +0.04 | buy |
| JANUS HENDERSON GROUP PLC | 593,642 | 598,122 | +4,480 | 0.01 | 0.02 | +0.00 | buy |
| Ameritas Advisory Services, LLC | 0 | 4,416 | +4,416 | 0.00 | 0.01 | +0.01 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 4,343 | +4,343 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 4,294 | +4,294 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 4,259 | +4,259 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 4,184 | +4,184 | 0.00 | 0.02 | +0.02 | buy |
| E Fund Management Co., Ltd. | 0 | 4,149 | +4,149 | 0.00 | 0.01 | +0.01 | buy |
| Allianz Asset Management GmbH | 0 | 4,100 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 8,900 | 12,800 | +3,900 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,252,689 | 1,256,188 | +3,499 | 0.00 | 0.01 | +0.00 | buy |
| Handelsbanken Fonder AB | 15,921 | 19,321 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 11,920 | 15,057 | +3,137 | 0.01 | 0.02 | +0.01 | buy |
| FEDERATED HERMES, INC. | 1,660,784 | 1,663,900 | +3,116 | 0.16 | 0.19 | +0.03 | buy |
| ProShare Advisors LLC | 10,916 | 13,958 | +3,042 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 13,000 | 15,700 | +2,700 | 0.01 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,391 | 32,502 | +2,111 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 6,878 | 8,498 | +1,620 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 9,913 | 11,469 | +1,556 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 40,415 | 41,887 | +1,472 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 49,771 | 50,852 | +1,081 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 5,449 | 6,285 | +836 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 31,000 | 31,800 | +800 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 88,700 | 89,300 | +600 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 12,627 | 13,168 | +541 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,820 | 2,211 | +391 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 657 | 927 | +270 | 0.00 | 0.00 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 19,010 | 19,260 | +250 | 0.03 | 0.04 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 5,318 | 5,546 | +228 | 0.01 | 0.01 | +0.00 | buy |
| Truvestments Capital LLC | 0 | 138 | +138 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 13 | 120 | +107 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 82 | +82 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 102,591 | 102,646 | +55 | 0.01 | 0.02 | +0.00 | buy |
| Geneos Wealth Management Inc. | 0 | 44 | +44 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 82 | 121 | +39 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 5 | 19 | +14 | 0.00 | 0.00 | +0.00 | buy |
| Continuum Advisory, LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 9 | 14 | +5 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 5 | 10 | +5 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 6,398,365 | 6,398,366 | +1 | 3.36 | 3.47 | +0.12 | buy |
| CANADA LIFE ASSURANCE Co | 11,578 | 11,578 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| WHITTIER TRUST CO | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TEXAS TREASURY SAFEKEEPING TRUST CO | 4,230 | 4,230 | 0 | 0.01 | 0.01 | +0.00 | hold |
| PRIVATE TRUST CO NA | 48 | 48 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,084,412 | 6,084,412 | 0 | 3.30 | 3.68 | +0.37 | hold |
| KBC Group NV | 1,263 | 1,263 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jasper Ridge Partners, L.P. | 5,639 | 5,639 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 17,659 | 17,659 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 213 | 213 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 227 | 227 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEA Management Company, LLC | 2,909,956 | 2,909,956 | 0 | 8.99 | 8.31 | -0.68 | hold |
| MetLife Investment Management, LLC | 31,652 | 31,652 | 0 | 0.01 | 0.01 | +0.00 | hold |