| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 6,267,538 | 6,302,215 | +34,677 | 0.01 | 0.01 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 5,561,359 | 5,681,359 | +120,000 | 5.92 | 7.07 | +1.15 | buy |
| BAKER BROS. ADVISORS LP | 5,604,483 | 5,604,483 | 0 | 3.44 | 4.09 | +0.65 | hold |
| VANGUARD GROUP INC | 3,589,114 | 4,996,427 | +1,407,313 | 0.00 | 0.01 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 4,878,037 | 4,262,859 | -615,178 | 0.24 | 0.33 | +0.09 | sell |
| NEA Management Company, LLC | 2,909,956 | 2,909,956 | 0 | 13.84 | 16.13 | +2.29 | hold |
| PERCEPTIVE ADVISORS LLC | 2,418,299 | 2,438,969 | +20,670 | 5.73 | 8.33 | +2.60 | buy |
| FMR LLC | 1,953,441 | 2,145,183 | +191,742 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,907,601 | 2,028,651 | +121,050 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,733,722 | 1,893,663 | +159,941 | 0.02 | 0.03 | +0.01 | buy |
| FEDERATED HERMES, INC. | 1,686,494 | 1,727,885 | +41,391 | 0.20 | 0.31 | +0.11 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,341,392 | 1,399,897 | +58,505 | 0.01 | 0.02 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,269,952 | 1,383,775 | +113,823 | 0.64 | 1.00 | +0.36 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,311,253 | 1,362,829 | +51,576 | 0.01 | 0.01 | +0.00 | buy |
| Polar Capital Holdings Plc | 1,250,870 | 1,244,932 | -5,938 | 0.41 | 0.61 | +0.19 | sell |
| JPMORGAN CHASE & CO | 783,559 | 1,188,069 | +404,510 | 0.00 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,411,902 | 1,160,887 | -251,015 | 0.04 | 0.05 | +0.01 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,629,468 | 1,069,004 | -560,464 | 0.43 | 0.45 | +0.02 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 1,017,700 | 1,017,700 | 0 | 0.31 | 0.46 | +0.15 | hold |
| ALLIANCEBERNSTEIN L.P. | 61,470 | 979,682 | +918,212 | 0.00 | 0.03 | +0.03 | buy |
| Checkpoint Capital L.P. | 1,060,000 | 763,707 | -296,293 | 31.21 | 25.84 | -5.37 | sell |
| Rock Springs Capital Management LP | 861,153 | 717,102 | -144,051 | 3.39 | 4.23 | +0.84 | sell |
| Pictet Asset Management Holding SA | 416,115 | 683,017 | +266,902 | 0.03 | 0.07 | +0.04 | buy |
| Capital Research Global Investors | 0 | 598,247 | +598,247 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 514,381 | 580,183 | +65,802 | 0.17 | 0.28 | +0.10 | buy |
| LORD, ABBETT & CO. LLC | 204,275 | 575,984 | +371,709 | 0.04 | 0.17 | +0.13 | buy |
| FRANKLIN RESOURCES INC | 543,802 | 567,782 | +23,980 | 0.01 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 314,893 | 546,593 | +231,700 | 0.03 | 0.07 | +0.05 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 341,000 | 544,000 | +203,000 | 0.04 | 0.09 | +0.05 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 461,438 | 527,922 | +66,484 | 0.01 | 0.01 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 591,454 | 527,439 | -64,015 | 0.05 | 0.06 | +0.02 | sell |
| NORTHERN TRUST CORP | 510,246 | 510,906 | +660 | 0.00 | 0.01 | +0.00 | buy |
| Siren, L.L.C. | 409,742 | 499,975 | +90,233 | 1.34 | 1.98 | +0.64 | buy |
| Clearbridge Investments, LLC | 312,445 | 484,732 | +172,287 | 0.02 | 0.04 | +0.02 | buy |
| MORGAN STANLEY | 524,480 | 465,190 | -59,290 | 0.00 | 0.00 | +0.00 | sell |
| Opaleye Management Inc. | 475,000 | 461,700 | -13,300 | 6.07 | 6.59 | +0.52 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 227,627 | 437,472 | +209,845 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 252,582 | 420,336 | +167,754 | 0.00 | 0.01 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 411,550 | +411,550 | 0.00 | 0.02 | +0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 400,772 | 369,996 | -30,776 | 5.18 | 5.41 | +0.23 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 338,804 | 368,263 | +29,459 | 0.08 | 0.12 | +0.05 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 54,088 | 350,008 | +295,920 | 0.01 | 0.07 | +0.06 | buy |
| Sofinnova Investments, Inc. | 586,010 | 246,966 | -339,044 | 2.52 | 1.53 | -0.99 | sell |
| Qube Research & Technologies Ltd | 240,345 | 238,819 | -1,526 | 0.02 | 0.03 | +0.01 | sell |
| Artisan Partners Limited Partnership | 174,479 | 236,841 | +62,362 | 0.02 | 0.03 | +0.02 | buy |
| Hood River Capital Management LLC | 543,688 | 235,836 | -307,852 | 0.48 | 0.28 | -0.20 | sell |
| BANK OF AMERICA CORP /DE/ | 222,152 | 233,150 | +10,998 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 237,998 | 224,128 | -13,870 | 0.02 | 0.03 | +0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 102,239 | 223,681 | +121,442 | 0.01 | 0.02 | +0.01 | buy |
| Candriam S.C.A. | 312,452 | 221,863 | -90,589 | 0.11 | 0.12 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 244,003 | 221,593 | -22,410 | 0.02 | 0.02 | +0.01 | sell |
| Integral Health Asset Management, LLC | 120,000 | 220,000 | +100,000 | 0.71 | 1.62 | +0.91 | buy |
| ORBIMED ADVISORS LLC | 248,512 | 215,152 | -33,360 | 0.39 | 0.52 | +0.13 | sell |
| COMERICA BANK | 301,661 | 209,325 | -92,336 | 0.07 | 0.08 | +0.01 | sell |
| Logos Global Management LP | 130,000 | 200,000 | +70,000 | 1.10 | 2.00 | +0.90 | buy |
| Bank of New York Mellon Corp | 184,109 | 182,365 | -1,744 | 0.00 | 0.00 | +0.00 | sell |
| First Light Asset Management, LLC | 0 | 180,484 | +180,484 | 0.00 | 1.72 | +1.72 | buy |
| MARSHALL WACE, LLP | 376,242 | 171,834 | -204,408 | 0.03 | 0.02 | -0.01 | sell |
| Russell Investments Group, Ltd. | 130,998 | 157,678 | +26,680 | 0.01 | 0.02 | +0.01 | buy |
| Invesco Ltd. | 68,924 | 143,555 | +74,631 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 351,198 | 142,385 | -208,813 | 0.01 | 0.01 | -0.00 | sell |
| ALGERT GLOBAL LLC | 60,219 | 140,284 | +80,065 | 0.08 | 0.24 | +0.16 | buy |
| AMERIPRISE FINANCIAL INC | 173,069 | 137,967 | -35,102 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 198,110 | 133,161 | -64,949 | 0.01 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 132,626 | +132,626 | 0.00 | 0.01 | +0.01 | buy |
| Man Group plc | 0 | 129,330 | +129,330 | 0.00 | 0.03 | +0.03 | buy |
| ROYAL BANK OF CANADA | 196,236 | 125,786 | -70,450 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 115,118 | 121,260 | +6,142 | 0.03 | 0.04 | +0.01 | buy |
| Nuveen, LLC | 121,855 | 117,964 | -3,891 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 36,779 | 116,742 | +79,963 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 17,659 | 111,544 | +93,885 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 90,600 | 102,300 | +11,700 | 0.00 | 0.01 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 95,517 | 101,372 | +5,855 | 0.01 | 0.02 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 176,752 | 91,444 | -85,308 | 3.60 | 1.86 | -1.73 | sell |
| PDT Partners, LLC | 97,638 | 86,136 | -11,502 | 0.35 | 0.55 | +0.20 | sell |
| Neuberger Berman Group LLC | 86,139 | 85,117 | -1,022 | 0.00 | 0.01 | +0.00 | sell |
| AXIOM INVESTORS LLC /DE | 52,460 | 83,031 | +30,571 | 0.03 | 0.06 | +0.03 | buy |
| RHUMBLINE ADVISERS | 87,526 | 82,068 | -5,458 | 0.00 | 0.01 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 73,714 | 80,903 | +7,189 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 49,040 | 79,780 | +30,740 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 58,618 | 75,131 | +16,513 | 0.00 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 7,095 | 73,010 | +65,915 | 0.00 | 0.01 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 119,466 | 64,614 | -54,852 | 0.03 | 0.03 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 68,132 | 60,917 | -7,215 | 0.00 | 0.01 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 56,000 | 59,564 | +3,564 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 58,480 | +58,480 | 0.00 | 0.67 | +0.67 | buy |
| Legal & General Group Plc | 52,681 | 57,376 | +4,695 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 51,611 | 55,734 | +4,123 | 0.01 | 0.02 | +0.01 | buy |
| Walleye Capital LLC | 0 | 50,181 | +50,181 | 0.00 | 0.04 | +0.04 | buy |
| Granahan Investment Management, LLC | 41,172 | 49,728 | +8,556 | 0.11 | 0.21 | +0.10 | buy |
| ADAR1 Capital Management, LLC | 45,390 | 49,571 | +4,181 | 0.47 | 0.50 | +0.03 | buy |
| Nan Fung Group Holdings Ltd | 49,120 | 49,120 | 0 | 4.89 | 8.32 | +3.43 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,917 | 48,934 | +6,017 | 0.00 | 0.01 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 48,162 | +48,162 | 0.00 | 0.41 | +0.41 | buy |
| Harvest Investment Services, LLC | 15,466 | 48,140 | +32,674 | 0.22 | 0.98 | +0.76 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 47,733 | +47,733 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 42,368 | 47,134 | +4,766 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 51,079 | 44,731 | -6,348 | 0.13 | 0.16 | +0.03 | sell |
| RAYMOND JAMES FINANCIAL INC | 10,546 | 44,093 | +33,547 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 16,241 | 42,883 | +26,642 | 0.00 | 0.00 | +0.00 | buy |