| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 380,828 | 2,154,110 | +1,773,282 | 0.29 | 2.21 | +1.92 | buy |
| JANUS HENDERSON GROUP PLC | 1,065,745 | 621,892 | +443,853 | 0.02 | 0.02 | 0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 274,524 | 598,905 | +324,381 | 0.08 | 0.33 | +0.25 | buy |
| ExodusPoint Capital Management, LP | 152,443 | 40,197 | +112,246 | 0.05 | 0.02 | 0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 131,662 | 65,544 | +66,118 | 0.02 | 0.01 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 40,146 | 66,708 | +26,562 | 0.06 | 0.18 | +0.12 | buy |
| PROFUND ADVISORS LLC | 27,818 | 20,491 | +7,327 | 0.04 | 0.04 | 0.00 | sell |
| Atom Investors LP | 19,386 | 24,931 | +5,545 | 0.10 | 0.20 | +0.10 | buy |
| China Universal Asset Management Co., Ltd. | 1,458 | 6,837 | +5,379 | 0.01 | 0.06 | +0.05 | buy |
| ALGERT GLOBAL LLC | 33,413 | 28,803 | +4,610 | 0.04 | 0.05 | 0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 13,421 | 10,593 | +2,828 | 0.00 | 0.00 | 0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 16,406 | 17,406 | +1,000 | 0.03 | 0.07 | +0.04 | buy |
| ALPS ADVISORS INC | 41,951 | 40,215 | -1,736 | 0.01 | 0.01 | +0.01 | sell |
| VIRTUS ADVISERS, LLC | 17,193 | 7,597 | -9,596 | 0.24 | 0.22 | -0.02 | sell |
| Zimmer Partners, LP | 82,500 | 61,800 | -20,700 | 0.05 | 0.10 | +0.06 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 177,000 | 151,843 | -25,157 | 0.02 | 0.02 | +0.01 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 104,720 | 76,507 | -28,213 | 0.05 | 0.06 | +0.02 | sell |
| Bellevue Group AG | 73,300 | 32,869 | -40,431 | 0.03 | 0.02 | -0.00 | sell |
| Rafferty Asset Management, LLC | 162,804 | 121,654 | -41,150 | 0.02 | 0.02 | +0.00 | sell |
| Opaleye Management Inc. | 653,000 | 610,000 | -43,000 | 4.87 | 7.46 | +2.59 | sell |
| ORBIMED ADVISORS LLC | 583,642 | 536,642 | -47,000 | 0.29 | 0.49 | +0.21 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 157,426 | 89,605 | -67,821 | 0.23 | 0.24 | +0.01 | sell |
| Rock Springs Capital Management LP | 1,597,123 | 1,522,893 | -74,230 | 0.98 | 1.72 | +0.74 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 260,537 | 174,248 | -86,289 | 2.23 | 2.47 | +0.25 | sell |
| Clearbridge Investments, LLC | 182,825 | 91,158 | -91,667 | 0.00 | 0.00 | -0.00 | sell |
| Samsara BioCapital, LLC | 345,293 | 172,647 | -172,646 | 2.42 | 1.23 | -1.19 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 8,267,421 | 8,052,648 | -214,773 | 0.16 | 0.29 | +0.13 | sell |
| Cormorant Asset Management, LP | 850,000 | 550,000 | -300,000 | 1.14 | 1.21 | +0.07 | sell |
| BAKER BROS. ADVISORS LP | 6,702,349 | 6,398,365 | -303,984 | 0.89 | 3.35 | +2.46 | sell |
| Commodore Capital LP | 2,075,000 | 1,550,000 | -525,000 | 5.56 | 6.23 | +0.67 | sell |
| VR Adviser, LLC | 1,090,000 | 495,983 | -594,017 | 2.63 | 1.56 | -1.07 | sell |
| Polar Capital Holdings Plc | 2,500,000 | 1,750,000 | -750,000 | 0.43 | 0.50 | +0.07 | sell |