| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 6,889,258 | 6,950,715 | +61,457 | 0.01 | 0.01 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 7,216,911 | 6,571,190 | -645,721 | 0.28 | 0.28 | +0.01 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 6,084,412 | 6,084,412 | 0 | 3.68 | 4.53 | +0.86 | hold |
| BAKER BROS. ADVISORS LP | 6,398,366 | 6,084,249 | -314,117 | 3.47 | 3.64 | +0.16 | sell |
| PERCEPTIVE ADVISORS LLC | 3,560,214 | 3,680,473 | +120,259 | 4.00 | 5.74 | +1.74 | buy |
| VANGUARD GROUP INC | 3,447,911 | 3,442,600 | -5,311 | 0.00 | 0.00 | +0.00 | sell |
| NEA Management Company, LLC | 2,909,956 | 2,909,956 | 0 | 8.31 | 9.19 | +0.89 | hold |
| Frazier Life Sciences Management, L.P. | 2,416,952 | 1,869,808 | -547,144 | 5.08 | 4.34 | -0.73 | sell |
| STATE STREET CORP | 1,993,166 | 1,840,870 | -152,296 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 3,879,796 | 1,812,206 | -2,067,590 | 0.04 | 0.02 | -0.02 | sell |
| FEDERATED HERMES, INC. | 1,663,900 | 1,549,635 | -114,265 | 0.19 | 0.19 | -0.00 | sell |
| Polar Capital Holdings Plc | 1,500,000 | 1,500,000 | 0 | 0.38 | 0.47 | +0.09 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,299,490 | 1,290,975 | -8,515 | 0.58 | 0.60 | +0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,256,188 | 1,255,799 | -389 | 0.01 | 0.01 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 598,122 | 1,219,554 | +621,432 | 0.02 | 0.03 | +0.02 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 1,167,700 | 1,167,700 | 0 | 0.34 | 0.38 | +0.04 | hold |
| Rock Springs Capital Management LP | 1,228,093 | 1,162,718 | -65,375 | 2.09 | 2.48 | +0.38 | sell |
| Checkpoint Capital L.P. | 663,381 | 727,982 | +64,601 | 17.24 | 20.74 | +3.50 | buy |
| MARSHALL WACE, LLP | 406,615 | 692,803 | +286,188 | 0.03 | 0.05 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 550,530 | 685,152 | +134,622 | 0.00 | 0.00 | +0.00 | buy |
| Hood River Capital Management LLC | 614,598 | 643,691 | +29,093 | 0.52 | 0.53 | +0.01 | buy |
| LOOMIS SAYLES & CO L P | 636,628 | 618,485 | -18,143 | 0.04 | 0.04 | -0.00 | sell |
| MORGAN STANLEY | 464,604 | 560,087 | +95,483 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 498,466 | 545,314 | +46,848 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 500,000 | 500,000 | 0 | 4.37 | 4.90 | +0.53 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 433,866 | 440,250 | +6,384 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 435,900 | 400,000 | -35,900 | 0.42 | 0.46 | +0.05 | sell |
| Cormorant Asset Management, LP | 400,000 | 400,000 | 0 | 1.11 | 1.23 | +0.12 | hold |
| Sofinnova Investments, Inc. | 276,678 | 397,428 | +120,750 | 1.20 | 1.63 | +0.43 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 353,323 | 380,537 | +27,214 | 0.07 | 0.08 | +0.01 | buy |
| Pictet Asset Management Holding SA | 329,339 | 375,349 | +46,010 | 0.02 | 0.02 | +0.00 | buy |
| Candriam S.C.A. | 395,377 | 332,392 | -62,985 | 0.12 | 0.11 | -0.01 | sell |
| Invesco Ltd. | 264,417 | 302,846 | +38,429 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 255,578 | 273,896 | +18,318 | 3.02 | 3.43 | +0.41 | buy |
| FRANKLIN RESOURCES INC | 259,416 | 268,205 | +8,789 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 81,592 | 264,585 | +182,993 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 76,634 | 254,264 | +177,630 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 225,373 | 218,544 | -6,829 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 41,268 | 208,016 | +166,748 | 0.65 | 2.92 | +2.27 | buy |
| NORGES BANK | 66,276 | 205,649 | +139,373 | 0.00 | 0.00 | +0.00 | buy |
| Samsara BioCapital, LLC | 172,647 | 172,647 | 0 | 1.74 | 1.33 | -0.41 | hold |
| LORD, ABBETT & CO. LLC | 102,646 | 160,651 | +58,005 | 0.02 | 0.03 | +0.01 | buy |
| Integral Health Asset Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.74 | +0.74 | buy |
| Bank of New York Mellon Corp | 148,926 | 148,246 | -680 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 0 | 144,342 | +144,342 | 0.00 | 0.08 | +0.08 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 138,363 | +138,363 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 106,397 | 135,397 | +29,000 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 70,762 | 118,337 | +47,575 | 0.00 | 0.01 | +0.00 | buy |
| FMR LLC | 50,295 | 113,109 | +62,814 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 106,261 | +106,261 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 106,250 | 104,488 | -1,762 | 0.00 | 0.00 | +0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 100,961 | 99,447 | -1,514 | 0.25 | 0.25 | +0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 102,832 | 97,169 | -5,663 | 0.01 | 0.01 | +0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 95,235 | +95,235 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 89,300 | 90,200 | +900 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 14,425 | 85,249 | +70,824 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 82,755 | +82,755 | 0.00 | 0.25 | +0.25 | buy |
| RHUMBLINE ADVISERS | 80,714 | 82,731 | +2,017 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 112,804 | 80,517 | -32,287 | 0.01 | 0.01 | -0.00 | sell |
| CITIGROUP INC | 41,197 | 69,777 | +28,580 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 63,078 | +63,078 | 0.00 | 0.50 | +0.50 | buy |
| ALLIANCEBERNSTEIN L.P. | 59,570 | 61,470 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 48,703 | 59,969 | +11,266 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 30,535 | 59,700 | +29,165 | 0.01 | 0.02 | +0.01 | buy |
| JANE STREET GROUP, LLC | 109,186 | 58,415 | -50,771 | 0.01 | 0.01 | -0.00 | sell |
| Global IMC LLC | 0 | 56,936 | +56,936 | 0.00 | 0.57 | +0.57 | buy |
| AMERIPRISE FINANCIAL INC | 41,887 | 53,367 | +11,480 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 50,852 | 51,803 | +951 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 21,481 | 50,664 | +29,183 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 64,576 | 50,394 | -14,182 | 0.01 | 0.01 | -0.00 | sell |
| Artia Global Partners LP | 0 | 50,000 | +50,000 | 0.00 | 1.13 | +1.13 | buy |
| ALPS ADVISORS INC | 0 | 49,700 | +49,700 | 0.00 | 0.02 | +0.02 | buy |
| Nan Fung Group Holdings Ltd | 49,120 | 49,120 | 0 | 2.22 | 2.35 | +0.13 | hold |
| DEUTSCHE BANK AG\ | 33,264 | 48,745 | +15,481 | 0.00 | 0.00 | +0.00 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 48,844 | 48,411 | -433 | 0.04 | 0.05 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 4,294 | 48,198 | +43,904 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 31,800 | 47,800 | +16,000 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 11,500 | 43,583 | +32,083 | 0.05 | 0.22 | +0.16 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,916 | 43,533 | -383 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 54,171 | 41,551 | -12,620 | 0.08 | 0.05 | -0.02 | sell |
| CITADEL ADVISORS LLC | 102,778 | 40,419 | -62,359 | 0.01 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 37,426 | 37,426 | 0 | 0.68 | 0.78 | +0.10 | hold |
| WELLS FARGO & COMPANY/MN | 29,474 | 37,324 | +7,850 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 32,586 | 36,884 | +4,298 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 35,004 | +35,004 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 33,766 | +33,766 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 29,021 | 33,522 | +4,501 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 31,652 | 33,498 | +1,846 | 0.01 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,502 | 33,156 | +654 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 32,453 | 32,262 | -191 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 0 | 30,941 | +30,941 | 0.00 | 0.36 | +0.36 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 41,368 | 30,252 | -11,116 | 0.09 | 0.07 | -0.02 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 12,386 | 28,092 | +15,706 | 0.01 | 0.02 | +0.01 | buy |
| Corebridge Financial, Inc. | 29,274 | 27,220 | -2,054 | 0.01 | 0.01 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 27,716 | 25,555 | -2,161 | 0.00 | 0.00 | +0.00 | sell |
| Crestline Management, LP | 18,998 | 25,062 | +6,064 | 0.06 | 0.05 | -0.01 | buy |
| Bellevue Group AG | 15,700 | 23,596 | +7,896 | 0.01 | 0.03 | +0.01 | buy |
| FIDUCIARY TRUST CO | 20,000 | 20,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| STIFEL FINANCIAL CORP | 19,842 | 19,516 | -326 | 0.00 | 0.00 | +0.00 | sell |
| Engineers Gate Manager LP | 0 | 19,183 | +19,183 | 0.00 | 0.02 | +0.02 | buy |