| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 598,122 | 1,219,554 | +621,432 | 0.02 | 0.04 | 0.00 | buy |
| STEMPOINT CAPITAL LP | 41,268 | 208,016 | +166,748 | 0.65 | 2.92 | +2.27 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 550,530 | 685,152 | +134,622 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 276,678 | 397,428 | +120,750 | 1.15 | 1.62 | +0.47 | buy |
| PERCEPTIVE ADVISORS LLC | 3,560,214 | 3,680,473 | +120,259 | 3.95 | 5.68 | +1.73 | buy |
| Checkpoint Capital L.P. | 663,381 | 727,982 | +64,601 | 17.24 | 20.74 | +3.50 | buy |
| Candriam S.C.A. | 271,398 | 332,392 | +60,994 | 0.07 | 0.11 | +0.04 | buy |
| LORD, ABBETT & CO. LLC | 102,646 | 160,651 | +58,005 | 0.02 | 0.03 | +0.01 | buy |
| PDT Partners, LLC | 11,500 | 43,583 | +32,083 | 0.05 | 0.22 | +0.16 | buy |
| Hood River Capital Management LLC | 614,598 | 643,691 | +29,093 | 0.52 | 0.53 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 255,578 | 273,896 | +18,318 | 3.02 | 3.43 | +0.41 | buy |
| ALGERT GLOBAL LLC | 54,171 | 41,551 | +12,620 | 0.08 | 0.06 | 0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 41,368 | 30,252 | +11,116 | 0.09 | 0.07 | 0.00 | sell |
| NATIXIS | 11,187 | 997 | +10,190 | 0.00 | 0.00 | 0.00 | sell |
| Bellevue Group AG | 15,700 | 23,596 | +7,896 | 0.01 | 0.03 | +0.01 | buy |
| Crestline Management, LP | 18,998 | 25,062 | +6,064 | 0.05 | 0.05 | -0.01 | buy |
| ProShare Advisors LLC | 13,958 | 18,328 | +4,370 | 0.00 | 0.00 | 0.00 | buy |
| PROFUND ADVISORS LLC | 13,358 | 10,481 | +2,877 | 0.03 | 0.02 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 11,758 | 13,031 | +1,273 | 0.07 | 0.07 | +0.00 | buy |
| WHITTIER TRUST CO | 2,000 | 1,760 | +240 | 0.00 | 0.00 | 0.00 | sell |
| OMERS ADMINISTRATION Corp | 7,800 | 7,600 | +200 | 0.00 | 0.00 | +0.00 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 48,844 | 48,411 | -433 | 0.04 | 0.05 | +0.00 | sell |
| CASTLEARK MANAGEMENT LLC | 19,260 | 18,390 | -870 | 0.04 | 0.04 | -0.01 | sell |
| Chicago Partners Investment Group LLC | 4,725 | 3,696 | -1,029 | 0.01 | 0.01 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 7,423 | 6,280 | -1,143 | 0.18 | 0.14 | -0.04 | sell |
| Hennion & Walsh Asset Management, Inc. | 100,961 | 99,447 | -1,514 | 0.25 | 0.25 | +0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,299,490 | 1,290,975 | -8,515 | 0.58 | 0.60 | +0.01 | sell |
| Rafferty Asset Management, LLC | 64,576 | 50,394 | -14,182 | 0.01 | 0.01 | -0.00 | sell |
| LOOMIS SAYLES & CO L P | 636,628 | 618,485 | -18,143 | 0.04 | 0.04 | -0.00 | sell |
| Aberdeen Group plc | 112,804 | 80,517 | -32,287 | 0.01 | 0.01 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 435,900 | 400,000 | -35,900 | 0.42 | 0.46 | +0.05 | sell |
| JGP Global Gestao de Recursos Ltda. | 56,378 | 5,378 | -51,000 | 5.76 | 0.69 | -5.08 | sell |
| Candriam S.C.A. | 395,377 | 332,392 | -62,985 | 0.12 | 0.11 | -0.01 | sell |
| Rock Springs Capital Management LP | 1,228,093 | 1,162,718 | -65,375 | 2.09 | 2.48 | +0.38 | sell |
| BAKER BROS. ADVISORS LP | 6,398,366 | 6,084,249 | -314,117 | 3.47 | 3.64 | +0.16 | sell |
| Frazier Life Sciences Management, L.P. | 2,416,952 | 1,869,808 | -547,144 | 5.08 | 4.34 | -0.73 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 7,216,911 | 6,571,190 | -645,721 | 0.28 | 0.28 | +0.01 | sell |