| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 5,681,359 | 6,666,837 | +985,478 | 7.07 | 7.31 | +0.24 | buy |
| JENNISON ASSOCIATES LLC | 411,550 | 918,567 | +507,017 | 0.02 | 0.06 | +0.03 | buy |
| Capital Research Global Investors | 598,247 | 985,086 | +386,839 | 0.01 | 0.02 | +0.01 | buy |
| Integral Health Asset Management, LLC | 220,000 | 475,000 | +255,000 | 1.62 | 2.58 | +0.96 | buy |
| Checkpoint Capital L.P. | 763,707 | 992,200 | +228,493 | 25.84 | 33.65 | +7.81 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 546,593 | 341,193 | +205,400 | 0.08 | 0.06 | -0.02 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,069,004 | 1,267,158 | +198,154 | 0.45 | 0.57 | +0.11 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,399,897 | 1,560,847 | +160,950 | 0.02 | 0.02 | +0.00 | buy |
| First Light Asset Management, LLC | 180,484 | 295,844 | +115,360 | 1.72 | 2.42 | +0.70 | buy |
| PERCEPTIVE ADVISORS LLC | 2,438,969 | 2,546,391 | +107,422 | 8.33 | 4.86 | -3.47 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 544,000 | 621,585 | +77,585 | 0.09 | 0.10 | +0.01 | buy |
| SummitTX Capital, L.P. | 11,869 | 80,729 | +68,860 | 0.05 | 0.26 | +0.21 | buy |
| Candriam S.C.A. | 221,863 | 287,907 | +66,044 | 0.12 | 0.15 | +0.04 | buy |
| LORD, ABBETT & CO. LLC | 575,984 | 619,542 | +43,558 | 0.17 | 0.20 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 121,260 | 149,373 | +28,113 | 0.04 | 0.04 | +0.00 | buy |
| Artisan Partners Limited Partnership | 236,841 | 263,591 | +26,750 | 0.03 | 0.04 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 215,152 | 239,800 | +24,648 | 0.52 | 0.53 | +0.00 | buy |
| Sofinnova Investments, Inc. | 246,966 | 271,394 | +24,428 | 1.36 | 1.25 | -0.11 | buy |
| CASTLEARK MANAGEMENT LLC | 42,539 | 64,479 | +21,940 | 0.12 | 0.20 | +0.08 | buy |
| Clearbridge Investments, LLC | 484,732 | 506,109 | +21,377 | 0.04 | 0.04 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 75,131 | 93,677 | +18,546 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,362,829 | 1,375,729 | +12,900 | 0.01 | 0.01 | 0.00 | buy |
| Swiss National Bank | 102,300 | 111,300 | +9,000 | 0.01 | 0.01 | +0.00 | buy |
| Penserra Capital Management LLC | 30,436 | 21,514 | +8,922 | 0.04 | 0.03 | -0.01 | sell |
| PROFUND ADVISORS LLC | 12,457 | 21,046 | +8,589 | 0.04 | 0.07 | 0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 16,721 | 24,334 | +7,613 | 0.01 | 0.01 | 0.00 | buy |
| DnB Asset Management AS | 5,528 | 11,163 | +5,635 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 37,482 | 42,867 | +5,385 | 0.93 | 1.18 | +0.25 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,934 | 53,537 | +4,603 | 0.01 | 0.01 | +0.00 | buy |
| Granahan Investment Management, LLC | 49,728 | 53,452 | +3,724 | 0.21 | 0.24 | +0.04 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 37,205 | 40,896 | +3,691 | 0.29 | 0.34 | 0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 24,312 | 21,350 | +2,962 | 0.02 | 0.02 | -0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 6,700 | 9,200 | +2,500 | 0.00 | 0.01 | +0.00 | buy |
| Empowered Funds, LLC | 2,145 | 4,164 | +2,019 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 49,571 | 51,349 | +1,778 | 0.50 | 0.41 | -0.08 | buy |
| ProShare Advisors LLC | 11,299 | 12,622 | +1,323 | 0.00 | 0.00 | 0.00 | buy |
| Hood River Capital Management LLC | 235,836 | 237,043 | +1,207 | 0.28 | 0.28 | -0.00 | buy |
| AXIOM INVESTORS LLC /DE | 83,031 | 83,554 | +523 | 0.06 | 0.08 | +0.02 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 39,575 | 39,887 | +312 | 0.09 | 0.09 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 34,084 | 34,127 | +43 | 0.02 | 0.03 | +0.00 | buy |
| Avior Wealth Management, LLC | 3,541 | 3,572 | +31 | 0.01 | 0.01 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,429 | 1,310 | -119 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 55,734 | 55,526 | -208 | 0.02 | 0.02 | +0.00 | sell |
| Hillsdale Investment Management Inc. | 42,600 | 42,300 | -300 | 0.13 | 0.12 | -0.00 | sell |
| JGP Global Gestao de Recursos Ltda. | 3,253 | 2,866 | -387 | 0.19 | 0.18 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 11,642 | 10,875 | -767 | 0.10 | 0.09 | -0.01 | sell |
| Leo Wealth, LLC | 7,867 | 6,952 | -915 | 0.10 | 0.05 | -0.05 | sell |
| Virtus Investment Advisers, LLC | 7,052 | 6,017 | -1,035 | 0.20 | 0.18 | -0.03 | sell |
| Bayforest Capital Ltd | 1,171 | 134 | -1,037 | 0.06 | 0.01 | -0.05 | sell |
| Informed Momentum Co LLC | 58,480 | 57,327 | -1,153 | 0.67 | 0.68 | +0.02 | sell |
| Bellevue Group AG | 9,053 | 7,504 | -1,549 | 0.02 | 0.02 | -0.00 | sell |
| E. Ohman J:or Asset Management AB | 8,213 | 6,589 | -1,624 | 0.02 | 0.02 | -0.00 | sell |
| STRS OHIO | 14,800 | 12,000 | -2,800 | 0.01 | 0.00 | -0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 47,733 | 44,805 | -2,928 | 0.01 | 0.01 | -0.00 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 22,244 | 19,247 | -2,997 | 0.04 | 0.04 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 12,335 | 9,301 | -3,034 | 0.00 | 0.00 | -0.00 | sell |
| CIBC WORLD MARKETS CORP | 6,706 | 3,502 | -3,204 | 0.00 | 0.00 | -0.00 | sell |
| Harvest Investment Services, LLC | 48,140 | 43,953 | -4,187 | 0.98 | 0.89 | -0.09 | sell |
| TD ASSET MANAGEMENT INC | 59,564 | 55,050 | -4,514 | 0.00 | 0.00 | -0.00 | sell |
| Entropy Technologies, LP | 8,502 | 2,492 | -6,010 | 0.06 | 0.01 | -0.05 | sell |
| PFM Health Sciences, LP | 48,162 | 40,210 | -7,952 | 0.37 | 0.43 | +0.06 | sell |
| Logos Global Management LP | 200,000 | 190,000 | -10,000 | 2.00 | 1.36 | -0.64 | sell |
| Quantedge Capital Pte Ltd | 17,800 | 5,600 | -12,200 | 0.98 | 0.29 | -0.70 | sell |
| Voleon Capital Management LP | 26,897 | 5,025 | -21,872 | 0.07 | 0.01 | -0.05 | sell |
| Rock Springs Capital Management LP | 717,102 | 695,010 | -22,092 | 4.23 | 3.81 | -0.42 | sell |
| LOOMIS SAYLES & CO L P | 527,439 | 503,901 | -23,538 | 0.06 | 0.07 | +0.00 | sell |
| PDT Partners, LLC | 86,136 | 59,436 | -26,700 | 0.55 | 0.41 | -0.14 | sell |
| Cinctive Capital Management LP | 35,156 | 3,225 | -31,931 | 0.18 | 0.02 | -0.16 | sell |
| STEMPOINT CAPITAL LP | 91,444 | 58,915 | -32,529 | 1.86 | 1.08 | -0.78 | sell |
| Hennion & Walsh Asset Management, Inc. | 44,731 | 10,908 | -33,823 | 0.16 | 0.04 | -0.12 | sell |
| Polar Capital Holdings Plc | 1,244,932 | 1,185,392 | -59,540 | 0.61 | 0.58 | -0.03 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,383,775 | 1,285,222 | -98,553 | 1.00 | 0.93 | -0.07 | sell |
| Opaleye Management Inc. | 461,700 | 330,000 | -131,700 | 6.59 | 4.66 | -1.93 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 369,996 | 135,950 | -234,046 | 5.41 | 2.11 | -3.30 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 4,262,859 | 3,478,669 | -784,190 | 0.33 | 0.28 | -0.05 | sell |