| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 4,996,427 | 6,210,916 | +1,214,489 | 0.01 | 0.01 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 5,681,359 | 6,666,837 | +985,478 | 7.07 | 7.31 | +0.24 | buy |
| JENNISON ASSOCIATES LLC | 411,550 | 918,567 | +507,017 | 0.02 | 0.06 | +0.03 | buy |
| Point72 Asset Management, L.P. | 0 | 429,420 | +429,420 | 0.00 | 0.07 | +0.07 | buy |
| Capital Research Global Investors | 598,247 | 985,086 | +386,839 | 0.01 | 0.02 | +0.01 | buy |
| Integral Health Asset Management, LLC | 220,000 | 475,000 | +255,000 | 1.62 | 2.58 | +0.96 | buy |
| JPMORGAN CHASE & CO | 1,188,069 | 1,423,989 | +235,920 | 0.01 | 0.01 | +0.00 | buy |
| Checkpoint Capital L.P. | 763,707 | 992,200 | +228,493 | 25.84 | 33.65 | +7.81 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 24,477 | 250,156 | +225,679 | 0.00 | 0.00 | +0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,069,004 | 1,267,158 | +198,154 | 0.45 | 0.57 | +0.11 | buy |
| MORGAN STANLEY | 465,190 | 651,402 | +186,212 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,028,651 | 2,198,615 | +169,964 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,399,897 | 1,560,847 | +160,950 | 0.02 | 0.02 | +0.00 | buy |
| Invesco Ltd. | 143,555 | 291,150 | +147,595 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 0 | 146,303 | +146,303 | 0.00 | 1.79 | +1.79 | buy |
| M&G Plc | 0 | 137,074 | +137,074 | 0.00 | 0.08 | +0.08 | buy |
| FRANKLIN RESOURCES INC | 567,782 | 695,735 | +127,953 | 0.01 | 0.02 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 137,967 | 261,160 | +123,193 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 182,365 | 301,080 | +118,715 | 0.00 | 0.01 | +0.00 | buy |
| Capital World Investors | 0 | 115,693 | +115,693 | 0.00 | 0.00 | +0.00 | buy |
| First Light Asset Management, LLC | 180,484 | 295,844 | +115,360 | 1.72 | 2.42 | +0.70 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 437,472 | 549,020 | +111,548 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 580,183 | 688,779 | +108,596 | 0.28 | 0.29 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 2,438,969 | 2,546,391 | +107,422 | 8.33 | 4.99 | -3.34 | buy |
| Zweig-DiMenna Associates LLC | 0 | 81,600 | +81,600 | 0.00 | 0.62 | +0.62 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 544,000 | 621,585 | +77,585 | 0.09 | 0.10 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 75,141 | +75,141 | 0.00 | 0.09 | +0.09 | buy |
| Qube Research & Technologies Ltd | 238,819 | 310,919 | +72,100 | 0.03 | 0.05 | +0.01 | buy |
| SummitTX Capital, L.P. | 11,869 | 80,729 | +68,860 | 0.05 | 0.26 | +0.21 | buy |
| NORGES BANK | 0 | 66,213 | +66,213 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 221,863 | 287,907 | +66,044 | 0.12 | 0.15 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 133,161 | 186,709 | +53,548 | 0.01 | 0.01 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 575,984 | 619,542 | +43,558 | 0.17 | 0.20 | +0.03 | buy |
| Nicholas Investment Partners, LP | 0 | 34,710 | +34,710 | 0.00 | 0.27 | +0.27 | buy |
| Squarepoint Ops LLC | 0 | 32,829 | +32,829 | 0.00 | 0.01 | +0.01 | buy |
| Magnetar Financial LLC | 0 | 29,598 | +29,598 | 0.00 | 0.03 | +0.03 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 221,593 | 249,874 | +28,281 | 0.02 | 0.03 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 121,260 | 149,373 | +28,113 | 0.04 | 0.04 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 3,585 | 31,356 | +27,771 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 236,841 | 263,591 | +26,750 | 0.03 | 0.04 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 47,134 | 72,617 | +25,483 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 215,152 | 239,800 | +24,648 | 0.52 | 0.53 | +0.00 | buy |
| Sofinnova Investments, Inc. | 246,966 | 271,394 | +24,428 | 1.53 | 1.25 | -0.28 | buy |
| Atom Investors LP | 0 | 22,929 | +22,929 | 0.00 | 0.19 | +0.19 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 101,372 | 123,537 | +22,165 | 0.02 | 0.02 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 42,539 | 64,479 | +21,940 | 0.12 | 0.20 | +0.08 | buy |
| Clearbridge Investments, LLC | 484,732 | 506,109 | +21,377 | 0.04 | 0.04 | +0.01 | buy |
| Fulcrum Asset Management LLP | 0 | 21,179 | +21,179 | 0.00 | 0.82 | +0.82 | buy |
| CITADEL ADVISORS LLC | 132,626 | 153,322 | +20,696 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 75,131 | 93,677 | +18,546 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,362,829 | 1,375,729 | +12,900 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 116,742 | 129,123 | +12,381 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 10,433 | +10,433 | 0.00 | 0.03 | +0.03 | buy |
| Knights of Columbus Asset Advisors LLC | 0 | 10,314 | +10,314 | 0.00 | 0.06 | +0.06 | buy |
| GUGGENHEIM CAPITAL LLC | 2,285 | 12,401 | +10,116 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 102,300 | 111,300 | +9,000 | 0.01 | 0.01 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 8,632 | +8,632 | 0.00 | 0.08 | +0.08 | buy |
| PROFUND ADVISORS LLC | 12,457 | 21,046 | +8,589 | 0.04 | 0.07 | +0.03 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27,122 | 34,901 | +7,779 | 0.00 | 0.01 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 16,721 | 24,334 | +7,613 | 0.01 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 80,903 | 88,505 | +7,602 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 420,336 | 427,236 | +6,900 | 0.01 | 0.01 | +0.00 | buy |
| Jump Financial, LLC | 0 | 6,759 | +6,759 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 6,105 | +6,105 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 31,658 | 37,432 | +5,774 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 5,528 | 11,163 | +5,635 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 37,482 | 42,867 | +5,385 | 0.93 | 1.18 | +0.25 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 4,943 | +4,943 | 0.00 | 0.07 | +0.07 | buy |
| Caption Management, LLC | 0 | 4,614 | +4,614 | 0.00 | 0.02 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,934 | 53,537 | +4,603 | 0.01 | 0.01 | +0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 0 | 4,560 | +4,560 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 527,922 | 532,447 | +4,525 | 0.01 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 4,504 | +4,504 | 0.00 | 0.00 | +0.00 | buy |
| Advisors Asset Management, Inc. | 14,178 | 18,524 | +4,346 | 0.02 | 0.03 | +0.01 | buy |
| Granahan Investment Management, LLC | 49,728 | 53,452 | +3,724 | 0.21 | 0.24 | +0.04 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 37,205 | 40,896 | +3,691 | 0.29 | 0.34 | +0.05 | buy |
| DIMENSIONAL FUND ADVISORS LP | 28,378 | 32,018 | +3,640 | 0.00 | 0.00 | +0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 0 | 3,271 | +3,271 | 0.00 | 0.00 | +0.00 | buy |
| Yorktown Management & Research Co Inc | 0 | 3,050 | +3,050 | 0.00 | 0.26 | +0.26 | buy |
| Rockefeller Capital Management L.P. | 8,868 | 11,771 | +2,903 | 0.00 | 0.00 | +0.00 | buy |
| Blueshift Asset Management, LLC | 0 | 2,881 | +2,881 | 0.00 | 0.09 | +0.09 | buy |
| CIBC Asset Management Inc | 0 | 2,848 | +2,848 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 6,700 | 9,200 | +2,500 | 0.00 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 42,883 | 45,381 | +2,498 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 0 | 2,140 | +2,140 | 0.00 | 0.05 | +0.05 | buy |
| M&T BANK CORP | 0 | 2,101 | +2,101 | 0.00 | 0.00 | +0.00 | buy |
| Empowered Funds, LLC | 2,145 | 4,164 | +2,019 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 15,521 | 17,521 | +2,000 | 0.00 | 0.01 | +0.00 | buy |
| Cambria Investment Management, L.P. | 0 | 1,997 | +1,997 | 0.00 | 0.01 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 497 | 2,415 | +1,918 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 49,571 | 51,349 | +1,778 | 0.50 | 0.41 | -0.08 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,726 | 12,435 | +1,709 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 954 | 2,441 | +1,487 | 0.01 | 0.03 | +0.02 | buy |
| Persistent Asset Partners Ltd | 0 | 1,446 | +1,446 | 0.00 | 0.07 | +0.07 | buy |
| LPL Financial LLC | 3,990 | 5,427 | +1,437 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 11,299 | 12,622 | +1,323 | 0.00 | 0.00 | -0.00 | buy |
| Quantinno Capital Management LP | 2,558 | 3,831 | +1,273 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,753 | 2,962 | +1,209 | 0.00 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 235,836 | 237,043 | +1,207 | 0.28 | 0.28 | -0.00 | buy |
| KLP KAPITALFORVALTNING AS | 11,000 | 12,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |