| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 5,681,359 | 6,666,837 | +985,478 | 7.07 | 7.31 | +0.24 | buy |
| BlackRock, Inc. | 6,302,215 | 6,297,334 | -4,881 | 0.01 | 0.01 | +0.00 | sell |
| VANGUARD GROUP INC | 4,996,427 | 6,210,916 | +1,214,489 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 5,604,483 | 5,604,483 | 0 | 4.09 | 3.51 | -0.58 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 4,262,859 | 3,478,669 | -784,190 | 0.33 | 0.28 | -0.05 | sell |
| NEA Management Company, LLC | 2,909,956 | 2,909,956 | 0 | 16.13 | 15.88 | -0.24 | hold |
| PERCEPTIVE ADVISORS LLC | 2,438,969 | 2,546,391 | +107,422 | 8.33 | 4.99 | -3.34 | buy |
| STATE STREET CORP | 2,028,651 | 2,198,615 | +169,964 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,893,663 | 1,830,866 | -62,797 | 0.03 | 0.03 | +0.00 | sell |
| FMR LLC | 2,145,183 | 1,706,317 | -438,866 | 0.01 | 0.01 | -0.00 | sell |
| FEDERATED HERMES, INC. | 1,727,885 | 1,623,841 | -104,044 | 0.31 | 0.29 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,399,897 | 1,560,847 | +160,950 | 0.02 | 0.02 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,188,069 | 1,423,989 | +235,920 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,362,829 | 1,375,729 | +12,900 | 0.01 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,383,775 | 1,285,222 | -98,553 | 1.00 | 0.93 | -0.07 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,069,004 | 1,267,158 | +198,154 | 0.45 | 0.57 | +0.11 | buy |
| Polar Capital Holdings Plc | 1,244,932 | 1,185,392 | -59,540 | 0.61 | 0.58 | -0.03 | sell |
| JANUS HENDERSON GROUP PLC | 1,160,887 | 1,126,125 | -34,762 | 0.05 | 0.05 | +0.00 | sell |
| Checkpoint Capital L.P. | 763,707 | 992,200 | +228,493 | 25.84 | 33.65 | +7.81 | buy |
| Capital Research Global Investors | 598,247 | 985,086 | +386,839 | 0.01 | 0.02 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 979,682 | 930,233 | -49,449 | 0.03 | 0.03 | +0.00 | sell |
| JENNISON ASSOCIATES LLC | 411,550 | 918,567 | +507,017 | 0.02 | 0.06 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 567,782 | 695,735 | +127,953 | 0.01 | 0.02 | +0.00 | buy |
| Rock Springs Capital Management LP | 717,102 | 695,010 | -22,092 | 4.23 | 3.82 | -0.42 | sell |
| Woodline Partners LP | 580,183 | 688,779 | +108,596 | 0.28 | 0.29 | +0.01 | buy |
| MORGAN STANLEY | 465,190 | 651,402 | +186,212 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 544,000 | 621,585 | +77,585 | 0.09 | 0.10 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 575,984 | 619,542 | +43,558 | 0.17 | 0.20 | +0.03 | buy |
| Pictet Asset Management Holding SA | 683,017 | 614,663 | -68,354 | 0.07 | 0.06 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 437,472 | 549,020 | +111,548 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 527,922 | 532,447 | +4,525 | 0.01 | 0.01 | +0.00 | buy |
| Clearbridge Investments, LLC | 484,732 | 506,109 | +21,377 | 0.04 | 0.04 | +0.01 | buy |
| LOOMIS SAYLES & CO L P | 527,439 | 503,901 | -23,538 | 0.06 | 0.07 | +0.00 | sell |
| Siren, L.L.C. | 499,975 | 499,975 | 0 | 1.98 | 1.60 | -0.38 | hold |
| NORTHERN TRUST CORP | 510,906 | 488,216 | -22,690 | 0.01 | 0.01 | +0.00 | sell |
| Integral Health Asset Management, LLC | 220,000 | 475,000 | +255,000 | 1.62 | 2.58 | +0.96 | buy |
| Point72 Asset Management, L.P. | 0 | 429,420 | +429,420 | 0.00 | 0.07 | +0.07 | buy |
| UBS Group AG | 420,336 | 427,236 | +6,900 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 546,593 | 341,193 | -205,400 | 0.07 | 0.06 | -0.02 | sell |
| Opaleye Management Inc. | 461,700 | 330,000 | -131,700 | 6.59 | 4.66 | -1.93 | sell |
| Qube Research & Technologies Ltd | 238,819 | 310,919 | +72,100 | 0.03 | 0.05 | +0.01 | buy |
| Bank of New York Mellon Corp | 182,365 | 301,080 | +118,715 | 0.00 | 0.01 | +0.00 | buy |
| First Light Asset Management, LLC | 180,484 | 295,844 | +115,360 | 1.72 | 2.42 | +0.70 | buy |
| Invesco Ltd. | 143,555 | 291,150 | +147,595 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 221,863 | 287,907 | +66,044 | 0.12 | 0.15 | +0.04 | buy |
| Sofinnova Investments, Inc. | 246,966 | 271,394 | +24,428 | 1.53 | 1.25 | -0.28 | buy |
| Artisan Partners Limited Partnership | 236,841 | 263,591 | +26,750 | 0.03 | 0.04 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 137,967 | 261,160 | +123,193 | 0.00 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 24,477 | 250,156 | +225,679 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 221,593 | 249,874 | +28,281 | 0.02 | 0.03 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 215,152 | 239,800 | +24,648 | 0.52 | 0.53 | +0.00 | buy |
| Hood River Capital Management LLC | 235,836 | 237,043 | +1,207 | 0.28 | 0.28 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 233,150 | 224,484 | -8,666 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 200,000 | 190,000 | -10,000 | 2.00 | 1.36 | -0.64 | sell |
| MILLENNIUM MANAGEMENT LLC | 133,161 | 186,709 | +53,548 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 223,681 | 164,563 | -59,118 | 0.02 | 0.01 | -0.01 | sell |
| CITADEL ADVISORS LLC | 132,626 | 153,322 | +20,696 | 0.01 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 121,260 | 149,373 | +28,113 | 0.04 | 0.04 | +0.00 | buy |
| First Turn Management, LLC | 0 | 146,303 | +146,303 | 0.00 | 1.79 | +1.79 | buy |
| M&G Plc | 0 | 137,074 | +137,074 | 0.00 | 0.08 | +0.08 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 369,996 | 135,950 | -234,046 | 5.41 | 2.11 | -3.30 | sell |
| Russell Investments Group, Ltd. | 157,678 | 134,180 | -23,498 | 0.02 | 0.02 | -0.00 | sell |
| BARCLAYS PLC | 142,385 | 131,436 | -10,949 | 0.01 | 0.01 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 116,742 | 129,123 | +12,381 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 101,372 | 123,537 | +22,165 | 0.02 | 0.02 | +0.00 | buy |
| Nuveen, LLC | 117,964 | 115,934 | -2,030 | 0.00 | 0.00 | +0.00 | sell |
| Capital World Investors | 0 | 115,693 | +115,693 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 102,300 | 111,300 | +9,000 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 75,131 | 93,677 | +18,546 | 0.01 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 80,903 | 88,505 | +7,602 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 140,284 | 88,250 | -52,034 | 0.24 | 0.15 | -0.09 | sell |
| AXIOM INVESTORS LLC /DE | 83,031 | 83,554 | +523 | 0.06 | 0.08 | +0.02 | buy |
| Zweig-DiMenna Associates LLC | 0 | 81,600 | +81,600 | 0.00 | 0.62 | +0.62 | buy |
| SummitTX Capital, L.P. | 11,869 | 80,729 | +68,860 | 0.05 | 0.26 | +0.21 | buy |
| ExodusPoint Capital Management, LP | 0 | 75,141 | +75,141 | 0.00 | 0.09 | +0.09 | buy |
| Neuberger Berman Group LLC | 85,117 | 73,572 | -11,545 | 0.01 | 0.01 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 47,134 | 72,617 | +25,483 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 350,008 | 72,282 | -277,726 | 0.07 | 0.01 | -0.06 | sell |
| RHUMBLINE ADVISERS | 82,068 | 71,212 | -10,856 | 0.01 | 0.01 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 79,780 | 70,046 | -9,734 | 0.01 | 0.00 | -0.00 | sell |
| NORGES BANK | 0 | 66,213 | +66,213 | 0.00 | 0.00 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 42,539 | 64,479 | +21,940 | 0.12 | 0.20 | +0.08 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 368,263 | 60,575 | -307,688 | 0.12 | 0.02 | -0.10 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 60,917 | 59,609 | -1,308 | 0.01 | 0.01 | +0.00 | sell |
| PDT Partners, LLC | 86,136 | 59,436 | -26,700 | 0.55 | 0.41 | -0.14 | sell |
| STEMPOINT CAPITAL LP | 91,444 | 58,915 | -32,529 | 1.86 | 1.08 | -0.78 | sell |
| Informed Momentum Co LLC | 58,480 | 57,327 | -1,153 | 0.67 | 0.68 | +0.02 | sell |
| Rafferty Asset Management, LLC | 55,734 | 55,526 | -208 | 0.02 | 0.02 | +0.00 | sell |
| Legal & General Group Plc | 57,376 | 55,075 | -2,301 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 59,564 | 55,050 | -4,514 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,934 | 53,537 | +4,603 | 0.01 | 0.01 | +0.00 | buy |
| Granahan Investment Management, LLC | 49,728 | 53,452 | +3,724 | 0.21 | 0.24 | +0.04 | buy |
| PRUDENTIAL FINANCIAL INC | 73,010 | 53,145 | -19,865 | 0.01 | 0.01 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 49,571 | 51,349 | +1,778 | 0.50 | 0.41 | -0.08 | buy |
| Nan Fung Group Holdings Ltd | 49,120 | 49,120 | 0 | 8.32 | 4.71 | -3.62 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 42,883 | 45,381 | +2,498 | 0.00 | 0.00 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 47,733 | 44,805 | -2,928 | 0.01 | 0.01 | -0.00 | sell |
| Harvest Investment Services, LLC | 48,140 | 43,953 | -4,187 | 0.98 | 0.89 | -0.09 | sell |
| HighVista Strategies LLC | 37,482 | 42,867 | +5,385 | 0.93 | 1.18 | +0.25 | buy |
| Hillsdale Investment Management Inc. | 42,600 | 42,300 | -300 | 0.13 | 0.12 | -0.00 | sell |