| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 0 | 11,111,111 | +11,111,111 | 0.00 | 0.87 | +0.87 | buy |
| BlackRock, Inc. | 9,263,312 | 10,589,990 | +1,326,678 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 8,889,000 | +8,889,000 | 0.00 | 0.25 | +0.25 | buy |
| Commodore Capital LP | 0 | 8,889,000 | +8,889,000 | 0.00 | 1.72 | +1.72 | buy |
| ADAR1 Capital Management, LLC | 0 | 8,889,000 | +8,889,000 | 0.00 | 1.35 | +1.35 | buy |
| Paradigm Biocapital Advisors LP | 0 | 5,586,625 | +5,586,625 | 0.00 | 0.34 | +0.34 | buy |
| Opaleye Management Inc. | 1,926,997 | 3,861,930 | +1,934,933 | 0.63 | 1.13 | +0.51 | buy |
| Woodline Partners LP | 0 | 3,555,497 | +3,555,497 | 0.00 | 0.04 | +0.04 | buy |
| Vivo Capital, LLC | 0 | 3,555,250 | +3,555,250 | 0.00 | 1.05 | +1.05 | buy |
| GOLDMAN SACHS GROUP INC | 558,577 | 2,614,036 | +2,055,459 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,311,789 | 2,569,072 | +257,283 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 3,972,160 | 2,468,919 | -1,503,241 | 0.02 | 0.01 | -0.00 | sell |
| Logos Global Management LP | 0 | 2,222,000 | +2,222,000 | 0.00 | 0.31 | +0.31 | buy |
| STATE STREET CORP | 2,076,122 | 2,191,803 | +115,681 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 210,308 | 2,037,287 | +1,826,979 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 1,943,893 | 1,901,002 | -42,891 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 1,947,384 | 1,862,494 | -84,890 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 1,370,497 | 1,572,242 | +201,745 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,549,063 | 1,332,976 | -216,087 | 0.00 | 0.00 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 1,293,848 | 1,318,947 | +25,099 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,457,715 | 1,039,001 | -418,714 | 0.01 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,052,457 | 1,032,133 | -20,324 | 0.06 | 0.06 | +0.00 | sell |
| MACKENZIE FINANCIAL CORP | 730,054 | 878,042 | +147,988 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 868,032 | +868,032 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 861,326 | 868,032 | +6,706 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 0 | 852,700 | +852,700 | 0.00 | 0.17 | +0.17 | buy |
| NORTHERN TRUST CORP | 742,443 | 819,693 | +77,250 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 393,754 | 750,763 | +357,009 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 1,977,509 | 521,213 | -1,456,296 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 0 | 498,997 | +498,997 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 332,933 | 477,099 | +144,166 | 0.01 | 0.02 | +0.01 | buy |
| Eversept Partners, LP | 290,919 | 458,809 | +167,890 | 0.05 | 0.08 | +0.03 | buy |
| Casdin Capital, LLC | 0 | 445,000 | +445,000 | 0.00 | 0.07 | +0.07 | buy |
| PEAK6 LLC | 0 | 415,441 | +415,441 | 0.00 | 0.03 | +0.03 | buy |
| GSA CAPITAL PARTNERS LLP | 434,413 | 367,147 | -67,266 | 0.07 | 0.08 | +0.01 | sell |
| BIT Capital GmbH | 0 | 326,000 | +326,000 | 0.00 | 0.04 | +0.04 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 309,395 | +309,395 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 140,428 | 271,186 | +130,758 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 272,567 | 262,625 | -9,942 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 0 | 231,827 | +231,827 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 231,115 | +231,115 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 0 | 230,000 | +230,000 | 0.00 | 0.01 | +0.01 | buy |
| IEQ CAPITAL, LLC | 197,418 | 217,785 | +20,367 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 662,389 | 212,761 | -449,628 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 136,462 | 211,880 | +75,418 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 167,530 | 187,930 | +20,400 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 183,859 | +183,859 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 170,470 | +170,470 | 0.00 | 0.11 | +0.11 | buy |
| Mariner, LLC | 145,540 | 169,291 | +23,751 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 178,483 | 161,878 | -16,605 | 0.00 | 0.00 | +0.00 | sell |
| Green Alpha Advisors, LLC | 160,142 | 156,046 | -4,096 | 0.39 | 0.34 | -0.05 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 115,131 | 151,406 | +36,275 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 145,602 | 149,264 | +3,662 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 141,082 | 144,805 | +3,723 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 582,309 | 137,355 | -444,954 | 0.01 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 126,000 | 126,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Point72 Asset Management, L.P. | 116,995 | 125,234 | +8,239 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 102,030 | 120,753 | +18,723 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 108,465 | 119,429 | +10,964 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 107,200 | 117,417 | +10,217 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 132,661 | 115,578 | -17,083 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 106,780 | 111,198 | +4,418 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 99,365 | +99,365 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 112,186 | 97,062 | -15,124 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 0 | 92,596 | +92,596 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 88,369 | 92,094 | +3,725 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 57,733 | 78,602 | +20,869 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 80,532 | 74,782 | -5,750 | 0.00 | 0.00 | +0.00 | sell |
| OSAIC HOLDINGS, INC. | 51,424 | 70,124 | +18,700 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 88,707 | 68,268 | -20,439 | 0.00 | 0.00 | -0.00 | sell |
| Joel Isaacson & Co., LLC | 68,144 | 68,144 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 5,981 | 63,974 | +57,993 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 7,298 | 61,964 | +54,666 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 42,433 | 56,216 | +13,783 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 45,080 | 56,132 | +11,052 | 0.00 | 0.00 | +0.00 | buy |
| MML INVESTORS SERVICES, LLC | 32,110 | 52,088 | +19,978 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 22,309 | 50,349 | +28,040 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 23,084 | 45,572 | +22,488 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,323 | 44,424 | +27,101 | 0.00 | 0.01 | +0.01 | buy |
| WINTON GROUP Ltd | 43,800 | 43,700 | -100 | 0.00 | 0.00 | +0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 42,400 | +42,400 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 41,472 | +41,472 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 0 | 40,000 | +40,000 | 0.00 | 0.01 | +0.01 | buy |
| Vanguard Personalized Indexing Management, LLC | 39,676 | 38,305 | -1,371 | 0.00 | 0.00 | +0.00 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 25,782 | 37,644 | +11,862 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 37,638 | +37,638 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 36,452 | +36,452 | 0.00 | 0.01 | +0.01 | buy |
| SCS Capital Management LLC | 35,000 | 35,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 33,873 | 33,873 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Thrive Wealth Management, LLC | 33,500 | 33,500 | 0 | 0.01 | 0.01 | +0.00 | hold |
| TWO SIGMA SECURITIES, LLC | 10,459 | 33,138 | +22,679 | 0.00 | 0.01 | +0.01 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 30,957 | 31,207 | +250 | 0.01 | 0.01 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 27,950 | 30,296 | +2,346 | 0.00 | 0.00 | +0.00 | buy |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 29,010 | 27,680 | -1,330 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 27,388 | 27,265 | -123 | 0.00 | 0.00 | +0.00 | sell |
| Focus Partners Wealth | 21,597 | 27,264 | +5,667 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 26,944 | +26,944 | 0.00 | 0.02 | +0.02 | buy |
| Prime Capital Investment Advisors, LLC | 27,111 | 26,471 | -640 | 0.00 | 0.00 | +0.00 | sell |
| Vise Technologies, Inc. | 0 | 25,794 | +25,794 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 26,284 | 25,663 | -621 | 0.00 | 0.00 | +0.00 | sell |