| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 0 | 11,111,111 | +11,111,111 | 0.00 | 0.87 | +0.87 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 8,889,000 | +8,889,000 | 0.00 | 0.25 | +0.25 | buy |
| Commodore Capital LP | 0 | 8,889,000 | +8,889,000 | 0.00 | 1.72 | +1.72 | buy |
| ADAR1 Capital Management, LLC | 0 | 8,889,000 | +8,889,000 | 0.00 | 1.35 | +1.35 | buy |
| Paradigm Biocapital Advisors LP | 0 | 5,586,625 | +5,586,625 | 0.00 | 0.34 | +0.34 | buy |
| Woodline Partners LP | 0 | 3,555,497 | +3,555,497 | 0.00 | 0.04 | +0.04 | buy |
| Vivo Capital, LLC | 0 | 3,555,250 | +3,555,250 | 0.00 | 1.05 | +1.05 | buy |
| Logos Global Management LP | 0 | 2,222,000 | +2,222,000 | 0.00 | 0.31 | +0.31 | buy |
| GOLDMAN SACHS GROUP INC | 558,577 | 2,614,036 | +2,055,459 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 1,926,997 | 3,861,930 | +1,934,933 | 0.63 | 1.13 | +0.51 | buy |
| MARSHALL WACE, LLP | 210,308 | 2,037,287 | +1,826,979 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 9,263,312 | 10,589,990 | +1,326,678 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 868,032 | +868,032 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 0 | 852,700 | +852,700 | 0.00 | 0.17 | +0.17 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 498,997 | +498,997 | 0.00 | 0.00 | +0.00 | buy |
| Casdin Capital, LLC | 0 | 445,000 | +445,000 | 0.00 | 0.07 | +0.07 | buy |
| PEAK6 LLC | 0 | 415,441 | +415,441 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 393,754 | 750,763 | +357,009 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 326,000 | +326,000 | 0.00 | 0.04 | +0.04 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 309,395 | +309,395 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,311,789 | 2,569,072 | +257,283 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 231,827 | +231,827 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 231,115 | +231,115 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 0 | 230,000 | +230,000 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,370,497 | 1,572,242 | +201,745 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 183,859 | +183,859 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 170,470 | +170,470 | 0.00 | 0.11 | +0.11 | buy |
| Eversept Partners, LP | 290,919 | 458,809 | +167,890 | 0.05 | 0.08 | +0.03 | buy |
| MACKENZIE FINANCIAL CORP | 730,054 | 878,042 | +147,988 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 332,933 | 477,099 | +144,166 | 0.01 | 0.02 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 140,428 | 271,186 | +130,758 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,076,122 | 2,191,803 | +115,681 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 99,365 | +99,365 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 92,596 | +92,596 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 742,443 | 819,693 | +77,250 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 136,462 | 211,880 | +75,418 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 5,981 | 63,974 | +57,993 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 7,298 | 61,964 | +54,666 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 42,400 | +42,400 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 41,472 | +41,472 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 0 | 40,000 | +40,000 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 37,638 | +37,638 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 36,452 | +36,452 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 115,131 | 151,406 | +36,275 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 22,309 | 50,349 | +28,040 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,323 | 44,424 | +27,101 | 0.00 | 0.01 | +0.01 | buy |
| EntryPoint Capital, LLC | 0 | 26,944 | +26,944 | 0.00 | 0.02 | +0.02 | buy |
| Vise Technologies, Inc. | 0 | 25,794 | +25,794 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 1,293,848 | 1,318,947 | +25,099 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 24,646 | +24,646 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 145,540 | 169,291 | +23,751 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 10,459 | 33,138 | +22,679 | 0.00 | 0.01 | +0.01 | buy |
| Creative Planning | 23,084 | 45,572 | +22,488 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 57,733 | 78,602 | +20,869 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 167,530 | 187,930 | +20,400 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 197,418 | 217,785 | +20,367 | 0.00 | 0.00 | +0.00 | buy |
| MML INVESTORS SERVICES, LLC | 32,110 | 52,088 | +19,978 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 102,030 | 120,753 | +18,723 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 51,424 | 70,124 | +18,700 | 0.00 | 0.00 | +0.00 | buy |
| BRIGHTON JONES LLC | 0 | 17,751 | +17,751 | 0.00 | 0.00 | +0.00 | buy |
| StoneX Group Inc. | 0 | 16,213 | +16,213 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 14,359 | +14,359 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 42,433 | 56,216 | +13,783 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 25,782 | 37,644 | +11,862 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 45,080 | 56,132 | +11,052 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 108,465 | 119,429 | +10,964 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 107,200 | 117,417 | +10,217 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 14,598 | 22,954 | +8,356 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 116,995 | 125,234 | +8,239 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 171 | 7,365 | +7,194 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 861,326 | 868,032 | +6,706 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,143 | 17,642 | +6,499 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 21,597 | 27,264 | +5,667 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 16,089 | 20,536 | +4,447 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 106,780 | 111,198 | +4,418 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 17,380 | 21,540 | +4,160 | 0.01 | 0.01 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 7,162 | 11,028 | +3,866 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 88,369 | 92,094 | +3,725 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 141,082 | 144,805 | +3,723 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 145,602 | 149,264 | +3,662 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 27,950 | 30,296 | +2,346 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 7,778 | 9,708 | +1,930 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 5,092 | 6,863 | +1,771 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 19,828 | 21,518 | +1,690 | 0.00 | 0.00 | +0.00 | buy |
| DLK Investment Management, LLC | 16,619 | 17,702 | +1,083 | 0.02 | 0.04 | +0.02 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,174 | 3,033 | +859 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 3,488 | 4,180 | +692 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 15,674 | 16,153 | +479 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 2,941 | 3,316 | +375 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 590 | 914 | +324 | 0.00 | 0.00 | +0.00 | buy |
| SJS Investment Consulting Inc. | 42 | 360 | +318 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 14,443 | 14,703 | +260 | 0.01 | 0.01 | +0.00 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 30,957 | 31,207 | +250 | 0.01 | 0.01 | +0.00 | buy |
| Quarry LP | 0 | 112 | +112 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 727 | 829 | +102 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 407 | 506 | +99 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 25 | 123 | +98 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 1,200 | 1,282 | +82 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 332 | 412 | +80 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 63 | 108 | +45 | 0.00 | 0.00 | 0.00 | buy |