| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 9,786 | 180,956 | +171,170 | 0.01 | 0.47 | +0.46 | buy |
| Paradigm Biocapital Advisors LP | 616,024 | 666,024 | +50,000 | 3.96 | 8.34 | +4.39 | buy |
| XY Capital Ltd | 24,603 | 60,415 | +35,812 | 5.07 | 10.83 | +5.76 | buy |
| Long Corridor Asset Management Ltd | 18,400 | 37,000 | +18,600 | 2.55 | 7.37 | +4.82 | buy |
| Atle Fund Management AB | 10,900 | 25,141 | +14,241 | 0.95 | 3.02 | +2.07 | buy |
| Artisan Partners Limited Partnership | 279,648 | 287,400 | +7,752 | 0.08 | 0.13 | +0.05 | buy |
| Fiera Capital Corp | 8,442 | 14,164 | +5,722 | 0.00 | 0.01 | +0.01 | buy |
| JGP Global Gestao de Recursos Ltda. | 9,374 | 11,995 | +2,621 | 3.94 | 2.50 | -1.44 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 2,715 | 4,957 | +2,242 | 0.09 | 0.22 | +0.13 | buy |
| ABN AMRO INVESTMENT SOLUTIONS | 24,408 | 26,560 | +2,152 | 0.08 | 0.15 | +0.07 | buy |
| Vestmark Advisory Solutions, Inc. | 1,652 | 3,338 | +1,686 | 0.01 | 0.02 | +0.01 | buy |
| Bellevue Group AG | 34,229 | 35,329 | +1,100 | 0.12 | 0.22 | +0.09 | buy |
| SECTORAL ASSET MANAGEMENT INC | 2,010 | 2,927 | +917 | 0.25 | 0.62 | +0.37 | buy |
| NEOS Investment Management LLC | 6,249 | 7,083 | +834 | 0.03 | 0.04 | +0.01 | buy |
| TEMA ETFS LLC | 6,249 | 7,083 | +834 | 0.48 | 0.58 | +0.10 | buy |
| PROFUND ADVISORS LLC | 4,586 | 5,195 | +609 | 0.03 | 0.06 | +0.03 | buy |
| Avanza Fonder AB | 675 | 907 | +232 | 0.00 | 0.01 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 1,571 | 1,638 | +67 | 0.02 | 0.04 | +0.01 | buy |
| NewEdge Wealth, LLC | 1,663 | 1,683 | +20 | 0.01 | 0.01 | +0.00 | buy |
| Venturi Wealth Management, LLC | 1,538 | 1,544 | +6 | 0.01 | 0.02 | +0.01 | buy |
| LVW Advisors, LLC | 1,132 | 1,029 | -103 | 0.03 | 0.03 | +0.01 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 691 | 179 | -512 | 0.03 | 0.01 | -0.02 | sell |
| Bridgewater Associates, LP | 1,610 | 772 | -838 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 9,403 | 8,394 | -1,009 | 0.16 | 0.21 | +0.05 | sell |
| Capital Group Investment Management Pte. Ltd. | 16,436 | 14,793 | -1,643 | 0.58 | 0.82 | +0.25 | sell |
| BNP Paribas Asset Management Holding S.A. | 80,044 | 78,388 | -1,656 | 0.04 | 0.06 | +0.02 | sell |
| EFG Asset Management (North America) Corp. | 9,986 | 7,620 | -2,366 | 0.25 | 0.34 | +0.09 | sell |
| Exome Asset Management LLC | 10,000 | 6,500 | -3,500 | 1.39 | 1.58 | +0.19 | sell |
| Nan Fung Group Holdings Ltd | 19,997 | 15,722 | -4,275 | 3.16 | 3.49 | +0.33 | sell |
| CAPITAL INTERNATIONAL LTD /CA/ | 76,048 | 69,492 | -6,556 | 0.57 | 0.82 | +0.25 | sell |
| M&G Plc | 193,163 | 186,031 | -7,132 | 0.22 | 0.24 | +0.02 | sell |
| Capital Group Private Client Services, Inc. | 159,297 | 152,156 | -7,141 | 0.27 | 0.40 | +0.13 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 27,923 | 15,619 | -12,304 | 0.00 | 0.00 | -0.00 | sell |
| FIL Ltd | 13,640 | 183 | -13,457 | 0.00 | 0.00 | -0.00 | sell |
| Capital International Sarl | 152,710 | 139,005 | -13,705 | 0.65 | 0.86 | +0.21 | sell |
| BARINGS LLC | 71,422 | 55,604 | -15,818 | 0.31 | 0.38 | +0.06 | sell |
| Greenwoods Asset Management Hong Kong Ltd. | 30,658 | 9,329 | -21,329 | 0.18 | 0.08 | -0.10 | sell |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 88,290 | 59,460 | -28,830 | 0.28 | 0.29 | +0.01 | sell |
| BAILLIE GIFFORD & CO | 3,671,195 | 3,630,710 | -40,485 | 0.52 | 0.86 | +0.34 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 5,098,904 | 5,055,504 | -43,400 | 0.73 | 1.14 | +0.41 | sell |
| Capital International, Inc./CA/ | 554,926 | 437,382 | -117,544 | 1.21 | 1.44 | +0.23 | sell |
| Siren, L.L.C. | 653,721 | 498,689 | -155,032 | 5.34 | 7.66 | +2.32 | sell |
| Temasek Holdings (Private) Ltd | 1,525,329 | 993,752 | -531,577 | 1.11 | 1.09 | -0.02 | sell |
| BAKER BROS. ADVISORS LP | 9,531,880 | 8,799,053 | -732,827 | 18.81 | 26.50 | +7.69 | sell |
| Capital International Investors | 6,113,165 | 5,090,970 | -1,022,195 | 0.21 | 0.27 | +0.06 | sell |
| HHLR ADVISORS, LTD. | 3,804,406 | 1,034,306 | -2,770,100 | 24.34 | 7.95 | -16.39 | sell |