| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 8,799,053 | 8,799,053 | 0 | 15.65 | 15.00 | -0.65 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 4,980,581 | 4,975,181 | -5,400 | 1.15 | 1.16 | +0.02 | sell |
| Capital International Investors | 5,113,866 | 4,158,726 | -955,140 | 0.24 | 0.29 | +0.05 | sell |
| FMR LLC | 3,992,627 | 3,693,610 | -299,017 | 0.06 | 0.06 | -0.00 | sell |
| Capital World Investors | 0 | 1,622,687 | +1,622,687 | 0.00 | 0.07 | +0.07 | buy |
| HHLR ADVISORS, LTD. | 1,034,306 | 1,034,306 | 0 | 10.12 | 18.36 | +8.24 | hold |
| CITADEL ADVISORS LLC | 533,517 | 1,032,298 | +498,781 | 0.11 | 0.22 | +0.11 | buy |
| Temasek Holdings (Private) Ltd | 919,587 | 862,643 | -56,944 | 0.90 | 0.86 | -0.04 | sell |
| BlackRock, Inc. | 676,210 | 657,501 | -18,709 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,372,679 | 539,769 | -832,910 | 0.04 | 0.02 | -0.03 | sell |
| Siren, L.L.C. | 500,000 | 465,000 | -35,000 | 4.53 | 3.83 | -0.70 | sell |
| MORGAN STANLEY | 437,661 | 464,472 | +26,811 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 152,087 | 415,330 | +263,243 | 0.01 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 378,832 | 405,273 | +26,441 | 0.01 | 0.01 | +0.00 | buy |
| Baird Financial Group, Inc. | 304,339 | 349,651 | +45,312 | 0.14 | 0.16 | +0.02 | buy |
| Capital International, Inc./CA/ | 307,660 | 302,243 | -5,417 | 0.74 | 0.69 | -0.04 | sell |
| Candriam S.C.A. | 197,261 | 259,731 | +62,470 | 0.30 | 0.40 | +0.10 | buy |
| Man Group plc | 248,514 | 241,922 | -6,592 | 0.14 | 0.15 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 125,825 | 241,426 | +115,601 | 0.03 | 0.05 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 31,451 | 204,846 | +173,395 | 0.01 | 0.05 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 94,594 | 201,641 | +107,047 | 0.01 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 194,124 | 196,429 | +2,305 | 0.02 | 0.02 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 193,951 | 184,356 | -9,595 | 0.04 | 0.04 | -0.00 | sell |
| Capital International Sarl | 152,515 | 173,879 | +21,364 | 0.74 | 0.85 | +0.10 | buy |
| MARSHALL WACE, LLP | 152,296 | 172,643 | +20,347 | 0.04 | 0.05 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 23,213 | 155,002 | +131,789 | 0.05 | 0.34 | +0.29 | buy |
| JENNISON ASSOCIATES LLC | 76,438 | 154,465 | +78,027 | 0.01 | 0.03 | +0.02 | buy |
| M&G Plc | 129,791 | 138,163 | +8,372 | 0.20 | 0.21 | +0.01 | buy |
| Artisan Partners Limited Partnership | 165,241 | 137,216 | -28,025 | 0.08 | 0.07 | -0.01 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 56,326 | 110,586 | +54,260 | 0.01 | 0.02 | +0.01 | buy |
| VAN ECK ASSOCIATES CORP | 90,010 | 108,305 | +18,295 | 0.02 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 148,714 | 96,677 | -52,037 | 0.01 | 0.00 | -0.00 | sell |
| Patient Square Capital LP | 69,312 | 80,542 | +11,230 | 4.51 | 4.24 | -0.26 | buy |
| JPMORGAN CHASE & CO | 7,445 | 77,538 | +70,093 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL INTERNATIONAL LTD /CA/ | 67,722 | 76,515 | +8,793 | 0.73 | 0.84 | +0.12 | buy |
| JANE STREET GROUP, LLC | 0 | 75,953 | +75,953 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 68,900 | 74,124 | +5,224 | 0.04 | 0.05 | +0.01 | buy |
| ROYAL BANK OF CANADA | 67,992 | 70,391 | +2,399 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 65,456 | +65,456 | 0.00 | 0.03 | +0.03 | buy |
| LAZARD ASSET MANAGEMENT LLC | 48,221 | 62,917 | +14,696 | 0.02 | 0.03 | +0.01 | buy |
| Legal & General Group Plc | 54,185 | 59,812 | +5,627 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 56,366 | 59,611 | +3,245 | 0.01 | 0.00 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 32,941 | 57,320 | +24,379 | 0.04 | 0.06 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 49,064 | 56,879 | +7,815 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 51,494 | 52,063 | +569 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 39,833 | 49,344 | +9,511 | 0.01 | 0.01 | +0.00 | buy |
| ABN AMRO INVESTMENT SOLUTIONS | 32,076 | 47,564 | +15,488 | 0.14 | 0.18 | +0.04 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 33,020 | 43,430 | +10,410 | 0.14 | 0.19 | +0.04 | buy |
| BARINGS LLC | 42,815 | 42,815 | 0 | 0.24 | 0.21 | -0.03 | hold |
| Atle Fund Management AB | 40,432 | 41,717 | +1,285 | 3.92 | 3.92 | +0.00 | buy |
| NORTHERN TRUST CORP | 40,629 | 36,132 | -4,497 | 0.00 | 0.00 | -0.00 | sell |
| Fiera Capital Corp | 29,900 | 33,782 | +3,882 | 0.03 | 0.03 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 34,065 | 33,728 | -337 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 8,400 | 33,543 | +25,143 | 0.00 | 0.01 | +0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 30,089 | 32,532 | +2,443 | 0.11 | 0.11 | -0.00 | buy |
| NOMURA HOLDINGS INC | 31,062 | 30,942 | -120 | 0.03 | 0.08 | +0.05 | sell |
| ASSETMARK, INC | 24,814 | 29,569 | +4,755 | 0.02 | 0.02 | +0.00 | buy |
| Capital Group Private Client Services, Inc. | 41,783 | 28,656 | -13,127 | 0.20 | 0.14 | -0.06 | sell |
| Slow Capital, Inc. | 27,301 | 28,492 | +1,191 | 0.99 | 1.10 | +0.11 | buy |
| DEUTSCHE BANK AG\ | 60,656 | 27,877 | -32,779 | 0.01 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 26,252 | 27,105 | +853 | 0.00 | 0.00 | +0.00 | buy |
| AIA Group Ltd | 22,647 | 26,077 | +3,430 | 0.10 | 0.11 | +0.01 | buy |
| BARCLAYS PLC | 24,801 | 25,222 | +421 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 42,207 | 23,740 | -18,467 | 0.04 | 0.02 | -0.02 | sell |
| Russell Investments Group, Ltd. | 21,077 | 23,438 | +2,361 | 0.01 | 0.01 | +0.00 | buy |
| Erste Asset Management GmbH | 21,900 | 21,900 | 0 | 0.06 | 0.06 | +0.00 | hold |
| Asset Management One Co., Ltd. | 19,998 | 21,346 | +1,348 | 0.02 | 0.02 | +0.00 | buy |
| Walleye Capital LLC | 2,942 | 21,051 | +18,109 | 0.01 | 0.04 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 17,908 | 20,828 | +2,920 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 14,123 | 19,178 | +5,055 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 17,555 | 19,047 | +1,492 | 0.00 | 0.00 | +0.00 | buy |
| Capital Group Investment Management Pte. Ltd. | 14,710 | 16,688 | +1,978 | 0.73 | 0.85 | +0.12 | buy |
| Nan Fung Group Holdings Ltd | 15,722 | 15,722 | 0 | 4.28 | 3.85 | -0.42 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 3,517 | 14,808 | +11,291 | 0.00 | 0.01 | +0.00 | buy |
| Rokos Capital Management LLP | 0 | 14,335 | +14,335 | 0.00 | 0.08 | +0.08 | buy |
| Tidal Investments LLC | 908 | 12,633 | +11,725 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 12,338 | 12,346 | +8 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 9,148 | 12,245 | +3,097 | 0.02 | 0.03 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 0 | 11,701 | +11,701 | 0.00 | 0.21 | +0.21 | buy |
| STIFEL FINANCIAL CORP | 10,967 | 11,469 | +502 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 24,584 | 10,980 | -13,604 | 0.08 | 0.03 | -0.05 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 10,692 | 10,692 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 11,654 | 10,486 | -1,168 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 5,598 | 10,188 | +4,590 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 9,266 | 10,158 | +892 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 15,752 | 10,014 | -5,738 | 0.00 | 0.00 | -0.00 | sell |
| Pinpoint Asset Management (Singapore) Pte. Ltd. | 4,374 | 9,610 | +5,236 | 0.28 | 0.67 | +0.39 | buy |
| KBC Group NV | 8,986 | 9,488 | +502 | 0.01 | 0.01 | +0.00 | buy |
| Quantinno Capital Management LP | 6,690 | 8,312 | +1,622 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 8,386 | 8,145 | -241 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 7,495 | 7,815 | +320 | 0.00 | 0.01 | +0.01 | buy |
| Crossmark Global Holdings, Inc. | 8,214 | 7,661 | -553 | 0.04 | 0.03 | -0.00 | sell |
| STATE STREET CORP | 8,271 | 7,065 | -1,206 | 0.00 | 0.00 | -0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 190 | 6,465 | +6,275 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 6,254 | 6,377 | +123 | 0.00 | 0.00 | -0.00 | buy |
| Jefferies Financial Group Inc. | 6,200 | 6,200 | 0 | 0.02 | 0.02 | +0.01 | hold |
| MACKENZIE FINANCIAL CORP | 30,859 | 6,081 | -24,778 | 0.01 | 0.00 | -0.01 | sell |
| Long Corridor Asset Management Ltd | 7,731 | 6,020 | -1,711 | 0.15 | 0.43 | +0.28 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,947 | 5,863 | +916 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 5,129 | 5,672 | +543 | 0.12 | 0.13 | +0.01 | buy |