| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 10,568,897 | 10,568,897 | 0 | 20.73 | 19.27 | -1.46 | hold |
| Capital International Investors | 7,064,428 | 7,013,568 | -50,860 | 0.22 | 0.21 | -0.02 | sell |
| HHLR ADVISORS, LTD. | 5,176,906 | 5,176,906 | 0 | 17.58 | 18.22 | +0.64 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 5,001,839 | 4,986,289 | -15,550 | 0.58 | 0.52 | -0.07 | sell |
| BAILLIE GIFFORD & CO | 3,728,730 | 3,681,949 | -46,781 | 0.45 | 0.41 | -0.04 | sell |
| Temasek Holdings (Private) Ltd | 3,014,171 | 3,014,171 | 0 | 2.61 | 2.00 | -0.61 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,026,094 | 2,272,822 | +246,728 | 0.04 | 0.04 | -0.00 | buy |
| FMR LLC | 1,680,463 | 1,647,156 | -33,307 | 0.02 | 0.02 | -0.00 | sell |
| Capital International, Inc./CA/ | 858,364 | 855,134 | -3,230 | 1.81 | 1.62 | -0.19 | sell |
| Point72 Asset Management, L.P. | 0 | 381,382 | +381,382 | 0.00 | 0.18 | +0.18 | buy |
| PUBLIC INVESTMENT FUND | 354,385 | 354,385 | 0 | 0.31 | 0.29 | -0.02 | hold |
| Vestal Point Capital, LP | 325,000 | 350,000 | +25,000 | 4.20 | 3.72 | -0.48 | buy |
| Artal Group S.A. | 404,782 | 303,369 | -101,413 | 1.63 | 1.11 | -0.52 | sell |
| BANK OF AMERICA CORP /DE/ | 353,102 | 287,349 | -65,753 | 0.01 | 0.00 | -0.00 | sell |
| Baird Financial Group, Inc. | 250,867 | 262,105 | +11,238 | 0.08 | 0.08 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 221,831 | 250,351 | +28,520 | 0.04 | 0.04 | +0.00 | buy |
| Artisan Partners Limited Partnership | 144,930 | 208,418 | +63,488 | 0.03 | 0.05 | +0.01 | buy |
| Capital Group Private Client Services, Inc. | 208,800 | 192,840 | -15,960 | 0.33 | 0.28 | -0.06 | sell |
| Capital International Sarl | 191,942 | 192,425 | +483 | 1.00 | 0.84 | -0.16 | buy |
| M&G Plc | 190,056 | 179,779 | -10,277 | 0.11 | 0.10 | -0.01 | sell |
| Soleus Capital Management, L.P. | 148,100 | 137,700 | -10,400 | 2.03 | 1.73 | -0.30 | sell |
| TD ASSET MANAGEMENT INC | 112,779 | 114,378 | +1,599 | 0.02 | 0.02 | -0.00 | buy |
| Invesco Ltd. | 206,158 | 111,309 | -94,849 | 0.01 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 82,143 | 110,000 | +27,857 | 2.09 | 2.47 | +0.38 | buy |
| Pictet Asset Management Holding SA | 164,324 | 108,831 | -55,493 | 0.03 | 0.02 | -0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 98,073 | 97,629 | -444 | 0.04 | 0.04 | -0.00 | sell |
| VAN ECK ASSOCIATES CORP | 87,761 | 95,577 | +7,816 | 0.02 | 0.02 | -0.00 | buy |
| ROYAL BANK OF CANADA | 90,485 | 92,927 | +2,442 | 0.00 | 0.00 | -0.00 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 92,890 | 92,890 | 0 | 0.24 | 0.23 | -0.02 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 65,616 | 86,876 | +21,260 | 0.04 | 0.05 | +0.01 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 95,034 | 86,414 | -8,620 | 0.03 | 0.03 | -0.00 | sell |
| Legal & General Group Plc | 76,563 | 86,259 | +9,696 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 122,778 | 85,833 | -36,945 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 73,861 | 84,288 | +10,427 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 58,385 | 81,126 | +22,741 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 83,125 | 80,489 | -2,636 | 0.00 | 0.00 | -0.00 | sell |
| CAPITAL INTERNATIONAL LTD /CA/ | 74,874 | 74,692 | -182 | 0.56 | 0.49 | -0.07 | sell |
| Squarepoint Ops LLC | 70,312 | 72,055 | +1,743 | 0.05 | 0.04 | -0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 64,786 | 63,140 | -1,646 | 0.00 | 0.00 | -0.00 | sell |
| AXA S.A. | 53,467 | 53,498 | +31 | 0.03 | 0.02 | -0.00 | buy |
| Long Corridor Asset Management Ltd | 10,046 | 52,623 | +42,577 | 1.39 | 7.11 | +5.72 | buy |
| MARSHALL WACE, LLP | 104,415 | 51,987 | -52,428 | 0.03 | 0.01 | -0.02 | sell |
| BARINGS LLC | 31,100 | 51,763 | +20,663 | 0.12 | 0.18 | +0.06 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 46,347 | 50,262 | +3,915 | 0.01 | 0.01 | -0.00 | buy |
| MACQUARIE GROUP LTD | 45,668 | 45,719 | +51 | 0.01 | 0.01 | -0.00 | buy |
| Woodline Partners LP | 0 | 45,078 | +45,078 | 0.00 | 0.06 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 36,075 | 37,814 | +1,739 | 0.00 | 0.00 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 37,000 | 37,000 | 0 | 0.60 | 0.54 | -0.06 | hold |
| ExodusPoint Capital Management, LP | 18,171 | 35,275 | +17,104 | 0.04 | 0.06 | +0.02 | buy |
| Exome Asset Management LLC | 36,800 | 33,200 | -3,600 | 4.93 | 4.22 | -0.71 | sell |
| Aberdeen Group plc | 21,138 | 33,068 | +11,930 | 0.01 | 0.01 | +0.00 | buy |
| ABN AMRO INVESTMENT SOLUTIONS | 28,439 | 28,439 | 0 | 0.08 | 0.07 | -0.00 | hold |
| OPPENHEIMER ASSET MANAGEMENT INC. | 18,124 | 26,924 | +8,800 | 0.04 | 0.05 | +0.01 | buy |
| Handelsbanken Fonder AB | 20,754 | 26,370 | +5,616 | 0.01 | 0.02 | +0.00 | buy |
| Bellevue Group AG | 24,929 | 25,629 | +700 | 0.06 | 0.06 | -0.00 | buy |
| Hudson Bay Capital Management LP | 20,000 | 25,000 | +5,000 | 0.03 | 0.03 | -0.00 | buy |
| SEI INVESTMENTS CO | 23,400 | 24,248 | +848 | 0.01 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 38,194 | 24,181 | -14,013 | 0.00 | 0.00 | -0.00 | sell |
| Nan Fung Group Holdings Ltd | 23,022 | 23,022 | 0 | 3.34 | 3.50 | +0.17 | hold |
| AIA Group Ltd | 18,497 | 21,665 | +3,168 | 0.09 | 0.09 | -0.00 | buy |
| CITIGROUP INC | 8,201 | 20,902 | +12,701 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 16,677 | 18,608 | +1,931 | 0.01 | 0.01 | -0.00 | buy |
| Asset Management One Co., Ltd. | 17,860 | 17,860 | 0 | 0.01 | 0.01 | -0.00 | hold |
| EFG Asset Management (North America) Corp. | 14,610 | 17,780 | +3,170 | 0.39 | 0.44 | +0.05 | buy |
| STIFEL FINANCIAL CORP | 17,499 | 17,173 | -326 | 0.00 | 0.00 | -0.00 | sell |
| CANADA LIFE ASSURANCE Co | 28,304 | 17,018 | -11,286 | 0.01 | 0.00 | -0.00 | sell |
| Swedbank AB | 16,599 | 16,599 | 0 | 0.02 | 0.00 | -0.02 | hold |
| JANE STREET GROUP, LLC | 0 | 16,033 | +16,033 | 0.00 | 0.00 | +0.00 | buy |
| Capital Group Investment Management Pte. Ltd. | 16,030 | 16,030 | 0 | 0.45 | 0.49 | +0.04 | hold |
| Walleye Capital LLC | 1,473 | 15,097 | +13,624 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 4,720 | 13,783 | +9,063 | 0.00 | 0.00 | +0.00 | buy |
| GMT CAPITAL CORP | 0 | 13,622 | +13,622 | 0.00 | 0.07 | +0.07 | buy |
| DekaBank Deutsche Girozentrale | 13,600 | 13,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 12,600 | 12,600 | 0 | 0.03 | 0.02 | -0.00 | hold |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 12,508 | +12,508 | 0.00 | 2.25 | +2.25 | buy |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 0 | 12,379 | +12,379 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 12,297 | 12,297 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS Group AG | 28,647 | 12,086 | -16,561 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 11,081 | 11,760 | +679 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 5,253 | 11,499 | +6,246 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 31,505 | 11,100 | -20,405 | 1.35 | 0.32 | -1.03 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 11,094 | +11,094 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 12,828 | 10,747 | -2,081 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 10,178 | 10,589 | +411 | 0.00 | 0.00 | -0.00 | buy |
| Focus Partners Wealth | 10,211 | 10,511 | +300 | 0.01 | 0.01 | -0.01 | buy |
| JGP Global Gestao de Recursos Ltda. | 10,471 | 10,464 | -7 | 1.05 | 1.90 | +0.84 | sell |
| Old Well Partners, LLC | 18,038 | 10,438 | -7,600 | 2.51 | 1.76 | -0.76 | sell |
| BANK OF MONTREAL /CAN/ | 10,016 | 10,031 | +15 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 6,835 | 9,177 | +2,342 | 0.00 | 0.00 | +0.00 | buy |
| Parkwood LLC | 11,330 | 9,055 | -2,275 | 0.19 | 0.16 | -0.02 | sell |
| KBC Group NV | 8,937 | 8,937 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,921 | 8,569 | +2,648 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 30 | 8,331 | +8,301 | 0.00 | 0.02 | +0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 8,185 | +8,185 | 0.00 | 0.01 | +0.01 | buy |
| Taikang Asset Management (Hong Kong) Co Ltd | 7,000 | 7,000 | 0 | 0.23 | 0.16 | -0.08 | hold |
| NEOS Investment Management LLC | 2,516 | 6,031 | +3,515 | 0.02 | 0.04 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 7,442 | 5,853 | -1,589 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 5,780 | +5,780 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 4,943 | 5,684 | +741 | 0.00 | 0.00 | +0.00 | buy |
| Bleakley Financial Group, LLC | 5,661 | 5,539 | -122 | 0.03 | 0.02 | -0.00 | sell |