| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 8,799,053 | 8,799,053 | 0 | 26.50 | 20.66 | -5.84 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 5,055,504 | 5,088,279 | +32,775 | 1.14 | 0.98 | -0.16 | buy |
| Capital International Investors | 5,090,970 | 4,885,006 | -205,964 | 0.27 | 0.20 | -0.07 | sell |
| FMR LLC | 3,453,576 | 3,449,793 | -3,783 | 0.06 | 0.05 | -0.01 | sell |
| HHLR ADVISORS, LTD. | 1,034,306 | 1,034,306 | 0 | 7.95 | 8.06 | +0.11 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,713,418 | 1,020,127 | -1,693,291 | 0.09 | 0.03 | -0.06 | sell |
| Temasek Holdings (Private) Ltd | 993,752 | 1,010,465 | +16,713 | 1.09 | 0.95 | -0.14 | buy |
| CITADEL ADVISORS LLC | 982,161 | 537,156 | -445,005 | 0.26 | 0.11 | -0.15 | sell |
| Siren, L.L.C. | 498,689 | 509,990 | +11,301 | 7.66 | 6.39 | -1.27 | buy |
| BlackRock, Inc. | 582,290 | 501,189 | -81,101 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 477,143 | 467,590 | -9,553 | 0.17 | 0.13 | -0.04 | sell |
| Paradigm Biocapital Advisors LP | 666,024 | 347,787 | -318,237 | 8.34 | 3.59 | -4.75 | sell |
| Capital International, Inc./CA/ | 437,382 | 345,559 | -91,823 | 1.44 | 0.81 | -0.63 | sell |
| Nuveen, LLC | 346,451 | 344,207 | -2,244 | 0.03 | 0.02 | -0.01 | sell |
| Baird Financial Group, Inc. | 274,396 | 342,442 | +68,046 | 0.14 | 0.15 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 291,606 | 302,999 | +11,393 | 0.35 | 0.26 | -0.09 | buy |
| Candriam S.C.A. | 285,893 | 280,286 | -5,607 | 0.49 | 0.39 | -0.10 | sell |
| BANK OF AMERICA CORP /DE/ | 292,787 | 279,493 | -13,294 | 0.01 | 0.01 | -0.00 | sell |
| Artisan Partners Limited Partnership | 287,400 | 270,153 | -17,247 | 0.13 | 0.10 | -0.03 | sell |
| MORGAN STANLEY | 411,929 | 268,474 | -143,455 | 0.01 | 0.00 | -0.00 | sell |
| Man Group plc | 153,823 | 243,861 | +90,038 | 0.13 | 0.13 | +0.00 | buy |
| PUBLIC INVESTMENT FUND | 354,385 | 227,177 | -127,208 | 0.49 | 0.30 | -0.19 | sell |
| MILLENNIUM MANAGEMENT LLC | 186,910 | 201,355 | +14,445 | 0.05 | 0.04 | -0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 180,956 | 198,203 | +17,247 | 0.47 | 0.38 | -0.09 | buy |
| UBS Group AG | 65,101 | 181,515 | +116,414 | 0.00 | 0.01 | +0.01 | buy |
| M&G Plc | 186,031 | 170,202 | -15,829 | 0.24 | 0.23 | -0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 171,880 | 158,372 | -13,508 | 0.04 | 0.03 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 140,574 | 158,200 | +17,626 | 0.05 | 0.04 | -0.01 | buy |
| Capital Group Private Client Services, Inc. | 152,156 | 148,613 | -3,543 | 0.40 | 0.31 | -0.09 | sell |
| FIRST TRUST ADVISORS LP | 223,186 | 140,339 | -82,847 | 0.05 | 0.03 | -0.03 | sell |
| Capital International Sarl | 139,005 | 133,924 | -5,081 | 0.86 | 0.62 | -0.23 | sell |
| Qube Research & Technologies Ltd | 35,229 | 107,546 | +72,317 | 0.01 | 0.04 | +0.02 | buy |
| JPMORGAN CHASE & CO | 138,310 | 88,014 | -50,296 | 0.00 | 0.00 | -0.00 | sell |
| VAN ECK ASSOCIATES CORP | 80,430 | 87,946 | +7,516 | 0.03 | 0.02 | -0.00 | buy |
| LMR Partners LLP | 24,658 | 78,369 | +53,711 | 0.13 | 0.30 | +0.16 | buy |
| Jump Financial, LLC | 82,200 | 70,300 | -11,900 | 0.36 | 0.22 | -0.14 | sell |
| GOLDMAN SACHS GROUP INC | 98,138 | 70,255 | -27,883 | 0.01 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 69,470 | 68,900 | -570 | 0.05 | 0.04 | -0.01 | sell |
| ROYAL BANK OF CANADA | 67,302 | 67,471 | +169 | 0.00 | 0.00 | -0.00 | buy |
| CAPITAL INTERNATIONAL LTD /CA/ | 69,492 | 66,321 | -3,171 | 0.82 | 0.62 | -0.21 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 61,128 | 62,220 | +1,092 | 0.01 | 0.00 | -0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 33,900 | 60,554 | +26,654 | 0.01 | 0.02 | +0.00 | buy |
| Iron Triangle Partners LP | 97,840 | 60,000 | -37,840 | 4.20 | 2.30 | -1.90 | sell |
| Jain Global LLC | 65,810 | 59,441 | -6,369 | 0.37 | 0.22 | -0.14 | sell |
| Legal & General Group Plc | 60,236 | 57,243 | -2,993 | 0.00 | 0.00 | -0.00 | sell |
| BARINGS LLC | 55,604 | 55,604 | 0 | 0.38 | 0.31 | -0.06 | hold |
| WELLS FARGO & COMPANY/MN | 50,784 | 51,412 | +628 | 0.00 | 0.00 | -0.00 | buy |
| Long Corridor Asset Management Ltd | 37,000 | 47,500 | +10,500 | 7.37 | 4.15 | -3.22 | buy |
| MACKENZIE FINANCIAL CORP | 40,255 | 41,328 | +1,073 | 0.02 | 0.01 | -0.00 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 59,460 | 41,010 | -18,450 | 0.29 | 0.16 | -0.13 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 39,000 | 39,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Bellevue Group AG | 35,329 | 38,698 | +3,369 | 0.22 | 0.21 | -0.01 | buy |
| Walleye Capital LLC | 72,747 | 36,645 | -36,102 | 0.22 | 0.08 | -0.14 | sell |
| AXA S.A. | 33,665 | 35,910 | +2,245 | 0.03 | 0.02 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 37,001 | 35,616 | -1,385 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 33,907 | 32,848 | -1,059 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 21,994 | 30,515 | +8,521 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 18,607 | 30,069 | +11,462 | 0.01 | 0.01 | +0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 30,159 | 29,537 | -622 | 0.10 | 0.08 | -0.02 | sell |
| JANE STREET GROUP, LLC | 89,727 | 25,170 | -64,557 | 0.04 | 0.01 | -0.03 | sell |
| ABN AMRO INVESTMENT SOLUTIONS | 26,560 | 24,915 | -1,645 | 0.15 | 0.12 | -0.03 | sell |
| BARCLAYS PLC | 42,746 | 24,903 | -17,843 | 0.01 | 0.00 | -0.00 | sell |
| AIA Group Ltd | 24,587 | 24,587 | 0 | 0.16 | 0.13 | -0.03 | hold |
| Atle Fund Management AB | 25,141 | 24,386 | -755 | 3.02 | 2.53 | -0.49 | sell |
| LAZARD ASSET MANAGEMENT LLC | 12,495 | 23,692 | +11,197 | 0.01 | 0.01 | +0.00 | buy |
| ASSETMARK, INC | 19,776 | 21,147 | +1,371 | 0.01 | 0.01 | -0.00 | buy |
| Trexquant Investment LP | 0 | 21,049 | +21,049 | 0.00 | 0.06 | +0.06 | buy |
| Fiera Capital Corp | 14,164 | 20,912 | +6,748 | 0.01 | 0.02 | +0.00 | buy |
| HSBC HOLDINGS PLC | 15,593 | 20,639 | +5,046 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 23,280 | 20,514 | -2,766 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 20,500 | 20,500 | 0 | 0.07 | 0.04 | -0.03 | hold |
| Asset Management One Co., Ltd. | 20,453 | 20,453 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Slow Capital, Inc. | 12,237 | 18,083 | +5,846 | 0.45 | 0.54 | +0.09 | buy |
| NORTHERN TRUST CORP | 17,296 | 16,594 | -702 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 16,031 | 16,503 | +472 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 881 | 16,254 | +15,373 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 15,722 | 15,722 | 0 | 3.49 | 6.00 | +2.51 | hold |
| Greenwoods Asset Management Hong Kong Ltd. | 9,329 | 15,502 | +6,173 | 0.08 | 0.13 | +0.05 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,149 | 15,149 | 0 | 0.01 | 0.00 | -0.00 | hold |
| ExodusPoint Capital Management, LP | 0 | 14,906 | +14,906 | 0.00 | 0.04 | +0.04 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 17,873 | 14,420 | -3,453 | 0.02 | 0.01 | -0.01 | sell |
| Capital Group Investment Management Pte. Ltd. | 14,793 | 14,244 | -549 | 0.82 | 0.61 | -0.21 | sell |
| STATE STREET CORP | 0 | 13,778 | +13,778 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 13,600 | 13,600 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Russell Investments Group, Ltd. | 14 | 13,586 | +13,572 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 12,310 | 12,338 | +28 | 0.00 | 0.00 | -0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 11,995 | 11,995 | 0 | 2.50 | 1.42 | -1.08 | hold |
| STIFEL FINANCIAL CORP | 12,448 | 11,224 | -1,224 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 10,385 | 10,385 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 23,936 | 10,360 | -13,576 | 0.11 | 0.10 | -0.01 | sell |
| Verition Fund Management LLC | 18,728 | 10,208 | -8,520 | 0.03 | 0.01 | -0.02 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 1,880 | 9,377 | +7,497 | 0.01 | 0.06 | +0.05 | buy |
| KBC Group NV | 8,937 | 8,986 | +49 | 0.01 | 0.01 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 15,619 | 8,614 | -7,005 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 8,394 | 8,293 | -101 | 0.21 | 0.19 | -0.02 | sell |
| GUGGENHEIM CAPITAL LLC | 8,681 | 8,037 | -644 | 0.02 | 0.02 | -0.01 | sell |
| BANK OF MONTREAL /CAN/ | 7,976 | 7,981 | +5 | 0.00 | 0.00 | -0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 5,511 | 7,866 | +2,355 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 2,927 | 7,716 | +4,789 | 0.62 | 1.23 | +0.61 | buy |
| NEOS Investment Management LLC | 7,083 | 7,707 | +624 | 0.04 | 0.02 | -0.01 | buy |