| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 8,799,053 | 8,799,053 | 0 | 20.66 | 21.66 | +1.00 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 5,088,279 | 5,080,461 | -7,818 | 0.98 | 1.33 | +0.35 | sell |
| Capital International Investors | 4,885,006 | 5,046,058 | +161,052 | 0.20 | 0.28 | +0.07 | buy |
| FMR LLC | 3,449,793 | 3,784,935 | +335,142 | 0.05 | 0.07 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,020,127 | 1,630,571 | +610,444 | 0.03 | 0.06 | +0.03 | buy |
| HHLR ADVISORS, LTD. | 1,034,306 | 1,034,306 | 0 | 8.06 | 8.61 | +0.55 | hold |
| Temasek Holdings (Private) Ltd | 1,010,465 | 1,011,464 | +999 | 0.95 | 1.20 | +0.25 | buy |
| BlackRock, Inc. | 501,189 | 496,090 | -5,099 | 0.00 | 0.00 | +0.00 | sell |
| Siren, L.L.C. | 509,990 | 492,990 | -17,000 | 6.39 | 6.57 | +0.18 | sell |
| MORGAN STANLEY | 268,474 | 353,294 | +84,820 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 279,493 | 345,256 | +65,763 | 0.01 | 0.01 | +0.00 | buy |
| Baird Financial Group, Inc. | 342,442 | 342,922 | +480 | 0.15 | 0.19 | +0.04 | buy |
| Capital International, Inc./CA/ | 345,559 | 325,844 | -19,715 | 0.81 | 0.89 | +0.08 | sell |
| MARSHALL WACE, LLP | 467,590 | 312,437 | -155,153 | 0.13 | 0.12 | -0.02 | sell |
| Nuveen, LLC | 344,207 | 306,511 | -37,696 | 0.02 | 0.03 | +0.00 | sell |
| Artisan Partners Limited Partnership | 270,153 | 249,844 | -20,309 | 0.10 | 0.12 | +0.03 | sell |
| Candriam S.C.A. | 280,286 | 212,568 | -67,718 | 0.39 | 0.38 | -0.01 | sell |
| Man Group plc | 243,861 | 209,016 | -34,845 | 0.13 | 0.14 | +0.01 | sell |
| Capital International Sarl | 133,924 | 148,559 | +14,635 | 0.62 | 0.87 | +0.25 | buy |
| FIRST TRUST ADVISORS LP | 140,339 | 139,410 | -929 | 0.03 | 0.04 | +0.01 | sell |
| M&G Plc | 170,202 | 120,721 | -49,481 | 0.23 | 0.22 | -0.01 | sell |
| UBS Group AG | 181,515 | 104,915 | -76,600 | 0.01 | 0.01 | -0.00 | sell |
| VAN ECK ASSOCIATES CORP | 87,946 | 98,586 | +10,640 | 0.02 | 0.03 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 158,372 | 96,707 | -61,665 | 0.03 | 0.03 | -0.00 | sell |
| 1832 Asset Management L.P. | 0 | 80,000 | +80,000 | 0.00 | 0.05 | +0.05 | buy |
| JENNISON ASSOCIATES LLC | 0 | 73,598 | +73,598 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 67,471 | 70,508 | +3,037 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 68,900 | 69,830 | +930 | 0.04 | 0.05 | +0.01 | buy |
| CAPITAL INTERNATIONAL LTD /CA/ | 66,321 | 66,792 | +471 | 0.62 | 0.82 | +0.21 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 62,220 | 63,252 | +1,032 | 0.00 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 107,546 | 62,392 | -45,154 | 0.04 | 0.03 | -0.01 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 2,085 | 55,734 | +53,649 | 0.00 | 0.01 | +0.01 | buy |
| BARINGS LLC | 55,604 | 55,604 | 0 | 0.31 | 0.36 | +0.05 | hold |
| Legal & General Group Plc | 57,243 | 54,022 | -3,221 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 51,412 | 52,191 | +779 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 88,014 | 48,812 | -39,202 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 47,755 | +47,755 | 0.00 | 0.05 | +0.05 | buy |
| GOLDMAN SACHS GROUP INC | 70,255 | 44,231 | -26,024 | 0.00 | 0.00 | -0.00 | sell |
| Capital Group Private Client Services, Inc. | 148,613 | 43,728 | -104,885 | 0.31 | 0.25 | -0.06 | sell |
| Mirae Asset Global Investments Co., Ltd. | 3,824 | 42,816 | +38,992 | 0.00 | 0.05 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 16,254 | 41,967 | +25,713 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 23,692 | 41,380 | +17,688 | 0.01 | 0.02 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 30,515 | 39,792 | +9,277 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 37,000 | +37,000 | 0.00 | 0.06 | +0.06 | buy |
| CITADEL ADVISORS LLC | 537,156 | 36,205 | -500,951 | 0.11 | 0.01 | -0.10 | sell |
| MACKENZIE FINANCIAL CORP | 41,328 | 36,096 | -5,232 | 0.01 | 0.01 | +0.00 | sell |
| Bellevue Group AG | 38,698 | 33,797 | -4,901 | 0.21 | 0.24 | +0.03 | sell |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 41,010 | 33,020 | -7,990 | 0.16 | 0.17 | +0.02 | sell |
| AIA Group Ltd | 24,587 | 32,303 | +7,716 | 0.13 | 0.19 | +0.07 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 29,537 | 31,674 | +2,137 | 0.08 | 0.12 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 20,514 | 30,514 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 24,386 | 30,333 | +5,947 | 2.53 | 4.07 | +1.54 | buy |
| MACQUARIE GROUP LTD | 32,848 | 29,273 | -3,575 | 0.01 | 0.01 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 35,616 | 29,149 | -6,467 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 0 | 27,377 | +27,377 | 0.00 | 0.01 | +0.01 | buy |
| Jain Global LLC | 59,441 | 27,197 | -32,244 | 0.22 | 0.12 | -0.10 | sell |
| Fiera Capital Corp | 20,912 | 25,117 | +4,205 | 0.02 | 0.03 | +0.01 | buy |
| ASSETMARK, INC | 21,147 | 22,981 | +1,834 | 0.01 | 0.02 | +0.00 | buy |
| NORTHERN TRUST CORP | 16,594 | 22,934 | +6,340 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 20,500 | 21,900 | +1,400 | 0.04 | 0.07 | +0.03 | buy |
| Asset Management One Co., Ltd. | 20,453 | 19,910 | -543 | 0.02 | 0.02 | +0.00 | sell |
| Russell Investments Group, Ltd. | 13,586 | 18,309 | +4,723 | 0.00 | 0.01 | +0.00 | buy |
| Slow Capital, Inc. | 18,083 | 18,021 | -62 | 0.54 | 0.72 | +0.19 | sell |
| MILLENNIUM MANAGEMENT LLC | 201,355 | 17,849 | -183,506 | 0.04 | 0.00 | -0.04 | sell |
| RAYMOND JAMES FINANCIAL INC | 16,503 | 17,196 | +693 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,149 | 15,895 | +746 | 0.00 | 0.01 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 15,722 | 15,722 | 0 | 6.00 | 8.99 | +2.99 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 10,385 | 15,490 | +5,105 | 0.00 | 0.01 | +0.00 | buy |
| ABN AMRO INVESTMENT SOLUTIONS | 24,915 | 15,197 | -9,718 | 0.12 | 0.11 | -0.01 | sell |
| Capital Group Investment Management Pte. Ltd. | 14,244 | 14,380 | +136 | 0.61 | 0.82 | +0.21 | buy |
| DekaBank Deutsche Girozentrale | 13,600 | 13,600 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 2,012 | 13,578 | +11,566 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 24,903 | 13,408 | -11,495 | 0.00 | 0.00 | -0.00 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 7,866 | 13,404 | +5,538 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 198,203 | 13,361 | -184,842 | 0.38 | 0.03 | -0.35 | sell |
| JANE STREET GROUP, LLC | 25,170 | 13,078 | -12,092 | 0.01 | 0.01 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 12,338 | 12,338 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 30,069 | 12,050 | -18,019 | 0.01 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,503 | 11,435 | +7,932 | 0.02 | 0.11 | +0.08 | buy |
| STIFEL FINANCIAL CORP | 11,224 | 10,699 | -525 | 0.00 | 0.00 | +0.00 | sell |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 10,360 | 10,360 | 0 | 0.10 | 0.14 | +0.04 | hold |
| ExodusPoint Capital Management, LP | 14,906 | 9,933 | -4,973 | 0.04 | 0.05 | +0.00 | sell |
| Long Corridor Asset Management Ltd | 47,500 | 9,900 | -37,600 | 4.15 | 1.38 | -2.77 | sell |
| KBC Group NV | 8,986 | 8,986 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Creative Planning | 5,981 | 8,951 | +2,970 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 13,778 | 8,787 | -4,991 | 0.00 | 0.00 | -0.00 | sell |
| Generali Investments, Management Co LLC | 0 | 8,000 | +8,000 | 0.00 | 0.04 | +0.04 | buy |
| BANK OF MONTREAL /CAN/ | 7,981 | 7,950 | -31 | 0.00 | 0.00 | +0.00 | sell |
| SEI INVESTMENTS CO | 7,371 | 7,826 | +455 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 1,539 | 7,383 | +5,844 | 0.00 | 0.01 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 7,716 | 7,201 | -515 | 1.23 | 1.51 | +0.28 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 8,614 | 7,095 | -1,519 | 0.00 | 0.00 | +0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 8,037 | 7,030 | -1,007 | 0.02 | 0.02 | +0.00 | sell |
| NEOS Investment Management LLC | 7,707 | 6,771 | -936 | 0.02 | 0.02 | -0.01 | sell |
| TEMA ETFS LLC | 7,707 | 6,771 | -936 | 0.50 | 0.19 | -0.30 | sell |
| CITIGROUP INC | 4,749 | 6,469 | +1,720 | 0.00 | 0.00 | +0.00 | buy |
| Crossmark Global Holdings, Inc. | 5,050 | 6,241 | +1,191 | 0.02 | 0.03 | +0.01 | buy |
| Rockefeller Capital Management L.P. | 0 | 6,138 | +6,138 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,293 | 5,892 | -2,401 | 0.19 | 0.17 | -0.02 | sell |
| PROFUND ADVISORS LLC | 4,740 | 5,831 | +1,091 | 0.04 | 0.06 | +0.02 | buy |